Education
- 2015-2020 Charles University, Faculty of Pharmacy, (Master degree), Thesis: Derivatives of Amaryllidaceae alkaloids and their biological activity: Derivatives of tazettine I.
- Since 2020 a postgraduate study at Charles University, Faculty of Pharmacy, Department of Pharmaceutical Botany in the study programme: Pharmacognosy and Nutraceuticals. Doctoral Thesis theme: Natural products as potential drugs for treatment of neurodegenerative diseases.
Research focus
- preparation of synthetic and semisynthetic derivatives of isolated compounds.
- screening biological activity of isolated compounds (AChE, BuChE, POP, GSK-3β and anticancer).
Current position
- a doctoral student at Charles University, Faculty of Pharmacy in Hradec Králové, Department of Pharmaceutical Botany
Publications
Original papers
2023
PIDANY, F., KROUSTKOVA, J., AL MAMUN, A., SUCHANKOVA, D., BRAZZOLOTTO, X., NACHON, F., CHANTEGREIL, F., DOLEZAL, R., PULKRABKOVÁ, L., MUCKOVA, L., HRABINOVA, M., FINGER, V., KUFA, M., SOUKUP, O., JUN, D., JENCO, J., KUNES, J., NOVAKOVA, L., KORABECNY, J., CAHLIKOVA, L.: Highly selective butyrylcholinesterase inhibitors related to Amaryllidaceae alkaloids - design, synthesis, and biological evaluation. Eur. J. Med. Chem. 252, 115301 (2023). https://doi.org/10.1016/j.ejmech.2023.115301
KOUTOVÁ, D., MAAFI, N., MUTHNÁ, D., KRÁLOVEC, K., KROUSTKOVA, J., PIDANY, F., TIMBILLA, A., CERMAKOVA, E., CAHLIKOVA, L., REZACOVA, M., HAVELEK, R.: Antiproliferative activity and apoptosis-inducing mechanism of Amaryllidaceae alkaloid montanine on A549 and MOLT-4 human cancer cells. Biomed. Pharmacother. 166, 115295 (2023). https://doi.org/10.1016/j.biopha.2023.115295
2021
AL MAMUN, A., PIDANY, F., HULCOVA, D., MARIKOVA, J., KUCERA, T., SCHMIDT, M., CATAPANO, M.C., HRABINOVA, M., JUN, D., MUCKOVA, L., KUNES, J., JANOUSEK, J., ANDRYS R., NOVAKOVA, L., PERINOVA, R., MAAFI, N., SOUKUP, O., KORABECNY, J., CAHLIKOVA, L.: Amaryllidaceae alkaloids of norbelladine-type as inspiration for development of highly selective butyrylcholinesterase inhibitors: Synthesis, biological activity evaluation, and docking studies. In. J. Mol. Sci. 22, 8308 (2021). https://doi.org/10.3390/ijms22158308
MAAFI, N., PIDANY, F., MARIKOVA, J., KORABECNY, J., HULCOVA, D., KUCERA, T., SCHMIDT, M., AL SHAMMARI, L., SPULAK, M., CATAPANO, M.C., MECAVA, M., PRCHALD, L., KUNES, J., JANOUSEK, J., KOHELOVA, E., JENCO, J., NOVAKOVA, L., CAHLIKOVA, L.: Derivatives of montanine-type alkaloids and their implication for the treatment of Alzheimer´s disease: Synthesis, biological activity and in silico study. Bioorg. Med. Chem. Let. 51, 128374 (2021). https://doi.org/10.1016/j.bmcl.2021.128374
Reviews
2021
CAHLIKOVA, L., VRABEC, R., PIDANY, F., PERINOVA, R., MAAFI, N., AL MAMUN, A., RITOMSKA, A., WIJAYA, V., BLUNDEN, G.: Recent progress on biological activity of Amaryllidaceae and further isoquinoline alkaloids in connection with Alzheimer´s disease. Molecules 26, 5240 (2021). https://doi.org/10.3390/molecules26175240
Conferences
2021
11th Postgraduate and 9th Postdoc Conference, Hradec Králové, Czech Republic. Short presentation: Amaryllidaceae alkaloids of norbelladine-type as inspiration for development of selective butyrylcholinesterase inhibitors.