Prof. Radomír Hrdina, MD., Ph.D.

Name, surname: Prof. Radomír Hrdina, MD., Ph.D.
Date of birth: 27. 06. 1954
Employer: Charles University in Prague, Faculty of Pharmacy in Hradec Králové, Heyrovského st. 1203, 500 05 Hradec Králové, Czech Republic

Department of Pharmacology and Toxicology
Research group of Cardiovascular and respirator pharmacology and toxicology
Laboratory of cardiovascular pharmacology

Telephone: +420 495 067 245
e-mail: hrdina@faf.cuni.cz

 

Education

1973-1979 Charles University in Prague, Faculty of Medicine in Hradec Králové, Czech Republic

Doctoral thesis, date of defence

Effects of ergot alkaloids of dihydroergotoxine group on limb and hepatic circulation”. 11.3.1985.

Habilitation thesis, date of defence

  • „Selected aspects of the cardiovascular pharmacology”. 30. 3. 1999.
  • Appointment as a senior lecturer in pharmacology at Charles University in Prague
    24. 5. 1999
  • Appointment as a professor in pharmacology at Charles University in Prague
    8. 12. 2010

Employment

  • 1979 - 1980: military service – army unit physician
  • 1980 – 1984: doctoral study in the Institute of Experimental Medicine of the Czechoslovak Academy of Sciences in Prague
  • 1985 (January - October): Charles University in Prague, Faculty of Pharmacy in Hradec Králové, Department of Pharmacology and Toxicology - lecturer
  • 1985 (November) – 1991: Institute of Experimental Biopharmacy of the Czechoslovak Academy of Sciences in Hradec Králové – scientific researcher
  • 1992 – 1999 (April): Charles University in Prague, Faculty of Pharmacy in Hradec Králové, Department of Pharmacology and Toxicology - lecturer
  • 1999 (May) –2010 (December): Charles University in Prague, Faculty of Pharmacy in Hradec Králové, Department of Pharmacology and Toxicology – senior lecturer
    2011 (January) – up till now: Charles University in Prague, Faculty of Pharmacy in Hradec Králové, Department of Pharmacology and Toxicology – professor

Research fellowships

only short-term

Principal research activity

Experimental pharmacology of the cardiovascular system

Memberships in scientific and professional organisations

  • Member of the committee for the State exams on pharmacology: 1992-2004
  • Member and chairman (from 2008) of the committee for defence of diploma thesis: 1985 – to this day
  • Member of the committee for the State final exams: 2006 – to this day
  • Member of the committee for the State rigorous exam on pharmacology and toxicology: 2001 – to this day
  • Member of the committee for the State rigorous exam on clinical pharmacy: 2001 – to this day
  • Member of the committee for the State rigorous exam on toxicology of natural products: 2001 – to this day
  • Member and chairman (from 2008) of the Committee for graduate studies in pharmacology and toxicology: 2000 –to this day
  • Member of the Committee for graduate studies in clinical pharmacy: 2000 – to this day
  • Member of the Committee for graduate studies in toxicology of natural products: 2007 – to this day
  • Member of the Committee for graduate studies in theoretical medicine disciplines and pharmacy of the Faculty of Military Health Sciences in Hradec Králové, University of Defence in Brno: 2009 – to this day
  • Member of the Committee for graduate studies in medical pharmacology of the Faculty of Medicine in Hradec Králové, Charles University in Prague: 2009 – to this day

10 important publications

Books

HRDINA, R. et al. Pharmacological dictionary. 1st edition. Prague: Maxdorf, 1997. 410 p.

HRDINA, V. and HRDINA R. (eds.). Natural toxins and poisons. 1st edition. Prague:Galén, Karolinum, 2004. 302 p.

Original papers


HRDINA, R., GERŠL, V., VÁVROVÁ, J., HOLEČKOVÁ, M., PALIČKA, V., VOGLOVÁ, J., MAZUROVÁ, Y. and BAJGAR, J. Myocardial elements content and cardiac function after repeated i.v. administration of DMPS in rabbits. Hum Exp Toxicol, 1998, vol. 17, no. 4, p. 221-224 (1,301)

ADAMCOVÁ, M., GERŠL, V., HRDINA, R., MĚLKA, M., MAZUROVÁ, Y., VÁVROVÁ, J., PALIČKA, V. and KOKŠTEIN, Z. Cardiac troponin T as a marker of myocardial damage caused by antineoplastic drugs in rabbits. J Cancer Res Clin 1999, vol. 125, no. 5, p. 267-274 (2,194)

ŠIMŮNEK, T., BOER, CH., BOUWMAN, R. A., VLASBLOM, R., VERSTEILEN A.M.G., ŠTĚRBA, M., GERŠL, V., HRDINA, R., POŇKA, P., DE LANGE, J. J., PAULUS, W.J. and MUSTERS, R.J.P. SIH – a novel lipophilic iron chelator – protects H9c2 cardiomyoblasts from oxidative stress-induced mitochondrial injury and cell death. J Mol Cell Cardiol, 2005, vol. 39, no. 2, p. 345-354 (3,872)

MLADĚNKA, P., KALINOWSKI D. S., HAŠKOVÁ, P., BOBROVOVÁ, Z., HRDINA, R., ŠIMŮNEK, T., NACHTIGAL, P., SEMECKÝ, V., VÁVROVÁ, J., HOLEČKOVÁ, M., PALICKA, V., MazurovÁ, Y. , JANSSON, P. J. and RICHARDSON D. R. The novel iron chelator, 2-yridylcardoxaldehyde 2-thiophenecarboxyl hydrazone, reduces cetacholamine-mediated myocardial toxicity.Chem Res Toxicol 2009, vol. 22: p. 208-17 (3.508)

MLADĚNKA P, MACÁKOVÁ K, ZATLOUKALOVÁ L, ŘEHÁKOVÁ Z, SINGH BK, PRASAD AK, PARMAR VS, JAHODÁŘ L, HRDINA R and SASO L. In vitro interactions of coumarins with iron. Biochimie 2010, vol. 92, no. 9:p.1108-14 (3.897)

FILIPSKÝ T, MLADĚNKA P, MACÁKOVÁ K, HRDINA R, SASO L, MARCHETTI F, and PETTINARI C. In vitro characteristics of 1-phenyl-3-methyl-4-acylpyrazol-5-ones iron chelators. Biochemie 2012, vol.94: p.125-131 (3.787)

Reviews

HRDINA, R., GERŠL, V., KLIMTOVÁ, I., ŠIMŮNEK, T., MACHÁČKOVÁ, J. and ADAMCOVÁ, M. Anthracycline-induced cardiotoxicity. Acta Med (Hradec Králové), 2000, vol. 43, no. 3, p. 75-82

MLADĚNKA, P., ZATLOUKALOVÁ, L., FILIPSKÝ, T. and HRDINA, R. Cardiovascular effects of flavonoids are not caused only by direct antioxidant activity. Free Radical Biol Med, 2010, vol. 49, no. 6, p. 963-75 (6.081)

Awards

The best educational book in 1997: HRDINA, R. et al. Pharmacological dictionary. 1st edition. Prague: Maxdorf, 1997. 410 p., appraised by the Committee of the Czech Society for Experimental and Clinical Pharmacology and Toxicology, a branch of the Czech Medical Association J. Ev. Purkyne.

© 2017 Charles University, Faculty of Pharmacy in Hradec Králové, Akademika Heyrovského 1203, 500 05 Hradec Králové, Czech Republic
Website information | Powered by Kentico