Assoc. Prof. RNDr. Pavel Doležal, CSc.

Contant information

  • Charles University in Prague, Faculty of Pharmacy in Hradec Králové, Department of Pharmaceutical Technology, Heyrovského 1203, 500 05 Hradec Králové, Czech Republic
  • email: dolezal@faf.cuni.cz
  • phone: +420 495 518 002
  • fax: +420 495 518 002

Previous Education and Employment

  • 2002 Associate Professor in Pharmaceutical Technology, Faculty of Pharmacy in Hradec Králové
  • 1984 CSc. degree, ibid.
  • 1979 RNDr. degree, ibid.
  • 1997 University teacher ibid.
  • 1977 graduated pharmacist, ibid.

Research Interests

  • Dosage forms
  • Drug release and permeation of drug through biological membranes (dermal, pulmonary, rectal, sublingual)
  • Nanodispersion systems, nanofiber drug carriers

Professional Memberships

  • Since 2007 member of the American Chemical Society, Colloid and Surface, Chemistry Section
  • since 2002 Member of the Pharmaceutical Technology Section of Pharmacopoeia Board of the Ministry of Health of the Czech Republic
  • Since 2004 member of the European Association of Pharma Biotechnology
  • Since 2003 member of the European Federation of Biotechnology
  • Since 1991 - member of the Czech Pharmaceutical Society of JEP

Teaching

  • Since 2011  Chair of Subject-Area Board of Postgraduate Doctoral Studies in Pharmaceutical Technology
  • Since 2008 Guarantor of the subjects Pharmaceutical Technology, Cosmetology for Pharmacists, Industrial Production of Pharmaceutical Preparations
  • 2008 – 2011 Chair of Board of Rigorosal Studies in Pharmaceutical Technology
  • Since 2004 –Advisor of Rigorosal Degree Thesis (6 thesis defended)
  • Since 2004 Lecturer of Pharm. Technology at Qualified Persons Courses at
  • Institute of Postgraduate Education in HealthCare, Prague
  • Since 2000  Member of Scholarly Board of the Faculty of Pharmacy
  • 2000 – 2011 Head of the Department of Pharmaceutical Technology
  • Since 2000  Examiner´s Committee Member of the State Final Examination in Pharmacy
  • Since 1996 – Supervisor of Post-Graduate students (4 thesis defended
  • Since 1994 Member of Subject-Area Board of Pharmaceutical Technology)
  • Since 1991 – Lecturer and examiner in Pharmaceutical Technology, 
  • Cosmetology for Pharmacists , and Industrial Production of Pharmaceutical Preparations
  • Since 1985 – Advisor of Diploma Thesis (more than 100 diploma thesis students has defended)
  • Since 1978 – Tutor of Practical Training and Seminary Tutor in Pharmaceutical Technology

Grants Received

Research Grants

  1. MPO project FR-TI1/436 - "Use of nanofiber membranes for the controlled release of active substances". Pharmaceutical part of the project. Principal investigator: Ing. Denisa Stránská, Elmarco Liberec. 2009 - 2012.
  2. Project MSM 0021620822 "Research of drug structures" Coordination of pharmaceutical-technological part of the roject. Principal investigator and director: Prof. RNDr. Rolf Karlíček, DrSc., Charles University in Prague, Faculty of Pharmacy in Hradec Králové. 2005 - 2011.
  3. MPO project FT-TA2/012 "Modulators transdermal permeation". Pharmaceutical-technological part of the project. Recipient: Ing. Michael Bartoš, VÚOS Pardubice VÚOS Pardubice/Fac. Pharm. Hradec Králové/Dep. Pharm. Technol. 2006 - 2008.
  4. MPO project 2A-1TP1/015 "New procedures and formulation of microdispersed nanodispersed lipid systems as transport systems of pharmacologically active substances". Pharmaceutical-technological part of the Project. Principal investigator: Dr. Jan Mikeska, PhD. Biomedica Prague / Dep. Pharm. Tech., Faculty of  Pharmacy in Hradec Králové. 2007 - 2008.
  5. GAČR project 203/95/0602 "Salts of carbamic acids as transdermal penetration enhancers". Principal investigator 1995 -1998.
  6. Project MO AČR 114/3/93. "Transdermal administration of antidotes OFI".Principal investigator: 1993 - 1996.

Main Education Grant

Developmental Project MSMT 432 and Developmental Project MSMT 567„Harmonization of Doctoral Studies in Advanced Drug Delivery".Principal investigator 2005, 2006, 2007.

Awards/Prizes

Gold Medal, Brussels Eureka Expo '97 (Belgium) for the „Transdermal permeation accelerant Transkarbam 12“.

Publications

  • Number of papers: 23
  • Number of citation: 224 (without autocitation)
  • H index: 12
  • Number of patents: 12

The most important publications in the last 3 years

VRBATA, P., BERKA, P.,  STRÁNSKÁ, D., DOLEŽAL, P., MUSILOVÁ, M., ČIŽINSKÁ, L. Electrospun drug loaded membranes for sublingual administration of sumatriptan and naproxen. Int. J. Pharm., 2013, 457, 168-176

VRBATA, P., BERKA, P.,  STRÁNSKÁ, D., DOLEŽAL, P., LÁZNÍČEK, M. Electrospinning of diosmin from aqueous solutions for improved dissolution and oral absorption. Int. J. Pharm. 2014, 473, 407-413.

The most important 5 patents:
1. Stránská D, Klabanová A, Doležal P, Vrbata P, Berka P, Musilová M: A carrier for oromucosal, especially sublingual administration of physiologically active substances, especially drugs. PCT/WO CZ 2011/000116 (2011)

2. Vávrová K, Doležal P, Hrabálek A: Pseudoceramides and pharmaceutical and / or cosmetic compositions designed for administration to the skin containing the same. WO 2007/147370 A2. (2007)

3. Hrabálek A, Doležal P, Farsa O, Krebs A, Kroutil A, Roman M, Šklubalová Z: ε-amino acid derivatives, processes of their preparation and use. U.S. Pat 6,187,938 (2001), Eur. Pat 0,973,710 B1 (2002)

4.  Doležal P, Vachek J, Hrabálek A, Formánek J, Doležalová J.: Pharmaceutical composition for prophylactic and / or therapeutic transdermal administration of cholinesterase reactivators. CZ Pat. 282,476 (1997); Implemented in Czech Army, Special Chemical Troops as the preparation „Transant“.

5. Doležal P, Klimeš J, Sochor J, Korner J; Transdermal therapeutic system. CZ. Pat. 261,105 (1989)
 

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