Prof. PharmDr. Kateřina Vávrová, Ph.D.

Head of Skin Barrier Research Group, member of the Hrabalek group

Born: December 10, 1975
Address: Department of Inorganic and Organic Chemistry, Charles University in Prague, Faculty of Pharmacy Hradec Kralove, Heyrovskeho 1203, CZ-50005 Hradec Kralove, Czech Republic

Tel: +420-495-067 497, Fax: +420-495-067 166
E-mail: katerina.vavrova@faf.cuni.cz

Research interests

Education, professional experience

  • since 2009: associate professor in Medicinal chemistry at the Charles University in Prague, Faculty of Pharmacy
  • 2005 - 2011: researcher at the Centre “New antivirals and antineoplastics“ and “Research of new drugs“
  • 2004 - 2005: visiting researcher at the University of Franche-Comte, Faculty of Medicine and Pharmacy, Laboratory of Cutaneous Biology, Besancon, France
  • 2003 - 2009: researcher at the Department of Inorganic and Organic Chemistry, Charles University in Prague
  • 1999 - 2003: PhD in Bioorganic chemistry, Charles University in Prague
  • 1994 - 1999: MSc in Pharmacy, Charles University in Prague

Teaching activities

  • teaching of Organic chemistry I, Organic chemistry II and Solved problems in organic chemistry for Pharmacy and Organic chemistry and Solved problems in organic chemistry for Healthcare bioanalytics at the Faculty of Pharmacy, Charles University in Prague
  • supervisor of PhD (10; 5 defended), PharmD (5; 4 defended) and MSc students (31; 26 defended)
  • e-learning course “Solved problems in organic chemistry” (in Czech)
  • presentations at Schola ludus and Summer School (2013), Day of Science (2012), Czech TV series “About Science and Scientists” (2014)

Scientific grants

Principal researcher:

  • since 2016: Czech Science Foundation-German Science Foundation joint project 16-25687J (with Freie Universitaet Berlin): Interdependencies between Inflammatory Processes and Barrier Lipids in Diseased Skin
  • 2016: Graпt of the Representative of the Czech Republic in the Committee of Рlепiроtепtiаries of JINR "Role of the structural variability of ceramides in the arrangement of the stratum corneum model membranes" (with Frank Laboratory of Neutron Physics, Joint Institute of Nuclear Research, Dubna, Russia - Dr. Norbert Kučerka)
  • since 2013: Czech Science Foundation: Lipid membrane models – a new tool for studying pathophysiology of skin diseases at a molecular level (13-23891S)
  • 2011 - 2013: Czech Science Foundation: Synthesis and structure-activity relationships of skin ceramides and compounds targeting them (207/11/0365)
  • 2004 - 2006: Czech Science Foundation post-doc project: Ceramide analogues as transdermal permeation enhancers (203/04/P042)
  • 2004 - 2006: Charles University: Modification of skin barrier properties by biodegradable amino acid derivatives (407/2004/B-CH/FaF)
  • 2001 - 2003: Charles University: Transdermal permeation enhancers: effects of their similarity to ceramides on their enhancing activity
  • 2002: Ministry of education, „Modification of skin barrier properties by synthetic ceramide analogs”

Mentor: operational programme ECOP (CZ.1.07/2.3.00/30.0061) (Increasing of the R&D capacity at Charles University through new positions for graduates of doctoral studies); Ph.D. student projects of the Charles University (8)

Co-worker: Centre for new antivirals and antineoplastics 1M6138896301 (2005-2011), Research of new drugs MSM 0021620822 (2005-2011), University centre for research of toxic and protective effects of drugs on cardiovascular system UNCE 204019/304019/2012 (since 2012), projects of the Czech Science Foundation (3), Charles University, Ministry of industry and trade and Ministry of education

Membership

  • Scientific council of the Faculty of Pharmacy, Charles University (since 2014)
  • Scientific council of the Faculty of Military Health, University of Defense (since 2015)
  • PhD board in Bioorganic Chemistry, PhD board in Pharmaceutical Technology, PharmD, MSc and Bc boards at the Faculty of Pharmacy, Charles University in Prague
  • Agency for Healthcare Research of the Czech republic (Agentura pro Zdravornický Výzkum ČR) - panel 08 (biomedical technologies)
  • Scientific jury of the Sanofi Pharmacy Prize (2012-2014)
  • American Chemical Society, European Epidermal Barrier Research Network, Czech Chemical Society

