PharmDr. Mgr. Martin Krátký, Ph.D.

Contact information:

Address:
Department of Organic and Bioorganic Chemistry, Charles University, Faculty of Pharmacy in Hradec Králové, Akademika Heyrovského 1203, CZ-50005 Hradec Králové, the Czech Republic

E-mail:
martin.kratky@faf.cuni.cz

Education

Doctoral Studies

Charles University in Prague, Faculty of Pharmacy, subject of study: Bioorganic Chemistry (Ph.D. degree obtained in February 2012) – Department of Inorganic and Organic Chemistry, supervisor: Prof. RNDr. Jarmila Vinšová, Ph.D., title of the thesis: Design and synthesis of compounds active especially against multidrug-resistant mycobacterial strains.

University

  • Charles University in Prague, Faculty of Pharmacy, subject of study: Pharmacy, final state exam in 2008 (summa cum laude) – master degree (Mgr., equivalent to MSc.)
  • Charles University in Prague, Faculty of Pharmacy– PharmDr. degree in Bioorganic Chemistry (2012)
  • University of Hradec Králové, Faculty of Education, subject of study: Upbringing and Education, Social Pedagogy Specialized in Ethopedy, final state exam in 2009 (summa cum laude) – master degree (Mgr.)
  • University of Hradec Králové, Faculty of Education, subject of study: Teacher of Secondary School, final state exam in 2010 – certificate in lifelong learning

Secondary School

  • Grammar School in Lanškroun, maturita (leaving) exam in 2003 (summa cum laude)

Professional qualifications and skills, professional membership

  • Teaching Qualification
  • Driving Licence
  • Computer Skills: advanced user
  • Language Skills: English (C1), German (B2), Latin (professional Latin)
  • Member of Czech Chemical Society (from 2009)
  • Training course in the interpretation of IR spectra (2009, 1 weak, organizer – Czech Spectroscopic Society)
  • Training course in the organocatalysis (2011, 1 weak, organizer – Zentiva company, prof. Pavel Kočovský)

Scientific grants

  • Main investigator of the Charles University Grant No. 27610/2010 Synthesis of novel salicylanilide prodrugs with potential antibacterial and antifungal activity (2010-2012)
  • Co-investigator of the Grant for the Development of Universities No. 665/G6 Synthesis of antimicrobial active benzanilide/salicylanilide derivatives (2012)
  • Co-investigator of the Charles University Grant No. 76807/2007 Modeling and synthesis of prodrugs of tuberculosis active compounds (2007-2009)
  • Pre-seed II UK (CZ.1.05/3.1.00/14.0299) – team member (2015)
  • main investigator of the Czech Science Foundation grant number 17-27514Y “Peptide Drug Delivery Systems Targeting Macrophages for Antimycobacterial Active Compounds“ (2017-2019)

Interests

Research

  • salicylanilides, their biological activities, mechanism of action, modifications
  • synthesis of potential drugs and prodrugs active against tuberculosis, bacteria and fungi
  • design and synthesis of potential enzyme inhibitors (InhA, cholinesterases)
  • peptide drug delivery systems for antimycobacterial agents – synthesis and investigation of their properties

Personal

  • Scouting, self-education, botany, history, hiking, paddling, andragogy, accountancy of non-profit organizations

