Publications

List of selected publications of the group

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Publication 2019

• Hyrsova L, Vanduchova A, Dusek J, Smutny T, Carazo A, Maresova V, Trejtnar F, Barta P, Anzenbacher P, Dvorak Z and Pavek P. Trans-resveratrol, but not other natural stilbenes occurring in food, carries the risk of drug-food interaction via inhibition of cytochrome P450 enzymes or interaction with xenosensor receptors. Toxicol. Lett. 2019; 300:81-91. doi: 10.1016/j.toxlet.2018.10.028.

• Janousek J, Barta P, Novy Z, Zilkova K and Trejtnar F. Antiangiogenic Human Monoclonal Antibody Ramucirumab Radiolabelling: In Vitro Evaluation on VEGFR2-positive Cell Lines. Anticancer. Res. 2019; 39(2):735-744. doi: 10.21873/anticanres.13170.

Publication 2018

• Carazo A, Dusek J, Holas O, Skoda J, Hyrsova L, Smutny T, Soukup T, Dosedel M and Pávek P. Teriflunomide Is an Indirect Human Constitutive Androstane Receptor (CAR) Activator Interacting With Epidermal Growth Factor (EGF) Signaling.  Front. Pharmacol. 2018; 9:993. doi: 10.3389/fphar.2018.00993

Publication 2017

• Barta P, Janousek J, Zilkova K and Trejtnar F. In vitro evaluation of concentration, labeling effectiveness and stability for 131 I-labeled radioimmunoassay ligand using real-time detection technology. J. Labelled. Comp. Radiopharm. 2017; 60(1):80-86. doi: 10.1002/jlcr.3478.

• Bouz G, Juhás M, Niklová P, Janďourek O, Paterová P, Janoušek J, Tůmová L, Kovalíková Z, Kastner P, Doležal M, Zítko J. Ureidopyrazine Derivatives: Synthesis and Biological Evaluation as Anti-Infectives and Abiotic Elicitors. Molecules. 2017; 22(10). doi: 10.3390/molecules22101797.

• Dusek J, Carazo A, Trejtnar F, Hyrsova L, Holas O, Smutny T, Micuda S, Pavek P. Steviol, an aglycone of steviol glycoside sweeteners, interacts with the pregnane X (PXR) and aryl hydrocarbon (AHR) receptors in detoxification regulation. Food Chem Toxicol. 2017;109(Pt 1):130-142. doi: 10.1016/j.fct.2017.09.007. PubMed PMID: 28887089.

• Encarnação JC, Barta P, Fornstedt T, Andersson K. Impact of assay temperature on antibody binding characteristics in living cells: A case study. Biomed Rep. 2017 Nov;7(5):400-406. doi: 10.3892/br.2017.982.

• Krátký M, Dzurková M, Janoušek J, Konečná K, Trejtnar F, Stolaříková J, Vinšová J. Sulfadiazine Salicylaldehyde-Based Schiff Bases: Synthesis, Antimicrobial Activity and Cytotoxicity. Molecules. 2017;22(9). doi: 10.3390/molecules22091573. PubMed PMID: 28925956.

• Krátký M, Štěpánková Š, Vorčáková K, Navrátilová L, Trejtnar F, Stolaříková J, Vinšová J. Synthesis of readily available fluorophenylalanine derivatives and investigation of their biological activity. Bioorg. Chem. 2017;71:244-256. doi: 10.1016/j.bioorg.2017.02.010. PubMed PMID: 28245905.

• Navrátilová L, Ramos Mandíková J, Pávek P, Mladěnka P, Trejtnar F. Honey flavanoids inhibit hOATP1A2 transporters and hOATP-mediated rosuvastatin cell uptake in vitro. Xenobiotica. 2017:1-11. doi: 10.1080/00498254.2017.1258469. PubMed PMID: 28745105.

• Paraskevopoulos G, Monteiro S, Vosátka R, Krátký M, Navrátilová L, Trejtnar F, Stolaříková J and Vinšová J. Novel salicylanilides from 4,5-dihalogenated salicylic acids: Synthesis, antimicrobial activity and cytotoxicity. Bioorg. Med. Chem. 2017; 25(4):1524-1532.

