Eva Dolezelova, PharmD., PhD.

Born: June 25, 1982, Košice, Slovak Republic

 

Education, Academic and Scientific Degrees:

2011 – PharmD. (at Faculty of Pharmacy (FPharm HK)), 2009 – PhD. in Pharmacology and Toxicology (FPharm HK), 2005 – MSc. in Pharmacy (FPharm HK)

Working Experience:

Since 2016 – Researcher (FPharm HK), Since 2009 – Assistant professor (FPharm HK), 2009-2011 – Research assistant (at Faculty of Medicine HK (FMed HK)), Department of Pharmacology)

Research Interests

Molecular pharmacology, hepatology, study of molecular mechanisms of bile formation, cholestasis, soluble endoglin effect on bile formation, transport of bile acids and cholesterol in livers and intestine

Teaching

Since 2014 – guarantor of Cell Biology and Genetics (FPharm HK), Since 2009 continual teaching of Cell Biology, Genetics and Pathology (FPharm HK), 2009 – 2011 teaching of seminars and practical classes of Pharmacology I and II in students of General Medicine (FMed HK)

International Experience:

3.5 months – Lab. of Molecular Targets, Department of Pharmacognosy, University of Vienna, Austria

Memberships in Scientific Societies:

Czech Society for Experimental and Clinical Pharmacology and Toxicology

Czech Society of Hepatology

Czech Society for Atherosclerosis

Member of the Expert Committee for Ensuring the Welfare of Animals at Charles University, Faculty of Pharmacy in Hradec Kralove

Awards

2011 - 1st price award for the best poster presentation on May Hepatology days, Karlovy Vary

2009 - 1st price award for the best article of the year published in 2009 from Czech Society for Experimental and Clinical Pharmacology and Toxicology

2009 - 1st price award for the best article published in 2009 from Czech Society for Atherosclerosis.

2008 - 1st price award for the best article published in 2008 from Czech Society for Experimental and Clinical Pharmacology and Toxicology

Peer Review

Master´s thesis (4x/ FPharm HK)

Bachelor´s thesis (1x/ FPharm HK)

Grant Projects

Principal investigator of one grant project (2007-2008, GA UK). Co-worker of 3 grant projects. Now co-investigator of 2 grant projects (AZV, GAČR).

Publications and Citations (in total):

Number of publications in WoS/Scopus: 31/42

Number of citations in WoS/Scopus – total 285/329, without self-citations 244/240.

H-index in WoS/Scopus (with self-citations) = 10/12.

Summary of Publications (in last 5 years, 2012-2017):

in WoS/Scopus: 10/12, cumulative IF (summa IF) = 47.664, average IF = 2.979.