Work experience

  • senior lecturer at the Department of Inorganic and Organic Chemistry, Faculty of Pharmacy in Hradec Králové (subjects: Laboratory Technique, General and Inorganic Chemistry, Organic Chemistry, Bioorganic Chemistry – laboratory trainings, seminars, selected lectures) – from 5/2016
  • Postdoc fellow at the Department of Inorganic and Organic Chemistry, Faculty of Pharmacy in Hradec Králové, Charles University – 2012-2016 (grants Postdoc I CZ.1.07/2.3.00/30.0022 and TEAB – European project CZ.1.07/2.3.00/20.0235); topic: design, synthesis and evaluation of new antimicrobial active compounds and enzyme inhibitors
  • Teaching of pregradual students at the Department of Inorganic and Organic Chemistry, Faculty of Pharmacy in Hradec Králové (subjects Laboratory Technique, Organic and Bioorganic Chemistry – laboratory training, seminars) – 2008-2016
  • Researcher at the Department of Inorganic and Organic Chemistry, Faculty of Pharmacy in Hradec Králové – 2011 (full-time job), 2013-2015 (part-time job, employee of the grant Ministry of Health IGA NT 13346: Design and enzyme targeting of antibacterial active compounds against multidrug resistant strains)
  • Teaching of pregradual students at the Department of Chemistry, Faculty of Natural Sciences, J. E. Purkynje University in Ústí nad Labem (subjects related to toxicology) – 2015
  • Teaching of pregradual students at the Department of Chemistry, Faculty of Natural Sciences, University of Hradec Králové (subject Organic Chemistry) – 2012
  • Free time education and upbringing – different institutions, from 2002 till today (pedagogue, economist, medic)

Foreign experience

  • exchange scholarship at the Research Group of Peptide Chemistry, Eötvös Loránd University and Hungarian Academy of Science, Budapest, supervisor: Assoc. Prof. Szilvia Bösze, Ph.D. (9-12/2013 and 8-11/2014; topics: peptide synthesis and purification, peptide conjugates, cytotoxicity evaluation, cellular uptake studies)
  • Comenius University in Bratislava, Faculty of Natural Sciences, Department of Biochemistry, Slovakia; supervisor: Assoc. Prof. Katarína Mikušová, Ph.D. (6/2015; topics: working with mycobacteria, radioactive labels, investigation of potential mechanism of action of novel antimycobacterial drugs)

International cooperation

  • Assoc. Prof. Szilvia Bösze (Research Group of Peptide Chemistry, Hungarian Academy of Sciences, Budapest, Hungary)
  • Assoc. Prof. Katarína Mikušová, Ph.D., and Assoc. Prof. Jana Korduláková, Ph.D. (Department of Biochemistry, Faculty of Natural Sciences, Comenius University in Bratislava, Slovakia)
  • Dr. Frank Wolschendorf (Department of Medicine, Division of Infectious Diseases, University of Alabama at Birmingham, USA)

Other

  • supervisor, co-supervisor and reviewer of diploma, rigorosum and bachelor theses (Faculty of Pharmacy in Hradec Králové, Charles University; Department of Chemistry, Faculty of Science, J. E. Purkinje University in Ústí nad Labem)
  • external reviewer for scientific journals: European Journal of Medicinal Chemistry, Plos One, Saudi Journal of Biological Sciences, Arabian Journal of Chemistry, Current Medicinal Chemistry, Bioorganic and Medicinal Chemistry, Bioorganic and Medicinal Chemistry Letters, Chemical Papers, Journal of Microbiological Methods, Current Pharmaceutical Design, Research on Chemical Intermediates etc.

List of publications

  • Author of 37 original papers in journals with impact factor, 1 Czech patent, 1 international patent application, author or co-author of more than 50 conference contributions (posters, lectures including three invited lectures), co-author of one monograph and one book chapter, one Czech patent and international patent application.
  • sum of the times cited: 309 (WOS; 24.7.2017)
  • Sum of citations excluding self-citations – 164
  • H-index: 10 (WOS)

Articles

1. KRÁTKÝ, Martin - VINŠOVÁ, Jarmila - BUCHTA, Vladimír. New amino acid esters of salicylanilides active against MDR-TB and other microbes. European Journal of Medicinal Chemistry, 2010, 45 (12), 6106-6113. ISSN 0223-5234. DOI 10.1016/j.ejmech.2010.09.040. IF2016 = 4.519

