Ing. Kateřina Macáková, Ph.D.

Research focus

  • biological activity of plant and mushroom extracts and compounds isolated from them - antioxidant activity, chelation of transition metals, inhibition of various enzymes, antiaggregatory activity

Education

  • 1998-2004 Czech University of Life Sciences, Institut of Tropics and Subtropics, Plant Production (Master  degree), Thesis: Antimicrobial activity of some Withania species
  • 2004-2011 Charles University in Prague, Faculty of Pharmacy in Hradec Králové, Department of Pharmaceutical Botany and Ecology, (Doctoral degree), Thesis: Biological activity of selected taxa of mushrooms from divisions Ascomycota and Basidiomycota

Teaching activities

  • Pharmaceutical botany
  • Recognizing of medicinal plants

Grants recieved

  • Chlebek, J., Cahlíková, L., Macáková, K., Opletal, L.: Plant secondary metabolites from subclasses Magnoliidae, Ranunculidae, Cornidae and Lamiidae influencing in vitro activity of human cholinesterases as a contribution to study of Alzheimerʼs disease: bio-guided isolation strategy. Grant Agency of Charles University, No. 122309/2009/B-BIO (2009–2011).
  • Kolečkář, V., Brojerová, E., Kubíková, K., Opletal, L.: Screening of natural compounds on antioxidant and platelet-antiaggregatory activity. Grant Agency of Charles University, No. 124/2005/B-BIO/FaF (2005–2007).
  • Macáková, K., Řeháková, Z., Opletal, L., Jahodář, L., Hrdina, R., Mladěnka, P., Stonawská, M., Zatloukalová, L., Bobrovová, Z., Bílek, T.: The study of the influence of phenolic compounds an a model of ischemia-reperfusion myocardial injury with regard to their iron-chelating and antiaggregant properties: in vitrp and in vivo study. Grant Agency of Charles University, No. 53707/2007/B-BIO (2007-2009).
  • Opletal, L., Solich, P., Jahodář, L., Vytlačilová, J., Matysová, L., Macáková, K., Cahlíková, L., Polášek, M.: Innovation of laboratories for teaching courses dealing with the isolation of natural products and their analytical evaluation. FRVŠ 664/2011 (2011).

Award

  • 2012 Prize of Danone Institute  – The prize of a young scientist (2.-3. prize)

Publications

Monographs (and chapters)

2012

MACÁKOVÁ, K., KOLEČKÁŘ, V., CAHLÍKOVÁ, L., CHLEBEK, J., HOŠŤÁLKOVÁ, A., KUČA, K., JUN, D., OPLETAL, L.: Chapter 9 Tannins and their influence on health. In Recent advances in medicinal chemistry vol. 1. Bentham Science Publishers, p. 249-293 (2012).

2010

OPLETAL, L., MACÁKOVÁ, K., CAHLÍKOVÁ, L.: Antiinvazní látky přírodního původu jako preventivní faktor v ontogenezi zvířat, in: OPLETAL, L., SKŘIVANOVÁ, V. (eds): Přírodní látky a jejich biologická aktivita. Sv. 2: Využití látek pro ovlivnění fyziologických procesů hospodářských zvířat, s. 203–309, Karolinum, Praha 2010, ISBN 978-80-246-1801-2.

Original papers

2016

DOSKOČIL, I., HAVLÍK, J., VERLOTTA, R., TAUCHEN, J., VESELA, L., MACAKOVA, K., OPLETAL, L., KOKOSKA, L., RADA, V.: In vitro immunomodulatory activity, cytotoxicity and Chemistry of some central European polypores.  Pharm. Biol. 54, 2369-2376 (2016).

CHLEBEK, J., NOVÁK, Z., KASSEMOVÁ, D., ŠAFRATOVÁ, M., KOSTELNÍK, J., MALÝ, L., LOČÁREK, M., OPLETAL, L., HOŠŤÁLKOVÁ, A., HRABINOVÁ, M., KUNEŠ, J., NOVOTNÁ, P., URBANOVÁ, M., NOVÁKOVÁ, L., MACÁKOVÁ, K., HULCOVÁ, D., SOLICH, P., MARTÍN, C.P., JUN, D., CAHLÍKOVÁ, L..: Isoquinoline alkaloids from Fumaria officinalis L. and their biological activities related to Alzheimer’s disease. Chem. Biodivers. 13, 91-99 (2016).