Summary of all publications

  1. Rathouska J, Fikrova P, Mrkvicova A, Blazickova K, Varejckova M, Dolezelova E, Nemeckova I, Vitverova B, Peslova L, Gallardo-Vara E, Pericacho M, Nachtigal P. High soluble endoglin levels do not induce changes in structural parameters of mouse heart. Heart Vessels. 2017;(Epub ahead of print) (IF2017 = 2.293)
  2. Varejckova M, Gallardo-Vara E, Vicen M, Vitverova B, Fikrova P, Dolezelova E, Rathouska J, Prasnicka A, Blazickova K, Micuda S, Bernabeu C, Nemeckova I, Nachtigal P. Soluble endoglin modulates the pro-inflammatory mediators NF-κB and IL-6 in cultured human endothelial cells. Life sciences. 2017;175:52-60 (IF2017 = 2.761)
  3. Dolezelova E, Stein E, Derosa G, Maffioli P, Nachtigal P, Sahebkar A. Effect of ezetimibe on plasma adipokines: a systematic review and meta-analysis. Br J Clin Pharmacol. 2017;83:1380-1396 (IF2017 = 3.830)
  4. Cermanova J, Prasnicka A, Dolezelova E, Rozkydalova L, Hroch M, Chládek J, Tomsik P, Kloeting I, Micuda S. Pharmacokinetics of boldine in control and Mrp2-deficient rats. Physiol Res. 2016;65:489-497 (IF2016 = 1.643)
  5. Jezkova K, Rathouska J, Nemeckova I, Fikrova P, Dolezelova E, Varejckova M, Vitverova B, Tysonova K, Serwadczak A, Buczek E, Bernabeu C, Lopez-Novoa JM, Chlopicki S, Nachtigal P. High Levels of Soluble Endoglin Induce a Proinflammatory and Oxidative-Stress Phenotype Associated with Preserved NO-Dependent Vasodilatation in Aortas from Mice Fed a High-Fat Diet. J Vasc Res. 2016;53:149-162 (IF2016 = 2.186)
  6. Zagorova M, Prasnicka A, Kadova Z, Dolezelova E, Kazdova L, Cermanova J, Rozkydalova L, Hroch M, Mokry J, Micuda S. Boldine attenuates cholestasis associated with nonalcoholic fatty liver disease in hereditary hypertriglyceridemic rats fed by high-sucrose diet. Physiol Res. 2015; 64:467-76 (IF2015 = 2.544)
  7. Muchova L, Vanova K, Suk J, Micuda S, Dolezelova E, Fuksa L, Cerny D, Farghali H, Zelenkova M, Lenicek M, Wong RJ, Vreman HJ, Vitek L. Protective effect of heme oxygenase induction in ethinylestradiol-induced cholestasis. J Cell Mol Med. 2015; 19:924-33 (IF2015 = 3.368)
  8. Kadova Z, Dolezelova E, Cermanova J, Hroch M, Laho T, Muchova L, Staud F, Vitek L, Mokry J, Chladek J, Havlinova Z, Holecek M, Micuda S. IL-1 receptor blockade alleviates endotoxin-mediated impairment of renal drug excretory functions in rats. Am J Physiol Renal Physiol. 2014;308:388-99 (IF2014 = 3.300)
  9. Cermanova J, Kadova Z, Dolezelova E, Zagorova M, Safka V, Hroch M, Laho T, Holeckova M, Mokry J, Kovarikova P, Bures J, Sterba M, Micuda S. Deferoxamine but not dexrazoxane alleviates liver injury induced by endotoxemia in rats. Shock. 2014; 42:372-9 (IF2014 = 2.732)
  10. Ahmadimoghaddam D, Zemankova L, Nachtigal P, Dolezelova E, Neumanova Z, Cerveny L, Ceckova M, Kacerovský M, Micuda S, Staud F. Organic cation transporter 3 (OCT3/SLC22A3) and multidrug and toxin extrusion 1 (MATE1/SLC47A1) transporter in the placenta and fetal tissues: expression profile and fetus protective role at different stages of gestation. Biol Reprod. 2013;88:55 (IF2013 = 4.027)
  11. Hirsova P, Karlasova G, Dolezelova E, Cermanova J, Zagorova M, Kadova Z, Hroch M, Sispera L, Tomsik P, Lenicek M, Vitek L, Pavek P, Kucera O, Cervinkova Z, Micuda S (2013) Cholestatic effect of epigallocatechin gallate in rats is mediated via decreased expression of Mrp2. Toxicology 303:9-15. (IF2013 = 4.017)
  12. Jirkovsky E, Popelová O, Kriváková-Stanková P, Vávrová A, Hroch M, Hasková P, Brcáková-Dolezelová E, Micuda S, Adamcová M, Simůnek T, Cervinková Z, Gersl V, Sterba M. Chronic anthracycline cardiotoxicity: molecular and functional analysis with focus on nuclear factor erythroid 2-related factor 2 and mitochondrial biogenesis pathways. J Pharmacol Exp Ther. 2012;343:468-78 (IF2012 = 3.891)
