Mgr. Martin Krátký, Ph.D.

Contact information:

Address:
Department of Inorganic and Organic Chemistry, Charles University in Prague, Faculty of Pharmacy in Hradec Králové, Heyrovského 1203, CZ- 50005 Hradec Králové, the Czech Republic

E-mail:
martin.kratky@faf.cuni.cz

Education

Doctoral Studies

       Charles University in Prague, Faculty of Pharmacy, subject of study: Bioorganic Chemistry (Ph.D. degree obtained in February 2012) – Department of Inorganic and Organic Chemistry, supervisor: Prof. RNDr. Jarmila Vinšová, Ph.D., title of the thesis: Design and synthesis of compounds active especially against multidrug-resistant mycobacterial strains

University

  • Charles University in Prague, Faculty of Pharmacy, subject of study: Pharmacy, final state exam in 2008 (summa cum laude) – master degree (Mgr., equivalent to MSc.)
  • University of Hradec Králové, Faculty of Education, subject of study: Upbringing and Education, Social Pedagogy Specialized in Ethopedy, final state exam in 2009 (summa cum laude) – master degree (Mgr.)
  • University of Hradec Králové, Faculty of Education, subject of study: Teacher of Secondary School, final state exam in 2010 – certificate in lifelong learning

Secondary School

  • Grammar School in Lanškroun, maturita (leaving) exam in 2003 (summa cum laude)

Professional qualifications and skills, professional membership

Teaching Qualification

  • Driving Licence
  • Computer Skills: advanced user
  • Language Skills: English (intermediate), German (intermediate), Latin (professional Latin)
  • Member of Czech Chemical Society (from 2009)
  • Training course in the interpretation of IR spectra (2009, 1 weak, organizer – Czech Spectroscopic Society)
  • Training course in the organocatalysis (2011, 1 weak, organizer – Zentiva company, prof. Pavel Kočovský)
  • Main investigator of the Charles University Grant No. 27610/2010 Synthesis of novel salicylanilide prodrugs with potential antibacterial and antifungal activity (2010-2012)
  • Co-investigator of the Grant for the Development of Universities No. 665/G6 Synthesis of antimicrobial active benzanilide/salicylanilide derivatives (2012)
  • Co-investigator of the Charles University Grant No. 76807/2007 Modeling and synthesis of prodrugs of tuberculosis active compounds (2007-2009)

Interests

Research

  • Salicylanilides, their biological activities and modifications; drugs and prodrugs active against tuberculosis, bacteria and fungi

Personal

  • Scouting, self-education, botany, history, hiking, paddling

Work experience

  • Exchange scholarship at the Research Group of Peptide Chemistry, Eötvös Loránd University and Hungarian Academy of Science, Budapest, supervisor: Assoc. Prof. Szilvia Bösze, Ph.D. – 9/2013-12/2013
  • Postdoc fellow at the Department of Inorganic and Organic Chemistry, Faculty of Pharmacy in Hradec Králové, Charles University – from 2012 till today
  • Teaching of pregradual students at the Department of Inorganic and Organic Chemistry, Faculty of Pharmacy in Hradec Králové (subjects Laboratory Technique and Organic and Bioorganic Chemistry – laboratory training) – from 2008 till today
  • Researcher at the Department of Inorganic and Organic Chemistry, Faculty of Pharmacy in Hradec Králové – 2011 (full-time job) and from 2013 (part-time job)
  • Teaching of pregradual students at the Department of Chemistry, Faculty of Natural Sciences, University of Hradec Králové (subject Organic Chemistry) – 2012
  • Free time education and upbringing – different institutions, from 2002 till today (pedagogue, economist, medic)

