-
Bartonkova I., Novotna A., Dvorak Z.Novel stably transfected human reporter cell line AIZ-AR as a tool for an assessment of human androgen receptor transcriptional activity. PLoS ONE (2015), 10(3): e0121316
-
Brtko J., Dvorak Z. Triorganotin compounds - ligands for "rexinoid" inducible transcription factors: Biologicaleffects. Toxicol Lett (2015), 234:50-58
-
Srovnalova A., Vanduchova A., Svecarova M., Anzenbacherova E., Tomankova V.,Anzenbacher P., Dvorak Z. Effects of sulforaphane and its S- and R- enantiomers on the expression and activities of human drug-metabolizing cytochromes P450. J Funct Foods (2015), 14:487-501
-
Sedlacek J., Svecarova M.METODY STANOVENÍ AKTIVITY PROTEASOMU A JEJICH APLIKACE. Chem Listy (2015), 109:198-203
-
Bialesova L., Novotna A., Macejova D., Brtko J., Dvorak Z. Agonistic effect of selected isoflavones on arylhydrocarbon receptor in a novel AZ-AhR transgenic gene reporter human cell line. Gen Physiol Biophys (2015), 34(3):331-334
-
Najmanová I., Doseděl M., Hrdina R., Anzenbacher P, Filipský T., Říha M., Mladěnka P. Cardiovascular Effects of Coumarins Besides their Antioxidant Activity. Curr Top Med Chem, (2015), 15(9): 830-849
-
Filipsky T, Riha M, Macakova K, Anzenbacherova E, Karlickova J, Mladenka P. Antioxidant Effects of Coumarins Include Direct Radical Scavenging, Metal Chelation and Inhibition of ROS-Producing Enzymes. Curr Top Med Chem, (2015), 15(5):415-431
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Tomankova V., Liskova B., Skalova L., Bartikova H., Bousova I., Jourova L., Anzenbacher P., Ulrichova J., Anzenbacherova E. Altered cytochrome P450 activities and expression levels in the liver and intestines of the monosodium glutamate-induced mouse model of human obesity. Life Sci, (2015), 133:15-20
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Imran S., Ferretti P., Vrzal R. Different regulation of aryl hydrocarbon receptor-regulated genes in response to dioxin in undifferentiated and neuronally differentiated human neuroblastoma SH-SY5Y cells. Toxicol Mech Method, (2015), 25(9):689-697
-
Illes P., Brtko J., Dvorak Z. Development and Characterization of a Human Reporter Cell Line for the Assessment of Thyroid Receptor Transcriptional Activity: A Case of Organotin Endocrine Disruptors. J Agric Food Chem, (2015), 63:7074-7083
-
Grycova A., Doricakova A., Dvorak Z. Impurities contained in antifungal drug ketoconazole are potent activators of human aryl hydrocarbon receptor. Toxicol Lett, (2015), 239:67-72
-
Bousova I., Bartikova H., Matouskova P., Lnenickova K., Zappe L., Valentova K., Szotakova B., Martin J., Skalova L. Cranberry extract–enriched diets increase NAD(P)H:quinone oxidoreductase and catalase activities in obese but not in nonobese mice. Nutrition Research, (2015), 35:901-909
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Boušová I., Matoušková P., Bártíková H., Szotáková B., Hanušová V., Tománková V., Anzenbacherová E., Lišková B., Anzenbacher P., Skálová L. Influence of diet supplementation with green tea extract on drugmetabolizing enzymes in a mouse model of monosodium glutamateinduced obesity. Eur J Nutr, (2016), 55:361-371
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Dvorak Z. Opportunities and challenges in using human hepatocytes in cytochrome P450 induction assays. Expert Opin Drug Metab Toxicol, (2015), 12(2):169-174
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Vrzal R. Anthocyanidins but not anthocyanins inhibit P-glycoprotein-mediated calcein extrusion – possible implication for orally administered drugs. Fundamental & Clinical Pharmacology, (2016), 30(3):248-252.
