Mgr. Barbora Školová, Ph.D.

Current job:

Since 2013:

Research Assistant/Lecturer at the Department of Pharmaceutical Technology, Charles University in Prague, Faculty of Pharmacy in Hradec Králové

Researcher of a Czech Science Foundation project “Lipid membrane models – a new tool for studying pathophysiology of skin diseases at a molecular level“, Charles University in Prague, Faculty of Pharmacy in Hradec Králové, Department of Inorganic and Organic Chemistry

2005 – 2013

Guide and worker in depositories in the Czech Pharmaceutical Museum in Kuks

Education:

2010 – 2015

Doctor´s degree in Bioorganic Chemistry, Charles University in Prague, Faculty of Pharmacy in Hradec Králové

Dissertation thesis: “Synthesis and study of ceramide analogs” at the Department of Inorganic and Organic Chemistry, supervisor: Assoc. Prof. PharmDr. Kateřina Vávrová, Ph.D.

2005 – 2010

Master´s degree in Pharmacy, Charles University in Prague, Faculty of Pharmacy in Hradec Králové

Diploma thesis: “Synthesis of ceramide analogs with various sphingosine length and evaluation of their effects on the skin barrier” at the Department of Inorganic and Organic Chemistry, supervisor: Assoc. Prof. PharmDr. Kateřina Vávrová, Ph.D.

2001 – 2005

Grammar school in Český Těšín

Awards:

2015

Josef Hlávka Prize
Medal of the City Hradec Králové
3rd place in the Sanofi Prize for Pharmacy

2010

Award of the Dean of the Faculty of Pharmacy, Charles University
First prize at The International Student Research Conference

Grants:

Since 2013

Co-worker of Czech Science Foundation project 13-23891S “Lipid membrane models – a new tool for studying pathophysiology of skin diseases at a molecular level“

Since 2013

Co-worker of Charles University project 1404213 “Study of transdermal permeation enhancers”

2012 – 2014

Principal investigator of Charles University project 652412 “Study of relationships between ceramide structure and their barrier function in the skin – synthesis of ceramide analogues, preparation of model skin lipid membranes, evaluation of their permeability and biophysical properties“

2011 – 2013

Co-worker of Czech Science Foundation project 207/11/0365 “Synthesis and structure-activity relationships of ceramides and compounds targeting them“

Visiting fellowships:

2013

University of Leipzig, Germany (4 months)

2013

Martin Luther University Halle-Wittenberg, Germany (2 months)

Presentations at conferences:

2016

International Conference on Dermal Drug Delivery by Nanocarriers, Berlin, Germany

2015

Gordon Research Conference: Barrier Function of Mammalian Skin, Waterville, New Hampshire, USA (poster; “Travel Award for Outstanding Contribution“)

15th Interdisciplinary Meeting of Young Biologists, Biochemists and Chemists, Devět skal – Milovy, Czech Republic (poster)

2014

44th Annual Meeting of the European Society for Dermatological Research, Copenhagen, Denmark (poster)

Skin Forum (Percutaneous Penetration – Measurement, Modulation and Modelling), Prague, Czech Republic (oral presentation, poster; “Poster Award“)

Perspectives in Percutaneous Penetration, La Grande Motte, France (poster)

2013

Gordon Research Conference: Barrier Function of Mammalian Skin, Waterville, New Hampshire, USA (poster)

11th Meeting of the European Epidermal Barrier Research Network at the International Investigative Dermatology Meeting, Edinburgh, UK (poster)

48th Advances in Organic, Bioorganic and Pharmaceutical Chemistry, Špindlerův Mlýn, Czech Republic (poster)

2012

Perspectives in Percutaneous Penetration, La Grande Motte, France (poster)

47th Advances in Organic, Bioorganic and Pharmaceutical Chemistry, Lázně Bělohrad, Czech Republic (poster)

2011

Drug synthesis and analysis, Brno, Czech Republic (oral presentation)

Research Interests:

