Research funding
Ongoing funding projects
- Co. researcher 2024-2028 New Technologies for Translational Research in Pharmaceutical Sciences /NETPHARM, project ID CZ.02.01.01/00/22_008/0004607, which is co-funded by the European Union
- GAUK: projects
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Past funding projects
- Main researcher 2022-2024 GAČR grant project: Impact of direct endoglin modulation on the development of major complications of metabolic syndrome: atherogenesis and non-alcoholic steatohepatitis.
- Main researcher 2017-2020 AZV grant project: The relationship of soluble endoglin and hypercholesterolemia in patients with type 2 diabetes mellitus and the impact of therapeutical intervention.
- 2015-2017 GACR project: Tissue and soluble endoglin and their importance in endothelial dysfunction and atherogenesis in vivo and in vitro.
- 2012-2017 Charles University: UNCE project “Centre for investigation of toxic and protective effects of drugs on cardiovascular system” (UNCE 33/2012)
- 2002 – 2004: post-doc project GACR „The comparison of the effect of various statins on the expression of cell adhesion molecules in the vessel after induction of hypercholesterolemia”
GAUK: projects
- 2001 – 2003 „Study of cell adhesion molecules in large and middle sized blood vessels in various pathological situations”
- 2008 – 2010 “The study of expression and function of endoglin in experimental atherogenesis”
- 2010 – 2012 The study of potential antiatherogenic effect of Spirulina platensis in mice models of atherosclerosis.
- 2011 – 2013 Study of cholesterol and statins effects on the expression and activation of endoglin/Smad cascade in endothelial and macrophage cell lines.
- 2011 – 2013 Study of endoglin/Smad signaling cascade in different stages of atherogenesis and after statin treatment.
- 2016-2018 GAUK Project: Soluble endoglin as a potential risk factor for the development of vascular diseases.
- 2015-2017 GACR project: Tissue and soluble endoglin and their importance in endothelial dysfunction and atherogenesis in vivo and in vitro.
- 2017-2019 GAUK Project: Monitoring of oxysterol, soluble endoglin and atorvastatin effects on the expression of endoglin and levels of soluble endoglin in endotelial cells
- 2021-2023 GAUK Project: Carotuximab effects on endoglin expression and signaling, soluble endoglin levels in altered mouse liver
- 2020-2022 GAUK Project: Carotuximab effects on endoglin expression, signaling and function in inflammation and oxysterol induced endothelial dysfunction in endothelial cells
- 2019-2021 GAUK Project: Soluble endoglin as a risk factor of estrogen-induced cholestasis?
- 2022-2024: The impact of dapagliflozin treatment on soluble endoglin-induced endothelial dysfunction in diabetic endothelial cells
- 2023-2025: The impact of endoglin overexpression on endothelial dysfunction and nonalcoholic steatohepatitis development in mice