2015

HAVLÍKOVÁ, L., MACÁKOVÁ, K., OPLETAL, L., SOLICH, P: Rapid Determination of alpha-Hederin and Hederacoside C in Extracts of Hedera helix Leaves Available in the Czech Republic and Poland. Nat. Prod. Commun. 10, 1529-1531 (2015).

FILIPSKÝ, T., ŘÍHA, M., MACÁKOVÁ, K., ANZENBACHEROVÁ, E., KARLÍČKOVÁ, J., MLADĚNKA P. Antioxidant effects of coumarins include direct radical scavenging, metal chelation and inhibition of ros-producing enzymes. Curr. Top. Med. Chem. 15, 415-431.

CAHLÍKOVÁ, L., HULOVÁ, L., HRABINOVÁ, M., CHLEBEK, J., HOŠŤÁLKOVÁ, A., ADAMCOVÁ, M., ŠAFRATOVÁ, M., JUN, D., OPLETAL, L., LOČÁREK, M., MACÁKOVÁ, K.: Isoquinoline alkaloids as potential prolyl oligopeptidase inhibitors. Fitoterapia 103, 192-196 (2015).

2014

ŘEHÁKOVÁ, Z., KOLEČKÁŘ, V., JAHODÁŘ, L., OPLETAL, L., MACÁKOVÁ, K., CAHLÍKOVÁ, L., JUN, D., KUČA, K.: Evaluation of the antioxidant activity of several naturally occuring coumarins and their synthesized analouges by „ferric reducing antioxidant power“ assay. J. Enzyme Inhib. Med. Chem. 29, 49-54 (2014).

ŘÍHA, M., KARLÍČKOVÁ, J., FILIPSKÝ, T., MACÁKOVÁ, K., ROCHA, L., BOVICELLI, P., PROIETTI SILVESTRI, I., SASO, L., JAHODÁŘ, L., HRDINA, R., MLADĚNKA, P.: In vitro evaluation of copper-chelating properties of flavonoids. RSC Adv. 4, 32628-32638 (2014).

ŠAFRATOVÁ, M., NOVÁK, Z., KULHÁNKOVÁ, A., KUNEŠ, J., HRABINOVÁ,M., JUN, D., MACÁKOVÁ K., OPLETAL, L., CAHLÍKOVÁ, L.: Revised NMR data for 9-O-demethylgalanthine: an alkaloid from Zephyranthes robusta (Amaryllidaceae and its biological aktivity. Nat. Prod. Commun.  9, 787-788 (2014).

2013

HALAMOVÁ, K., KOKOŠKA, L., POLESNÝ, Z., MACÁKOVÁ, K., FLESAR, J., RADA, V.: Selective in vitro growth inhibitory activity of Withania somnifera on human pathogenic bacteria and bifidobacteria. Pak. J. Bot. 45, 667-670 (2013).

ŘÍHA, M., KARLÍČKOVÁ, J., FILIPSKÝ, T., MACÁKOVÁ, K., HRDINA, R., MLADĚNKA, P.: Novel method for rapid copper chelation assessment confirmed low affinity of D-penicillamine for copper in comparison with trientine and 8-hydroxyquinolines. J. Inorg. Biochem. 123, 80-87 (2013).

CAHLÍKOVÁ, L., HRABINOVÁ, M., KULHÁNKOVÁ, A., BENEŠOVÁ, N., CHLEBEK, J., JUN, D., NOVÁK, Z., KUČA, K., MACÁKOVÁ, K., OPLETAL, L. Alkaloids from Chlidanthus fragrans Herb. and their acetylcholinesterase, butyrylcholinesterase and prolyl oligopeptidase inhibition activity. Nat. Prod. Commun. 8, 1541-1544 (2013).

KULHÁNKOVÁ, A., CAHLÍKOVÁ, L., NOVÁK, Z., MACÁKOVÁ, K., KUNEŠ, J., OPLETAL, L.: Alkaloids from Zephyranthes robusta Baker and their acetylcholinesterase and butyrylcholinesterase inhibition activity. Chem. Biodivers. 10, 1120-1127 (2013).

2012

FILIPSKÝ, T., MLADĚNKA, P., MACÁKOVÁ, K., HRDINA, R., SASO, L., MARCHETTI, F., PETTINARI, C.: In vitro chracteristics of 1-phenyl-3-methyl-4-acylpyrazol-5-ones iron chelators. Biochimie 94, 125-131 (2012).