  • Skin Barrier, Ceramides
  • Stratum Corneum Lipid Model Membranes, Permeability Studies, Transdermal Drug Delivery
  • Biophysical Methods – Infrared Spectroscopy, Powder X-ray Diffraction, Differential Scanning Calorimetry, Langmuir Monolayers, Brewster Angle Microscopy

Other Skills:

Interpretation of infrared spectra (training course “Interpretation of vibrational spectra”, Prague 2012)

Publications:

  1. Školová, B., Janůšová, B., Vávrová, K. Ceramides with a pentadecasphingosine chain and short acyls have strong permeabilization effects on skin a model lipid membranes. Biochim. Biophys. Acta 2016; 1858 (2): 220-232. [IF 2014: 3.8]

  2. Školová, B., Jandovská, K., Pullmannová, P., Tesař, O., Roh, J., Hrabálek, A., Vávrová, K. The role of the trans double bond in skin barrier sphingolipids: permeability and infrared spectroscopic study of model ceramide and dihydroceramide membranes. Langmuir 2014; 30 (19): 5527-35. [IF 2014: 4.6]

  3. Školová, B., Hudská, K., Pullmannová, P., Kováčik, A., Palát, K., Roh, J., Fleddermann, J., Estrela-Lopis, I., Vávrová, K. Different phase behavior and packing of ceramides with long (C16) and very long (C24) acyls in model membranes: infrared spectroscopy using deuterated lipids. J. Phys. Chem. B 2014; 118 (35): 10460-70. [IF 2014: 3.3]

  4. Školová, B., Janůšová, B., Zbytovská, J., Gooris, G., Bouwstra, J., Slepička, P., Berka, P., Roh, J., Palát, K., Hrabálek, A., Vávrová, K. Ceramides in the skin lipid membranes: length matters. Langmuir 2013; 29 (50): 15624-33. [IF 2013: 4.2]

  5. Stahlberg, S., Školová, B., Madhu, P. K., Vogel, A., Vávrová, K., Huster, D. Probing the role of the ceramide acyl chain length and sphingosine unsaturation in model skin barrier lipid mixtures by 2H solid-state NMR spectroscopy. Langmuir 2015; 31 (17): 4906-4915. [IF 2014: 4.5]

  6. Janůšová B., Školová B., Tükörová K., Wojnarová L., Šimůnek T., Mladěnka P., Filipský T., Říha M., Roh J., Palát K., Hrabálek A., Vávrová K. Amino acid derivatives as transdermal permeation enhancers. J. Control. Release 2013; 165 (2): 91-100. [IF 2013: 7.3]

  7. Diblíková D., Kopečná M., Školová, B., Krečmerová M., Roh J., Hrabálek A., Vávrová K. Transdermal delivery and cutaneous targeting of antivirals using a penetration enhancer and lysolipid prodrugs. Pharm. Res. 2014; 31: 1071-81. [IF 2014: 3.4]

  8. Vávrová K., Kovaříková P., Školová B., Líbalová M., Roh J., Čáp R., Holý A., Hrabálek A. Enhanced topical and transdermal delivery of antineoplastic and antiviral acyclic nucleoside phosphonate cPr PMEDAP. Pharm. Res. 2011; 28 (12): 3105-15. [IF 2011: 4.1]

  9. Pullmannová, P., Staňková, K., Pospíšilová, M., Školová, B., Zbytovská, J., Vávrová, K. Effects of sphingomyelin/ceramide ratio on the permeability and microstructure of model stratum corneum lipid membranes. Biochim. Biophys. Acta 2014. 1838 (8): 2015-26. [IF 2014: 3.8]

  10. Vávrová K., Henkes D., Strüver K., Sochorová M., Školová B., Witting M.Y., Friess W., Schreml S., Meier R.J., Schäfer-Korting M., Fluhr J.W., Küchler S. Filaggrin deficiency leads to impaired lipid profile and altered acidification pathways in a 3D skin construct. J. Invest. Dermatol. 2014; 134 (3): 746-53. [IF 2014: 7.2]

© 2017 Charles University, Faculty of Pharmacy in Hradec Králové, Akademika Heyrovského 1203, 500 05 Hradec Králové, Czech Republic

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