• Jandourek O, Tauchman M, Paterova P, Konecna K, Navratilova L, Kubicek V, Holas O, Zitko J and Dolezal M. Synthesis of Novel Pyrazinamide Derivatives Based on 3-Chloropyrazine-2-carboxamide and Their Antimicrobial Evaluation. Molecules. 2017; 22(2). pii: E223. doi: 10.3390/molecules22020223.

• Semelková L, Janďourek O, Konečná K, Paterová P, Navrátilová L, Trejtnar F, Kubíček V, Kuneš J, Doležal M, Zitko J. 3-Substituted N-Benzylpyrazine-2-carboxamide Derivatives: Synthesis, Antimycobacterial and Antibacterial Evaluation. Molecules. 2017;22(3). doi: 10.3390/molecules22030495. PubMed PMID: 28335571.

Publication 2016

• Zitko J, Servusova-Vanaskova B, Paterova P, Navratilova L, Trejtnar F, Kunes J and Dolezal M. Design, synthesis and anti-mycobacterial evaluation of some new N-phenylpyrazine-2-carboxamides. Chemical Papers 2016, Volume 70, Issue 5, Pages 649–657.

• Mandikova J, Volkova M, Pavek P, Navratilova L, Hyrsova L, Janeba Z, Pavlik J, Barta P and Trejtnar F. Entecavir Interacts with Influx Transporters hOAT1, hCNT2, hCNT3, but Not with hOCT2: The Potential for Renal Transporter-Mediated Cytotoxicity and Drug–Drug Interactions. Front. Pharmacol. 2016; 6:304. doi: 10.3389/fphar.2015.00304

• Hyrsova L, Smutny T, Carazo A, Moravcik S, Mandikova J, Trejtnar F, Gerbal-Chaloin S and Pavek P. The pregnane X receptor down-regulates organic cation transporter 1 (SLC22A1) in human hepatocytes by competing for ("squelching") SRC-1 coactivator. Br. J. Pharmacol. 2017; 173(10):1703-15. doi: 10.1111/bhp.13472

• Hyrsova L, Smutny T, Trejtnar F and Pavek P. Expression of organic cation transporter 1 (OCT1): unique patterns of indirect regulation by nuclear receptors and hepatospecific gene regulation. Drug Metab. Rev. 2016; 48(2):139-58. doi: 10.1080/03602532.2016.1188936.

Publication 2015

• Mandíková J, Volková M, Pávek P, Navrátilová L, Hyršová L, Janeba Z, Pavlík J, Bárta P and Trejtnar F. Entecavir interacts with influx transporters hOAT1, hCNT2, hCNT3, but not with hOCT2: the potential for renal transporter-mediated cytotoxicity and drug-drug interactions. Front. Pharmacol. 2016; 6:304. doi: 10.3389/fphar.2015.00304. eCollection 2015.

• Prchal L, Bartikova H, Becanova A, Jirasko R, Vokral I, Stuchlikova L, Skalova L, Kubicek V, Lamka J, Trejtnar F and Szotakova B. Biotransformation of anthelmintics and the activity of drug-metabolizing enzymes in the tapeworm Moniezia expansa. Parasitology. 2015; 142(5):648-659.

• Cesnek M, Jansa P, Smidkova M, Mertlikova-Kaiserova H, Dracinsky M, Brust TF, Pavek P, Trejtnar F, Watts VJ and Janeba Z. Bisamidate Prodrugs of 2-Substituted 9-[2-(Phosphonomethoxy)ethyl]adenine (PMEA, adefovir) as Selective Inhibitors of Adenylate Cyclase Toxin from Bordetella pertussis. ChemMedChem. 2015;10(8):1351-64.

• Volkova M, Mandikova J, Barta P, Navratilova L, Laznickova A and Trejtnar F. The in vivo disposition and in vitro transmembrane transport of two model radiometabolites of DOTA-conjugated receptor-specific peptides labelled with (177) Lu. J Labelled Comp Radiopharm. 2015;58(13-14):483-9.