Invited lectures

4th EJTEMM conference Bratislava (2016), Freie Universitat Berlin (2015), 11th European Epidermal Barrier Research Network (E2BRN) meeting, Edinburgh, UK (2013), 10th European Epidermal Barrier Research Network (E2BRN) meeting, Venice, Italy (2012), Joint Meeting in Medicinal Chemistry, Catania, Italy (2011), Skin Research Group, Leiden University, The Netherlands (2011), Congres of practical pharmacy, Olomouc, Czech Republic (2010)

Awards

  • 2009: Medal of the Faculty of Pharmacy, Charles University
  • 2003: winner of the Prix de Pharmacie organized by the French Institute in Prague and Jean-Marie Lehn, a Nobel Prize laureate in Chemistry; and Award of the Minister of education, youth and sports
  • 2002: Josef Hlávka Award
  • 1999: Award of the Dean of the Faculty of Pharmacy, Charles University

Publications

82 publications (ΣIF > 250), 2 Czech patents, 3 book chapters, over 700 citations (WoS); ORCID, ResearchGate

2016

Kováčik A, Šilarová M, Pullmannová P, Maixner J, Vávrová K. Effects of 6-hydroxyceramides on the thermotropic phase behavior and permeability of model skin lipid membranes. Langmuir 2017, in press

Schroeter A, Stahlberg S, Školová B, Sonnenberger S, Eichner A, Huster D, Vavrova K, Hauß T, Dobner B, Neubert R, Vogel A, Phase separation in Ceramide [NP] containing lipid model membranes: Neutron diffraction and solid-state NMR. Soft Matter, 2017, in press.

Kopečná M, Macháček M, Prchalová E, Štěpánek P, Drašar P, Kotora M, Vávrová K. Dodecyl amino glucoside enhances transdermal and topical drug delivery via reversible interaction with skin barrier lipids. Pharm. Res. 2017; in press, doi: 10.1007/s11095-016-2093-z. Springer sharing link

Školová B, Kováčik A, Tesař O, Opálka L, Vávrová K. Phytosphingosine, sphingosine and dihydrosphingosine ceramides in model skin lipid membranes: permeability and biophysics. Biochim. Biophys. Acta - Biomembranes. 2017; in press.

Karabanovich G, Němeček J, Valášková L, Carazo A, Konečná K, Stolaříková J, Hrabálek A, Pavliš O, Pávek P, Vávrová K, Roh J, Klimešová V.  S-substituted 3,5-dinitrophenyl 1,3,4-oxadiazole-2-thiols and tetrazole-5-thiols as highly efficient antitubercular agents. Eur. J. Med. Chem. 2017; 126: 369-383

2016

Opálka L, Kováčik A, Maixner J, Vávrová K. Omega-O-acylceramides in Skin Lipid Membranes: Effects of Concentration, Sphingoid Base and Model Complexity on Microstructure and Permeability. Langmuir 2016; 32(48):12894–12904. DOI: 10.1021/acs.langmuir.6b03082 - Open Access

Zoschke C, Ulrich M, Sochorová M, Wolff C, Vávrová K, Ma N, Ulrich C, Brandner J, Schäfer-Korting M. The barrier function of organotypic non-melanoma skin cancer models. J. Control. Release. 2016; 233:10-18.

Kováčik A, Opálka L, Šilarová M, Roh J, Vávrová K. Synthesis of 6-Hydroxyceramide Using Ruthenium-Catalyzed Hydrosilylation-Protodesilylation. Unexpected Formation of a Long Periodicity Lamellar Phase in Skin Lipid Membranes. RSC Adv. 2016, 6(77), 73343-73350.

Školová B; Janůšová B; Vávrová K. Ceramides with a pentadecasphingosine chain and short acyls have strong permeabilization effects on skin and model lipid membranes. Biochim Biophys Acta. Biomembranes 2016; 1858(2):220–232.

