Research

The goal of our research is summarized in the scheme:

research_scheme1.jpg

We are developing potential antibacterial and antifungal drugs and prodrugs that can deliver the agents to the site of the therapeutic action, increase the drug bio-availability and selectivity of the therapeutic action, and overcome various problems associated with the oral administration and cell membrane permeability.

research_scheme2.jpg

The synthesized compounds are based on the following general structures:

Salicylanilides

esters

formula-esters.jpg

carbamates

formula-carbonates.jpg

carbonates

formula-carbonates-(1).jpg

Anilides/thioanilides

formula-anilides-thioanilides.jpg

Benzoxazoles

formula-benzoxazoles.jpg

Isonicotinoyl-hydrazones

formula-isonicotinoyl-hydrazones-(1).jpg

 

© 2017 Charles University, Faculty of Pharmacy in Hradec Králové, Akademika Heyrovského 1203, 500 05 Hradec Králové, Czech Republic
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