Dr. Georgios Paraskevopoulos, Ph.D.

Present position

Contact information

  • Work address: Heyrovského 1203, 500 05, Hradec Králové, Czech Republic
  • Email: paraskeg@faf.cuni.cz
  • Tel.: +420 495 067 412

 

WORKING EXPERIENCE:

  • Charles University in Prague, Faculty of Pharmacy in Hradec Králové, Department of Inorganic and Organic Chemistry, Hradec Králové, Czech Republic
    Postdoctoral Researcher, September 2013-December 2015

  • University of Birmingham, School of Biosciences, Institute of Microbiology and Infection, Birmingham, United Kingdom
    Visiting Postdoctoral Researcher, October 2014-March 2015

  • University of Ioannina, School of Sciences, Department of Chemistry, Ioannina, Greece
    Researcher, September 2012-August 2013

  • University of Pennsylvania, Perelman School of Medicine, Department of Pathology and Laboratory Medicine, Philadelphia, PA, USA
    Postdoctoral Researcher, November 2011-June 2012

STUDIES:

  • University of Ioannina, School of Sciences, Department of Chemistry, Ioannina, Greece
    PhD in Organic Chemistry, October 2011 (Distinction)
    MSc in Chemistry, 2007 (Chemical and Biochemical Technologies- Distinction)
    BSc in Chemistry, 2004 (Bachelor thesis: Synthesis of isoflavonoids)

PUBLICATIONS:

  1. Paraskevopoulos, G.; Krátký, M.; Mandíková,J.; Trejtnar, F.; Stolařiková, J.; Pávek, P.; Besra, G. S.; Vinšová, J., Novel derivatives of nitro-substituted salicylic acids: Synthesis, antimicrobial activity and cytotoxicity, Bioorganic & Medicinal Chemistry, 2015, 23, 7292

  2. Theodorou, V.; Paraskevopoulos, G.; Skobridis, K., A mild alkaline hydrolysis of N, N-substituted amides and nitriles, ARKIVOC, 2015, (vii) 101

  3. Paraskevopoulos, G.; Alivertis, D.; Theodorou, V.; Skobridis, K., New Calix[4]arene-cored Peripherally Fuctionalized Dendrimers: Synthesis and Conformational Characteristics, Helvetica Chimica Acta, 2015, 98, 593

  4. Krátký, M.; Bősze, S.; Baranyai, Z.; Szabó, I.; Stolařiková, J.; Paraskevopoulos, G.; Vinšová, J., Synthesis and in vitro biological evaluation of 2-(phenylcarbamoyl)phenyl 4-substituted benzoates, Bioorganic & Medicinal Chemistry, 2015, 23, 868.

  5. Skobridis, K.; Theodorou, V.; Paraskevopoulos, G.; Seichter, W.; Weber, E., 3,3’’-Bis(9-hydroxyfluoren-9-yl)-1,1’:3’,1’’-terphenyl, Acta Crystallographica E, 2013, 69, 10, o1514

  6. Ricklin, D.; Qu, H.K.; Huang, Y.J.; Bai, H.J.; Reis, E.S.; Chen, H.; DeAngelis, R.A.; Tzekou, A.; Paraskevopoulos, G.; Li, Y.X.; Maciejewsi, M.; Resuello, R.R.G.; Lupu, F.; Barlow, P.N.; Lambris, J.D., Bringing Compstatin to the next level: novel analogs with improved potency, pharmacokinetic profiles and administration options suitable for systemic application, (Conference Abstract) Immunobiology, 2012, 217, 11, 1141

  7. Skobridis, K.; Theodorou, V.; Paraskevopoulos, G.; Seichter, W.; Weber, E., Crystalline host-guest complexes of constitutionally isomeric diol hosts. A structural case study, Crystal Growth & Design, 2011, 11 (12), 5275

  8. Theodorou, V.; Gogou, M.; Philippidou, M.; Ragoussis, V.; Paraskevopoulos, G.; Skobridis, K., Synthesis of β,γ-unsaturated primary amides from α,β-unsaturated acids and investigation of the mechanism, Tetrahedron, 2011, 67, 5630

  9. Alivertis, D.; Paraskevopoulos, G.; Theodorou, V.; Skobridis, K., Dendritic effects of crown ether-fuctionalized dendrimers on the solvent extraction of metal ions, Tetrahedron Letters, 2009, 50, 6019

  10. Alivertis, D.; Theodorou, V.; Paraskevopoulos, G.; Skobridis, K., Searching for new host compounds: synthesis and characterization of novel crown ether-functionalized Dendrimers, Tetrahedron Letters, 2007, 48, 4091

PATENTS:

