Publications

List of selected publications by the Group of Experimental Pharmacokinetics and Drug Interactions; for a full list of group publications, go to: PubMed Search. If you cannot access any of the papers, do not hesitate to contact us and we will send you a PDF or hardcopy.


2016

Reznicek J, Ceckova M, Cerveny L, Müller F, Staud F. Emtricitabine is a substrate of MATE1 but not of OCT1, OCT2, P-gp, BCRP or MRP2 transporters. Xenobiotica. 2016 Apr 6:1-9. [Epub ahead of print]

Ceckova M, Reznicek J, Ptackova Z, Cerveny L, Müller F, Kacerovsky M, Fromm MF, Glazier JD, Staud F. Interaction of lamivudine with ABC and SLC transporters: role in placental transport. Antimicrob Agents Chemother. 2016 Jul 11. pii: AAC.00648-16. [Epub ahead of print]

Neumanova Z, Cerveny L, Ceckova M, Staud, F. Role of ABCB1, ABCG2, ABCC2 and ABCC5 transporters in placental passage of zidovudine. Biopharm Drug Dispos 2016; 37, 28-38.

Cerveny L, Neumanova Z, Karbanova S, Havlova I, Staud, F. Long-term administration of tenofovir or emtricitabine to pregnant rats; Effect on Abcb1a, Abcb1b and Abcg2 expression in the placenta and in maternal and fetal organs. J Pharm Pharmacol 2015; 68, 84-92.

Hofman J, Kucera R, Klimes J, Ceckova M, Staud F. Placental passage of olomoucine II, but not purvalanol A, is affected by p-glycoprotein (ABCB1), breast cancer resistance protein (ABCG2) and multidrug resistance-associated proteins (ABCCs). Xenobiotica 2016; 46, 416-423.

2015

Cihalova D, Ceckova M, Kucera R, Klimes J, Staud F. Dinaciclib, a cyclin-dependent kinase inhibitor, is a substrate of human ABCB1 and ABCG2 and an inhibitor of human ABCC1 in vitro. Biochemical Pharmacology 2015

Neumanova Z, Cerveny L, Greenwood SL, Ceckova M, Staud F. Effect of drug efflux transporters on placental transport of antiretroviral agent abacavir. Reproductive Toxicology 2015; 57, 176-182.

Cihalova D, Staud F, Ceckova M. Interactions of cyclin-dependent kinase inhibitors AT-7519, flavopiridol and SNS-032 with ABCB1, ABCG2 and ABCC1 transporters and their potential to overcome multidrug resistance in vitro. Cancer Chemotherapy and Pharmacology 2015; 19 May 2015; (76(1), 105-116.

Staud F, Ceckova M. Regulation of drug transporter expression and function in the placenta. Expert Opinion on Drug Metabolism and Toxicology 2015; 11(4), 533-555.

2014

Neumanova Z, Cerveny L, Ceckova M, Staud F. Interactions of tenofovir and tenofovir disoproxil fumarate with drug efflux transporters ABCB1, ABCG2, and ABCC2; role in transport across the placenta. AIDS 2014; 28 (1):9-17 (doi: 10.1097/QAD.0000000000000112)

2013

Cihalova D, Hofman J, Ceckova M, Staud F. Purvalanol A, Olomoucine II and Roscovitine Inhibit ABCB1 Transporter and Synergistically Potentiate Cytotoxic Effects of Daunorubicin In Vitro. PLoS One. 2013;23;8(12):e83467

Hofman J, Kučera R, Cihalova D, Klimes J, Ceckova M, Staud F. Olomoucine II, but not purvalanol A, is transported by breast cancer resistance protein (ABCG2) and P-glycoprotein (ABCB1). PLoS One. 2013 8;8(10):e75520

Staud F, Cerveny L, Ahmadimoghaddam D, Ceckova M. 2013 Multidrug and toxin extrusion proteins (MATE/SLC47); role in pharmacokinetics. Int J Biochem Cell Biol. 2013 Sep;45(9):2007-11 (doi: 10.1016/j.biocel.2013.06.022)

Ahmadimoghaddam D, Staud F. Transfer of Metformin across the Rat Placenta is Mediated by Organic Cation Transporter 3 (OCT3/SLC22A3) and Multidrug and Toxin Extrusion 1 (MATE1/SLC47A1) Protein. Reprod Toxicol 2013;39:17-22 (doi: 10.1016/j.reprotox.2013.03.001)

Ahmadimoghaddam D, Zemankova L, Nachtigal P, Dolezelova E, Cerveny L, Ceckova M, Kacerovský M, Neumanová Z, Micuda S, Staud F. Organic Cation Transporter 3 (OCT3/SLC22A3) and Multidrug and Toxin Extrusion 1 (MATE1/SLC47A1) Transporter in the Placenta and Fetal Tissues; Expression Profile and Fetus Protective Role at Different Stages of Gestation. Biol Reprod 2013;88 (doi: 10.1095/biolreprod.112.105064)

Cerveny L, Straskova A, Dankova V, Hartlova A, Ceckova M, Staud F, Stulik J. Tetratricopeptide Repeat Motifs in the World of Bacterial Pathogens; Role in Virulence Mechanisms. Infect Immun 2013;81:629-35 (doi: 10.1128/IAI.01035-12)

2012

Staud F, Cerveny L, Ceckova M. Pharmacotherapy in pregnancy; effect of ABC and SLC transporters on drug transport across the placenta and fetal drug exposure. J Drug Target 2012;20:736-63 (doi: 10.3109/1061186X.2012.716847)

Hofman J, Ahmadimoghaddam D, Hahnova L, Pavek P, Ceckova M, Staud F. Olomoucine II and purvalanol A inhibit ABCG2 transporter in vitro and in situ and synergistically potentiate cytostatic effect of mitoxantrone. Pharmacol Res 2012;65:312-9 (doi: 10.1016/j.phrs.2011.11.017)

Ahmadimoghaddam D, Hofman J, Zemankova L, Nachtigal P, Dolezelova E, Cerveny L, Staud F. Synchronized Activity of Organic Cation Transporter 3 (Oct3/Slc22a3) and Multidrug and Toxin Extrusion 1 (Mate1/Slc47a1) Transporter in Transplacental Passage of MPP+ in Rat. Toxicol Sci 2012;128:471-81 (doi: 10.1093/toxsci/kfs160)

2011 and older

Hahnova-Cygalova L, Ceckova M, Staud F. Fetoprotective activity of breast cancer resistance protein (BCRP, ABCG2): expression and function throughout pregnancy. Drug Metab Rev 2011;43:53-68.

Staud F, Ceckova M, Micuda S, Pavek P. Expression and function of p-glycoprotein in normal tissues: effect on pharmacokinetics. Methods Mol Biol 2010;596:199-222.

Vackova Z, Vagnerova K, Libra A, Miksik I, Pacha J, Staud F. Dexamethasone and betamethasone administration during pregnancy affects expression and function of 11 beta-hydroxysteroid dehydrogenase type 2 in the rat placenta. Reprod Toxicol 2009;28:46-51.

Pavek P, Ceckova M, Staud F. Variation of drug kinetics in pregnancy. Curr Drug Metab 2009;10:520-9.

Cygalova LH, Hofman J, Ceckova M, Staud F. Transplacental pharmacokinetics of glyburide, rhodamine 123, and BODIPY FL prazosin: effect of drug efflux transporters and lipid solubility. J Pharmacol Exp Ther 2009;331:1118-25.

Vagnerova K, Vackova Z, Klusonova P, Staud F, Kopecky M, Ergang P, et al. Reciprocal changes in maternal and fetal metabolism of corticosterone in rat during gestation. Reprod Sci 2008;15:921-31.

Cygalova L, Ceckova M, Pavek P, Staud F. Role of breast cancer resistance protein (Bcrp/Abcg2) in fetal protection during gestation in rat. Toxicol Lett 2008;178:176-80.

Ceckova M, Vackova Z, Radilova H, Libra A, Buncek M, Staud F. Effect of ABCG2 on cytotoxicity of platinum drugs: Interference of EGFP. Toxicol In Vitro 2008;22:1846-52.

Vackova Z, Libra A, Ceckova M, Pavek P, Staud F. Effect of dexamethasone and betamethasone on 11beta-hydroxysteroid dehydrogenase type 2 expression in human choriocarcinoma Jeg3 cells. Biomed Pap 2007;151:95-7.

Cerveny L, Svecova L, Anzenbacherova E, Vrzal R, Staud F, Dvorak Z, et al. Valproic acid induces CYP3A4 and MDR1 gene expression by activation of constitutive androstane receptor and pregnane X receptor pathways. Drug Metab Dispos 2007;35:1032-41.

Bremer S, Brittebo E, Dencker L, Knudsen LE, Mathisien L, Olovsson M, Staud F et al. In vitro tests for detecting chemicals affecting the embryo implantation process. The report and recommendations of ECVAM workshop 62 -- a strategic workshop of the EU ReProTect project. Altern Lab Anim 2007;35:421-39.

Staud F, Vackova Z, Pospechova K, Pavek P, Ceckova M, Libra A, et al. Expression and Transport Activity of Breast Cancer Resistance Protein (Bcrp/Abcg2) in Dually Perfused Rat Placenta and HRP-1 Cell Line. J Pharmacol Exp Ther 2006;319:53-62.

Staud F, Mazancova K, Miksik I, Pavek P, Fendrich Z, Pacha J. Corticosterone transfer and metabolism in the dually perfused rat placenta: effect of 11beta-hydroxysteroid dehydrogenase type 2. Placenta 2006;27:171-80.

Libra A, Fernetti C, Lorusso V, Visigalli M, Anelli PL, Staud F, et al. Molecular determinants in the transport of a bile Acid-derived diagnostic agent in tumoral and nontumoral cell lines of human liver. J Pharmacol Exp Ther 2006;319:809-17.

Cerveny L, Pavek P, Malakova J, Staud F, Fendrich Z. Lack of Interactions between Breast Cancer Resistance Protein (BCRP/ABCG2) and Selected Antiepileptic Agents. Epilepsia 2006;47:461-8.

Ceckova-Novotna M, Pavek P, Staud F. P-glycoprotein in the placenta: Expression, localization, regulation and function. Reprod Toxicol 2006;22:400-10.

Ceckova M, Libra A, Pavek P, Nachtigal P, Brabec M, Fuchs R, Staud F. Expression and functional activity of breast cancer resistance protein (bcrp, abcg2) transporter in the human choriocarcinoma cell line bewo. Clin Exp Pharmacol Physiol 2006;33:58-65.

Staud F, Pavek P. Breast cancer resistance protein (BCRP/ABCG2). Int J Biochem Cell Biol 2005;37:720-5.

Novotna M, Libra A, Kopecky M, Pavek P, Fendrich Z, Semecky V, Staud F. P-glycoprotein expression and distribution in the rat placenta during pregnancy. Reprod Toxicol 2004;18:785-92.

Pavek P, Staud F, Fendrich Z, Sklenarova H, Libra A, Novotna M, et al. Examination of the functional activity of P-glycoprotein in the rat placental barrier using rhodamine 123. J Pharmacol Exp Ther 2003;305:1239-50.

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