Junior Fond – List of Post-Doctoral Fellowships

A new call for applications has been announced!

Applicants can apply in 2021 for positions in project announced below:

Study of drug resistance in acute myeloid leukaemia, effect of cell-to-cell communication and bone marrow microenvironment

 

Description:

Acute myeloid leukaemia (AML) is a highly heterogenous blood cancer disease still characterized by very poor curability, numerous relapses, and low survival rate. The therapy failure and relapse induction is mainly driven by resistant leukemic stem cells (LSCs) characterized with increased expression of genes ensuring better survival and proliferation. This project focuses on the study of the drug resistance mechanisms in context of bone marrow microenvironment and LSC growth promotion through cell-to-cell communication. The applicant will be involved in addressing the mechanisms of intercellular communication (organelle exchange and EV/miRNA) with the particular focus on affected membrane transport characteristics and metabolic enzyme activity of LSCs, with the main goal to enable precise in time minimal residual disease detection and treatment optimisation.

Requirements for applicant:

  • PhD in pharmacology, molecular biology, molecular genetics, haematology or related discipline, max. 5 years after graduation.
  • Excellent English skills both in oral and written form.
  • High motivation, ability to conduct collaborative research.
  • The applicant must have excellent technical skills in cell culture (cell lines, primary cells) and advanced experience in molecular and cell biology field (e.g. PCR technique and/or gene sequencing, western blotting, immunocytochemistry, fluorescence microscopy, biostatistics).
  • Knowledge and skills in flow cytometry/cell sorting and liquid biopsy field is an advantage.
  • Track record of publications in peer-reviewed journals: at least 3 publications in IF journals (IF>1.5), at least one as the first author.

Workplace/Institution: Research Group of Cellular Pharmacology and Oncology, Charles University, Faculty of Pharmacy in Hradec Králové

Supervisor: Assoc. Prof. Dr. Martina Ceckova, Ph.D.
Email: martina.ceckova@faf.cuni.cz
Phone: +420 495 067 218

Position available from: 1st of January 2022

Deadline date for applications: 12th of July 2021

Applicants must submit: all required documents including description of prior research, technical skills and scientific experience, to the project supervisor, Assoc. Prof. Dr. Martina Ceckova, Ph.D. (martina.ceckova@faf.cuni.cz)

For more information on Junior Fond, please click here.

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