MACÁKOVÁ, K., MLADĚNKA, P., FILIPSKÝ, T., ŘÍHA, M., JAHODÁŘ, L., TREJTNAR, F., BOVICELLI, P., SILVESTRI, IP., HRDINA, R., SASO, L.: Iron reduction potentiates hydroxyl radical formation only in flavonols. Food. Chem. 135, 2584-2592 (2012).

MACÁKOVÁ, K., ŘEHÁKOVÁ, Z., MLADĚNKA, P., KARLÍČKOVÁ, J, FILIPSKÝ, T., ŘÍHA, M., PRASAD, AK., PARMAR, VS., JAHODÁŘ, L., PÁVEK, P., HRDINA, R., SASO, L.: In vitro platelet antiagg.regatory properties of 4-methylcoumarins. Biochimie 94, 2681-2686 (2012).

ZATLOUKALOVÁ, L., FILIPSKÝ, T., MLADĚNKA, P., SEMECKÝ, V., MACÁKOVÁ, K., HOLEČKOVÁ, M., VÁVROVÁ, J., PALIČKA, V., HRDINA, R.: Dexrazoxane provided moderate protection in a catecholamine model of severe cardiotoxicity. Can. J. Physiol. Pharm. 90, 473-484 (2012).

NOVÁK, Z., CHLEBEK, J., OPLETAL, L., JIROŠ, P., MACÁKOVÁ, K., KUNEŠ, J., CAHLÍKOVÁ, L.: Corylucinine, a new alkaloid from Corydalis cava (Fumariaceae), and its cholinesterase activity. Nat. Prod. Commun. 7, 859-860 (2012).

CAHLÍKOVÁ, L., BENEŠOVÁ, N., MACÁKOVÁ, K., KUČERA, R., HRSTKA, V., KLIMEŠ, J., JAHODÁŘ, L., OPLETAL, L.: Alkaloids of some Amaryllidaceae species and their cholinesterase activity. Nat. Prod. Commun. 7, 571-574 (2012).

2011

CAHLÍKOVÁ, L., ZAVADIL, S. MACÁKOVÁ, K., VALTEROVÁ, I., KULHÁNKOVÁ, A., HOŠŤÁLKOVÁ, A., KUNEŠ, J., OPLETAL, L.: Isolation and cholinesterase activity of Amaryllidaceae alkaloids from Nerine bowdenii. Nat. Prod. Commun. 6, 1827-1830 (2011).

CAHLÍKOVÁ, L., BENEŠOVÁ, N., MACÁKOVÁ, K., URBANOVÁ, K., OPLETAL, L.: GC/MS Analysis of three Amaryllidaceae species and their cholinesterase activity. Nat. Prod. Commun. 9, 1255-1258 (2011).

CHLEBEK, J., MACÁKOVÁ, K., CAHLÍKOVÁ, L., KURFÜRST, M., KUNEŠ, J., OPLETAL, L.: Acetylcholinesterase and butyrylcholinesterase inhibitory compounds from Corydalis cava Schweigger. & Korte (Fumariaceae). Nat. Prod. Commun. 6, 607-610 (2011).

FRYDRYCHOVÁ, S., OPLETAL, L., MACÁKOVÁ, K., LUSTYKOVÁ, A., ROZKOT, M., LIPENSKÝ, J.: Effects of herbal prepapration on libido and semen quality in boars. Reprod. Domest. Anim. 46, 573-578 (2011).

MLADĚNKA, P., MACÁKOVÁ, K., FILIPSKÝ, T., ZATLOUKALOVÁ, L., JAHODÁŘ, L., BOVICELLI, P., SILVESTRI, P., HRDINA, R., SASO, L.: In vitro analysis of iron chelating activity of flavonoids. J. Inorg. Biochem. 105, 693-701 (2011).

CAHLÍKOVÁ, L., MACÁKOVÁ, K., ZAVADIL, S., JIROŠ, P., OPLETAL, L., URBANOVÁ, K., JAHODÁŘ, L.: Analysis of Amaryllidaceae alkaloids from Chlidanthus fragrans and their cholinesterase aktivity. Nat. Prod. Commun. 6, 603-606 (2011).

CAHLÍKOVÁ, L., VALTEROVÁ, I., MACÁKOVÁ, K., OPLETAL, L.: Analysis of Amaryllidaceae alkaloids from Zephyranthes grandiflora Lindl. by GC/MS and their cholinesterase activity. Revista Brasileira de Farmacognosia/Bras. J. Pharmacognosy 21, 575-580 (2011).

