Prof. RNDr. Jiří Klimeš, PhD.

Department of Pharmaceutical Chemistry and Pharmaceutical Analysis, Faculty of Pharmacy
in Hradec Kralove

Head of Pharmaceutical Analysis Group

Contact information

  • Address: Department of Pharmaceutical Chemistry and Pharmaceutical Analysis, Faculty of Pharmacy in Hradec Kralove, Charles University, Heyrovskeho 1203, Hradec Kralove, 500 05, Czech Republic
  • e-mail: klimes@faf.cuni.cz
  • Tel. +420 495067409

Previous Education and Employment

2002 - 2015 - Head of Department of Pharmaceutical Chemistry and Pharmaceutical Analysis, Faculty of Pharmacy in Hradec Kralove, Charles University

2010 – Professorship Appointment Procedure in Pharmaceutical Chemistry, Faculty of Pharmacy, Veterinary and Pharmaceutical University in Brno. Appointed in 2011 for the field of Pharmaceutical Chemistry.

2009 – Habilitation in Pharmaceutical Chemistry (Assoc. Prof. degree), Faculty of Pharmacy, Veterinary and Pharmaceutical University in Brno. (Degree thesis: Pharmaceutical analytical and bioanalytical studies of pharmaceuticals using liquid chromatography.

1993 –IInd Degree Specialization Certificate in Pharmaceutical Analysis, Institute for Postgraduate Education of Physicians and Pharmacists in Prague

1988 – Habilitation (Assoc. Prof. degree) in Pharmaceutical Chemistry, Faculty of Pharmacy in Hradec Kralove, Charles University in Prague. Habilitation lecture:  Bioanalytical studies of drugs using HPLC.

1987 – Greifswald University, Pharmacy Section, Institute of Pharmaceutical Chemistry/ Pharmaceutical Analysis (1 month)

1983 – Ist Degree Specialization Certificate in Pharmaceutical Analysis, Institute for Postgraduate Education of Physicians and Pharmacists in Prague

1982 – CSc. (PhD) degree in Pharmaceutical Chemistry, Faculty of Pharmacy in Hradec Kralove, Charles University in Prague. Thesis: Utilization of HPLC in stability studies of selected sulphonamides.

1980 – Research Institute for Pharmacy and Biochemistry in Prague, professional affiliation (2 months)

1979 – State Institute for Drug Control in Prague, professional affiliation (1 month)

1976 –RNDr. degree in Pharmaceutical Chemistry, Faculty of Pharmacy in Hradec Kralove, Charles University in Prague. Thesis: Synthesis of piperazine-2,5-diones as potential antiviral agents

1975-76 – Assistant Pharmacist, District Pharmacy in Blansko.

1970-1975 Course of Studies at the Faculty of Pharmacy in Hradec Kralove, Charles University in Prague.  (MSc. degree)

Research Interests

  • Progressive methods in liquid chromatography and their use in pharmaceutical-analytical studies of drugs and other biologically active substances.
  • Analytical studies connected with the research and development of new pharmaceuticals.
  • Bioanalytical studies of potential new drugs, including modern techniques of adjustment of biological samples prior to analysis.
  • Stability studies of active pharmaceutical ingredients and new drug products.
  • Simulation of natural degradation of drug residues in surface water.

Teaching

  • Lectures in the subject Pharmaceutical Analysis I. and Pharmaceutical Analysis II.
  • Concept of the subject Therapeutic Drug Monitoring, which is taught at the Faculty of Pharmacy, CU, since 1993 and contributes to biologization of the field of Pharmaceutical Analysis.
  • Chair, Committee for the Complex State Final Exam in the study programme of Pharmacy.
  • Chair, Committee for examination procedure in the field of Pharmaceutical Analysis (for obtaining PharmDr. degree).
  • Concept of the doctoral study programme Pharmaceutical Analysis (for obtaining Ph.D. degree).
  • Supervisor of 13 postgraduate students in the doctoral study programme, 9 of which have successfully defended their doctoral theses.
  • Principal author of 5 university textbooks in Pharmaceutical Analysis.
  • Principal author of the monograph “Control-analytical evaluation of drugs using pharmacopoeial methods”, Nucleus, 2011 (ISBN 978-80-87009-29-1)