List of publications

  1. Vinšová J., Imramovský A., Krátký M., Férriz J. M., Palát K., Lyčka A., Růžička A. Unprecedented rearrangement of salicylanilide derivatives: imidazolinone intermediate formation. Tetrahedron Lett., 2010, 51, 23-26. [ISSN 0040-4039, IF2009 = 2.618]
  2. Krátký, M.; Vinšová, J. Pokroky ve vývoji antituberkulotik působících na multilékově resistentní kmeny. Chem. Listy 2010, 104, 998-1005 [ISSN 0009-2770, IF2010 = 0.620]
  3. Vinšová J., Krátký M. Tuberculosis – The Development of New MDR-TB Drugs (chapter in the book Drug-Resistant Tuberculosis). Nova Science Publishers, 2009, ISBN 978-1-60876-055-8.
  4. Vinšová J., Krátký M. Development of New MDR-TB Drugs. Nova Biomedical. New York 2010. ISBN 978-1-6168-233-0
  5. Imramovský A., Férriz J. M., Pauk K., Krátký M., Vinšová J. A Synthetic Route for the Preparation of a Synthetic Route for the Preparation of 2-Hydroxy-N-[1-(2-hydroxyphenylamino)-1-oxoalkan-2-yl]benzamides. J. Comb. Chem. 2010, 12, 414-416 [ISSN: 1520-4766, IF2010 = 3.125]
  6. Krátký M., Vinšová J., Buchta V., Horvati K., Bösze S., Stolaříková J. New amino acid esters of salicylanilides active against MDR-TB and others microbes. Eur. J. Med. Chem. 2010, 45, 6106-6113 [ISSN 0223-5234, IF2010 = 3.193]
  7. Krátký M., Vinšová J. Antiviral Activity of Substituted Salicylanilides – a Review. Mini Rev. Med. Chem. 2011, 11, 956-967 [ISSN: 1389-5575, IF2010 = 2.622]
  8. Krátký M., Vinšová J. Salicylanilide Ester Prodrugs as Potential Antimicrobial Agents – a Review. Curr. Pharm. Des. 2011, 17, 3494-3505 [ISSN 1381-6128, IF2010 = 4.774]
  9. Krátký M., Vinšová J., Buchta V. In vitro Antibacterial and Antifungal Activity of Salicylanilide Pyrazine-2-carboxylates. Med. Chem. 2012, 8, 732-741 [ISSN 1573-4064, IF2012 = 1.373]
  10. Krátký M., Vinšová J., Rodriguez N.G., Stolaříková J: Antimycobacterial Activity of Salicylanilide Benzenesulfonates. Molecules 2012, 17, 492-503 [ISSN 1420-3049 IF2010 = 1.988]
  11. Krátký M., Vinšová J., Buchta V. In Vitro Antibacterial and Antifungal Activity of Salicylanilide Benzoates. 2012, The Scientific World Journal [ISSN 1537-744X, IF2012= 1.730]
  12. Krátký M., Vinšová J., Novotná E., Wsól V., Ulmann V., Stolaříková J., Fernandes S., Bhat S., Liu J. O. Salicylanilide Derivatives Block Mycobacterium tuberculosis through Inhibition of Isocitrate Lyase and Methionine Aminopeptidase. Tuberculosis 2012, 92, 434-439 [ISSN 1472-9792, IF2012 = 3.033]
  13. Krátký M., Vinšová J., Volková M., Buchta V., Trejtnar F., Stolaříková, J. Antimicrobial activity of sulfonamides containing 5-chloro-2-hydroxybenzaldehyde and 5-chloro-2-hydroxybenzoic acid scaffold. Eur. J. Med. Chem. 2012, 50, 433-440 [ISSN 0223-5234, IF2012= 3.346]
  14. Krátký M., Vinšová J. Advances in Mycobacterial Isocitrate Lyase Targeting and Inhibitors. Curr. Med. Chem. 2012, 19, 6126-6137 [ISSN 0929-8673, IF2012 = 4.070]
  15. Krátký M., Vinšová J., Stolaříková J. Antimycobacterial Assessment of Salicylanilide Benzoates including Multidrug-Resistant Tuberculosis Strains. Molecules 2012, 17, 12812-12820 [ISSN 1420-3049, IF2012 = 2.428]
  16. Krátký M., Vinšová J. Antifungal Activity of Salicylanilides and Their Esters with 4-(Trifluoromethyl)benzoic Acid. Molecules 2012, 17, 9426-9442 [ISSN 1420-3049, IF2012 = 2.428]
  17. Krátký M., Vinšová J., Novotná E., Mandíková J., Trejtnar F., Stolaříková J. Antibacterial Activity of Salicylanilide 4-(Trifluoromethyl)benzoates. Molecules 2013, 18, 3674-3688 [ISSN 1420-3049, IF2012 = 2.428]
  18. Krátký M., Vinšová J. Antimycobacterial Activity of Quaternary Pyridinium Salts and Pyridinium N-oxides – Review. Curr. Pharm. Des. 2013, 19, 1343-1355 [ISSN 1381-6128, IF2012 = 3.311]
  19. Krátký M., Vinšová J., Novotná E., Stolaříková J. Salicylanilide Pyrazinoates Inhibit in Vitro Multidrug-Resistant Mycobacterium Tuberculosis Strains, Atypical Mycobacteria and Isocitrate Lyase. Eur. J. Pharm. Sci. 2014, 53, 1-9 [ISSN 0928-0987, IF2012 = 2.987]
  20. Vinšová J., Kozic J., Krátký M., Stolaříková J., Mandíková J., Trejtnar F., Buchta, V. Salicylanilide Diethyl Phosphates: Synthesis, Antimicrobial Activity and Cytotoxicity. Bioorg. Med. Chem. 2014, 22, 728-737 [ISSN 0968-0896, IF2012 = 2.903]
  21. Rychtarčíková Z., Krátký M., Gazvoda M., Komlóová M., Polanc S., Kočevar M., Stolaříková J., Vinšová J. N-Substituted 2-isonicotinoylhydrazinecarboxamides – new anti-mycobacterial active molecules. Molecules 2014, 19, 3851-3868 [ISSN 1420-3049, IF2012 = 2.428]
  22. Krátký M., Volková M., Novotná E., Trejtnar F., Stolaříková J., Vinšová J. Synthesis and Biological Activity of New Salicylanilide N,N-Disubstituted Carbamates and Thiocarbamates. Bioorg. Med. Chem. 2014, under revision.
  23. Vinšová J., Krátký M., Komlóová M., Dadapeer E., Štěpánková Š., Vorčáková K., Stolaříková, J. Diethyl 2-(Phenylcarbamoyl)phenyl Phosphorothioates: Synthesis, Antimycobacterial Activity and Cholinesterases Inhibition. Molecules 2014, under revision.

© 2017 Charles University, Faculty of Pharmacy in Hradec Králové, Akademika Heyrovského 1203, 500 05 Hradec Králové, Czech Republic

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