2010

CAHLÍKOVÁ, L., OPLETAL, L., KURFÜRST, M., MACÁKOVÁ, K., KULHÁNKOVÁ, A., HOŠŤÁLKOVÁ, A.: Acetylcholinesterase and butyrylcholinesterase inhibitory compounds from Chelidonium majus (Papaveraceae). Nat. Prod. Commun. 5, 1751-1754 (2010).

CAHLÍKOVÁ, L., KULHÁNKOVÁ, A., URBANOVÁ, K., VALTEROVÁ, I., MACÁKOVÁ, K., KUNEŠ, J.: Analysis of Amaryllidaceae alkaloids from Zephyranthes robusta by GC-MS and their cholinesterase activity. Nat. Prod. Commun. 5, 1201-1204 (2010).

CAHLÍKOVÁ, L., MACÁKOVÁ, K., KUNEŠ, J., KURFÜRST, M., OPLETAL, L., CVAČKA, J., CHLEBEK, J., BLUNDEN, G.: Acetylcholinesterase and butyrylcholinesterase inhibitory compounds from Eschscholzia californica (Papaveraceae). Nat. Prod. Commun. 5, 1035-1038 (2010).

MLADĚNKA, P., MACÁKOVÁ, K., ZATLOUKALOVÁ, L., ŘEHÁKOVÁ, Z., SINGH, B.K., PRASAD, A.K., PARMAR, V.S., JAHODÁŘ, L., HRDINA, R., SASO, L.: In vitro interactions of coumarins with iron. Biochimie 92, 1108-1114 (2010).

2008

KOLEČKÁŘ, V., BROJEROVÁ, E., ŘEHÁKOVÁ, Z., KUBÍKOVÁ, K., ČERVENKA, F., KUČA, K., JUN, D., HRONEK, M., OPLETALOVÁ, V., OPLETAL, L.: In vitro antiplatelet activity of flavonoids from Leuzea carthamoides. Drug. Chem Toxicol. 31, 27-35 (2008).

2003

JANOVSKÁ, D., KUBÍKOVÁ, K., KOKOŠKA, L.: Screening for antimicrobial activity of some medicinal plants species of traditional Chinese medicine. Czech. J. Food. Sci. 21, 107-110 (2003).

Reviews

2014

MACÁKOVÁ, K., KOLEČKÁŘ, V., CAHLÍKOVÁ, L., CHLEBEK, J., HOŠŤÁLKOVÁ, A., KUČA, K., JUN, D., OPLETAL, L.: Tannins and their influence on health. Recent Advances in Medicinal Chemistry. Bentham Science Publishers 1, 159-208 (2014).

CAHLÍKOVÁ, L., MACÁKOVÁ, K., BENEŠOVÁ, N., CHLEBEK, J., HOŠŤÁLKOVÁ, A., OPLETAL, L.: Natural componuds (small molecules) as potential and real drugs of Alzehimer´s disease: a critical review, in: Studies in Natural Procucts Chemistry (ATTA-ur-RAHMAN, ed.), Chapter 6, Elsevier: Amsterdam 2014, pp. 153-194, ISBN: 978-0-444-63281-4.

2013

OPLETAL, L., CHLEBEK, J., MACÁKOVÁ, K., BENEŠOVÁ, N., HOŠŤÁLKOVÁ, A., CAHLÍKOVÁ, L.: Antioxidanty a degenerativní onemocnění. Prakt. Lékáren. 9, 135-138 (2013).

2012

KOLEČKÁŘ, V., ŘEHÁKOVÁ, Z., BROJEROVÁ, E., KUČA, K., JUN, D., MACÁKOVÁ, K., OPLETAL, L., DRAŠAR, P., JAHODÁŘ, L., CHLEBEK, J., CAHLÍKOVÁ, L.: Proanthocyanidiny a jejich antioxidační aktivita. Chem. Listy 106, 113-121 (2012).

2011

CAHLÍKOVÁ, L., MACÁKOVÁ, K., CHLEBEK, J., HOŠŤÁLKOVÁ, A., KULHÁNKOVÁ, A., OPLETAL, L.: Ecdysterone and its activity on some degenerative diseases. Nat. Prod. Commun. 6, 707-718 (2011).

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