PharmDr. Anna Hošťálková, Ph.D.

Research focus

  • isolation of secondary metabolites from the family Amaryllidaceae, Berberidaceae, Magnoliaceae (isolation, analysis, structural identification)
  • in vitro biological activities of isolated compounds (AChE, BuChE, POP and cytotoxicity)


  • 2004-2009 Charles University in Prague, Faculty of Pharmacy, (Master degree), Thesis: Pyrazine derivatives as potential drugs III.
  • 2009-2015 Charles University in Prague, Faculty of Pharmacy, (Ph.D. degree), Dissertation: Study of Chemical Constituents of Taxons from Order Laurales and Ranunculales with Potential Neuroprotective Activity.

Current position

  • an assistant at the Department of Pharmaceutical Botany and Ecology, Charles University in Prague, Faculty of Pharmacy in Hradec Králové


  • Dietary supplements – Nutraceuticals
  • Pharmaceutical Botany (practises)


Monographs (and chapters)


MACÁKOVÁ, K., KOLEČKÁŘ, V., CAHLÍKOVÁ, L., CHLEBEK, J., HOŠŤÁLKOVÁ, A., KUČA, K., JUN, D., OPLETAL, L.: Tannins and their influence on health. Recent Advances in Medicinal Chemistry. Bentham Science Publishers 1, 159-208 (2014).

CAHLÍKOVÁ, L., MACÁKOVÁ, K., BENEŠOVÁ, N., CHLEBEK, J., HOŠŤÁLKOVÁ, A., OPLETAL, L.: Natural compounds (small molecules) as potential and real drugs of Alzehimers disease: A critical review, in: Studies in natural products chemistry (ATTA-ur-RAHMAN, ed.), Chapter 6, Elsevier: Amsterdam 2014, pp. 153-194, ISBN: 978-0-444-63281-4.

Original papers


VANĚČKOVÁ, N., HOŠŤÁLKOVÁ, A., ŠAFRATOVÁ, M., KUNEŠ, J., HULCOVÁ, D., HRABINOVÁ, H., DOSKOČIL, I., ŠTĚPÁNKOVÁ, Š., OPLETAL, L., NOVÁKOVÁ, L., JUN, D., CHLEBEK, J., CAHLÍKOVÁ, L.: Alkaloids from Nerine bowdenii W. Watson (Amaryllidaceae) and their biological activity. RSC Advances 6, 80114-80120 (2016).

HROCH, M., HAVELEK, R., CAHLÍKOVÁ, L., HOŠŤÁLKOVÁ, A., HULCOVÁ, D., CERMANOVÁ, J., MIČUDA, S.: LC-MS/MS method for determination of haemanthamine in rat plasma, bile and urine: application to a pilot pharmacokinetic study. Biomed. Chrom. 30, 1083-1091 (2016).

CHLEBEK, J., DOSKOČIL, I., HULCOVÁ, D., BREITEROVÁ, K., ŠAFRATOVÁ, M., HAVELEK, R., HABARTOVÁ, K., HOŠŤÁLKOVÁ, A., VOLŠTÁTOVÁ, T., CAHLÍKOVÁ, L.: Cytotoxicity of naturally occurring isoquinoline alkaloids of different structural types. Nat. Prod. Commun11, 753-756 (2016).

CHLEBEK, J., NOVÁK, Z., KASSEMOVÁ, D., ŠAFRATOVÁ, M., KOSTELNÍK, J., MALÝ, L., LOČÁREK, M., OPLETAL, L., HOŠŤÁLKOVÁ, A., HRABINOVÁ, M., KUNEŠ, J., NOVOTNÁ, P., URBANOVÁ, M., NOVÁKOVÁ, L., MACÁKOVÁ, K., HULCOVÁ, D., SOLICH, P., MARTÍN, C.P., JUN, D., CAHLÍKOVÁ, L..: Isoquinoline alkaloids from Fumaria officinalis L. and their biological activities related to Alzheimer’s disease. Chem. Biodivers. 13, 91-99 (2016).

CHLEBEK, J., DE SIMONE, A., HOŠŤÁLKOVÁ, A., OPLETAL, L., PERÉZ, C., PERÉZ, D.I., HAVLÍKOVÁ, L., CAHLÍKOVÁ, L., ANDRISANO, V.: Application of BACE1 immobilized enzyme reactor for the characterization of multifunctional alkaloids from Corydalis cava (Fumariaceae) as Alzheimer’s disease targets. Fitoterapia 109, 241-247 (2016).


ZEMANOVA, L., HOFMAN, J., NOVOTNA, E., MUSILEK, K., LUNDOVA, T., HAVRANKOVA, J., HOSTALKOVA, A., CHLEBEK, J., CAHLIKOVA, L., WSOL, V.: Flavones inhibit the activity of AKR1B10, a promising therapeutic target for cancer treatment. J. Nat. Prod. 78, 2666-2674 (2015).

NOVÁK, Z., HOŠŤÁLKOVÁ, A., OPLETAL, L., NOVÁKOVÁ, L., HRABINOVÁ, M., KUNEŠ, J., CAHLÍKOVÁ, L.: (+)-Chenabinol (revised NMR data) and two new alkaloids from Berberis vulgaris L. and their biological activity. Nat. Prod. Commun. 10, 1695-1697 (2015). 

LOČÁREK, M., NOVÁKOVÁ, J., KLOUČEK, P., HOŠŤÁLKOVÁ, A., KOKOŠKA, L., GÁBRLOVÁ, L., ŠAFRATOVÁ, M., OPLETAL, L., CAHLÍKOVÁ, L.: Antifungal and antibacterial activity of extracts and alkaloids of selected Amaryllidaceae species. Nat. Prod. Commun. 10, 1537-1540 (2015).