2. VINŠOVÁ, Jarmila - Imramovský, Aleš - KRÁTKÝ, Martin. An unprecedented rearrangement of salicylanilide derivatives: imidazolinone intermediate formation. Tetrahedron Letters 2010, 51 (1), 23-26. ISSN 0040-4039. DOI 10.1016/j.tetlet.2009.10.084. IF2016 = 2.193

3. Imramovský, Aleš - Férriz, Juana Monreal - PAUK, Karel - KRÁTKÝ, Martin. Synthetic Route for the Preparation of 2-Hydroxy-N-[1-(2-hydroxyphenylamino)-1-oxoalkan-2-yl]benzamides. Journal of Combinatorial Chemistry 2010, 12 (4), 414-416. DOI 10.1021/cc900168s. IF2012 = 4.933, now as ACS Combinatorial Science - IF2016 = 3.168

4. KRÁTKÝ, Martin - VINŠOVÁ, Jarmila. Pokroky ve vývoji antituberkulotik působících na multilékově rezistentní kmeny. Chemické Listy 2010, 104 (11), 998-1005. ISSN 0009-2770. IF2016 = 0.387

5. KRÁTKÝ, Martin - VINŠOVÁ, Jarmila. Antiviral Activity of Substituted Salicylanilides - A Review. Mini-Reviews in Medicinal Chemistry, 2011, 11 (11), 956-967. ISSN 1389-5575. DOI 10.2174/138955711797068382. IF2016 = 2.661

6. KRÁTKÝ, Martin - VINŠOVÁ, Jarmila. Salicylanilide Ester Prodrugs as Potential Antimicrobial Agents - a Review. Current Pharmaceutical Design, 2011, 17 (32), 3494-3505. ISSN 1381-6128. DOI 10.2174/138161211798194521. IF2016 = 2.611

7. KRÁTKÝ, Martin - VINŠOVÁ, Jarmila - STOLARÍKOVÁ, Jirina. Antimycobacterial Assessment of Salicylanilide Benzoates including Multidrug-Resistant Tuberculosis Strains. Molecules, 2012, 17 (11), 12812-12820. ISSN 1420-3049. DOI 10.3390/molecules171112812. IF2016 = 2.861

8. KRÁTKÝ, Martin - VINŠOVÁ, Jarmila - GUISADO RODRIGUEZ, Nabila. Antimycobacterial Activity of Salicylanilide Benzenesulfonates. Molecules, 2012, 17 (1), 492-503. ISSN 1420-3049. DOI 10.3390/molecules17010492. IF2016 = 2.861

9. KRÁTKÝ, Martin - VINŠOVÁ, Jarmila - BUCHTA, Vladimír. In Vitro Antibacterial and Antifungal Activity of Salicylanilide Pyrazine-2-carboxylates. Medicinal Chemistry, 2012, 8 (4), 732-741. ISSN 1573-4064. DOI 10.2174/157340612801216346. IF2016 = 2.331

10. KRÁTKÝ, Martin - VINŠOVÁ, Jarmila. Antifungal Activity of Salicylanilides and Their Esters with 4-(Trifluoromethyl)benzoic Acid. Molecules, 2012, 17 (8), 9426-9442. ISSN 1420-3049. DOI 10.3390/molecules17089426. IF2016 = 2.861

11. KRÁTKÝ, Martin - VINŠOVÁ, Jarmila - NOVOTNÁ, Eva. Salicylanilide derivatives block Mycobacterium tuberculosis through inhibition of isocitrate lyase and methionine aminopeptidase. Tuberculosis, 2012, 92 (5), 434-439. ISSN 1472-9792. DOI 10.1016/j.tube.2012.06.001. IF2016 = 2.873

12. KRÁTKÝ, Martin - VINŠOVÁ, Jarmila - VOLKOVÁ, Marie. Antimicrobial activity of sulfonamides containing 5-chloro-2-hydroxybenzaldehyde and 5-chloro-2-hydroxybenzoic acid scaffold. European Journal of Medicinal Chemistry, 2012, 50 (1), 433-440. ISSN 0223-5234. DOI 10.1016/j.ejmech.2012.01.060. IF2016 = 4.519

