Publications

Selected publication over last 5 years:

  1. Lucie Hyrsova, Tomas Smutny, Alejandro Carazo, Stefan Moravcik, Jana Mandikova, Frantisek Trejtnar, Sabine Gerbal-Chaloin, Petr Pavek. The pregnane X receptor down-regulates  organic cation transporter 1 (SLC22A1) in human hepatocytes  by squelching SRC-1 coactivator. Br J Pharmacol. 173(10):1703-15

  2. Karabanovich G, Zemanová J, Smutný T, Székely R, Šarkan M, Centárová I, Vocat A, Pávková I, Čonka P, Němeček J, Stolaříková J, Vejsová M, Vávrová K, Klimešová V, Hrabálek A, Pávek P, Cole ST, Mikušová K, Roh J. Development of 3,5-Dinitrobenzylsulfanyl-1,3,4-oxadiazoles and Thiadiazoles as Selective Antitubercular Agents Active Against Replicating and Nonreplicating Mycobacterium tuberculosis. J Med Chem. 2016;59(6):2362-80.

  3. Carazo Fernández A, Smutny T, Hyrsová L, Berka K, Pavek P. Chrysin, baicalein and galangin are indirect activators of the human constitutive androstane receptor (CAR). Toxicol Lett. 2015;233(2):68-77.

  4. Smutny, Tomas; Tebbens, Jurjen Duintjer; Pavek, P. Bioinformatic analysis of miRNAs targeting the key nuclear receptors regulating CYP3A4 gene expression: The challenge of the CYP3A4 "missing heritability'' enigma Journal of OURNAL OF APPLIED BIOMEDICINE 2014, 13: 3, 181-188.

  5. Soukup T, Dosedel M, Pavek P, Nekvindova J, Barvik I, Bubancova I, Bradna P, Kubena AA, Carazo AF, Veleta T, Vlcek J. The impact of C677T and A1298C MTHFR polymorphisms on methotrexate therapeutic response in East Bohemian region rheumatoid arthritis patients. Rheumatol Int. 2015 Jul;35(7):1149-61

  6. Soukup T, Dosedel M, Nekvindova J, Toms J, Vlcek J, Pavek P. Genetic polymorphisms in metabolic pathways of leflunomide in the treatment of rheumatoid arthritis. Clin Exp Rheumatol. 2015 May-Jun;33(3):426-32.

  7. Smutny T, Bitman M, Urban M, Dubecka M, Vrzal R, Dvorak Z, Pavek P. U0126, a mitogen-activated protein kinase kinase 1 and 2 (MEK1 and 2) inhibitor, selectively up-regulates main isoforms of CYP3A subfamily via a pregnane X receptor (PXR) in HepG2 cells. Arch Toxicol. 2014;88(12):2243-59.

  8. Aatsinki SM, Buler M, Salomäki H, Koulu M, Pavek P, Hakkola J. Metformin induces PGC-1α expression and selectively affects hepatic PGC-1α functions. British Journal of Pharmacology 2014;171(9):2351-63

  9. Smutny T, Mani S, Pavek P. Post-translational and Post-transcriptional Modifications of Pregnane X Receptor (PXR) in Regulation of the Cytochrome P450 Superfamily. Curr Drug Metab. 2013;14(10):1059-69.

  10. Matoulková P, Pávek P, Malý J, Vlček J. Cytochrome P450 enzyme regulation by glucocorticoids and consequences in terms of drug interaction. Expert Opin Drug Metab Toxicol. 2014 Mar;10(3):425-35.

  11.   Stejskalova, L., Rulcova, A.,Vrzal, R., Dvorak, Z., Pavek, P*.  Dexamethasone accelerates degradation of aryl hydrocarbon receptor (AHR) and suppresses CYP1A1 induction in placental JEG-3 cell line. Toxicology Letters. 2013 25;223(2):183-91.

  12. Pavek, P* and Smutny, T. Nuclear receptors in regulation of biotransformation enzymes and drug transporters in the placental barrier. Drug Metab Reviews 2014;46(1):19-32.

  13. Kamenickova, A., Anzenbacherova, E., Pavek, P., Soshilov, A.A., Denison, M.S., Zapletalova, M., Anzenbacher, P., Dvorak, Z. Effects of anthocyanins on the AhR-CYP1A1 signaling pathway in human hepatocytes and human cancer cell lines. Toxicology Letters. 2013, 221, 1-8. 

  14. Kamenickova A., Anzenbacherova E., Pavek P., Soshilov A.A., Denison M.S., Anzenbacher P., Dvorak Z. Pelargonidin activates the AhR and induces CYP1A1 in primary human hepatocytes and human cancer cell lines HepG2 and LS174T. Toxicology Letters. 2013, vol. 218(3), p. 253-259.

  15. Novotna, A., Pavek, P., Dvorak, Z. Construction and characterization of a reporter gene cell line for assessment of human glucocorticoid receptor activation. European Journal of  Pharmaceutical  Sciences. 2012, vol. 47(5), p.842-847.

  16. Doricakova, A., Novotna, A., Vrzal, R., Pavek, P., Dvorak, Z. The role of residues T248, Y249 and T422 in the function of human pregnane X receptor. Archives in Toxicology. 2013, vol. 87(2), p. 291-301.

  17. Novotna, A., Pavek, P, Dvorak, Z. Novel stably transfected gene reporter human hepatoma cell line for assessment of aryl hydrocarbon receptor transcriptional activity: construction and characterization. Environental Science and Technology. 2011, vol. 45(23), p. 10133-10139.

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