Petr Pávek, PhD, Professor

Department of Pharmacology and Toxicology and Centre for Drug Development, Professor

Laboratory of clinical and molecular pharmacotherapy
e-mail: Pavek@faf.cuni.cz
address: Heyrovského 1203, Hradec Kralove 500 05
phone: +420 495 067 334
fax: +420 495 067 170

Previous Education and Emplyoment

M.Sc. 1996 – Faculty of Pharmacy, Charles University in Prague

Ph.D. 2000 – Pharmacology and Toxicology - Department of Pharmacology and Toxicology, Faculty of Pharmacy, Charles University in Prague

Assistant, 2000-2008, Associate Professor 2008, Professor 2014 - present, Department of Pharmacology and Toxicology,

POS-DOC 2003 The Netherlands Cancer Institute, Division of Experimental Therapy

2014 –Professor of pharmacology

Research Interests

Aspects of gene regulation of proteins involved in pharmacokinetics, cytochrome P450 gene regulation, drug transporters, pharmacokinetics (DMPK), ADME-Tox, Drug-drug and drug-food interactions, pharmacogenetics

Teaching

Pharmacology and toxicology, clinical pharmacy, modern methods in molecular and cellular biology, gene therapy

Professional Memberships

  • Scientific Secretary of the Czech Society for Experimental and Clinical Pharmacology and Toxicology
  • Chair of the Section of Cellular and Molecular Pharmacology CSECPT
  • Advisory Board of Czech Scientific Foundation

Current grants

Novel mechanisms of CYP3A4 enzyme regulation based on posttranslational modification of nuclear receptors - implications for pharmacotherapy
Main Investigator: As. Prof. PharmDr. Petr Pávek, Ph.D.  2012-2016 Czech Scientific Foundation, P303/12/0472

Centre Excelence: Centre of drug-dietary supplements interactions and nutrigenetics
Main Investigator : As. Prof. PharmDr. Petr Pávek, Ph.D.    2012-2018 Czech Scientific Foundation, P303/12/G163

Generation of hepatocyte-derived cellular models for preclinical testing of drugs
2010-2012 Czech Scientific Foundation, GAP304/10/0149

Awards/Prizes/Fellowships

2002, 2003, 2006, 2009, 2011 – Award of the Czech Society for Experimental and Clinical Pharmacology and Toxicology -as a first author

2004 – Stasek´s Award in Oncology by Janssen Foundation

2003 – The International Pharmaceutical Federation Fellowship

2001-2003- the Czech Science Foundation POST-DOC Fellowship

Publications

more than 70 papers in international journals

H-index 23 (WoS), 1530 citation

Selected publication over last 5 years:

* Corresponding author

  1. Carazo Fernández A, Smutny T, Hyrsová L, Berka K, Pavek P*. Chrysin, baicalein and galangin are indirect activators of the human constitutive androstane receptor (CAR).Toxicol Lett. 2015 Mar 4;233(2):68-77.

  2. Smutny, Tomas; Tebbens, Jurjen Duintjer; Pavek, P*. Bioinformatic analysis of miRNAs targeting the key nuclear receptors regulating CYP3A4 gene expression: The challenge of the CYP3A4 "missing heritability'' enigma JOURNAL OF APPLIED BIOMEDICINE

  3. Soukup T, Dosedel M, Pavek P, Nekvindova J, Barvik I, Bubancova I, Bradna P, Kubena AA, Carazo AF, Veleta T, Vlcek J. The impact of C677T and A1298C MTHFR polymorphisms on methotrexate therapeutic response in East Bohemian region rheumatoid arthritis patients. Rheumatol Int. 2015 Jul;35(7):1149-61

  4. Soukup T, Dosedel M, Nekvindova J, Toms J, Vlcek J, Pavek P. Genetic polymorphisms in metabolic pathways of leflunomide in the treatment of rheumatoid arthritis. Clin Exp Rheumatol. 2015 May-Jun;33(3):426-32.

  5. Smutny T, Bitman M, Urban M, Dubecka M, Vrzal R, Dvorak Z, Pavek P*. U0126, a mitogen-activated protein kinase kinase 1 and 2 (MEK1 and 2) inhibitor, selectively up-regulates main isoforms of CYP3A subfamily via a pregnane X receptor (PXR) in HepG2 cells. Arch Toxicol. 2014 88(12):2243-59.

  6. Matoulková P, Pávek P, Malý J, Vlček J. Cytochrome P450 enzyme regulation by glucocorticoids and consequences in terms of drug interaction. . 2014 Mar;10(3):425-35.

  7. Aatsinki SM, Buler M, Salomäki H, Koulu M, Pavek P, Hakkola J. Metformin induces PGC-1α expression and selectively affects hepatic PGC-1α functions. British Journal of Pharmacology 2014;171(9):2351-63

  8. Smutny T, Mani S, Pavek P*. Post-translational and Post-transcriptional Modifications of Pregnane X Receptor (PXR) in Regulation of the Cytochrome P450 Superfamily. Curr Drug Metab. 2013 Dec;14(10):1059-69.

  9. Stejskalova, L., Rulcova, A.,Vrzal, R., Dvorak, Z., Pavek, P*.  Dexamethasone accelerates degradation of aryl hydrocarbon receptor (AHR) and suppresses CYP1A1 induction in placental JEG-3 cell line. Toxicology Letters. 2013 25;223(2):183-91.

  10. Pavek, P* and Smutny, T. Nuclear receptors in regulation of biotransformation enzymes and drug transporters in the placental barrier. Drug Metab Reviews 2014 Feb;46(1):19-32.

  11. Novotna, A., Pavek, P., Dvorak, Z. Construction and characterization of a reporter gene cell line for assessment of human glucocorticoid receptor activation. European Journal of  Pharmaceutical  Sciences. 2012, vol. 47(5), p.842-847.

  12. Doricakova, A., Novotna, A., Vrzal, R., Pavek, P., Dvorak, Z. The role of residues T248, Y249 and T422 in the function of human pregnane X receptor. Archives in Toxicology. 2013, vol. 87(2), p. 291-301.

  13. Novotna, A., Pavek, P, Dvorak, Z. Novel stably transfected gene reporter human hepatoma cell line for assessment of aryl hydrocarbon receptor transcriptional activity: construction and characterization. Environental Science and Technology. 2011, vol. 45(23), p. 10133-10139.

  14. Novotna, A., Doricakova, A., Vrzal, R., Pavek, P, Dvorak, Z.Construction and characterization of hepatocyte nuclear factor HNF4alpha1 over-expressing cell line derived from human hepatoma HepG2 cells. European Journal of Pharmacology. 2011 vol. 669(1-3), p. 45-50.

  15. Krausova, L., Stejskalova, L., Wang, H., Vrzal, r., Dvorak, z., Mani, s., Pavek. p*. Metformin suppresses pregnane X receptor (PXR)-regulated transactivation of CYP3A4 gene. Biochemical Pharmacology 2011, vol. 82, pp.  1771-1780.

  16. Stejskalova, L., Vecerova, L., Peréz, L.M., Vrzal, R., Dvorak, Z., Nachtigal, P., Pavek, P*. Aryl hydrocarbon receptor (AHR) and aryl hydrocarbon nuclear translocator (ARNT) expression in human and rat placentas and transcription activity in human trophoblast cultures. Toxicological  Sciences. 2011, vol. 123, p. 26-36.

© 2017 Charles University, Faculty of Pharmacy in Hradec Králové, Akademika Heyrovského 1203, 500 05 Hradec Králové, Czech Republic

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