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Matalová P., Urbánek K., Anzenbacher P.Specific features of pharmacokinetics in children. Drug Metab Rev, (2016), 48(1):70-79
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Dvořák Z. Pivotal role of the aryl hydrocarbon receptor in modulations caused by benzo[a]pyrene and ketoconazole in the estrogenic responses induced by 17-estradiol in male goldfish. Environ Sci Pollut Res, (2016), 23(9):9247-9248
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Kubešová K., Dořičáková A., Trávníček Z., Dvořák Z. Mixed-ligand copper(II) complexes activate aryl hydrocarbon receptor AhR and induce CYP1A genes expression in human hepatocytes and human cell lines. Toxicol Lett, (2016), 255:24-35
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Spicakova A., Anzenbacher P., Liskova B., Kuca K., Fusek J., Anzenbacherova E. Evaluation of possible inhibition of human liver drug metabolizing cytochromes P450 by two new acetylcholinesterase oxime-type reactivators. Food Chem Toxicol, (2016), 88:100-104
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Scott E.E., C. Wolf C.R., Otyepka M., Humphreys S.C., Reed J.R., Henderson C.J., McLaughlin L.A., Paloncýová M., Navrátilová V., Berka K., Anzenbacher P., Dahal U.P., Barnaba C., Brozik J.A., Jones J.P., Estrada D.F., Laurence J.S., Park J.W., Backes W.L.The Role of Protein-Protein and Protein-Membrane Interactions on P450 Function. Drug Metab Dispos, (2016), 44:576–590
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Kubešová K., Trávníček Z., Dvořák Z. Pleiotropic effects of gold(I) mixed-ligand complexes of 9-deazahypoxanthine on transcriptional activity of receptors for steroid hormones, nuclear receptors and xenoreceptors in human hepatocytes and cell lines. Eur J Mech Chem, (2016), 121:530-540
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Vrzal R., Illes P., Dvorak Z. Transplant drugs affect the expression of phase II and antioxidant enzymes in human carcinoma cells HepG2 but not in primary cultures of human hepatocytes: In vitro comparative study. Pharmacol Rep, (2016), 68:1008-1014
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Cibíček N., Roubalová L., Vrba J., Zatloukalová M., Ehrmann J., Zapletalová J., Večeřa R., Křen V., Ulrichová J. Protective effect of isoquercitrin against acute dextran sulfate sodium-induced rat colitis depends on the severity of tissue damage. Pharmacol Rep, (2016), 68:1197-1204
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Bartonkova I., Grycova A., Dvorak Z. Profiling of vitamin D metabolic intermediates towards VDR using novel stable gene reporter cell lines IZ-VDRE and IZ-CYP24. Chem Res Toxicol, (2016), 29:1211-1222
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Vanduchová A., Tománková V., Anzenbacher P., Anzenbacherova E. Influence of Sulforaphane Metabolites on Activities of Human Drug-Metabolizing Cytochrome P450 and Determination of Sulforaphane in Human Liver Cells. J Med Food, (2016), 19(12):1141-1146
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Kopečná-Zapletalová M, Krasulová K, Anzenbacher P, Hodek P, Anzenbacherová E. Interaction of isoflavonoids with human liver microsomal cytochromes P450: inhibition of CYP enzyme activities. Xenobiotica, (2016), in press
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Kosina P., Dokoupilová A., Janda K., Sládková K., Silberová P., Pivodová V., Ulrichová J. Effect of Silybum marianum fruit constituents on the health status of rabbits in repeated 42day fattening experiment. Anim Feed Sci Technol, (2017), 223:128-140
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Soucek P, Hlavac V, Elsnerova K, Vaclavikova R, Kozevnikovova R, Raus K. Whole Exome Sequencing Analysis of ABCC8 and ABCD2 Genes Associating With Clinical Course of Breast Carcinoma. Physiol. Res. 2015; 64 (Suppl. 4): S549-S557
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Václavíková R, Hughes DJ, Souček P. Microsomal epoxide hydrolase 1 (EPHX1): Gene, structure, function, and role in human disease. Gene. 2015;571(1):1-8.