13. KRÁTKÝ, Martin - VINŠOVÁ, Jarmila - BUCHTA, Vladimír. In Vitro Antibacterial and Antifungal Activity of Salicylanilide Benzoates. The Scientific World Journal, 2012, 2012 (2012), nestránkováno. ISSN 1537-744X. DOI 10.1100/2012/290628. IF2013 = 1.219

14. KRÁTKÝ, Martin - VINŠOVÁ, Jarmila. Advances in Mycobacterial Isocitrate Lyase Targeting and Inhibitors. Current Medicinal Chemistry, 2012, 19 (36), 6126-6137. ISSN 0929-8673. DOI 10.2174/092986712804485782. IF2016 = 3.249

15. KRÁTKÝ, Martin - VINŠOVÁ, Jarmila. Antimycobacterial Activity of Quaternary Pyridinium Salts and Pyridinium N-oxides - Review. Current Pharmaceutical Design, 2013, 19 (7), 1343-1355. ISSN 1381-6128. DOI 10.2174/138161213804805711. IF2016 = 2.611

16. KRÁTKÝ, Martin - VINŠOVÁ, Jarmila - NOVOTNÁ, Eva. Antibacterial Activity of Salicylanilide 4-(Trifluoromethyl)benzoates. Molecules, 2013, 18 (4), 3674-3688. ISSN 1420-3049. DOI 10.3390/molecules18043674. IF2016 = 2.861

17. KRÁTKÝ, Martin - VOLKOVÁ, Marie - NOVOTNÁ, Eva. Synthesis and biological activity of new salicylanilide N,N-disubstituted carbamates and thiocarbamates. Bioorganic and Medicinal Chemistry, 2014, 22 (15), 4073-4082. ISSN 0968-0896. DOI 10.1016/j.bmc.2014.05.064. IF2016 = 2.93

18. RYCHTARCÍKOVÁ, Zuzana - KRÁTKÝ, Martin - GAZVODA, Martin. N-Substituted 2-Isonicotinoylhydrazinecarboxamides – New Antimycobacterial Active Molecules. Molecules, 2014, 19 (4), 3851-3868. ISSN 1420-3049. DOI 10.3390/molecules19043851. IF2016 = 2.861

19. VINŠOVÁ, Jarmila - KOZIC, Ján - KRÁTKÝ, Martin. Salicylanilide diethyl phosphates: Synthesis, antimicrobial activity and cytotoxicity. Bioorganic and Medicinal Chemistry, 2014, 22 (2), 728-737. ISSN 0968-0896. DOI 10.1016/j.bmc.2013.12.016. IF2016 = 2.93

20. VINŠOVÁ, Jarmila - KRÁTKÝ, Martin - KOMLÓOVÁ, Markéta. Diethyl 2-(Phenylcarbamoyl)phenyl Phosphorothioates: Synthesis, Antimycobacterial Activity and Cholinesterase Inhibition. Molecules, 2014, 19 (6), 7152-7168. ISSN 1420-3049. DOI 10.3390/molecules19067152. IF2016 = 2.861

21. KRÁTKÝ, Martin - NOVOTNÁ, Eva - SHALINI, Saxena. Salicylanilide Diethyl Phosphates as Potential Inhibitors of Some Mycobacterial Enzymes. The Scientific World Journal, 2014, 2014 (November), nestránkováno. ISSN 1537-744X. DOI 10.1155/2014/703053. IF2013 = 1.219

22. KRÁTKÝ, Martin - VINŠOVÁ, Jarmila - NOVOTNÁ, Eva. Salicylanilide pyrazinoates inhibit in vitro multidrug-resistant Mycobacterium tuberculosis strains, atypical mycobacteria and isocitrate lyase. European Journal of Pharmaceutical Sciences, 2014, 53 (March), 1-9. ISSN 0928-0987. DOI 10.1016/j.ejps.2013.12.001. IF2016 = 3.756

