Prof. RNDr. Jarmila Vinšová, Ph.D.

Head of Development of new potential drugs with antimicrobial activity research group

Address: Department of Inorganic and Organic Chemistry,
Charles University in Prague, Faculty of Pharmacy in Hradec Králové,
Heyrovského 1203, CZ- 50005 Hradec Králové, the Czech Republic

Tel: 495067343, Fax: 495067166

Education and Degrees

  • 2011 - Professor of Pharmaceutical Chemistry at the University of Veterinary and  Pharmaceutical Sciences Brno
  • 1997 - Associate Professor of Bioorganic Chemistry - Thesis - Relationships between chemical structure and biological activity of some heterocyclic compounds. Faculty of Pharmacy in Hradec Králové, Charles University in Prague
  • 1985 - Ph.D. Thesis - Synthesis of sulphur-containing derivatives of some pyridine carboxylic acids as potential antituberculotics, Faculty of Pharmacy in Hradec Králové, Charles University in Prague
  • 1976 - RNDr. (MSc. equivalent) - Thesis - Synthesis of potential antituberculotics and antimycotics from the group of sulphur-containing pyridine derivatives. Faculty of  Pharmacy in Hradec Králové, Charles University in Prague
  • 1969-74 - Faculty of Pharmacy in Hradec Králové, Charles University in Prague 

Teaching activity

  • Guarantor of study program of Pharmacy (since 2004)
  • Senior Advisor for foreign students (since 1994)
  • ERASMUS students co-coordinator (since 1998)
  • Lecturer and guarantor of the subjects:
    • Organic Chemistry I and II, Bioorganic Chemsitry for Pharmacy in Czech and English language, Exercises in Organic Chemistry
    • Constitution of Organic Compounds for foreigner students.
  • Lecturer and guarantor of the subject Organic Chemistry for Healthcare bioanalytics - daily and distant study.
  • Supervisor of 9 Ph.D. students (7 graduated), 39 diploma-students, and 13 ERASMUS students from abroad.

Membership of the scientific societies and scientific boards

  • Member of the Scientific Council, Charles University in Prague, Faculty of Pharmacy in Hradec Králové (since 2014)
  • Czech Chemical Society (since 1976), vice-president (2010-2013)
  • Czech Pharmaceutical Society of J.E.Purkyně (since 2003)
  • Member of scientific board of Joint Meeting on Medicinal Chemistry (since 2009)
  • Head of the scientific board for PharmDr (since 2006)
  • Member of scientific board for the Ph.D. in Bioorganic Chemistry at the Faculty of Pharmacy
  • Member of scientific board for the Ph.D. in Organic Chemistry at the Institute of Chemical Technology Prague (since 2011)
  • Coordinator of Paul Ehrlich MedChem Euro-Ph.D. network at the Faculty of Pharmacy in Hradec Králové, Charles University in Prague (since 2010)


Profesional and research activity

Design and synthesis of new compounds with antimicrobial activities, especially antimycobacterial and antifungal activity. Relationships between chemical structure and biological activity, prodrug modelling of new agents active against MDR TB. Study of oxidative deamination of amino acids and peptides by using di-tert-butylbenzoquinone as pyridoxal mimics. Modelling of biological active peptides and depsipetides.

Author of 98 original papers (72 in WOS), 4 patents, 1 patent applications, 6 university textbooks, 177 posters/lectures on symposia, principal or co-investigator of 31 grant projects (4 bilateral projects, 5 European). 

Scientific grants (principal investigator)

  • 2012-2015 - Ministry of Health IGA NT 13346: Design and enzyme targeting of antibacterial active compounds against multidrug resistant strains
  • 2010-2011 - Bilateral project Kontakt Czech Republic - Slovenia: Development of novel antituberculosis agents and prodrugs effective against multidrug resistant tuberculosis
  • 2009-2011 - Ministry of Health IGA NS 10367-3: Evaluation and development of new perspective antimycobacterial drugs and prodrugs active against multidrug resistant strains.
  • 2008-2009 - Bilateral project Kontakt Czech Republic - Slovenia: Synthesis of New Antibacterial Active Compounds.
  • 2006-2009 - Ministry of Education - Development project: Increasing levels of teaching in English for teachers at the Faculty of Pharmacy Charles University
  • 2006-2007 - Bilateral project Kontakt Czech Republic – Slovenia: New approach to antibacterial active molecules.
  • 2003 - FRVŠ G4/2994: Student research activities in the field of potential antituberculotics
  • 2002 - FRVŠ G4/2261: The scientific work of students in the field of peptide chemistry and depsipeptides
  • 2001-2003 - GAČR 203/01/042: Oxidative deamination of peptides – a new approach to  depsipeptide synthesis
  • 1998-2000 - GAUK 24/1998BCH/FaF: Modelling of biologically active depsipeptides
  • 1998 - FRVŠ PG 98385: XVth EFMC International Symposium on Medicinal Chemistry - Expanding of research and development - presentation
  • 1995-1997 - GAČR 203/95/1483: Relations between chemical structure and biological activity in the group of short peptides and depsipeptides
  • 1993-1995 - GAUK 55/1995: Modelling of biologically active spirocyclic
  • 1993 - FRVŠ 0032 2: Modelling of biologically active cyclic dipeptides

European Grants (Co-Investigator)

  • TEAB - European project (CZ.1.07/2.3.00/20.0235)
  • FAFIS - European project (CZ.1.07/2.2.00/28.0194)
  • Postdoc I (CZ.1.07/2.3.00/30.0022)
  • Postdoc II UK ECOP (CZ.1.07/2.3.00/30.0061)
  • Pre-seed II UK (CZ.1.05/3.1.00/14.0299)


  • Kutschy P., Vinšová J., Berkeš D., Török M.: Základy farmaceutickej Chémie. Košice 2004, ISBN 80-7097-544-X
  • Hrabálek A., Klimešová V., Kuneš J., Palát K., Pour M., Waisser K., Vinšová J.: Soubor otázek k přijímacím zkouškám na Farmaceutickou fakultu v Hradci Králové z Chemie. Hradec Králové 2001, ISBN 80-238-6793-S
  • Hrabálek A., Kubicová L., Kuneš J., Pour M., Vinšová J.: Laboratorní cvičení z organické chemie pro farmaceuty, Karolinum Praha 1999
  • Hrabálek A., Kuneš J., Klimešová V., Macháček M., Opletal L., Palát K., Roman M., Vinšová J.: Chemická laboratorní technika pro farmaceuty. Karolinum Praha 1997
  • Vinšová J.: Laboratory manual for organic chemistry. Charles University, Karolinum Praha 1995
  • Čeladník M., Waisser K., Vinšová J., Hrabálek A.: Laboratorní cvičení z organické chemie. SPN Praha, 1990


book-development-new-mdr-tuberculosis.jpgVinšová J., Krátký M.: Development of New MDR-Tuberculosis Drugs. Nova Biomedical. New York 2010. ISBN 978-1-6168-233-0 (100 pages)


book-drug-resistant-tubersulosis.jpgVinšová J., Krátký M.: Drug-Resistant Tuberculosis: Causes, Diagnosis and Treatments (Editors: Shui Ngụy and Zhou K'ung) (Chapter 2 - Tuberculosis — The Development of New MDR-TB Drugs). Nova Biomedical, New York, 2009, ISBN 978-1-60876-055-8.

book-antioxidant-polymers.jpgJ. Vinšová, E. Vavříková: Antioxidant Polymers by Chitosan Modification (chapter in book: Antioxidant polymers, Synthesis, Properties and Applications, Editors: G. Cirillo and F. Iemma). Wiley, Sp Scrivener, 2012, page 115-151, ISBN 978-1-118-20854-0.


Publications (since 2005)


  • Baranyai Zs, Krátký M., Vosátka M., Szabó N., Senoner Sz., Dávid S., Stolaříková J., Vinšová J., Bősze S. In vitro biological evaluation of new antimycobacterial salicylanilide-tuftsin conjugates. Europ. J. Med. Chem. 2017, 133, 152-173 [ISSN 0223-5234, IF2015 = 3.447].
  • Krátký M., Stolaříková J., Vinšová J. Novel Sulfamethoxazole Ureas and Oxalamides as Potential Antimicobacterial Agents. Molecules 2017, 22(4), 535 [ISSN 1420-3049, IF2015 = 2.416]. doi:10.3390/molecules22040535
  • Krátký M., Vinšová J., Štěpánková Š., Vorčáková K., Navrátilová L., Trejtnar F., Stolaříková J. Novel Fluorophenylalanine Derivatives: Synthesis and Investigation of Their Biological Activity. Bioorganic Chemistry 2017, 71, 244 - 256 [ISSN: 0045-2068, IF2015 = 2.252]. doi: 10.1016/j.bioorg.2017.02.010
  • Paraskevopoulos G., Monteiro S., Vosátka R., Krátký M., Navrátilová L., Trejtnar F., Stolaříková J., Vinšová J.* Novel salicylanilides from 4,5-dihalogenated salicylic acids: Synthesis, antimicrobial activity and cytotoxicity. Bioorg. Med. Chem. 2017, 25(4), 1524-1532 [ISSN 0968-0896, IF2015 = 2.923]. 


  • Krátký M.*, Štěpánková Š., Vorčáková K., Vinšová J. Synthesis and in vitro evaluation of novel rhodanine derivatives as potential cholinesterase inhibitors. Bioorganic Chemistry 2016, 68, 23-29  [ISSN 0045-2068, IF2015 = 2.252].
  • Kozic J.*, Novák Z., Římal V., Profant V., Kuneš J., Vinšová J. Conformations, equilibrium thermodynamics and rotational barriers of secondary thiobenzanilides. Tetrahedron, 2016, 72, 2072-2083 [ISSN: 0040-4020, IF2015 = 2.641]. doi:10.1016/j.tet.2016.02.035
  • Krátký M.*, Vinšová J. Salicylanilide N-monosubstituted carbamates: Synthesis and in vitro antimicrobial activity. Bioorg. Med. Chem. 201624(6), 1322-1330.   [ISSN 0968-0896, IF2015 = 2.923].
  • Krátký M.*, Štěpánková Š., Vorčáková K., Švarcová M, Vinšová J. Novel Cholinesterases Inhibitors Based on O-Aromatic N,N-Disubstituted Carbamates and Thiocarbamate, Molecules, 201621, 191-201. [ISSN 1420-3049, IF2015 = 2.416].
  • Krátký M.*, Vinšová J. Sulphur-Containing Heterocycles as Antimycobacterial Agents: Recent Advances in Thiophene and Thiadiazole Derivatives, Current Topics in Medicinal Chemistry, 201616(26), 2921-2952 [ISSN 1389-4501, IF2015 = 3.4021]. DOI: 10.2174/1568026616666160506131118


  • Krátký M., Štěpánková Š, Vorčáková K., Vinšová J.* Salicylanilide Diethyl Phosphates as Cholinesterases Inhibitors. Bioorg. Med. Chem. 2015, 58, 48-52. [ISSN 0968-0896, IF2015 = 2.923].
  • Zadrazilova I., Pospisilova S., Pauk K., Imramovsky A., Vinsova J., Cizek A., Jampilek J.* In vitro bactericidal activity of 4- and 5-chloro-2-hydroxy-N-[1-oxo-1-(phenylamino)alkan-2-yl]benzamides against MRSA, BioMed Research International, 2015 Article 349534[ISSN 2314-6133, IF2014 = 1.579].
  • Krátký M., Bősze S., Baranyai Zs., Szabó I., Stolaříková J., Paraskevopoulos G., Vinšová J.* Synthesis and In Vitro Biological Evaluation of 2-(Phenylcarbamoyl)phenyl 4-Substituted Benzoates. Bioorg. Med. Chem. 201524(4), 868–875.  [ISSN 0968-0896, IF2015 = 2.793].
  • Švarcová M., Krátký M., Vinšová J*. Investigation of potential inhibitors of chorismate-utilizing enzymes Curr. Med. Chem. 2015, 22(11), 1383-1399 [ISSN 0929-8673, IF2015 = 3.853].
  • Krátký M.*, Mandíková J., Trejtnar F., Buchta V., Stolaříková J., Vinšová J. Synthesis and antimicrobial activity of novel sulfamethoxazole ureas and 2,4,5- imidazolidin-2,4,5-triones. Chemical Papers,  2015, 69(8), 1108-1117. [ISSN 0366-6352, IF2015 = 1.326].
  • Zadrazilova I., Masarikova M., Pospisilova S., Imramovsky A., Ferriz J.M., Vinsova J., Cizek J., Jampilek J.* Salicylanilide carbamates: Promising antibacterial agents with high in vitro activity against methicillin-resistant Staphylococcus aureus (MRSA), Eur. J. Pharm. Sci., 2015, 77, 197-207. [ISSN 0928-0987, IF2015 = 3.350].
  • Baranyai Z., Krátký M., Vinšová J., Szabó N., Senoner Z., Horváti K., Stolaříková J., Dávid S., Bősze S.* Combating highly resistant emerging pathogen Mycobacterium abscessus and Mycobacterium tuberculosis with novel salicylanilide esters and carbamates. Europ. J. Med. Chem. 2015101, 692-704. [ISSN 0223-5234, IF2015 = 3.447].
  • Paraskevopoulos G., Krátký M., Mandíková J., Trejtnar F., Stolaříková J., Pávek P., Besra G.,Vinšová J.* Novel derivatives of nitro-substituted salicylic acids: Synthesis, antimicrobial activity and cytotoxicity. Bioorg. Med. Chem. 2015, 23, 7292-7301 [ISSN 0968-0896, IF2015 = 2.923].











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