Research

  • Study of Phase I and Phase II enzymes metabolizing drugs and other xenobiotics (cytochromes P450 - CYP1A, 2B, 2C, 2D6, 2E1, 3A; flavine monooxygenases; carbonyl reducing enzymes; glutathione S-transferases; UDP-glucuronosyl transferases…)
  • Study of enzymes of oxidative stress (peroxidase, glutathione peroxidase, catalase, superoxide dismutase, thioredoxin reductase…)
  • In
    • human
    • farm animals and free living animals
    • laboratory animals
    • tumor cell lines
    • hepatocytes
    • parasiting helminths
    • plants
  • Activities and properties of these enzymes
  • Their modulation (induction, inhibition) by drugs, dietary supplements and environmental contaminants
  • Identification of metabolites of xenobiotics
  • Pharmacokinetics of drugs in target animal species
  • Influence of flavonoids and isoprenoids on effectiveness of anticancer drugs

hepatocytes isolation

in the laboratory

 

© 2017 Charles University, Faculty of Pharmacy in Hradec Králové, Akademika Heyrovského 1203, 500 05 Hradec Králové, Czech Republic

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