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Publications

Synthetic Organic Chemistry and NMR Spectroscopy

 Recent papers

Cover-01ad.jpg Org. Chem. Front 2020

 

 Selected important publications

  1. Kadaník, M.; Frantsuzova, E.; Matouš, P.; Nováková, L.; Kuneš, J.; Bonsignore, M.; Andris, E.; Růžičková, Z.; Pour, M. Vicinal Bis(methylene) Heterocyclic Diene in Natural Product Synthesis: A Convergent Biomimetic Total Synthesis of Prunolactone A. Org. Lett. 2024, 26, 11080–11084. DOI: https://doi.org/10.1021/acs.orglett.4c04378
  2. Antal, R.; Staś, M.; Perdomo, S. M.; Štemberová, M.; Brůža, Z.; Matouš, P.; Kratochvíl, J.; Růžička, A.; Rulíšek, L.; Kuneš, J.; Kočovský, P.; Andris, E.; Pour, M. Synthesis of highly polarized [3]dendralenes and their Diels–Alder reactions. Org. Chem. Front., 2023, Advance Article. DOI: https://doi.org/10.1039/D3QO01221B
  3. Brožová, Z. R.; Dušek, J.; Palša, N.; Maixnerová, J.; Kamaraj, R.; Smutná, L.; Matouš, P.; Braeuning, A.; Pávek, P.; Kuneš, J.; Gathergood, N.; Špulák, M.; Pour, M.; Carazo, A. 2-Substituted quinazolines: Partial agonistic and antagonistic ligands of the constitutive androstane receptor (CAR). Eur. J. Med. Chem. 2023, vol. 259, 115631. DOI: https://doi.org/10.1016/j.ejmech.2023.115631
  4. Matouš, P.; Májek, M.; Kysilka, O.; Kuneš, J.; Maříková, J.; Růžička, A.; Pour, M.; Kočovský, P. Reaction Outcome Critically Dependent on the Method of Workup: An Example from the Synthesis of 1-Isoquinolones. J. Org. Chem. 2021, vol. 86. no. 12, p. 8078–8088. DOI: 10.1021/acs.joc.1c00561
  5. Matouš, P.; Kadaník, M.; Timoracký, M.; Kuneš, J.; Maříková, J.; Růžička, A.; Kočovský, P.; Pour, M. Nucleophile-assisted cyclization of beta-propargylamino acrylic compounds catalyzed by gold(I): a rapid construction of multisubstituted tetrahydropyridines and their fused derivatives. Org. Chem. Front. 2020, vol. 7. no. 21, p. 3356–3367.
  6. Brůža, Z.; Kratochvíl, J.; Harvey, J. N.; Rulíšek, L.; Nováková, L.; Maříková, J.; Kuneš, J.; Kočovský, P.; Pour, M. A New Insight into the Stereoelectronic Control of the Pd(0)-Catalyzed Allylic Substitution: Application for the Synthesis of Multisubstituted Pyran-2-ones via an Unusual 1,3-Transposition. Chem. Eur. J. 2019, vol. 25, no. 34, p. 8053–8060.
  7. Horký, P.; Voráčová, M.; Konečná, K.; Sedlák, D.; Bartůněk, P.; Vacek, J.; Kuneš, P., Pour, M. Nontoxic Combretafuranone Analogues with High in Vitro Antibacterial Activity. Eur. J. Med. Chem. 2018, vol. 143, p. 843–853.
  8. Špulák, M.; Ghavre, M.; Pour, M. Recent Advances in The Transition-metal Catalyzed Synthesis of Multisubstituted Pentenolides and Related Pyranones. Tetrahedron Lett. 2017, vol. 58, no. 4, p. 263–270.
  9. Mikušek, J.; Matouš, P.; Matoušová, E.; Janoušek, M.; Kuneš, J.; Pour, M. Substrate Control in Gold(I)- Catalyzed Cyclization of β-Propargylamino Acrylic Esters and Further Transformations of the Resultant Dihydropyridines. Adv. Synth. Catal. 2016, vol. 358, no. 18, p. 2912–2922.
  10. Ghavre, M.; Froese, J.; Pour, M.; Hudlický, T. Synthesis of Amaryllidaceae, Constituents and Unnatural Derivatives. Angew. Chem.-Int. Ed. 2016, vol. 55, no. 19, p. 5642–5691. 
  11. Krenk, O.; Kratochvíl, J.; Špulák, M.; Buchta, V.; Kuneš, J.; Nováková, L.; Ghavre, M.; Pour, M. Methodology for Synthesis of Enantiopure 3,5-Disubstituted Pyrrol-2-ones. Eur. J. Org. Chem. 2015, vol. 2015, no. 24, p. 5414–5423.
  12. Kratochvíl, J.; Novák, Z.; Ghavre, M.; Nováková, L.; Růžička, A.; Kuneš, J.; Pour, M. Fully Substituted Pyranones via Quasi-Heterogeneous Genuinely Ligand-Free Migita-Stille Coupling of Iodoacrylates. Org. Lett. 2015, vol. 17, no. 3, p. 520–523.
  13. Špulák, M.; Pourová, J.; Vopršálová, M.; Mikušek, J.; Kuneš, J.; Vacek, J.; Ghavre, M.; Gathergood, N.; Pour, M. Novel Bronchodilatory Quinazolines and Quinoxalines: Synthesis and Biological Evaluation. Eur. J. Med. Chem. 2014, vol. 74, p. 65–72.
  14. Špulák, M.; Novák, Z.; Palát, K.; Kuneš, J.; Pourová, J.; Pour, M. The Unambiguous Synthesis and NMR Assignment of 4-Alkoxy and 3-Alkylquinazolines. Tetrahedron. 2013, vol. 69, no. 6, p. 1705–1711.
     
