Ageing and Changes in the Therapeutic Value of Medications in the Aged Unit

Processes accompanying with aging (geriatric syndromes, frailty) significantly affect the therapeutic value of many medications and have a high impact on health, morbidity and mortality in geriatric population. The main goal of the research subgroup is to study therapeutic value of medications and drug procedures in geriatric patients in different settings of care, to identify specific changes in therapeutic value of medications/drug procedures, suboptimal prescribing practices and possibilities for improvements. Pharmacoepidemiological methods and clinical pharmacy skills are used in observational and analytical studies. Research data are collected prospectively on national level or used from previous and recent cooperation in European and international projects. Analyses are focused on the evaluation of associations between specifically geriatric patient-related factors, suboptimal drug prescribing and inappropriate health outcomes. Research group deals also with the development of explicit criteria of inappropriate prescribing in older adults in cooperation with other international and European expert groups.

  • Application of explicit criteria of medications potentially inappropriate in the old age in the evaluation of quality of prescribing
  • Evaluation of potentially inappropriate drugs and drug procedures in the old age
  • Evaluation of the rationality of analgetic drug treatment in geriatric patients
  • Evaluation of the quality of drug prescribing in the old age
  • Drugs negatively affecting cognitive functions in the old age
  • Comparison of guidelines focused on the rational treatment of osteoarthritis in the old age


PharmDr. Daniela Fialová, PhD.


Faculty of Pharmacy, Charles University is one of the main research institutions participating in EU H2020 “EUROAGEISM” project (2017-2021)

PharmDr. Fialová Daniela, PhD. is an expert in the field of rational geriatric pharmacotherapy, geriatric pharmacoepidemiology and clinical pharmacy in geriatrics at the national and international levels. She participated as researcher in the European research projects ADHOC “AgeD in HOme Care” (FP5, 2001-2005) and SHELTER “Services and Health in the Elderly in Long-Term Care” (FP7, 2009-2014). In 2005, she published an article in the Journal of American Medical Association, JAMA (IF=21,455), applying first InterRAI methodology combined with geriatric clinical pharmacy and pharmacoepidemiology. She participated in submissions of EU grants CARPOOL, REPAIR, EU COST Action 1402, OPTMED and EURO-AGEISM (2014- 2017). She has been awarded several awards for her scientific works: the Award of the Dean of the Faculty of Pharmacy, the French Prize for Pharmacy, Prize of the Czech Medical Association of J. B. Purkyně and the National Prize for Pharmacoeconomics and Drug Policy. She is a full fellow of the International InterRAI Corporation and she leads European working group WG1b “Healthy clinical strategies for healthy aging” supported by the EU COST Action 1402 (2015- 2018). She is the chair of the research subgroup “Aging and Changes in the Therapeutic Value of Medications in the AgeD” at the Department of Social and Clinical Pharmacy, Faculty of Pharmacy, Charles University in Prague, Czech Republic (FaP CU). She initiated the development of the Czech National Criteria of drugs and drug procedures potentially inappropriate in the old age during the works on the grant of Internal Grant Agency of the Ministry of Health of Czech Republic (grant entitled “Improving the quality of drug prescribing in seniors- validation of instruments for drug policy in the Czech Republic”, 2009-2014). In her scientific and teaching activities she focuses on clinical pharmacy in geriatrics, pharmacotherapy risks in the elderly, evaluation of combined drug regimens and polypharmacy in older patients. She founded University Educational Centre of Clinical Pharmacy (UCCP) at the FaP CU in 2014, is the Head of the Center and leads its educational activities. She is a member of the evaluation panel of the AZV- a national Agency for Healthcare Research- focusing on “Age-determined disorders” and acts as a reviewer of many international journals, including Drugs and Aging, International Journal of Clinical Pharmacy, Age and Ageing, etc.

prof. MUDr. Eva Topinková, CSc.
External cooperator, Department of Geriatrics and Gerontology, 1st Faculty of Medicine and General Teaching Hospital, Charles University in Prague, Czech Republic

Prof. Topinková participated in a number of European initiatives aimed at validating instruments for conducting comprehensive assessments of the health status in the elderly in home care, long-term nursing home care, etc. As a national coordinator and researcher, she participated in geriatric European projects ADHOC (FP5, 2001- 2005), CLESA (FP5, 2002-2004), NUTRI-SENEX (FP6, 2004-2006), PREDICT (FP7, 2008-2010), SHELTER (FP7, 2009-2014), MID-FRAIL (FP8, 2012 – 2017) and SPRINT (FP8, 2014-2019). As an investigator, she participated in a number of clinical trials for evaluating therapeutic approaches for Alzheimer's disease, mild cognitive impairment, decubitus ulcers and incontinence.

She is the Head of the Geriatric Clinic of the 1st Medical Faculty of the Charles University in Prague and a member of many national councils in geriatrics and gerontology (e.g. the Czech Medical Association J. B. Purkyně, Geriatric Boards of the Ministry of Health of the Czech Republic, Czech Agency for Healthcare Research (AZV), etc.). From 2007 to 2014, she worked as the president of “Clinical Section IAGG- ER” - International Association of Gerontology and Geriatrics-European region. She is a member of the “Geriatric Medicine Section” board of the European Union Geriatric Medicine Society (EUGMS), a member of the international research group “GERONTONET” and the international corporation InterRAI. She is a member of the editorial boards of the Journal of European Geriatric Medicine (EGM) and other geriatric journals. At the national level, she is also a member of the editorial boards of the Journals: Postgraduate Medicine, Geriatrics and Gerontology and the Czech and Slovak Psychiatry. She cooperates with the research subgroup “Aging and Changes in the Therapeutic Value of Medications in the Aged” as external cooperator.

  • H-index = 20 /Web of science, 2016/.

RNDr. Jindra Reissigová, Ph.D.
External cooperator, Academy of Science, Czech Republic

Dr. Reissigová, PhD. is a leading statistician of the subgroup with substantial experience in the works on statistical analyses in the European research projects. Since 1987, she has worked as a biostatistician at the EuroMISE CR centre at the Faculty of Mathematics and Physics, CU, she taught variety of topics in the field of biostatistics and has participated in the statistical evaluations of national and international studies. Since 2013, she has been working as a statistician at the Institute of Computer Science AS CR. She focuses on the statistical analyses of epidemiological and clinical studies, she is involved in determination of statistical design of epidemiological studies, descriptions of statistical methods, statistical analyses and the interpretation of statistical results. As a statistician, she participated in the European projects ADHOC (FP5, 2001- 2005) and SHELTER (FP7, 2009-2014), she was engaged in analyses of multifactorial multiple regression models. She worked abroad during research stays at the Instituto Nazionale per la Ricerca sul Cancri, Genoa, Italy (1994) and IARC, Lyon, France (1995), where she improved her statistical skills in methodology and evaluation of case-control studies and in statistical evaluations of the effectiveness of screening programmes. She works as external cooperator of research subgroup “Aging and Changes in the Therapeutic Value of Drugs in the AgeD”

  • H-index = 6 /Web of science, 2016/.

Mgr. Anna Ballóková-Lukačišinová, PhD.
External cooperator, State Institute for Drug Control, Czech Republic

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