  • CZ patent 305738, Vinšová, J.; Krátký, M.; Paraskevopoulos, G., Substituovaný derivát kyslíkatých kyselin fosforu, jeho použití a farmaceutický přípravek ho obsahující, PCT/CZ2015/000129

AWARDS:

  • State Scholarships Foundation in Greece (IKY) and German Academic Exchange Service (DAAD), “IKYDA 2006-2007 Programm für projektbezogenen Personenaustaush”

CONFERENCES AND SYMPOSIUMS:

  1. The 2015 TB Summit, London, United Kingdom, 24-26 March 2015, Poster: “2-methoxy-3-nitrobenzamides exhibit enhanced activity over Mtb and better cytotoxic profile than the corresponding 3-nitrosalicylanilides’’

  2. 5th Postgraduate & 3rd Postdoctoral Conference, Hradec Králové, Czech Republic, 3-4 February 2015, Oral Presentation: “Recent outcomes of novel modifications on the structure of salicylanilides”

  3. 1st International Congress: From Drug Discovery to Drug Delivery, Athens, Greece, 13-15 November 2014, Poster: “Nitro-substituted salicylanilides: Maintaining antitubercular activity while reducing toxicity” (Best Poster Award)

  4. 4th Meeting of the Paul Ehrlich MedChem Euro-PhD Network, Hradec Králové, Czech Republic, 20-22 June 2014, Poster: “The antimycobacterial activity of nitro-substituted salicylanilides”

  5. Towards New Therapeutics for Diseases of the Developing World, Madrid, Spain, 11-13 May 2014, Poster: “Structure activity relation (SAR) study of novel nitro-substituted salicylanilides as potentional antibacterial drugs”

  6. 4th Postgraduate & 2nd Postdoctoral Conference, Hradec Králové, Czech Republic, 28-29 January 2014, Oral Presentation: “Synthesis of novel nitro-substituted salicylanilides as potential antibacterial drugs”

  7. ΧΧΙV International Complement Workshop, Chania-Crete, Greece, 10-15 October 2012, Oral Presentation: “Bringing Compstatin to the next level: novel analogs with improved potency, pharmacokinetic profiles and administration options suitable for systemic application”

  8. International Dendrimer Symposium 5 IDS:5 Toulouse, France, 28 August – 1 September 2007, Poster: “Synthesis and complexing properties of dendrimer containing internal crown ether moieties”

  9. 20th Greek Conference of Chemistry, Ioannina, 20-25 September 2005, Oral Presentation: “Logical Design, Synthesis and Characterization of Calixarene dendrimer molecules”

  10. 4th International Conference of the Chemical Societies of the South-East European Countries, ICOSECS 4, Belgrade, Serbia and Montenegro, 18-21 July 2004, Poster: "Antiangiogenic properties of isoflavones"

TEACHING EXPERIENCE:

  • Assistantship in the Laboratory of Pharmaceutical Technology
    2016-today: Faculty of Pharmacy in Hradec Králové, Charles University in Prague, Hradec Králové, Czech Republic
     
  • Assistantship in the Laboratory of Organic Chemistry
    2005-2011: Department of Chemistry, University of Ioannina, Ioannina, Greece
    2013-2015: Faculty of Pharmacy in Hradec Králové, Charles University in Prague, Hradec Králové, Czech Republic
     
  • Teaching Organic Chemistry to Chemistry and Pharmacy Students
    2005-2011: Department of Chemistry, University of Ioannina, Ioannina, Greece
    2013-2015: Faculty of Pharmacy in Hradec Králové, Charles University in Prague, Hradec Králové, Czech Republic

PARTICIPATION IN FUNDED PROGRAMS:

  • European Social Fund and the state budget of the Czech Republic, 2013-2015, ‘’Increasing of the R&D capacity at Charles University through new positions for graduates of doctoral studies’’

  • European Regional Development Fund (ERDF), 2012-2013, Program title: “Design, synthesis and biological evaluation of protein kinase inhibitors for cancer treatment.”

  • Greek Ministry of Education, 2005-2006, Program title: Dendrimers Containing Macrocyclic Compounds (crown-ethers, calixarenes) as structural units for selective complexation of ions and radicals: Synthesis and applications in chemical catalysis, as chemical sensors and as radical receptors. (Pythagoras, Subproject 19)

COLLABORATIONS:

  • Prof. RNDr. Jarmila Vinšová, Department of Inorganic and Organic Chemistry, Faculty of Pharmacy in Hradec Králové, Charles University in Prague, Czech Republic

  • Prof. Gurdyal Besra, School of Biosciences, Institute of Microbiology and Infection, Birmingham, United Kingdom

© 2017 Charles University, Faculty of Pharmacy in Hradec Králové, Akademika Heyrovského 1203, 500 05 Hradec Králové, Czech Republic

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