Vávrová K. Emerging small-molecule compounds for treatment of atopic dermatitis: a review. Exp. Opin. Ther. Patents 2016; 26(1):21-34. 50 free reprints

Hrušková K, Potůčková E, Hergeselová T, Liptáková L, Hašková P, Mingas P, Kovaříková P, Šimůnek T, Vávrová K. Aroylhydrazone Iron Chelators: Tuning Antioxidant and Antiproliferative Properties by Hydrazide Modifications. Eur. J. Med. Chem. 2016; in press. doi: 10.1016/j.ejmech.2016.05.015

Karabanovich G, Zemanová J, Smutný T, Székely R, Šarkan M, Centárová I, Vocat A, Pávková I, Čonka P, Němeček J, Stolaříková J, Vejsová M, Vavrova K, Klimešová K, Hrabalek A, Pavek P, Cole ST, Mikušová K, Roh J. Development of 3,5-Dinitrobenzylsulfanyl-1,3,4-Oxadiazoles and Thiadiazoles as Selective Antitubercular Agents Active Against Replicating and Nonreplicating Mycobacterium tuberculosis. J. Med. Chem. 2016, 59 (6), pp 2362–2380.

Roh J, Karabanovich G, Novakova V, Šimůnek T, Vávrová K. Large-Scale Synthesis of Piperazine-2,6-dione and Its Use in the Synthesis of Dexrazoxane Analogues. Synthesis 2016; DOI: 10.1055/s-0035-1562618

2015

Opálka L, Kováčik A, Sochorová M, Roh J, Kuneš J, Lenčo J, Vávrová K. Scalable Synthesis of Human Ultralong Chain Ceramides. Org. Lett. 2015; 17(21):5456-5459. DOI: 10.1021/acs.orglett.5b02816 - Open Access

Wallmeyer L; Lehnen D; Eger N; Sochorová M; Opálka L; Kováčik A; Vávrová K, Hedtrich S. Stimulation of PPARalpha Normalizes the Skin Lipid Ratio and Improves the Skin Barrier of Normal and Filaggrin Deficient Reconstructed Skin. J. Dermatol. Sci. 2015; 80(2):102–110. doi:10.1016/j.jdermsci.2015.09.012.

Paloncýová M, Vávrová K, Sovová Ž, DeVane R, Otyepka M, Berka K. Structural Changes in Ceramide Bilayers Rationalize Increased Permeation through Stratum Corneum Models with Shorter Acyl Tails. J Phys Chem B. 2015;119(30):9811-9

Stahlberg S, Školová B, Madhu PK, Vogel A, Vávrová K, Huster D. Probing the Role of the Ceramide Acyl Chain Length and Sphingosine Unsaturation in Model Skin Barrier Lipid Mixtures by 2H Solid-State NMR Spectroscopy. Langmuir 2015;31(17):4906-15

Witting M, Boreham A, Brodwolf R, Vávrová K, Alexiev U, Friess W, Hedtrich S. Interactions of Hyaluronic Acid with the Skin and Implications for the Dermal Delivery of Biomacromolecules. Mol Pharm. 2015;12(5):1391-401

Karabanovich G, Roh J, Soukup O, Pasdiorová M, Tambor V, Stolaříková J, Vejsová M, Vávrová K, Klimešová V, Hrabálek A. Tetrazole Regioisomers in the Development of Nitro Group-Containing Antitubercular Agents. MedChemComm. 2015;6:174-181

Potůčková E; Roh J; Macháček M; Sahni S; Stariat J; Šesták V; Jansová H; Hašková P; Jirkovská A; Vávrová K; Kovaříková P; Kalinowski DS; Richardson DR; Simunek T. In Vitro Characterization of the Pharmacological Properties of the Anti-Cancer Chelator, Bp4eT, and its Phase I Metabolites. PLOS One. 2015; 10(10):e0139929. DOI: 10.1371/journal.pone.0139929.

Jirkovská-Vávrová A., Roh J., Lenčová-Popelová O., Jirkovský E., Hrušková K., Potůčková-Macková E., Jansová H., Hašková P., Martinková P., Eisner T., Kratochvíl M., Šůs J., Macháček M., Vostatková-Tichotová L., Geršl V., Kalinowski D.S., Muller M., Richardson D.R., Vávrová K., Štěrba M., Šimůnek T. Synthesis and analysis of novel analogues of dexrazoxane and its open-ring hydrolysis product for protection against anthracycline cardiotoxicity in vitro and in vivo. Toxicology Res. 2015;4:1098-1114

2014

Vávrová K, Henkes D, Strüver K, Sochorová M, Školová B, Witting M, Friess W, Schreml S, Meier RJ, Schäfer-Korting M, Fluhr JW, Küchler S. Filaggrin Deficiency Leads to Impaired Lipid Profile and Altered Acidification Pathways in a 3 D Skin Construct. J. Invest. Dermatol. 2014, 134(3): 746-753.

