Scientific cooperation

International

• Prof. dr. Jacqueline Cloos, dr. Gerrit Jansen - Department of Hematology, Amsterdam UMC, Netherland
  • characterisation of leukemic cells resistant to FLT3 inhibitors
• Dr. Csilla Özvegy-Laczka - Membrane Protein Research Group, Institute of Enzymology, Research Centre for Natural Sciences, Budapest, Hungary
  • cooperation in the topic of OATP transporters, evaluation of membrane transporters associated mechanisms of resistance
• Assoc. Prof. Dr. Christian Wadsack - Medical University of Graz, Department of Obstetrics and Gynecology, Graz, Austria
  • collaboration on placental transport and involvement of ABC as well as SLC transporters, in particular dual perfusion of human placenta and ex vivo isolated primary cell cultures

• Assoc. Prof. Dr. Claudia Gundacker & Assoc. Prof. Dr. Isabella Ellinger – Medical University of Vienna, Vienna, Austria
  • Collaboration in the investigation of placental MRP1 transporter, transporter visualisation

• Dr. Jocelyn Glazier & Dr. Susane Greenwood – St. Mary´s Hospital, University of Manchester, Great Britain
  • collaboration on SLC transporters in transplacental transfer of drugs

In the Czech Republic

• prof. MUDr. Pavel Žák, Ph.D., MUDr. Benjamín Víšek & MUDr. Alžběta Zavřelová – University Hospital Hradec Králové, The 4^th Department of Internal Medicine – Hematology
  • clinical part of the research, collection of  samples from patients diagnosed for acute leukemia
• RNDr. Ondřej Souček, Ph.D. – University Hospital Hradec Králové, Department of Clinical Immunology and Allergology
  • identification of leukemia-associated immunophenotypes
• Mgr. Marie Vajrychová, Ph.D. - Biomedical Research Center, University Hospital Hradec Králové
  • proteomic analysis 
• Assoc. Prof. PharmDr. Jan Korábečný, Ph.D. - Biomedical Research Center, University Hospital Hradec Králové
  • synthesis of new anti-AML compounds
• prof. MUDr. Martina Řezáčová, Ph.D. - Medical Faculty Hradec Králové, Charles University
  • analysis of apoptotic signalling pathways in drug resistance

• Prof. MUDr. Marian Kacerovský, Ph.D. – University Hospital Hradec Králové, Department of Obstetrics and Gynecology
  • collection of placental tissue, umbilical cord and cord blood, collaboration in the topic of ABC/SLC transporters in preterm birth
• Assoc. Prof. RNDr. Vladimír Kryštof, Ph.D. – University of Olomouc, Laboratory of Growth Regulators
  • cooperation on characterisation of new investigational drugs of cyclin-dependent kinase inhibitor group

At the Faculty of Pharmacy

• Prof. Ing. Vladimír Wsól, Ph.D., RNDr. Eva Novotná, Ph.D. – Department of Biochemical Sciences
  • collaboration on drug resistance to anthracyclines (carbonyl reductases associated mechanisms of drug resistance) and molecular docking
• Assoc. Prof. PharmDr. Radim Kučera, Ph.D. & Prof. PharmDr. Lucie Nováková, Ph.D. – Department of Pharmaceutical Chemistry and Drug Analysis
  • chemical analysis of the investigated drugs
• Assoc. Prof. Jakub Hofman, Ph.D. – Department of Pharmacology and Toxicology
  • pharmacokinetic resistance and its modulation by novel targeted drugs