Professor, Head of the Department of Pharmacology and Toxicology
Group leader – Experimental Pharmacology and Drug Interactions
Vice-dean for education!
Previous Education and Professional Experience
2012 – present: Head of the Department of Pharmacology and Toxicology, Faculty of Pharmacy, Charles University, Czech Republic
2011 – present: Professor of pharmacology, Department of Pharmacology and Toxicology, Faculty of Pharmacy, Charles University, Czech Republic
2001 - 2011: Associate Professor, Department of Pharmacology and Toxicology, Faculty of Pharmacy, Charles University, Czech Republic
1999 - 2001: Post-doc research fellow, School of Pharmaceutical Sciences, Manchester University, Great Britain.
1997 - 1999: Post-doc research fellow, School of Pharmaceutical Sciences, Kyoto University, Japan.
1994 - 1997: Research fellow, Department of Pharmacology and Toxicology, Faculty of Pharmacy, Charles University, Czech Republic
1994-1999: Masters Study, Charles University in Prague, Faculty of Pharmacy in Hradec Kralove, (M.Sc. in Pharmacy)
Research interests; current and past
- Functional expression of efflux drug transporters in tissues - effect on drug resistance and pharmacokinetics.
- Transplacental pharmacokinetics of drugs – influence of drug transporters and metabolizing enzymes.
- Drug interactions.
- Overcoming biological barriers for cancer gene therapy; application of fluorescence microscopy for tracing plasmids.
- Targeted delivery of macromolecules.
- Identification of factors controlling liver uptake and hepato-biliar transfer of macromolecules.
- Gene-delivery using cationic liposomes and polypeptides.
Lecturer and examiner of pharmacology for pre(post)gradual students.
Supervisor of numerous Ph.D. and diploma thesis students at the Department of Pharmacology and Toxicology.
Principal investigator and co-investigator of several grants.
- ASPET - American Society for Pharmacology and Experimental Therapeutics.
- ISSX - International Society for Study of Xenobiotics.
- Czech Society for Experimental and Clinical Pharmacology and Toxicology
- Member of the Scientific Council, Charles University in Prague, Faculty of Pharmacy in Hradec Kralove
- Grant Agency of the Charles University (section C – Medical sciences)
Awards and Prizes
- Best publication in experimental pharmacology by Czech Society for Experimental and Clinical Pharmacology and toxicology (J Pharmacol Exp Ther, 2006, vol. 319, no. 1, s. 53-62).
- Best publication in cardiovascular physiology by Blood Pressure (Placenta, 2006, vol. 27, no. 2-3, s. 171-180).
(based on Scopus database search as of October 2012)
Author/co-author of 50+ research articles, 5 review articles, 1 book chapter
700+ citations (without self-citations)
H-index = 17 (without self-citations)
List of selected important publications since 1998
For full list of Frantisek Staud’s publications, go to: PubMed Search “Staud F”.
If you cannot access any of the papers, do not hesitate to contact me and I will send you a PDF or hardcopy.
Staud F, Cerveny L, Ceckova M. Pharmacotherapy in pregnancy; effect of ABC and SLC transporters on drug transport across the placenta and fetal drug exposure. J Drug Target 2012:in press.
Hofman J, Ahmadimoghaddam D, Hahnova L, Pavek P, Ceckova M, Staud F. Olomoucine II and purvalanol A inhibit ABCG2 transporter in vitro and in situ and synergistically potentiate cytostatic effect of mitoxantrone. Pharmacol Res 2012;65:312-9.
Ahmadimoghaddam D, Hofman J, Zemankova L, Nachtigal P, Dolezelova E, Cerveny L, Staud F. Synchronized Activity of Organic Cation Transporter 3 (Oct3/Slc22a3) and Multidrug and Toxin Extrusion 1 (Mate1/Slc47a1) Transporter in Transplacental Passage of MPP+ in Rat. Toxicol Sci 2012;128:471-81.
Hahnova-Cygalova L, Ceckova M, Staud F. Fetoprotective activity of breast cancer resistance protein (BCRP, ABCG2): expression and function throughout pregnancy. Drug Metab Rev 2011;43:53-68.
Staud F, Ceckova M, Micuda S, Pavek P. Expression and function of p-glycoprotein in normal tissues: effect on pharmacokinetics. Methods Mol Biol 2010;596:199-222.
Vackova Z, Vagnerova K, Libra A, Miksik I, Pacha J, Staud F. Dexamethasone and betamethasone administration during pregnancy affects expression and function of 11 beta-hydroxysteroid dehydrogenase type 2 in the rat placenta. Reprod Toxicol 2009;28:46-51.
Pavek P, Ceckova M, Staud F. Variation of drug kinetics in pregnancy. Curr Drug Metab 2009;10:520-9.
Cygalova LH, Hofman J, Ceckova M, Staud F. Transplacental pharmacokinetics of glyburide, rhodamine 123, and BODIPY FL prazosin: effect of drug efflux transporters and lipid solubility. J Pharmacol Exp Ther 2009;331:1118-25.
Vagnerova K, Vackova Z, Klusonova P, Staud F, Kopecky M, Ergang P, et al. Reciprocal changes in maternal and fetal metabolism of corticosterone in rat during gestation. Reprod Sci 2008;15:921-31.
Cygalova L, Ceckova M, Pavek P, Staud F. Role of breast cancer resistance protein (Bcrp/Abcg2) in fetal protection during gestation in rat. Toxicol Lett 2008;178:176-80.