Kováčik A, Roh J, Vávrová K. The chemistry and biology of 6 hydroxyceramide, the youngest member of the human sphingolipid family. ChemBioChem 2014, 15:1555-1562.

Pullmannová P, Staňková K, Pospíšilová M, Skolová B, Zbytovská J, Vávrová K. Effects of sphingomyelin/ceramide ratio on the permeability and microstructure of model stratum corneum lipid membranes. Biochim Biophys Acta. 2014, 1838(8):2115-2126.

Školová B, Jandovská K, Pullmannová P, Tesař O, Roh J, Hrabálek A, Vávrová K. The role of the trans double bond in skin barrier sphingolipids: permeability and infrared spectroscopic study of model ceramide and dihydroceramide membranes. Langmuir. 2014; 30(19):5527-5535.

Školová B, Hudská K, Pullmannová P, Kováčik A, Palát K, Roh J, Fleddermann J, Estrela-Lopis I, Vávrová K. Different Phase Behavior and Packing of Ceramides with Long (C16) and Very Long (C24) Acyls in Model Membranes: Infrared Spectroscopy Using Deuterated Lipids. J Phys Chem B. 2014, 118 (35), 10460–10470.

Diblíková D, Kopečná M, Školová B, Krečmerová M, Roh J, Hrabálek A, Vávrová K. Transdermal Delivery and Cutaneous Targeting of Antivirals using a Penetration Enhancer and Lysolipid Prodrugs. Pharm. Res. 2014, 31(4):1071-1081.

Karabanovich G, Roh J, Smutný T, Němeček J, Vicherek P, Stolaříková J, Vejsová M, Dufková I, Vávrová K, Pávek P, Klimešová V, Hrabálek A. 1-Substituted-5-[(3,5-dinitrobenzyl)sulfanyl]-1H-tetrazoles and their isosteric analogs: A new class of selective antitubercular agents active against drug-susceptible and multidrug-resistant mycobacteria. Eur. J. Med. Chem. 2014; 82:324-340.

Potůčková E, Hrušková K, Bureš J, Kovaříková P, Špirková IA, Pravdíková K, Kolbabová L, Hergeselová T, Hašková P, Jansová H, Macháček M, Jirkovská A, Richardson V, Lane DJR, Kalinowski DS, Richardson DR, Vávrová K, Šimůnek T. Structure-activity relationships of novel salicylaldehyde isonicotinoyl hydrazone (SIH) analogs: iron chelation, anti-oxidant and cytotoxic properties. PLOS One. 2014; 9(11):e112059

2013

Školová B, Janůšová B, Zbytovská J, Gooris G, Bouwstra JA, Slepička P, Berka P, Roh J, Palát K, Hrabálek A, Vávrová K. Ceramides in the Skin Lipid Membranes: Length Matters. Langmuir 2013, 29(50):15624-15633.

Janůšová B, Školová B, Tükörová K, Wojnarová L, Šimůnek T, Mladěnka P, Filipský T, Říha M, Roh J, Palát K, Hrabálek A, Vávrová K. Amino acid derivatives as transdermal permeation enhancers. J. Control. Release 2013, 165(2):91-100.

Karabanovich G, Roh J, Padělková Z, Novák Z, Vávrová K, Hrabálek A. One-pot synthesis of 1-substituted-5-alkylselanyl-1H-tetrazoles from isoselenocyanates: unexpected formation of N-alkyl-N-arylcyanamides and (Z)-Se-alkyl-N-cyano-N,N′-diarylisoselenoureas. Tetrahedron 2013, 69(41):8798-8808.

Filipský T, Říha M, Hrdina R, Vávrová K, Mladěnka P, Mathematical calculations of iron complex stoichiometry by direct UV-Vis spectrophotometry. Bioorg. Chem. 2013, 49:1-8.

2012

Roh J, Vávrová K, Hrabálek A. Synthesis and Functionalization of 5-Substituted Tetrazoles. Eur. J. Org. Chem. 2012, 31:6101-6118.

Macková E, Hrušková K, Bendová P, Vávrová A, Jansová H, Hašková P, Kovaříková P, Vávrová K, Šimůnek T. Methyl and ethyl ketone analogs of salicylaldehyde isonicotinoyl hydrazone: Novel iron chelators with selective antiproliferative action. Chem.-Biol. Interact. 2012; 197(2–3):69-79.

Stariat J, Šesták V, Vávrová K, Nobilis M, Kollárová Z, Klimeš J, Kalinowski DS, Richardson DR, Kovaříková P. LC-MS/MS identification of the principal in vitro and in vivo phase I metabolites of the novel thiosemicarbazone anti-cancer drug, Bp4eT. Anal. Bioanal. Chem. 2012, 403(1):309-321.

2011

Vávrová K, Kovaříková P, Školová B, Líbalová M, Roh J, Čáp R, Holý A, Hrabálek A. Enhanced topical and transdermal delivery of antineoplastic and antiviral acyclic nucleoside phosphonate cPr‑PMEDAP. Pharm. Res. 2011; 28(12):3105-3115.

Janůšová B, Zbytovská J, Lorenc P, Vavrysová H, Palát K, Hrabálek A, Vávrová K. Effect of ceramide acyl chain length on skin permeability and thermotropic phase behavior of model stratum corneum lipid membranes. Biochim. Biophys. Acta Mol. Cell Biol. Lipids 2011; 1811(3):129-137.

Novotný M, Klimentová J, Janůšová B, Palát K. Hrabálek A, Vávrová K. Ammonium carbamates as highly active transdermal permeation enhancers with a dual mechanism of action. J. Control. Release 2011; 150(2):164-70.

Žebrakovská I, Máša M, Srp J, Horn M, Vávrová K, Mareš M. Complex modulation of peptidolytic activity of cathepsin D by sphingolipids. Biochim. Biophys. Acta Mol. Cell Biol. Lipids 2011; 1811(12):1097-1104.

Vavříková E, Polanc S, Kočevar M, Horváti K, Bősze S, Stolaříková J, Vávrová K, Vinšová J. New fluorine-containing hydrazones active against MDR-tuberculosis. Eur. J. Med. Chem. 2011, 46(10):4937-45.

Hašková P, Koubková L, Vávrová A, Macková E, Hrušková K, Kovaříková P, Vávrová K, Šimůnek T. Comparison of various iron chelators used in clinical practice as protecting agents against catecholamine-induced oxidative injury and cardiotoxicity. Toxicology 2011, 289(2-3):122-131.

Hrušková K, Kovaříková P, Bendová P, Hašková P, Macková E, Stariat J, Vávrová A, Vávrová K, Šimůnek T. Synthesis and initial in vitro evaluations of novel antioxidant aroylhydrazone iron chelators with increased stability against plasma hydrolysis. Chem. Res. Toxicol. 2011; 24(3):290-302.

Kovaříková P, Stariat J, Klimeš J, Hrušková K, Vávrová K. Hydrophilic interaction liquid chromatography in the separation of a moderately lipophilic drug from its highly polar metabolites - the cardioprotectant dexrazoxane as a model case. J. Chrom. A 2011; 1218(3):416-426.

2010

Novotný M, Hrabálek A, Janůšová B, Novotný J, Vávrová K. Transkarbams as transdermal permeation enhancers; Effects of ester position and ammonium carbamate formation. Bioorg. Med. Chem. Lett. 2010; 20(9): 2726-8.

Novotný J, Hrabálek A, Vávrová K. Synthesis and Structure-Activity Relationships of Skin Ceramides. Curr. Med. Chem. 2010; 17(21):2301-24.

Bendova P, Mackova E, Haskova P, Vavrova A, Jirkovsky E, Sterba M, Popelova O, Kalinowski DS, Kovarikova P, Vavrova K, Richardson DR, Simunek T. Comparison of clinically used and experimental iron chelators for protection against oxidative stress-induced cellular injury. Chem. Res. Toxicol. 2010; 23(6):1105-14.

Roh J, Vávrová K, Hrabálek A. One-pot regioselective vinylation of tetrazoles: preparation of 5-substituted 2-vinyl-2H-tetrazoles. Tetrahedron Lett. 2010; 51(10):1411-4.

Ferriz JM, Vávrová K, Kunc F, Imramovský A, Stolaříková J, Vavříková E, Vinšová J. Salicylanilide carbamates: Antitubercular agents active against multidrug-resistant Mycobacterium tuberculosis strains. Bioorg. Med. Chem. 2010; 18(3):1054-61.

2009

Novotný J, Pospěchová K, Hrabálek A, Čáp R, Vávrová K. Synthesis of Fluorescent C24-Ceramide: Evidence for Acyl Chain Length Dependent Differences in Penetration of Exogenous NBD-Ceramides into Human Skin. Bioorg. Med. Chem. Lett. 2009; 19(24): 6975-6977.

Zbytovská J, Vávrová K, Kiselev MA, Lessieur P, Wartewig S, Neubert RHH. The effects of transdermal permeation enhancers on thermotropic phase behaviour of a stratum corneum lipid model. Col. Surf. A 2009; 351:30-37.

Novotný M, Hrabálek A, Janůšová B, Novotný J, Vávrová K. Dicarboxylic acid esters as transdermal permeation enhancers: effects of chain number and geometric isomers. Bioorg. Med. Chem. Lett. 2009; 19(2):344-347.

Novotný J, Kovaříková P, Novotný M, Janůšová B, Hrabálek A, Vávrová K. Dimethylamino acid esters as biodegradable and reversible transdermal permeation enhancers: effects of linking chain length, chirality and polyfluorination. Pharm. Res. 2009;26(4):811-21.

Novotný J, Janůšová B, Novotný M, Hrabálek A, Vávrová K. Short-Chain Ceramides Decrease Skin Barrier Properties. Skin Pharmacol. Physiol. 2009; 22(1):22-30.

Roh J, Artamonova TV, Vávrová K, Koldobskii GI, Hrabálek A. Practical Synthesis of 5-Substituted Tetrazoles under Microwave Irradiation. Synthesis 2009; 13: 2175-2178.

2008

Vávrová K, Lorencová K, Novotný J, Holý A, Hrabálek A. Permeation enhancer dodecyl 6-(dimethylamino)hexanoate increases transdermal and topical delivery of adefovir; influence of pH, ion-pairing and skin species. Eur. J. Pharm. Biopharm. 2008; 70(3):901-7.

Klimentová J, Kosák P, Vávrová K, Holas T, Novotný J, Hrabálek A. Transkarbams with Terminal Branching as Transdermal Permeation Enhancers. Bioorg. Med. Chem. Lett. 2008; 18(5):1712-1715.

Vávrová K, Lorencová K, Klimentová J, Novotný J, Holý A, Hrabálek A. Transdermal and dermal delivery of adefovir; effects of pH and permeation enhancers. Eur. J. Pharm. Biopharm. 2008; 69(2):597-604.

Kovaříková P, Vávrová K, Tomalová K, Schöngut M, Hrušková K, Hašková P, Klimeš J. HPLC-DAD and MS/MS analysis of novel drug candidates from the group of aromatic hydrazones revealing the presence of geometric isomers. J. Pharm. Biomed. Anal. 2008; 48(2):295-302.

2007

Vávrová K, Hrabálek A, Mac-Mary S, Humbert P, Muret P. Ceramide analogue 14S24 selectively recovers perturbed human skin barrier. Brit. J. Dermatol. 2007; 157 (4):704-712.

Vávrová K, Lorencová K, Klimentová J, Novotný J, Hrabálek A. HPLC method for determination of in vitro delivery through and into porcine skin of adefovir (PMEA). J. Chromatogr. B. 2007; 853(1-2):198-203.

Hrabálek A, Vávrová K. Historie a současný stav ve vývoji akcelerantů transdermální permeace na Farmaceutické fakultě UK v Hradci Králové – od esterů 6-aminohexanové kyseliny k transkarbamům (II. část). Praktické lékárenství 2007; 3(6):299-300.

Hrabálek A, Doležal P, Vávrová K. Historie a současný stav ve vývoji akcelerantů transdermální permeace na Farmaceutické fakultě UK v Hradci Králové – od esterů 6-aminohexanové kyseliny k transkarbamům (I. část). Praktické lékárenství 2007; 3(2):90-2.

2006

Klimentová J, Kosák P, Vávrová K, Holas T, Hrabálek A. Influence of terminal branching on the transdermal permeation-enhancing activity in fatty alcohols and acids. Bioorg. Med. Chem. 2006; 14(23):7681-7.

