Group of experimental toxicokinetics and radiopharmacology

The main area of interest of the Group is investigation of selected aspects of pharmacokinetics in established or potential drugs. Our studies are aimed especially at distribution of compounds in the body, their renal and liver elimination but we have also carried out several studies on total pharmacokinetics in the organism. For this purpose, we use a set of pharmacological models in vitro (e.g., transfected cell lines, tissue slices, organ perfusion methods) and in vivo (details see in Equipment and methods) which enables us to obtain a relatively complex view on pharmacokinetics of drugs and xenobiotics under study. The work of the Group is actually concentrated on two groups of compounds: chemotherapeutics, specially antivirals, and radiolabeled compounds, potential radiopharmaceuticals. However, several other drug groups are planned to be studied in the close future. Since biodistribution and elimination of drugs is significantly dependent on membrane transporters, we pay a great attention to interactions of drugs with several types of influx (OATs, OCTs, nucleoside transporters) and efflux transporters (MDR1, BCRP). We also have studied relations between affinity of drugs to membrane transporters and their cellular toxicity. In addition, the research of the Group includes some pharmacodynamic aspects of drug-organism interactions such as evaluation of radiolabeled ligand binding to selected receptors.

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