Prof. PharmDr. Martin Doležal, Ph.D.

Faculty of Pharmacy in Hradec Králové, Department of Pharmaceutical Chemistry and Drug Control,
Heyrovskeho 1203, Hradec Kralove 500 05, Czech Republic

Head of Pharmaceutical Chemistry Group

email: martin.dolezal@faf.cuni.cz

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Education

1979-84 - Faculty of Pharmacy in Hradec Kralove, Charles University in Prague, 1986 - PharmDr.; 1997 - Ph.D.-Thesis - Ring substituted pyrazinecarboxylic acid derivatives as potential antituberculotics and antimycotics (supervisor: Assoc. Prof. RNDr. Jiří Hartl, CSc.)
Employment: Charles University in Prague, Faculty of Pharmacy in Hradec Kralove, Department of Pharmaceutical Chemistry and Pharmaceutical Analysis, Heyrovskeho 1203, Hradec Kralove 500 05, Czech Republic, 2002 – Assoc. Prof., 2011 – Professor in the field of Pharmaceutical Chemistry at the Charles University in Prague

Administrative duties

Head of Department of Pharmaceutical Chemistry and Pharmaceutical Analysis (2015-), member of Senate, Charles University in Prague, member of Committee for economy (2003-2015)

Membership

Czech Pharmaceutical Society (1985-), member of Committee (2005-), vice-president (2011-2014), president (2015-)
Editorial board: Prakticke Lekarenstvi (2005-)

Scientific Boards

Head of the Committee for Pharmaceutical Chemistry (2006-), member of committees (Control of Chemical Drugs, Bioorganic Chemistry) for post-graduate study;

Professional and research activities

Investigation of relationships between the chemical structure and biological activity of pyrazinecarboxylic acid derivatives as potential antituberculotics and antimycotics. Rational design and synthesis of novel potential therapeutic agents (non-steroidal antileucotrienics). Study of inhibition of photosynthetic electron transport in spinach chloroplasts in substituted amides of pyrazinecarboxylic acid. Design and synthesis of elicitors derived from pyrazine. Synthesis and evaluation of reactivators of inhibited acetylcholinesterase.
Author of 94 original papers (75 in the journals with impact factor), 24 reviews (11 in the journals with impact factor), more than 200 posters and 60 plenary or short lectures at symposia in the Czech Republic and world congresses abroad. Author (2 textbooks, 2 chapters) or co-author of 6 manual scripts and 11 grant projects.

Web of Science (July 2016)

  • results found: 86
  • Sum of the Times Cited: 1213
  • Citing Articles without self-citations: 547
  • h-index: 21

 

Dolezal1.jpg Dolezal2.png Dolezal3.jpg

Teaching activities

Lecturer and guarantor for the subjects Pharmaceutical chemistry and Technology of synthetic drugs, Chemical Drugs, Synthetic Drugs; supervisor of diploma-students (71 works defended) and doctor's degree works (12 works defended), tutor of post-graduate students (6 works defended).

Textbooks

book1.jpgDOLEŽAL, M.; OPLETALOVÁ, V.; MILETÍN, M., ZIMČÍK, P.; KUČEROVÁ, M. Pharmaceutical chemistry of drugs affecting autonomic nervous system. (in Czech language) 1st ed., Prague, Karolinum, 2009, 139 pp. [ISBN 978-80-246-1633-9]


 

book2.jpgMartin Doležal and Katarína Kráľová (2011). Synthesis and Evaluation of Pyrazine Derivatives with Herbicidal Activity, Herbicides, Theory and Applications, Sonia Soloneski and Marcelo L. Larramendy (Ed.), ISBN: 978-953-307-975-2, InTech, Available from: Synthesis and Evaluation of Pyrazine Derivatives with Herbicidal Activity

 

book3.jpgMartin Doležal, Jan Zitko and Josef Jampílek (2012). Pyrazinecarboxylic Acid Derivatives with Antimycobacterial Activity, Understanding Tuberculosis - New Approaches to Fighting Against Drug Resistance, Pere-Joan Cardona (Ed.), ISBN: 978-953-307-948-6, InTech, Available from: Pyrazinecarboxylic Acid Derivatives with Antimycobacterial Activity

 

Pharmaceutical chemistry of drugs affecting central nervous system. (in Czech language) 1st ed., Prague, Karolinum, 2013, 188 pp. [ISBN 978-80-246-2382-5]

© 2017 Charles University, Faculty of Pharmacy in Hradec Králové, Akademika Heyrovského 1203, 500 05 Hradec Králové, Czech Republic

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