Holas T, Vávrová K, Šíma M, Klimentová J, Hrabálek A. Synthesis and transdermal permeation-enhancing activity of carbonate and carbamate analogs of Transkarbam 12. Bioorg. Med. Chem. 2006; 14(23):7671-80.

Hrabálek A, Doležal P, Vávrová K, Zbytovská J, Holas T, Klimentová J, Novotný J. Synthesis and Enhancing Effect of Transkarbam 12 on the Transdermal Delivery of Theophylline, Clotrimazole, Flobufen, and Griseofulvin. Pharm. Res. 2006; 23(5):912-8.

Klimentová J, Hrabálek A, Vávrová K, Holas T, Kroutil A. Synthesis and transdermal penetration-enhancing activity of carbonic and carbamic acid esters-comparison with transkarbam 12. Bioorg. Med. Chem. Lett. 2006; 16(7):1981-4.

Holas T, Vávrová K, Klimentová J, Hrabálek A. Synthesis and transdermal permeation-enhancing activity of ketone, amide, and alkane analogs of Transkarbam 12. Bioorg. Med. Chem. 2006; 14(9):2896-2903.

Kovaříková P, Mokrý M, Klimeš J, Vávrová K. HPLC study on stability of pyridoxal isonicotinoyl hydrazone. J. Pharm. Biomed. Anal. 2006; 40(1):105-12.

Holas T, Zbytovská J, Vávrová K, Berka P, Mádlová M, Klimentová J, Hrabálek A. Thermotropic phase behavior of long-chain alkylammonium-alkylcarbamates. Thermochim. Acta 2006; 441(2):116-123

Vávrová K, Hrabálek A. Role ceramidů v kůži. Praktické lékárenství 2006; 2:55-58.

2005

Vávrová K, Zbytovská J, Hrabálek A. Amphiphilic transdermal permeation enhancers: structure-activity relationships. Curr. Med. Chem. 2005; 12(19):2273-91.

Hrabálek A, Vávrová K, Doležal P, Macháček M. Esters of 6-aminohexanoic acid as skin permeation enhancers: The effect of branching in the alkanol moiety. J. Pharm. Sci. 2005; 94(7):1494-9.

Vávrová K, Hrabálek A, Doležal P, Holas T, Klimentová J. Biodegradable derivatives of tranexamic acid as transdermal permeation enhancers. J. Control. Release. 2005; 104(1):41-9.

Hrabálek A, Vávrová K. Lze překonat kožní bariéru? Praktické lékárenství 2005; 1:8-11.

2004

Kovaříková P, Mokrý M, Klimeš J, Vávrová K. Chromatographic methods for the separation of biocompatible iron chelators from their synthetic precursors and iron chelates. J. Sep. Sci. 2004; 27(17-18):1503-10.

Vávrová K, Zbytovská J, Palát K, Holas T, Klimentová J, Hrabálek A, Doležal P. Ceramide analogue 14S24 ((S)-2-tetracosanoylamino-3-hydroxypropionic acid tetradecyl ester) is effective in skin barrier repair in vitro. Eur. J. Pharm. Sci. 2004; 21(5):581-7.

Hrabálek A, Myznikov L, Kuneš J, Vávrová K, Koldobskii G. A simple method for the preparation of 5-alkylsulfinyl-1-aryltetrazoles. Tetrahedron Lett. 2004; 45(42):7955-7.

2003

Vávrová K, Hrabálek A, Doležal P, Šámalová L, Palát K, Zbytovská J, Holas T, Klimentová J. Synthetic ceramide analogues as skin permeation enhancers: structure-activity relationships. Bioorg. Med. Chem. 2003; 11(24):5381-90.

Vávrová K, Hrabálek A, Doležal P, Holas T, Zbytovská J. L-Serine and glycine based ceramide analogues as transdermal permeation enhancers: polar head size and hydrogen bonding. Bioorg. Med. Chem. Lett. 2003; 13(14):2351-3.

Doležal P, Hrabálek A, Svozil M, Vávrová K, Zbytovská J. In vitro studies on transkarbam 12 and laurocapram effect on transdermal permeation of butorphanol. Farmacevtski Vestnik 2003; 54 (Spec. Iss.):527-8

2002

Vávrová K, Hrabálek A, Doležal P. Enhancement effects of (R) and (S) enantiomers and the racemate of a model enhancer on permeation of theophylline through human skin. Arch. Dermatol. Res. 2002; 294(8):383-5.

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