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Hlaváč V, Souček P. Role of family D ATP-binding cassette transporters (ABCD) in cancer. Biochem Soc Trans. 2015;43(5):937-942
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Petr Hodek , Johana Hrdinova, Iva Macova, Pavel Soucek, Iveta Mrizova, Kamila Burdova , Rene Kizek , Jiri Hudecek , Marie Stiborova. Preparation and application of anti-peptide antibodies for detection of orphan cytochromes P450. Neuroendocrinology Letters 2015, 36, 101-108
-
Marie Stiborova, František Barta · Katerřina Levova, Petr Hodek, Eva Frei, Volker M, Heinz H. Schmeiser.The infuence of ochratoxin A on DNA adduct for mation by the carcinogen ar istolochic acid in rats. Arch Toxicol 2015; 89:2141–2158
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Zdislava Bostikova, Michaela Moserova, Petr Pavek, Marie Stiborova, Petr Hodek. Role of dihydromyricetin in cytochrome P450-mediated metabolism and carcinogen Activation. Neuroendocrinology Letters 2015; 36, 101-107
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Frantisek Barta, Katerina Levova , Petr Hodek ,Heinz H. Schmeiser , Volker M. Arlt , Marie Stiborova. The effects of heavy metal ions, phthalates and ochratoxin A on oxidation of carcinogenic aristolochic acid I causing Balkan endemic nephropathy. Neuroendocrinology Letters 2015; 36 suppl 101-109
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Martin Ambrož, Iva Boušová , Adam Skarka , Veronika Hanušová 2, Věra Králová, Petra Matoušková , Barbora Szotáková and Lenka Skálová. The Influence of Sesquiterpenes from Myrica rubra on the Antiproliferative and Pro-Oxidative Effects of Doxorubicin.and Its Accumulation in Cancer Cells. Molecules 2015, 20, 15343-15358
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Hana Bártíková, Lenka Skálová, Kateřina Valentová, Petra Matoušková, Barbora Szotáková, Jan Martin, Vojtěch Kvita, Iva Boušová. Eff ect of oral administration of green tea extract in various dosage schemes on oxidative stress status of mice in vivo. Acta Pharm. 65 (2015) 65-73 DOI: 10.1515/acph-2015-0007
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Petra Matousková, Hana Bártíková, Iva Bousová, Lucie Levorová, Barbora Szotáková, and Lenka Skálová. Drug-Metabolizing and Antioxidant Enzymes in Monosodium L-Glutamate Obese Mice. Drug Metab Dispos, 2015; 43:258–265
-
Alejandro Carazo and Petr Pávek. The Use of the LanthaScreen TR-FRET CAR Coactivator Assay in the Characterization of Constitutive Androstane Receptor (CAR) Inverse Agonists. Sensors 2015;, 15, 9265-9276
-
Tomas Smutny , Jurjen Duintjer Tebbens , Petr Pavek. Bioinformatic analysis of miRNAs targeting the key nuclear receptors regulating CYP3A4 gene expression: The challenge of the CYP3A4 ‘‘missing heritability’’ enigma. Journal of Applied Biomedicine 2015, 13, 181-188
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Alejandro Carazo Fernández , Tomas Smutny , Lucie Hyrsová, Karel Berka, Petr Pavek. Chrysin, baicalein and galangin are indirect activators of the human constitutive androstane receptor (CAR). Toxicology Letters 2015; 233, 68–77
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Karlíčková J, Říha M, Filipský T, Macáková K, Hrdina R, Mladěnka P. Antiplatelet Effects of Flavonoids Mediated by Inhibition of Arachidonic Acid Based Pathway. Planta Med. 2015; 82(1-2):76-83.
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Krizkova V, Dubova M, Susova S, Vycital O, Bruha J, Skala M, Liska V, Daum O, Soucek P. Protein expression of ATP binding cassette transporters ABCC10 and ABCC11 associates with survival of colorectal cancer patients. Cancer Chemother Pharmacol. 2016; 78(3):595-603.
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Boušová, I., Skálová, L., Souček, P., Matoušková, P. The modulation of carbonyl reductase 1 by polyphenols. Drug Metabolism Reviews 47 (2015) 520-533
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Ambrož, M., Hanušová, V., Skarka, A., Boušová, I., Králová, V., Langhasová, L., Skálová, L. Essential oil from Myrica rubra leaves potentiated antiproliferative and pro-oxidative effect of doxorubicin and its accumulation in intestinal cancer cells. Planta Medica 82 (2016) 89-96
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Lněničková, K.; Procházková, E.; Skálová, L.; Matoušková, P.; Bártíková, H.; Souček, P.; Szotáková, B. Variously Affect Activities of Conjugation Enzymes in Proliferating and Differentiated Caco-2 Cells. Molecules 21 (2016) 1186-1197
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Karlíčková J, Říha M, Filipský T, Macáková K, Hrdina R, Mladěnka P. Antiplatelet Effects of Flavonoids Mediated by Inhibition of Arachidonic Acid Based Pathway. Planta Med. 2016 Jan;82(1-2):76-83.