  13. Hirsova P, Kolouchova G, Dolezelova E, Cermanova J, Hyspler R, Kadova Z, Micuda S. Epigallocatechin gallate enhances biliary cholesterol secretion in healthy rats and lowers plasma and liver cholesterol in ethinylestradiol-treated rats. Eur J Pharmacol. 2012;691:38-45 (IF2012 = 2.592)
  14. Ahmadimoghaddam D, Hofman J, Zemankova L, Nachtigal P, Dolezelova E, Cerveny L, Ceckova M, Micuda S, Staud F. Synchronized activity of organic cation transporter 3 (Oct3/Slc22a3) and multidrug and toxin extrusion 1 (Mate1/Slc47a1) transporter in transplacental passage of MPP+ in rat. Toxicol Sci. 2012;128:471-81 (IF2012 = 4.328)
  15. Grim, J, Jandík, P, Slánská, I, Doležalová-Brčáková, E, Fuksa, L, Ryška, A, Knížek, J, Petera, J, Mičuda, S, Hornychová, H. Low expression of NQO1 predicts pathological complete response to neoadjuvant chemotherapy in breast cancer patients treated with TAC regimen. Folia Biol. 2012;58:185-192 (IF2012 = 1.219)
  16. Vecerova L, Strasky Z, Rathouska J, Slanarova M, Brcakova E, Micuda S, Nachtigal P. Activation of TGF-β receptors and Smad proteins by atorvastatin is related to reduced atherogenesis in ApoE/LDLR double knockout mice. J Atheroscler Thromb. 2012;19:115-26 (IF2012 = 2.933)
  17. Cížková D, Vávrová J, Mičuda S, Filip S, Brčáková E, Brůčková L, Mokrý J. Role of transplanted bone marrow cells in response to skeletal muscle injury. Folia Biol. 2011;57:232-41 (IF2011 = 1.151)
  18. Kolouchova G, Brcakova E, Hirsova P, Cermanova J, Fuksa L, Mokry J, Nachtigal P, Lastuvkova H, Micuda S. Modification of hepatic iron metabolism induced by pravastatin during obstructive cholestasis in rats. Life Sci. 2011;89:717-724 (IF2011 = 2.451)
  19. Bruckova L, Soukup T, Visek B, Moos J, Moosova M, Pavelkova J, Rezabek K, Kucerova L, Micuda S, Brcakova E, Mokry J. Proliferative potential and phenotypic analysis of long-term cultivated human granulosa cells initiated by addition of follicular fluid. J Assist Reprod Genet. 2011;28:939-950 (IF2011 = 1.253)
  20. Strasky Z, Vecerova L, Rathouska J, Slanarova M, Brcakova E, Kudlackova Z, Andrys C, Micuda S, Nachtigal P. Cholesterol effects on endoglin and its downstream pathways in ApoE/LDLR double knockout mice. Circ J. 2011;75:1747-55 (IF2011 = 3.225)
  21. Kolouchova G, Brcakova E, Hirsova P, Sispera L, Tomsik P, Cermanova J, Hyspler R, Slanarova M, Fuksa L, Lotkova H, Micuda S. Pravastatin modulates liver bile acid and cholesterol homeostasis in rats with chronic cholestasis. J Gastroenterol Hepatol. 2011;26:1544-1551 (IF2011 = 2.410)
  22. Lotková H, Staňková P, Roušar T, Kučera O, Kohoutek L, Mičuda S, Brčáková E, Kolouchová G, Cervinková Z. Deteriorating effect of fluvastatin on the cholestatic liver injury induced by bile duct ligation in rats. Gen Physiol Biophys. 2011;30:66-74 (IF2011 = 1.146)
  23. Rathouska J, Vecerova L, Strasky Z, Slanarova M, Brcakova E, Mullerova Z, Andrys C, Micuda S, Nachtigal P. Endoglin as a possible marker of atorvastatin treatment benefit in atherosclerosis. Pharmacol Res. 2011;64:53-9 (IF2011 = 3.612)
  24. Stěrba M, Popelová O, Lenčo J, Fučíková A, Brčáková E, Mazurová Y, Jirkovský E, Simůnek T, Adamcová M, Mičuda S, Stulík J, Geršl V. Proteomic insights into chronic anthracycline cardiotoxicity. J Mol Cell Cardiol. 2011;50:849-62 (IF2011 = 5.499)
  25. Mokry J, Soukup T, Micuda S, Karbanova J, Visek B, Brcakova E, Suchanek J, Bouchal J, Vokurkova D, Ivancakova R. Telomere attrition occurs during ex vivo expansion of human dental pulp stem cells. J Biomed Biotechnol. 2010;673513 (IF2010 = 1.230)