Professional Memberships

  • Member, Scientific Board, Faculty of Pharmacy, Charles University.
  • Chair, Specialist Board of the doctoral study programme Pharmaceutical Analysis, Faculty of Pharmacy, Charles University.
  • Member, Specialist Boards of the doctoral study programme Pharmaceutical Chemistry, Pharmaceutical Technology, and Bioanalytical Chemistry, Faculty of Pharmacy, Charles University.
  • Member, Specialist Board of the doctoral study programme Pharmaceutical Chemistry, Faculty of Pharmacy, Veterinary and Pharmaceutical University in Brno.
  • Chair, Section for Pharmaceutical Control and Bioanalytics of the Czech Pharmaceutical Society.
  • Member, Examination Board of the Committee of the Ministry of Health of the Czech Republic for the field of Pharmaceutical Analysis for Approval Examinations of Foreigners in Pharmacy.
  • Chair, Accreditation Committee of the Ministry of Health of the Czech Republic for the field of specialization education in Pharmaceutical Control.

Grants Received

2013: Ministry of Education, Youth and Sports: Innovation and development of laboratory for practical training in the field of pharmaceutical analysis and drug bioanalysis (577/2013).

2005-2011:  Ministry of Education, Youth and Sports: Institutional research plan “Research of novel drug structures” (MSM0021620822), Coordinator Prof. Karlíček (J. Klimeš – Head of the Research Team of the Department of Pharmaceutical Chemistry and Drug Control).

2005-2007: Ministry of Industry and Trade: programme TANDEM, FT-TA2/012 “Modulators of skin barrier function and their use in the drug development”, Coordinator Ing. Bartoš (J. Klimeš – Head of the Research Team of the Section of Drug Control, Department of Pharmaceutical Chemistry and Drug Control).

2000 –2007: Ministry of Education, Youth and Sports: Development Project 6c,

 “Transformation, development, evaluation of quality and success of the doctoral study programme in the field of Drug Control and Pharmaceutical Analysis”.

2006: Investment grant project FRVŠ: “Innovation of the laboratory for practical training in pharmaceutical-analytical instrumental methods” (668/2006Aa).

2000 – 2002: Grant Agency of Charles University: “Determination of Lipophilicity of Potential Antituberculous Drugs by Reversed-Phase High Performance Liquid Chromatography“(237/2000/B-CH/FaF).

1999-2004: Ministry of Education, Youth and Sports: Institutional research plan “Development, preparation and technology of pharmaceuticals” (MSM 111600001), Coordinator Prof. Karlíček (J.Klimeš - Head of the Research Team of the Department of Pharmaceutical Chemistry and Drug Control).

1996-1998: Grant Agency of Charles University: “Pharmaceutical analytical studies of pharmaceuticals using liquid chromatography” (131/1996/C/FaF).

1995: grant project FRVŠ:  “Therapeutical Drug Monitoring” ( 0607/07/95).

1986-1990: Project of the State Plan of Technical Development (P12/335/822/01) “Evaluation and standardization of medicinal drugs”, Coordinator Prof. Elis (J. Klimeš – Head of the Research Team of the Section of Drug Control, Department of Pharmaceutical Chemistry and Drug Control).

Other: supervisor of 3 student Charles University projects, supervisor of 3 student  FRVŠ projects

Awards

1989 - Award of the Dean of the Faculty of Pharmacy, Charles University, for a significant contribution to the development of the Faculty.

2011- Award of the Dean of the Faculty of Pharmacy, Veterinary and Pharmaceutical University in Brno, for the development of cooperation and contribution to the Faculty. Commemorative Plaque on the occasion of the 20th anniversary of the foundation of the Faculty of Pharmacy, Veterinary and Pharmaceutical University in Brno.

Publications

Author and co-author of 117 publications, 83 of them in impact scientific journals

Author and co-author of 3 Czech patents

Principal author of 1 monograph

498 citations, H- index 13

© 2017 Charles University, Faculty of Pharmacy in Hradec Králové, Akademika Heyrovského 1203, 500 05 Hradec Králové, Czech Republic
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