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Iveta Najmanová´, Jana Pourová´, Marie Vopršalová´, Veronika Pilarova´, Vladimír Semecký´, Lucie Novákova´ and Přemysl Mladěnka. Flavonoid metabolite 3-(3-hydroxyphenyl)propionic acid formed by human mikroflóra decreases arterial blood pressure in rats. Mol. Nutr. Food Res. 2016, 60, 981–991
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Přemysl Mladěnka, Michal Říha, Jan Martin, Barbora Gorová, Aleš Matějíček, Jiřina Spilková. Fruit extracts of 10 varieties of elderberry (Sambucus nigra L.) interact differently with iron and copper. Phytochemistry Letters 18 (2016) 232–238
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Pavek P. Pregnane X Receptor (PXR)-Mediated Gene Repression and Cross-Talk of PXR with Other Nuclear Receptors via Coactivator Interactions. Front Pharmacol. 2016 Nov 25;7:456
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Hyrsova L, Smutny T, Trejtnar F, Pavek P. Expression of organic cation transporter 1 (OCT1): unique patterns of indirect regulation. by nuclear receptors and hepatospecific gene regulation. Drug Metab Rev. 2016 May;48(2):139-58.
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Lucie Hyrsova, Tomas Smutny, Alejandro Carazo, Stefan Moravcik, Jana Mandikova, Frantisek Trejtnar,Sabine Gerbal-Chaloin, Petr Pavek. Expression of organic cation transporter 1 (OCT1): unique patterns of indirect regulation by nuclear receptors and hepatospecific gene regulation. Br J Pharmacol 173(10):1703-15
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Stiborová M, Arlt VM, Schmeiser HH. Balkan endemic nephropathy: an update on its aetiology. Arch Toxicol. 2016, 90: 2595-2615.
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Tomankova V., Vlckova A., Anzenbacher P., Bachleda P., Anzenbacherova E. Užívání přípravků ze zlatobýlu obecného (Solidago virgaurea) neovlivňuje metabolizmus současně podávaných léčiv. Klin Farmakol Farm, (2016), 30(1): 5-10
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Hanušová, V., Skálová, L., Ambrož, M., Králová, V., Langhasová, L., Matoušková, P. The effect of Myrica rubra essential oil and its components α-humulene and trans-nerolidol on adhesion and apoptosis. Cancer Cell & Microenvironment 2 (2015) e1058
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Chapters in books:
Pavek, P a Smutny, T. Human Placental Trophoblasts Impact of Maternal Nutrition, Edited by by Asim K. Duttaroy, University of Oslo, Norway, Sanjay Basak National Institute of Nutrition (ICMR) Hyderabad, India. The Aryl Hydrocarbon Receptor in the Human Placental Trophoblast The Impact of Nutraceuticals and Natural Products. CRC Press, Boca Raton, FL, USA, 2016
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Bartonkova I., Novotna A., Dvorak Z. Novel stably transfected human reporter cell line AIZ-AR as a tool for an assessment of human androgen receptor transcriptional activity.PLoS ONE, 2015, 10(3): e0
exclusive dedication
-
Brtko J., Dvorak Z. Triorganotin compounds - ligands for "rexinoid" inducible transcription factors: Biological effects.Toxicology Letters, 2015, 234:50-58
Codedication for dr. Brtka (APVV-0160-11, APVV-0290-10,
VEGA 2/0171/14, CEMAN grants). Prof. Dvorak exclusive dedication.
-
Srovnalova A., Vanduchova A., Svecarova M., Anzenbacherova E., Tomankova V.,
Anzenbacher P., Dvorak Z. Effects of sulforaphane and its S- and R- enantiomers on the expression and activities of human drug-metabolizing cytochromes P450. Journal of Functional Foods, 2015, 14:487-501
exclusive dedication
-
Sedlacek J., Svecarova M.METODY STANOVENÍ AKTIVITY PROTEASOMU A JEJICH APLIKACE.Chemické Listy, 2015, 109:198-203
exclusive dedication
-
Bialesova L., Novotna A., Macejova D., Brtko J., Dvorak Z. Agonistic effect of selected isoflavones on arylhydrocarbon receptor in a novel AZ-AhR transgenic gene reporter human cell line.General Physiology and Biophysics, 2015, 34(3):331-334
exclusive dedication, Co-dedication dr. Brtka (APVV-0160-11, VEGA, 2/0171/14, CEMAN grants). ForProf. Dvorak exclusive dedication.
-
Najmanová I., Doseděl M., Hrdina R., Anzenbacher P, Filipský T., Říha M., Mladěnka P.Cardiovascular Effects of Coumarins Besides their Antioxidant ActivityCurrent Topics in Medicinal Chemistry, 2015, 15(9): 830-849.
exclusive dedication (+SVV 260 064)
-
Bousova I., Bartikova H., Matouskova P., Lnenickova K., Zappe L., Valentova K.,
Szotakova B., Martin J., Skalova L. Cranberry extract–enriched diets increase NAD(P)H:quinone oxidoreductase and catalase activities in obese but not in nonobese mice. Nutrition Research, 2015, 35:901-909
exclusive dedication (+SVV 260 065)
-
Filipsky T, Riha M, Macakova K, Anzenbacherova E, Karlickova J, Mladenka P. Antioxidant Effects of Coumarins Include Direct Radical Scavenging, Metal Chelation and Inhibition of ROS-Producing Enzymes. Current Topics in Medicinal Chemistry, 2015, 15(5):415-431
exclusive dedication (+SVV 260 064)
-
Imran S., Ferretti P., Vrzal R. Different regulation of aryl hydrocarbon receptor-regulated genes in response to dioxin in undifferentiated and neuronally differentiated human neuroblastoma SH-SY5Y cells.Toxicological Mechanisms and Methods, 2015, 25(9):689-697
Codedication to ESF CZ.1.07/2.3.00/30.0041
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Illes P., Brtko J., Dvorak Z. Development and Characterization of a Human Reporter Cell Line for the Assessment of Thyroid Receptor Transcriptional Activity: A Case of Organotin Endocrine Disruptors.Journal of Agricultural and Food Chemistry, 2015, 63:7074-7083.
Codedication to ESF CZ.1.07/2.3.00/30.0004 a
-
Grycova A., Doricakova A., Dvorak Z. Impurities contained in antifungal drug ketoconazole are potent activators of human aryl hydrocarbon receptor. Toxicology Letters, 2015, 239:67-72
Codedication SVV (studentský projekt UP IGA UP PrF-2015-003)
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Tomankova V., Liskova B., Skalova L., Bartikova H., Bousova I., Jourova L., Anzenbacher, P., Ulrichova J., Anzenbacherova E. Altered cytochrome P450 activities and expression levels in the liver and intestines of the monosodium glutamate-induced mouse model of human obesity. Life Sciences, 2015, 133:15-20.
Codedication to students projects UP (IGA UP LF-2015-004+IGA UP LF-2015-007) and
ESF (CZ.1.07/2.3.00/30.0004).
-
Boušová I., Matoušková P., Bártíková H., Szotáková B., Hanušová V., Tománková V.,
Anzenbacherová E., Lišková B., Anzenbacher P., Skálová L. Influence of diet supplementation with green tea extract on drugmetabolizing enzymes in a mouse model of monosodium glutamateinduced obesity. European Journal of Nutrition (in press)
Codedication to ESF CZ.1.07/2.3.00/30.0022 a CZ.1.07/2.3.00/30.0004
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Dvorak Z. Opportunities and challenges in using human hepatocytes in cytochrome P450 induction assays. Expert Opinions in Drug Metabolism and Toxicology (in press)
Codedication to IGA MZd NT/13591.
-
Soucek P, Hlavac V, Elsnerova K, Vaclavikova R, Kozevnikovova R, Raus K. Whole Exome Sequencing Analysis of ABCC8 and ABCD2 Genes Associating With Clinical Course of Breast Carcinoma.Physiol. Res. 2015; 64 (Suppl. 4): S549-S557
Codedikation to IGA14055-3, MŠMT, LO1503 and SZU NIPH, 75010330)
-
Václavíková R, Hughes DJ, Souček P. Microsomal epoxide hydrolase 1 (EPHX1): Gene, structure, function, and role in human disease. Gene. 2015;571(1):1-8.
codedicationto EU RDF CZ.1.05/2.1.00/03.
0076)
-
Hlaváč V, Souček P. Role of family D ATP-binding cassette transporters (ABCD) in cancer. Biochem Soc Trans. 2015;43(5):937-942.
Codedication to IGA13679-4 and SZU (NIPH, 75010330)
-
Petr Hodek, Johana Hrdinova, Iva Macova, Pavel Soucek 2, Iveta Mrizova, Kamila Burdova , Rene Kizek , Jiri Hudecek , Marie Stiborova. Preparation and application of anti-peptide antibodies for detection of orphan cytochromes P450. Neuroendocrinology Letters 2015, 36, 101-108
codedication grant MH CZ - DRO (NIPH, 75010330)
-
Marie Stiborova, František Barta · Katerina Levova, Petr Hodek, Eva Frei, Volker M.
Arlt , Heinz H. Schmeiser. The infuence of ochratoxin A on DNA adduct for mation
by the carcinogen ar istolochic acid in rats. Arch Toxicol 2015; 89:2141–2158
co-dedication to GAUK
-
Zdislava Bostikova, Michaela Moserova, Petr Pavek, Marie Stiborova, Petr Hodek. Role of dihydromyricetin in cytochrome P450-mediated metabolism and carcinogen activation. Neuroendocrinology Letters 2015; 36, 101-107 exclusive dedication
-
Frantisek Barta, Katerina Levova , Petr Hodek ,Heinz H. Schmeiser , Volker M. Arlt , Marie Stiborova. The effects of heavy metal ions, phthalates and ochratoxin A on oxidation of carcinogenic aristolochic acid I causing Balkan endemic nephropathy. Neuroendocrinology Letters 2015; 36 suppl 101-109
Codedication to GAUK
-
Martin Ambrož, Iva Boušová , Adam Skarka , Veronika Hanušová 2, Věra Králová ,
Petra Matoušková , Barbora Szotáková and Lenka Skálová. The Influence of Sesquiterpenes from Myrica rubra on the Antiproliferative and Pro-Oxidative Effects of Doxorubicin and Its Accumulation in Cancer Cells. Molecules 2015, 20, 15343-15358 codedication to GAUK and SVV
-
Hana Bartikova, Lenka Skalova, Katerina Valentova, Petra Matouskova, Barbora Szotakova, Jan Martin, Vojtech Kvita, Iva Bousova. Effect of oral administration of green tea extract in various dosage schemes on oxidative stress status of mice in vivo. Acta Pharm. 65 (2015) DOI: 10.1515/acph-2015-0007
Codedication to European Social Fund
-
Petra Matousková, Hana Bártíková, Iva Bousová, Lucie Levorová, Barbora Szotáková,
and Lenka Skálová. Drug-Metabolizing and Antioxidant Enzymes in Monosodium
L-Glutamate Obese Mice. Drug Metab Dispos, 2015; 43:258–265,
Codedication to Europiean Social Fund
-
Alejandro Carazo and Petr Pávek. The Use of the LanthaScreen TR-FRET CAR Coactivator Assay in the Characterization of Constitutive Androstane Receptor (CAR) Inverse Agonists. Sensors 2015;, 15, 9265-9276
Codedication to SVV
-
Tomas Smutny , Jurjen Duintjer Tebbens , Petr Pavek. Bioinformatic analysis of miRNAs targeting the key nuclear receptors regulating CYP3A4 gene expression: The challenge of the CYP3A4 ‘‘missing heritability’’ enigma. Journal of Applied Biomedicine 2015, 13, 181-188.
Codedication to student project
-
Alejandro Carazo Fernández , Tomas Smutny , Lucie Hyrsová, Karel Berka, Petr Pavek. Chrysin, baicalein and galangin are indirect activators of the human constitutive androstane receptor (CAR). Toxicology Letters 2015; 233, 68–77
exclusive dedication