• Paraskevopoulos G, Kratky M, Mandikova J, Trejtnar F, Stolarikova J, Pavek P, Besra G and Vinsova J. Novel derivatives of nitro-substituted salicylic acids: Synthesis, antimicrobial activity and cytotoxicity. Bioorg Med Chem. 2015;23(22):7292-301.

• Volkova M, Mandikova J, Laznickova A, Laznicek M, Barta P and Trejtnar F. The involvement of selected membrane transport mechanisms in the cellular uptake of (177)Lu-labeled bombesin, somatostatin and gastrin analogues. Nucl Med Biol. 2015;42(1):1-7.

Publication 2014

• Vlckova H, Janak J, Gottvald T, Trejtnar F, Solich P, Novakova L. How to address the sample preparation of hydrophilic compounds: Determination of entecavir in plasma and plasma ultrafiltrate with novel extraction sorbents. J Pharm Biomed Anal. 2014;88:337-344.

• Vinsova J, Kozic J, Kratky M, Stolarikova J, Mandikova J, Trejtnar F, Buchta V. Salicylanilide diethyl phosphates: synthesis, antimicrobial activity and cytotoxicity. Bioorg Med Chem. 2014;22(2):728-37.

• Novy Z, Laznickova A, Mandikova J, Barta P, Laznicek M, Trejtnar F. The effect of chelator type on in vitro receptor binding and stability in 177Lu-labeled cetuximab and panitumumab. J Labelled Comp Radiopharm. 2014;57(7):448-52.

• Barta P, Volkova M, Dascalu A, Spiegelberg D, Trejtnar F, Andersson K. Determination of receptor protein binding site specificity and relative binding strength using a time-resolved competition assay. J Pharmacol Toxicol Methods. 2014;70(2):145-51.

• Novy Z, Laznickova A, Mandikova J, Barta P, Laznicek M, Trejtnar F. The effect of chelator type on in vitro receptor binding and stability in 177Lu-labeled cetuximab and panitumumab. J Labelled Comp Radiopharm. 2014 15;57(7):448-52.

• Trejtnar F, Mandikova J, Kocincova J, Volkova M. Renal handling of amphotericin B and  amphotericin B-deoxycholate and potential renal drug-drug interactions with selected antivirals. Antimicrob Agents Chemother. 2014;58(10):5650-7.

• Barta P, Andersson K, Trejtnar F, Buijs J. Exploring Time-Resolved Characterization of the Heterogeneity and Dynamics of Ligand-Receptor Interactions on Living Cells. Journal of Analytical Oncology 2014;3(2):94-104. (Open Access)

Publication 2013

• Zitko J, Paterova P, Kubicek V, Mandikova J, Trejtnar F, Kunes J, Dolezal M. Synthesis and antimycobacterial evaluation of pyrazinamide derivatives with benzylamino substitution. Bioorg Med Chem Lett. 2013;23(2):476-9.

• Imramovsky A, Pejchal V, Stepankova S, Vorcaková K, Jampilek J, Vanco J, Simunek P, Kralovec K, Bruckova L, Mandikova J, Trejtnar F. Synthesis and in vitro evaluation of new derivatives of 2-substituted-6-fluorobenzo[d]thiazoles as cholinesterase inhibitors. Bioorg Med Chem. 2013;21(7):1735-48.

• Krátký M, Vinšová J, Novotná E, Mandíková J, Trejtnar F, Stolaková J. Antibacterial activity of salicylanilide 4-(trifluoromethyl)-benzoates. Molecules. 2013;18(4):3674-88.

• Mandíková J, Volková M, Pávek P, Česnek M, Janeba Z, Kubíček V, Trejtnar F. Interactions with selected drug renal transporters and transporter-mediated cytotoxicity in antiviral agents from the group of acyclic nucleoside phosphonates. Toxicology. 2013;311(3):135-46.

• Soukup O, Jun D, Zdarova-Karasova J, Patocka J, Musilek K, Korabecny J, Krusek J, Kaniakova M, Sepsova V, Mandikova J, Trejtnar F, Pohanka M, Drtinova L, Pavlik M, Tobin G, Kuca K. A resurrection of 7-MEOTA: a comparison with tacrine. Curr Alzheimer Res. 2013;10(8):893-906.

• Volková M, Forstová-Křížová V, Skálová L, Trejtnar F: Modulatory Effects of Quercetin and Rutin on the Activity, Expression and Inducibility of CYP1A1 in Intestinal HCT-8 Cells. Phytotherapy Res. 2013;27(12):1889-1893

Publication 2012

• Macáková K, Mladěnka P, Filipský T, Říha M, Jahodář L, Trejtnar F, Bovicelli P, Proietti Silvestri I, Hrdina R, Saso L. Iron reduction potentiates hydroxyl radical formation only in flavonols. Food Chem. 2012;135(4):2584-92.

• Kozic J, Novotná E, Volková M, Stolaříková J, Trejtnar F, Wsól V, Vinšová J. Synthesis and in vitro antimycobacterial and isocitrate lyase inhibition properties of novel 2-methoxy-2'-hydroxybenzanilides, their thioxo analogues and benzoxazoles. Eur J Med Chem. 2012; 56:108-19.

• Kozic J, Novotná E, Volková M, Stolaříková J, Trejtnar F, Vinšová J. Synthesis and in vitro antimycobacterial activity of 2-methoxybenzanilides and their thioxo analogues. Eur J Med Chem. 2012;56:387-95.

• Krátký M, Vinšová J, Novotná E, Mandíková J, Wsól V, Trejtnar F, Ulmann V, Stolaříková J, Fernandes S, Bhat S, Liu JO. Salicylanilide derivatives block Mycobacterium tuberculosis through inhibition of isocitrate lyase and methionine aminopeptidase. Tuberculosis (Edinb). 2012;92(5):434-9.

• Nováková L, Gottvald T, Vlčková H, Trejtnar F, Mandíková J, Solich P. Highly sensitive fast determination of entecavir in rat urine by means of hydrophilic interaction chromatography-ultra-high-performance liquid chromatography-tandem mass spectrometry. J Chromatogr A. 2012;1259:237-43.

• Novy Z, Barta P, Mandikova J, Laznicek M, Trejtnar F. A comparison of in vitro methods for determining the membrane receptor expression in cell lines. Nucl Med Biol. 2012;39(7):893-6.

• Trejtnar F, Laznickova A, Laznicek M, Novy Z, Maina T, Nock BA, Behe M. Distribution, elimination, and renal handling of (99m)technetium-Demogastrin 1. Cancer Biother Radiopharm. 2012;27(2):169-74.

• Szymański P, Lázničková A, Lázniček M, Bajda M, Malawska B, Markowicz M, Mikiciuk-Olasik E. 2,3-Dihydro-1H-cyclopenta[b]quinoline Derivatives as Acetylcholinesterase Inhibitors-Synthesis, Radiolabeling and Biodistribution. Int J Mol Sci. 2012;13(8):10067-90.

• Laznicek M, Laznickova A, Cozikova D, Velebny V. Preclinical pharmacokinetics of radiolabelled hyaluronan. Pharmacol Rep. 2012;64(2):428-37.

• Laznicek M, Laznickova A. Different radioactivity uptake between somatostatin analogues labelled with ¹¹¹In and ⁹⁰/⁸⁸Y in rat kidney. Anticancer Res. 2012;32(3):815-22.

• Laznicek M, Laznickova A, Maecke HR. Receptor affinity and preclinical biodistribution of radiolabeled somatostatin analogs. Anticancer Res. 2012;32(3):761-6.

• Barta P, Malmberg J, Melicharova L, Strandgård J, Orlova A, Tolmachev V, Laznicek M, Andersson K. Protein interactions with HER-family receptors can have different characteristics depending on the hosting cell line. Int J Oncol. 2012;40(5):1677-82.