23. KRÁTKÝ, Martin - ŠTĚPÁNKOVÁ, Šárka - VORČÁKOVÁ, Katarína. Salicylanilide diethyl phosphates as cholinesterases inhibitors. Bioorganic Chemistry, 2015, 58 (February), 48-52. ISSN 0045-2068. DOI 10.1016/j.bioorg.2014.11.005. IF2016 = 3.231

24. KRÁTKÝ, Martin - MANDÍKOVÁ, Jana - TREJTNAR, František. Synthesis and antimicrobial activity of sulphamethoxazole-based ureas and imidazolidine-2,4,5-triones. Chemical Papers, 2015, 69 (8), 1108-1117. ISSN 0366-6352. DOI 10.1515/chempap-2015-0109. IF2016 = 1.258

25. BARANYAI, Zsuzsa - KRÁTKÝ, Martin - VINŠOVÁ, Jarmila. Combating highly resistant emerging pathogen Mycobacterium abscessus and Mycobacterium tuberculosis with novel salicylanilide esters and carbamates. European Journal of Medicinal Chemistry, 2015, 101 (August), 692-704. ISSN 0223-5234. DOI 10.1016/j.ejmech.2015.07.001. IF2016 = 4.519

26. KRÁTKÝ, Martin - BOSZE, Szilvia - BARANYAI, Zsuzsa. Synthesis and in vitro biological evaluation of 2-(phenylcarbamoyl)phenyl 4-substituted benzoates. Bioorganic and Medicinal Chemistry, 2015, 23 (4), 868-875. ISSN 0968-0896. DOI 10.1016/j.bmc.2014.12.019. IF2016 = 2.93

27. PARASKEVOPOULOS, Georgios - KRÁTKÝ, Martin - MANDÍKOVÁ, Jana. Novel derivatives of nitro-substituted salicylic acids: Synthesis, antimicrobial activity and cytotoxicity. Bioorganic and Medicinal Chemistry, 2015, 23 (22), 7292-7301. ISSN 0968-0896. DOI 10.1016/j.bmc.2015.10.029. IF2016 = 2.93

28. ŠVARCOVÁ, Markéta - KRÁTKÝ, Martin - VINŠOVÁ, Jarmila. Investigation of Potential Inhibitors of Chorismate-Utilizing Enzymes. Current Medicinal Chemistry, 2015, 22 (11), 1383-1399. ISSN 0929-8673. DOI 10.2174/0929867322666150209152446. IF2016 = 3.249

29. KRÁTKÝ, Martin - ŠTĚPÁNKOVÁ, Šárka - VORČÁKOVÁ, Katarína. Novel Cholinesterase Inhibitors Based on O-Aromatic N,N-Disubstituted Carbamates and Thiocarbamates. Molecules, 2016, 21 (2), nestránkováno. ISSN 1420-3049. DOI 10.3390/molecules21020191. IF2016 = 2.861

30. KRÁTKÝ, Martin - ŠTĚPÁNKOVÁ, Šárka - VORČÁKOVÁ, Katarína. Synthesis and in vitro evaluation of novel rhodanine derivatives as potential cholinesterase inhibitors. Bioorganic Chemistry, 2016, 68 (October), 23-29. ISSN 0045-2068. DOI 10.1016/j.bioorg.2016.07.004. IF2016 = 3.231

31. KRÁTKÝ, Martin - VINŠOVÁ, Jarmila. Sulphur-Containing Heterocycles as Antimycobacterial Agents: Recent Advances in Thiophene and Thiadiazole Derivatives. Current Topics in Medicinal Chemistry, 2016, 16 (26), 2921-2952. ISSN 1568-0266. DOI 10.2174/1568026616666160506131118. IF2016 = 2.561