DOSKOČIL, I., HOŠŤÁLKOVÁ, A., ŠAFRATOVÁ, M., BENEŠOVÁ, N., HAVLÍK, J., HAVELEK, R., KUNEŠ, J., KRÁLOVEC, K., CHLEBEK, J., CAHLÍKOVÁ, L.: Cytotoxic activities of Amaryllidaceae alkaloids against gastrointestinal cancer cells. Phytochem. Lett. 13, 394-398 (2015).

CAHLÍKOVÁ, L., PÉREZ, D.I., ŠTĚPÁNKOVÁ, Š, CHLEBEK, J., ŠAFRATOVÁ, M., HOŠŤÁLKOVÁ, A., OPLETAL, L.: In vitro inhibitory effects of 8-O-demethylmaritidine and undulatine on acetylcholinesterase, and their predicted penetration across the blood-brain barrier. J. Nat. Prod. 78, 1189-1192 (2015).

HOŠŤÁLKOVÁ, A., OPLETAL, L., KUNEŠ, J., NOVÁK, Z., HRABINOVÁ, M., CHLEBEK, J., CAHLÍKOVÁ, L.: Alkaloids from Peumus boldus Mol. and their acetylcholinesterase, butyrylcholinesterase and prolyl oligopeptidase inhibition activity. Nat.. Prod. Commun. 10, 577-580 (2015).

CAHLÍKOVÁ, L., HULOVÁ, L., HRABINOVÁ, M., CHLEBEK, J., HOŠŤÁLKOVÁ, A., ADAMCOVÁ, M., ŠAFRATOVÁ, M., JUN, D., OPLETAL, L., LOČÁREK, M., MACÁKOVÁ, K.: Isoquinoline alkaloids as potential prolyl oligopeptidase inhibitors. Fitoterapia 103, 192-196 (2015).


OPLETAL, L., LOČÁREK, M., FRAŇKOVÁ, A., CHLEBEK, J., ŠMÍD, J., HOŠŤÁLKOVÁ, A., ŠAFRATOVÁ, M., HULCOVÁ, D., KLOUČEK P., ROZKOT, M., CAHLÍKOVÁ, L.: Antimicrobial activity of extracts and isoquinoline alkaloids of selected Papaveraceae plants. Nat. Prod. Commun. 9, 1709-1712 (2014).

ŠKARYDOVÁ, L., HOFMAN, J., CHLEBEK, J., HAVRÁNKOVÁ, J., KOŠANOVÁ, K., SKARKA, A., HOŠŤÁLKOVÁ, A., PLUCHA, T., CAHLÍKOVÁ, L., WSÓL, V.: Isoquinoline alkaloids as a novel type of AKR1C3 inhibitors. J. Steroid Biochem. Mol. Biol. 143, 250-258 (2014).


HOŠŤÁLKOVÁ, A., NOVÁK, Z., POUR, M., JIROŠOVÁ, A., OPLETAL, L., KUNEŠ, J., CAHLÍKOVÁ, L.: Berbanine: a new isoquinoline alkaloid from Berberis vulgaris (Berberidaceae). Nat. Prod. Commun. 8, 441-442 (2013).

HOŠŤÁLKOVÁ, A., KLINGELHöFER, I., MORLOCK, G. E.: Comparison of an HPTLC method with the Reflectoquant® assay for fast 5-hydroxymethylfurfural determination in honey. Anal. Bioanal. Chem. 405, 9207-9218 (2013).


CAHLÍKOVÁ, L., KUČERA, R., HOŠŤÁLKOVÁ, A., KLIMEŠ, J., OPLETAL, L.: Identification of pavinane alkaloids in the genera Argemone and Eschscholzia by GC-MS. Nat. Prod. Commun. 7, 1279-1281 (2012).


CAHLÍKOVÁ, L., ZAVADIL, S. MACÁKOVÁ, K., VALTEROVÁ, I., KULHÁNKOVÁ, A., HOŠŤÁLKOVÁ, A., KUNEŠ, J., OPLETAL, L.: Isolation and cholinesterase activity of Amaryllidaceae alkaloids from Nerine bowdenii. Nat. Prod. Commun. 6, 1827-1830 (2011).


CAHLÍKOVÁ, L., OPLETAL, L., KURFÜRST, M., MACÁKOVÁ, K., KULHÁNKOVÁ, A., HOŠŤÁLKOVÁ, A.: Acetylcholinesterase and butyrylcholinesterase inhibitory compounds from Chelidonium majus (Papaveraceae). Nat. Prod. Commun. 5, 1751-1754 (2010).



HOŠŤÁLKOVÁ, A., SIATKA, T., CHLEBEK, J., OPLETAL, L., DRAŠAR, P., CAHLÍKOVÁ, L.: Boldinové alkaloidy a perspektivity jejich využití. Chem. listy 109, 846-855 (2015).


OPLETAL, L., CHLEBEK, J., MACÁKOVÁ, K., BENEŠOVÁ, N., HOŠŤÁLKOVÁ, A., CAHLÍKOVÁ, L.: Antioxidanty a degenerativní onemocnění. Prakt. Lékáren. 9, 135-138 (2013).


CAHLÍKOVÁ, L., MACÁKOVÁ, K., CHLEBEK, J., HOŠŤÁLKOVÁ, A., KULHÁNKOVÁ, A., OPLETAL, L.: Ecdysterone and its activity on some degenerative diseases. Nat. Prod. Commun. 6, 707-718 (2011).

© 2017 Charles University, Faculty of Pharmacy in Hradec Králové, Akademika Heyrovského 1203, 500 05 Hradec Králové, Czech Republic

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