  26. Fuksa L, Brcakova E, Kolouchova G, Hirsova P, Hroch M, Cermanova J, Stud F, Micuda S. Dexamethasone reduces methotrexate biliary elimination and potentiates its hepatotoxicity in rats. Toxicology 2010;267: 165-171 (IF2010 = 3.241)
  27. Cermanova J, Fuksa L, Brcakova E, Hroch M, Kucera O, Kolouchova G, Hirsova P, Malakova J, Staud F, Martinkova J, Cervinkova Z and Micuda S. Up-regulation of renal Mdr1 and Mrp2 transporters during amiodarone pretreatment in rats. Pharmacol Res. 2010;61: 129-135 (IF2010 = 3,929)
  28. Prochazka E, Soukup T, Hroch M, Fuksa L, Brcakova E, Cermanova J, Kolouchova G, Urban K, Mokry J and Micuda S. Methotrexate released in vitro from bone cement inhibits human stem cell proliferation in S/G2 phase. Int Orthop 2010;34: 137-142 (IF2010 = 1.825)
  29. Brcakova E, Fuksa L, Cermanova J, Kolouchova G, Hroch M, Hirsova P, Martinkova J, Staud F and Micuda S. Alteration of methotrexate biliary and renal elimination during extrahepatic and intrahepatic cholestasis in rats. Biol. Pharm. Bull 2009;32:1978-85 [IF2009 = 1.765]
  30. Nachtigal P, Pospisilova N, Vecerova L, Micuda S, Brcakova E, Pospechova K and Semecky V. Atorvastatin Increases Endoglin, SMAD2, Phosphorylated SMAD2/3 and eNOS Expression in ApoE/LDLR Double Knockout Mice. J Atheroscler Thromb 2009;16:265-274 (IF2009 = 2.625)
  31. Nachtigal P., Vecerova L., Pospisilova N., Micuda S., Brcakova E., Navarro Hernandez E., Pospechova K. and Semecky V. Endoglin co-expression with eNOS, SMAD2 and phosphorylated SMAD2/3 in normocholesterolemic and hypercholesterolemic mice: an immunohistochemical study. Histol Histopathol 2009;24: 1499-1506 (IF2009 = 2.194)
  32. Cibickova L, Hyspler R, Micuda S, Cibicek N, Zivna H, Jun D, Ticha A, Brcakova E, Palicka V. The influence of simvastatin, atorvastatin and high-cholesterol diet on acetylcholinesterase activity, amyloid beta and cholesterol synthesis in rat brain. Steroids 2009;74: 13-19. (IF2009 = 2.588)
  33. Fuksa L, Brcakova E, Cermanova J, Hroch M, Chladek J, Kolouchova G, Malakova J, Martinkova J, Staud F and Micuda S. Amiodarone modulates pharmacokinetics of low-dose methotrexate in rats. Biopharm Drug Dispos 2008;29:289-299 (IF2008 = 1.542)
  34. Micuda S, Brcakova E, Fuksa L, Cermanova J, Osterreicher J, Hroch M, Mokry J, Pejchal J, Martinkova J and Staud F. P-glycoprotein function and expression during obstructive cholestasis in rats. Eur J Gastroenterol Hepatol 2008;20:404-412 (IF2008 = 2.080)
  35. Tomsik P, Sispera L, Rezacova M, Niang M, Stoklasova A, Cerman J, Knizek J, Brcakova E, Cermanova J and Micuda S. Increased melibiose/rhamnose ratio in bile of rats with acute cholestasis. J Gastroenterol Hepatol 2008;23:1934-1940 (IF2008 = 2.275)
  36. Micuda S, Fuksa L, Brcakova E, Osterreicher J, Cermanova J, Cibicek N, Mokry J, Staud F and Martinkova J. Zonation of multidrug resistance-associated protein 2 in rat liver after induction with dexamethasone. J Gastroenterol Hepatol 2008;23:225-230 (IF2008 = 2.275)
  37. Micuda S, Sispera L, Hodac M, Parizek P, Fuksa L, Brcakova E, Cerman J, Cermanova J and Martinkova J. Diurnal variation of 6beta-hydroxycortisol in cardiac patients. Physiol Res 2007;56:307-313 (IF2007 = 1.505)
  38. Micuda S, Fuksa L, Mundlova L, Osterreicher J, Mokry J, Cermanova J, Brcakova E, Staud F, Pokorna P and Martinkova J. Morphological and functional changes in p-glycoprotein during dexamethasone-induced hepatomegaly. Clin Exp Pharmacol Physiol 2007;34:296-303 (IF2007 = 2.038)
  39. Fuksa L, Mičuda S, Cermanová J, Brčáková E a Štaud F. Fyziologická funkce MRP2. Československá fyziologie 2006;55:57-65

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