32. KRÁTKÝ, Martin - VINŠOVÁ, Jarmila. Salicylanilide N-monosubstituted carbamates: Synthesis and in vitro antimicrobial activity. Bioorganic and Medicinal Chemistry, 2016, 24 (6), 1322-1330. ISSN 0968-0896. DOI 10.1016/j.bmc.2016.02.004. IF2016 = 2.93

33. Paraskevopoulos, Georgios - Monteiro, Sara - Vosátka, Rudolf - Krátký, Martin. Novel salicylanilides from 4,5-dihalogenated salicylic acids: Synthesis, antimicrobial activity and cytotoxicity. Bioorganic and Medicinal Chemistry 2017, 25 (4), 1524-1532. ISSN 0968-0896. DOI 10.1016/j.bmc.2017.01.016. IF2016 = 2.93

34. Krátký, Martin - STOLAŘÍKOVÁ, Jiřina - VINŠOVÁ, Jarmila. Antimicrobial activity of rhodanine-3-acetic acid derivatives. Bioorganic and Medicinal Chemistry 2017, 25 (6), 1839-1845. ISSN 0968-0896. DOI 10.1016/j.bmc.2017.01.045. IF2016 = 2.93

35. Krátký, Martin - STOLAŘÍKOVÁ, Jiřina - VINŠOVÁ, Jarmila. Novel Sulfamethoxazole Ureas and Oxalamides as Potential Antimicobacterial Agents. Molecules 2017, 22 (4), 535. ISSN 1420-3049. DOI 10.3390/molecules22040535. IF2016 = 2.861

36. KRÁTKÝ, Martin - VINŠOVÁ, Jarmila - ŠTĚPÁNKOVÁ, Šárka. Novel Fluorophenylalanine Derivatives: Synthesis and Investigation of Their Biological Activity. Bioorganic Chemistry 2017, 71, 244-256 . ISSN: 0045-2068.DOI 10.1016/j.bioorg.2017.02.010. IF2016 = 3.231

37. BARANYAI, Zsuzsa - KRÁTKÝ, Martin - Vosátka, Rudolf. In vitro biological evaluation of new antimycobacterial salicylanilide-tuftsin conjugates. European Journal of Medicinal Chemistry 2017, 133, 152-173. ISSN 0223-5234. DOI: 10.1016/j.ejmech.2017.03.047. IF2016 = 4.519

Others

UNIVERZITA KARLOVA V PRAZE, FARMACEUTICKÁ FAKULTA V HRADCI KRÁLOVÉ. Substituovaný derivát kyslíkatých kyselin fosforu, jeho použití a farmaceutický prípravek ho obsahující. Puvodce: Vinšová, Jarmila - Krátký, Martin - Paraskevopoulos, Georgios. patent c. 305738 udelen 13.01.2016.

UNIVERZITA KARLOVA V PRAZE, FARMACEUTICKÁ FAKULTA V HRADCI KRÁLOVÉ. Substituted derivative of oxyphosphorus acids, its use and pharmaceutical preparation containing it. Inventors: Vinšová, Jarmila - Krátký, Martin - Paraskevopoulos, Georgios. Patent application No. WO 2016095878 A1 (published 23.6.2016).

VINŠOVÁ, Jarmila - KRÁTKÝ, Martin. Tuberculosis — The Development of New MDR-TB Drugs. In: Drug-Resistant Tuberculosis: Causes, Diagnosis and Treatments. 1 vyd. New York: Nova Biomedical, 2009, neuvedeno, s. 59-141. ISBN 978-1-60876-055-8.

VINŠOVÁ, Jarmila - KRÁTKÝ, Martin. Development of New MDR-Tuberculosis Drugs. 1 vyd. New York: Nova Biomedical, 2010. 100 s. s. ISBN 978-1-6168-233-0.

© 2017 Charles University, Faculty of Pharmacy in Hradec Králové, Akademika Heyrovského 1203, 500 05 Hradec Králové, Czech Republic
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