  15. Tichotová, L.; Matoušová, E.; Špulák, M.; Kuneš, J.; Votruba, I.; Buchta, V.; Pour, M. Synthesis and Biological Activity of Desmethoxy Analogues of Coruscanone A. Bioorg. Med. Chem. Lett. 2011, vol. 21, no. 20, p. 6062–6066.
  16. Matoušová, E.; Růžička, A.; Kuneš, J.; Králová J.; Pour, M. TFP as Ligand in AuI-catalyzed Dihydropyran Synthesis. Unprecedented Rearrangement of Dihydropyrans into Cyclopentenones. Chem. Commun. 2011, vol. 47, no. 33, p. 9390–9392.
  17. Pourová, J.; Kottová, M.; Vopršalová, M.; Pour, M. Reactive oxygen and nitrogen species in normal physiological processes Acta Physiol. 2010, vol. 198, no. 1, p. 15–35.
  18. Schiller, R.; Tichotová, L.; Pavlík, J.; Buchta, V.; Melichar B.; Votruba, I.; Kuneš, J.; Špulák, M.; Pour, M. 3,5-Disubstituted Pyranone Analogues of Highly Antifungally Active Furanones: Conversion of Biological Effect from Antifungal to Cytostatic. Bioorg. Med. Chem. Lett. 2010, vol. 20, no. 24, p. 7358–7360.
  19. Špulák, M.; Lubojacký, R.; Šenel, P.; Kuneš, J.; Pour, M. Direct C-H Arylation and Alkenylation of 1-Substituted Tetrazoles: Phosphine As Stabilizing Factor J. Org. Chem. 2010, 75, no. 1, 241–244.
  20. Pavlík, J.; Šnajdr, I.; Kuneš, J.; Špulák, M.; Pour, M. A Short Entry to a-Substituted g-Alkylidene Pentenolides. Synthesis and Preliminary Biological Evaluation of Novel Gelastatin Analogues  J. Org. Chem. 2009, 74, 703-709.
  21. Opletalová, V.; Kalinowski, D. S.; Vejsová, M.; Kuneš, J.; Pour, M.; Jampílek, J.; Buchta, V.; Richardson, D. R. Identification and characterization of thiosemicarbazones with antifungal and antitumor effects: Cellular iron chelation mediating cytotoxic activity. Chem. Res. Toxicol. 2008, vol. 21, no. 9, p. 1878-1889.
  22. Schiller, R.; Pour, M.; Fáková, H.; Kuneš, J.; Císařová, I. Neighboring Group Effect in Pd-Catalyzed Carbonylation Terminated by Lactonization: A Need for a Protective Group and/or DMF. J. Org. Chem. 2004, vol. 69, no. 20, p. 6761-6765.
  23. Buchta, V.; Pour, M.; Kubanová, P.; Silva, L.; Votruba, I.; Vopršalová, M.; Schiller, R.; Fáková, H.; Špulák, M. In Vitro Antifungal Activity of 3-(Halogenated phenyl)-5-acyloxymethyl-2,5-dihydrofuran-2-ones against common and emerging yeasts and Aspergillus species. Antimicrob. Agents  Chemother. 2004, vol. 48, no. 3, p. 873-878.
  24. Pour, M.; Špulák, M.; Balšánek, V.; Kuneš, J.; Buchta, V. Synthesis and Structure-Antifungal Activity Relationships of 3-Aryl-5-alkyl-2,5-dihydrofuran-2-ones and Their Carbanalogues. Further Refinement of Tentative Pharmacophore Group.  Bioorg. Med. Chem. 2003, vol. 11, no.13, p. 2843-2866.
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