• Krátký M, Vinšová J, Volková M, Buchta V, Trejtnar F, Stolaříková J. Antimicrobial activity of sulfonamides containing 5-chloro-2-hydroxybenzaldehyde and 5-chloro-2-hydroxybenzoic acid scaffold. Eur J Med Chem. 2012;50:433-40.

Publication 2011 and earlier

• Radiolabeling of PAMAM dendrimers conjugated to a pyridine-N-oxide DOTA analog with ¹¹¹In: Optimization of reaction conditions and biodistribution. Biricová V, Lázničková A, Lázníček M, Polášek M, Hermann P. J Pharm Biomed Anal. 2011; 56(3):505-12.

• Vera DR, Eigner S, Beran M, Henke KE, Laznickova A, Laznicek M, Melichar F, Chinol M. Preclinical evaluation of (177)lu-nimotuzumab: a potential tool for radioimmunotherapy of epidermal growth factor receptor-overexpressing tumors. Cancer Biother Radiopharm. 2011; 26(3):287-97.

• Laznickova A, Laznicek M, Trejtnar F, Maecke HR, Eisenwiener KP, Reubi JC. Biodistribution of two octreotate analogs radiolabeled with indium and yttrium in rats. Anticancer Res. 2010;30(6):2177-84.

• Cozikova D, Laznickova A, Hermannova M, Svanovsky E, Palek L, Buffa R, Sedova P, Koppova R, Petrik M, Smejkalova D, Laznicek M, Velebny V. Preparation and the kinetic stability of hyaluronan radiolabeled with 111In, 125I and 14C. J Pharm Biomed Anal. 2010; 52(4):517-24.

• Försterová M, Petrík M, Láznicková A, Láznícek M, Hermann P, Lukes I, Melichar F. Complexation and biodistribution study of 111In and 90Y complexes of bifunctional phosphinic acid analogs of H4dota. Appl Radiat Isot. 2009;67(1):21-9.

• Trejtnar F, Novy Z, Petrik M, Laznickova A, Melicharova L, Vankova M, Laznicek M. In vitro comparison of renal handling and uptake of two somatostatin receptor-specific peptides labeled with indium-111. Ann Nucl Med. 2008;22(10):859-67.

• Svecova L, Vrzal R, Burysek L, Anzenbacherova E, Cerveny L, Grim J, Trejtnar F, Kunes J, Pour M, Staud F, Anzenbacher P, Dvorak Z, Pavek P. Azole antimycotics differentially affect rifampicin-induced pregnane X receptor-mediated CYP3A4 gene expression. Drug Metab Dispos. 2008;36(2):339-48.

• Svanovsky E, Velebny V, Laznickova A, Laznicek M. The effect of molecular weight on the biodistribution of hyaluronic acid radiolabeled with 111In after intravenous administration to rats. Eur J Drug Metab Pharmacokinet. 2008;33(3):149-57.

• Cihlo J, Melicharová L, Petrik M, Laznickova A, Laznicek M. Comparison of 111In-DOTA-NOC and 111I-DOTA-TATE distribution in the target and dose-limiting tissues: conflicting results in vitro and in vivo. Anticancer Res. 2008;28(4B):2189-95.

• Trejtnar F, Laznicek M, Laznickova A, Kopecky M, Petrik M, Béhé M, Schmidt J, Maecke H, Maina T, Nock B. Biodistribution and elimination characteristics of two 111In-labeled CCK-2/gastrin receptor-specific peptides in rats. Anticancer Res. 2007;27(2):907-12.

• Petrik M, Laznickova A, Laznicek M, Zalutsky MR. Radiolabelling of glucose-Tyr3-octreotate with 125I and analysis of its metabolism in rats: comparison with radiolabelled DOTA-Tyr3-octreotate. Anticancer Res. 2007;27(6B):3941-6.

• Kopecky M, Trejtnar F, Laznicek M, Laznickova A, Semecky V, Maina T, Nock B. 99mTc demotate 1: biodistribution and elimination characteristics in rats. Nucl Med Commun. 2005;26(6):549-54.

