Organic synthesis

1. Application of catalytic reactions of Pd on the synthesis of natural products and their analogs

Cyclization of enynes, couplings, carbonylative lactonization

Screening of the compounds (Xcelligence tests – Institute of Molecular Genetics, Czech Academy of Science, Prague; cytostatic activity and cytotoxicity -  School of Medicine, Palacký University, Olomouc; antifungal and antimicrobial activity – Department of Biological and Medical Sciences, Faculty of Pharmacy)

2. Specifically substituted heterocycles via enyne cyclization and direct activation of C-H bond

3. Analogues of quinazoline alkaloids as bronchodilatory compounds and/or organocatalysts

Bronchodilatory effect (isolated trachea model) – Laboratory of Respiratory Pharmacology, Faculty of Pharmacy