Design and Development of New Antimicrobial Agents

logo-group.jpg Group Leader: Prof. PharmDr. Martin Doležal, Ph.D.

  • Synthesis and biological evaluation of new antibacterial derivatives, mainly those based on pyrazine and similar heterocycles
  • Evaluation of antimycobacterial activity against M. tuberculosis H37Rv and non-tuberculous mycobacteria (M. avium, M. kansasii, M. smegmatis, M. aurum)
  • Evaluation of antibacterial activity against selected G+ and G- bacterial pathogens, including drug-resistant strains
  • Evaluation of antifungal activity against selected fungi and yeasts
  • Determination of photosynthesis inhibitory activity of pyrazine derivatives (with potential use as herbicides)
  • Pyrazine derivatives as abiotic elicitors (i.e. compounds capable of promoting synthesis of selected secondary metabolites in plants)
  • Synthesis and evaluation of reactivators and inhibitors of cholinesterases

© 2017 Charles University, Faculty of Pharmacy in Hradec Králové, Akademika Heyrovského 1203, 500 05 Hradec Králové, Czech Republic

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