Ceckova M, Vackova Z, Radilova H, Libra A, Buncek M, Staud F. Effect of ABCG2 on cytotoxicity of platinum drugs: Interference of EGFP. Toxicol In Vitro 2008;22:1846-52.
Vackova Z, Libra A, Ceckova M, Pavek P, Staud F. Effect of dexamethasone and betamethasone on 11beta-hydroxysteroid dehydrogenase type 2 expression in human choriocarcinoma Jeg3 cells. Biomed Pap 2007;151:95-7.
Cerveny L, Svecova L, Anzenbacherova E, Vrzal R, Staud F, Dvorak Z, et al. Valproic acid induces CYP3A4 and MDR1 gene expression by activation of constitutive androstane receptor and pregnane X receptor pathways. Drug Metab Dispos 2007;35:1032-41.
Bremer S, Brittebo E, Dencker L, Knudsen LE, Mathisien L, Olovsson M, Staud F et al. In vitro tests for detecting chemicals affecting the embryo implantation process. The report and recommendations of ECVAM workshop 62 -- a strategic workshop of the EU ReProTect project. Altern Lab Anim 2007;35:421-39.
Staud F, Vackova Z, Pospechova K, Pavek P, Ceckova M, Libra A, et al. Expression and Transport Activity of Breast Cancer Resistance Protein (Bcrp/Abcg2) in Dually Perfused Rat Placenta and HRP-1 Cell Line. J Pharmacol Exp Ther 2006;319:53-62.
Staud F, Mazancova K, Miksik I, Pavek P, Fendrich Z, Pacha J. Corticosterone transfer and metabolism in the dually perfused rat placenta: effect of 11beta-hydroxysteroid dehydrogenase type 2. Placenta 2006;27:171-80.
Libra A, Fernetti C, Lorusso V, Visigalli M, Anelli PL, Staud F, et al. Molecular determinants in the transport of a bile Acid-derived diagnostic agent in tumoral and nontumoral cell lines of human liver. J Pharmacol Exp Ther 2006;319:809-17.
Cerveny L, Pavek P, Malakova J, Staud F, Fendrich Z. Lack of Interactions between Breast Cancer Resistance Protein (BCRP/ABCG2) and Selected Antiepileptic Agents. Epilepsia 2006;47:461-8.
Ceckova-Novotna M, Pavek P, Staud F. P-glycoprotein in the placenta: Expression, localization, regulation and function. Reprod Toxicol 2006;22:400-10.
Ceckova M, Libra A, Pavek P, Nachtigal P, Brabec M, Fuchs R, Staud F. Expression and functional activity of breast cancer resistance protein (bcrp, abcg2) transporter in the human choriocarcinoma cell line bewo. Clin Exp Pharmacol Physiol 2006;33:58-65.
Staud F, Pavek P. Breast cancer resistance protein (BCRP/ABCG2). Int J Biochem Cell Biol 2005;37:720-5.
Novotna M, Libra A, Kopecky M, Pavek P, Fendrich Z, Semecky V, Staud F. P-glycoprotein expression and distribution in the rat placenta during pregnancy. Reprod Toxicol 2004;18:785-92.
Pavek P, Staud F, Fendrich Z, Sklenarova H, Libra A, Novotna M, et al. Examination of the functional activity of P-glycoprotein in the rat placental barrier using rhodamine 123. J Pharmacol Exp Ther 2003;305:1239-50.
Sklenarova H, Pavek P, Satinsky D, Solich P, Karlicek R, Staud F. Determination of rhodamine 123 by sequential injection technique for pharmacokinetic studies in the rat placenta. Talanta 2002;58:1145-149.
Pavek P, Fendrich Z, Staud F, Malakova J, Brozmanova H, Laznicek M, et al. Influence of P-glycoprotein on the transplacental passage of cyclosporine. J Pharm Sci 2001;90:1583-92.
Staud F, Nishikawa M, Takakura Y, Hashida M. Liver uptake and hepato-biliary transfer of galactosylated proteins in rats are determined by the extent of galactosylation. Biochim Biophys Acta 1999;1427:183-92.
Staud F, Nishikawa M, Morimoto K, Takakura Y, Hashida M. Disposition of radioactivity after injection of liver-targeted proteins labeled with 111In or 125I. Effect of labeling on distribution and excretion of radioactivity in rats. J Pharm Sci 1999;88:577-85.
Pavek P, Staud F, Fendrich Z, Malakova J, Palicka V. Transfer of clorazepate and nordiazepam across the umbilically perfused rat term placenta in situ: Comparison with flunitrazepam and diazepam. Trophoblast Res 1999;13:329-42.
Nishikawa M, Staud F, Takemura S, Takakura Y, Hashida M. Pharmacokinetic evaluation of biodistribution data obtained with radiolabeled proteins in mice. Biol Pharm Bull 1999;22:214-8.
Staud F, Morimoto K, Nishikawa M, Takakura Y, Hashida M. Pharmacokinetic analysis of the in vivo disposition of chemically modified proteins in rats: effect of radiolabeling method. J Pharm Sci (Japan) 1998;58:101.
Hobbies and Non-research activities
When not lecturing, examining or writing up yet another paper, grant application or report, I keep up many activities to distract myself:
I spend most of the time entertaining my family:
I love to travel the world as a photographer for magazines and agencies, see www.photostaud.com and www.phototravels.net
I also train my German Shepherd dog, Aaron Dan Klar:
And on nights, I tune up my Les Paul six-string, switch on a Marshall amp and wake up all my neighborhoods: