Prof. Ing. Vladimír Wsól, Ph.D.

Date and Place of Birth: 27 September 1967, Náchod, Czech Republic

Present Position:

Contact Information:

  • Work Address: Heyrovského 1203, 500 05 Hradec Králové, Czech Republic
  • E-mail: vladimir.wsol@faf.cuni.cz
  • Tel.: +420 495 067 370; Fax: +420 495 067 168; Skype: vlady_notebook

Previous Education and Training

1986-1990 Faculty of chemical technology, University of Pardubice 
1993 3 months stay in a laboratory of Pharmaceutical Chemistry at School of Pharmacy, University of Bradford, United Kingdom
1996 6 weeks stay in the Pharmaceutical Analysis Research Unit at School of Pharmacy, University of Bradford, United Kingdom
1998 Ph.D. in Pathobiochemistry and xenobiochemistry, Department of Biochemical Sciences, Faculty of Pharmacy, Charles University
1998 4 weeks stay in the Pharmaceutical Analysis Research Unit at School of Pharmacy, University of Bradford, United Kingdom 
1999 1999 Associate Professor in Biochemistry, Department of Biochemical Sciences, Faculty of Pharmacy, Charles University
2003-2005 22 months research stay in the Institute of Toxicology and Pharmacology at University in Kiel, Germany (Alexander von Humboldt)
2008 Professor in Biochemistry, Department of Biochemical Sciences, Faculty of Pharmacy, Charles University

Research Interests

  • Purification and characterization of membrane bound carbonyl reducing enzymes from human tissues
  • Cloning and characterization of human carbonyl reducing enzymes
    • Cloning and characterization of membrane-bound carbonyl reducing enzymes
    • Cloning and further characterization of cytosolic carbonyl reducing enzymes
  • Regulation of expression of human carbonyl reducing enzymes
  • Drug metabolism, identification of metabolites and enzymes involved

Teaching

General Biochemistry
Xenobiochemistry

  • since 2012: mentor of five post-doctoral research associates
  • since 1999: tutor of 17 Ph.D. students (13 already successfully finished); Head of the Examination Board of Ph.D. program Pathobiochemistry and Xenobiochemistry, and member of the Examination Board of Ph.D. program Bioanalytical Chemistry
  • since 2000: supervisor of 16 M.Sc. Pharmacy diploma theses of international ERASMUS students
  • since 1995: supervisor of >50 M.Sc. (Pharmacy and Medical Bioanalytics) diploma theses
  • since 2003: main lecturer and examiner of General Biochemistry for M.Sc. students (Pharmacy), Charles University in Prague, Faculty of Pharmacy in Hradec Králové
  • since 1997: main lecturer and examiner of Xenobiochemistry for M.Sc. students (Pharmacy and Medical Bioanalytics), Charles University in Prague, Faculty of Pharmacy in Hradec Králové

Professional Memberships

  • Chair of Specialists Board of the doctoral study programme Pathobiochemistry and xenobiochemistry, Faculty of Pharmacy, Charles University
  • Grant Agency of the Charles University – Member of the Medicine examination panel (section C)
  • International Society for the Study of Xenobiotics (ISSX)
  • Czech Society for Biochemistry and Molecular Biology (CSBMB)
  • American Chemical Society
  • American Association of Pharmaceutical Scientists

Grants Received

Investigator or co-investigator of more than 20 research grants from different areas (Pharmacy, Medicine, Natural Sciencies) received from Czech Science foundation, Grant agency of Ministry of Health Care, Grant agency of Ministry of Education, and Grant Agency of Charles University.

Recently:

  • principal investigator of European project FAFIS - Innovation of study program Pharmacy on Faculty of Pharmacy of Charles University - CZ.1.07/2.2.00/28.0194 - (2012-2014)      
  • co-investigator of  University Research Centre Study of Drugs and Other Biologically-Active Substances Perspective in Prevention and Treatment of Important Lifestyle Diseases - Charles University in Prague, UNCE 204026/2012 - (2012-2017)
  • co-investigator of project TEAB - Development of research team of experimental and applied biopharmacy - CZ.1.07/2.3.00/20.0235 - (2012-2015)      

Awards/Prizes

  • 1997: Hlavka Prize – for the best Czech PhD students
  • 2004: Alexander von Humboldt Award

Publications

Number of publications:    102
Number of citation >640 (WoS; excluding self-citation; February 2016)
h-index  16 (WoS; February 2016); 17 (Scopus; February 2016)

List of most cited publications

(Scopus – February 2016)

  1. Martin, HJ., Breyer-Pfaff, U., Wsól, V., Venz, S., Block, S., Maser, E.
    Purification and characterization of AKR1B10 from human liver: Role in carbonyl reduction of xenobiotics.
    Drug Metab. Dispos., 2006, 34, p. 464-470. (cited 79x)
  2. Szotáková, B., Baliharová, V., Lamka, J., Nožinová, E., Wsól, V., Velík, J., Machala, M., Neča, J., Souček, P., Šusová, S., Skálová, L.
    Comparison of in vitro activities of biotransformation enzymes in pig, cattle, goat and sheep.
    Res. Vet. Sci., 2004, 76, p. 43-51. (cited 60x)
  3. Pour, M., Špulák, M., Buchta, V., Kubanová, P., Vopršalová, M., Wsól, V., Fáková, H., Koudelka, P., Pourová, H., Schiller, R.
    3-Phenyl-5-acyloxymethyl-2H,5H-furan-2-ones: Synthesis and Biological Activity of a Novel Group of Potential Antifungual Drugs.
    J. Med. Chem., 2001, 44, p. 2701-2706. (cited 45x)
  4. Wsól, V., Skálová, L., Szotáková, B.
    Chiral inversion of drug – Coincidence or principle?
    Curr. Drug Metab., 2004, 5, p. 517-533. (cited 43x)
  5. Novotná, R., Wsól, V., Xiong, G., Maser, E.
    Inactivation of the original anticancer drugs doxorubicin and oracin by aldo-keto reductase (AKR) 1C3.
    Toxicol. Lett., 2008, 181, p. 1-6. (cited 32x)

 

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