Synthesis of dexrazoxane analogues and iron chelators

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Iron chelating agents have been long used to the treatment of the iron overload diseases. However, in recent years they have also been thouroughly studied for their other effects such as antiproliferative, cardio- and neuro-protective activities. Our research group has been engaged in a development of aroylhydrazone chelators as cardioprotective and antiproliferative agents. In the field of cardioprotection we also synthesize derivatives of dexrazoxane and its metabolite ADR-925.

 

Member of Charles University Research Centre (UNCE 204019/304019/2012)

Centre for the Study of Toxic and Protective Effects of Drugs on Cardiovascular System

 

NEWS

11. 5. 2017 - Jan Kubeš won the first prize of ZENTIVA company in Chemistry at the 16th International Pharmacy Student Research Conference

        

19. 4. 2017 - Jan Kubeš (on the left) won the first prize in Chemistry at the 25th Pharmacy Student Research Conference

© 2017 Charles University, Faculty of Pharmacy in Hradec Králové, Akademika Heyrovského 1203, 500 05 Hradec Králové, Czech Republic

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