• Kopecky M, Semecky V, Trejtnar F, Laznicek M, Laznickova A, Nachtigal P, Decristoforo C, Mather SJ, Mäcke HR. Analysis of accumulation of 99mTc-octreotide and 99mTc-EDDA/HYNIC-Tyr3-octreotide in the rat kidneys. Nucl Med Biol. 2004;31(2):231-9.

• Sovak M, Terry R, Abramjuk C, Faberová V, Fiserova M, Laznicek M, Leuschner J, Malinak J, Zahradnik P, Masner O, Seligson A. Iosimenol, a low-viscosity nonionic dimer: preclinical physicochemistry, pharmacology, and pharmacokinetics. Invest Radiol. 2004;39(3):171-81.

• Syrovatko M, Laznickova A, Laznicek M, Wsol V. HPLC-radiometric determination of quinlukast in biological fluids. J Pharm Biomed Anal. 2004;35(1):177-83.

• Trejtnar F, Král R, Pávek P, Wsól V. Stereoselective pharmacokinetics and metabolism of flobufen in guinea pigs. Chirality. 2003;15(8):724-9.

• Novakova K, Laznicek M, Rypacek F, Machova L. Pharmacokinetics and distribution of 125I-PLA-b-PEO block copolymers in rats. Pharm Dev Technol. 2003;8(2):153-61.

• Kastner P, Klimes J, Láznícek M, Jira T. HPLC assay in plasma and preliminary pharmacokinetic study of a quinazolinone derivative with spasmolytic effect. Pharmazie. 2003;58(4):242-4.

• Trejtnar F, Laznicek M, Laznickova A. Comparison of 99mTc-mercaptoacetyltriglycine and [131I]-o-iodohippurate elimination in perfused rat kidney. Nucl Med Biol. 2003;30(1):45-9.

• Laznicek M, Laznickova A, Trejtnar F, Lorenc P, Varvarigou A, Bouziotis P, Archimandritis S. Lanreotide labeled with 99mTc: preparation, preclinical testing and comparison with (111)In-DTPA-octreotide. Anticancer Res. 2002;22(4):2125-30.

• Trejtnar F, Laznicek M. Analysis of renal handling of radiopharmaceuticals. Q J Nucl Med. 2002;46(3):181-94.

• Laznickova A, Laznicek M, Trejtnar F, Melicharova L, Suzuki KH, Akizawa H, Arano Y, Yokoyama A. Distribution and elimination characteristics of 111In-DTPA-D-phe1-octreotide and 111In-DTPA-L-phe1-octreotide in rats. Eur J Drug Metab Pharmacokinet. 2002;27(1):37-43.

• Laznicek M, Laznickova A, Mäcke HR, Eisenwiener K, Reubi JC, Wenger S. Octreotide and octreotate derivatives radiolabeled with yttrium: pharmacokinetics in rats. Cancer Biother Radiopharm. 2002;17(5):527-33.

• Wsól V, Král R, Skálová L, Szotáková B, Trejtnar F, Flieger M. Stereospecificity and stereoselectivity of flobufen metabolic profile in male rats in vitro and in vivo: phase I of biotransformation. Chirality. 2001;13(10):754-9.

• Pávek P, Fendrich Z, Staud F, Malákova J, Brozmanová H, Láznícek M, Semecký V, Grundmann M, Palicka V. Influence of P-glycoprotein on the transplacental passage of cyclosporine. J Pharm Sci. 2001;90(10):1583-92.

• Trejtnar F, Laznicek M, Laznickova A, Mather SJ. Pharmacokinetics and renal handling of 99mTc-labeled peptides. J Nucl Med. 2000;41(1):177-82.

• Trejtnar F, Wsol V, Szotakova B, Skalova L, Pavek P, Kuchar M. Stereoselective pharmacokinetics of flobufen in rats. Chirality. 1999;11(10):781-6.

• Laznicek M, Laznickova A. Renal handling of iodobenzoates in rats. J Pharm Pharmacol. 1999;51(9):1019-23.