Research group of the experimental cardiovascular pharmacology
We are a research group studying the drugs acting on cardiovascular system, in particular in vivo but as well in vitro conditions. Are priorities are:
- professionalism
- collaboration (see video)
- friendly working environment
- international team - list of accepted foreign students
Current research topics
- Effects of flavonoids, other polyphenols and their metabolites on the organism in physiological and pathological conditions
- Screening of novel antiplatelet drugs and assessment of the mechanism of action
- Effects of drugs on vascular smooth muscles both ex vivo and in vivo
- In vitro screening of novel iron/copper/zinc/cobalt/magnesium/calcium chelators (comparison of chelating activity at different pHs, assessment of the abilities of these compounds to inhibit Fenton chemistry leading to highly reactive oxygen species and tissue derangement)
- Biologically relevant effects of endocrine disruptors
Current staff
Faculty employees
- Prof. Přemysl Mladěnka, Pharm.D., Ph.D.
- Jana Karlíčková, Pharm.D., Ph.D.
- Eduard Jirkovský, Pharm.D., Ph.D.
- Alejandro Carazo, Pharm.D., Ph.D.
- Zuzana Lomozová, Pharm.D., Ph.D
Postdocs
- Marcel Hrubša, PharmD., Ph.D.
Postgradual students
- Václav Tvrdý, MSc.
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Shamima Parvin, MSc.
- Patrícia Harčárová, MSc.
- Catherine Immaculate Gunaseelan (Molák), MSc.
- maternity/parental leave - Bogdan Adler, MSc.
- Akshay Acharya, MSc.
- Ganesh Dussa, MSc.
- Lenka Táborská, MSc.
- Magdalena Walková, MSc.
Publications
Collaboration
At the faculty
Internal (in the Czech republic)
- III. Internal Gerontometabolic Clinic, University Hospital and Faculty of Medicine Hradec Kralove, Hradec Králové
- School of Medicine and University Hospital, Institute for Clinical Biochemistry and Diagnostics, Hradec Králové
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Laboratory of Biotransformation, Institute of Microbiology of the Czech Academy of Sciences, Prague
International
- Prof. Luciano Saso, Department of Physiology and Pharmacology “Vittorio Erspamer”, Universita La Sapienza, Rome, Italy
- Assoc. Prof. Elisabetta Gavini, Deparment of Chemistry and Pharmacy, University of Sassari, Italy
- Prof. Des Richardson, Institute for Biomedicine and Glycomics, School of Environment and Science, Griffith University, Queensland, Australia
Grants
Current grants
- 2023-2025 Charles University, principal investigator: Saadat S, MSc. - VASODILATORY EFFECTS OF PRINCIPAL HAWTHORN CONSTITUENTS: EX VIVO AND IN VIVO STUDY
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2024-2026 Czech Science Foundation & Slovenian Research and Innovation Agency, principal investigator: Dr. Jirkovský, E - Bisphenol A substitutes: health risks to the endocrine and cardiovascular systems
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2025-2028 - Czech Health Research Council Czech Health Research Council: Prof. Mladěnka, P - Analysis of altered platelet aggregation signalling pathways in diabetes mellitus and the search for an effective antiplatelet drug in these patients
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2025-2028: PRIMUS (PRIMUS/25/MED/001): Carazo, A - Calcium kinetics modulation as a therapeutic approach in the treatment and prevention of enhanced platelet activation
Finished grants
- 2021-2024 Czech Health Research Council, principal investigator: Prof. Mladěnka P - CARDIOVASCULAR EFFECTS OF FLAVONOID METABOLITES AND THE IMPACT OF METABOLIC RISK FACTORS - final evaluation: excellent
- 2021-2024 Czech Health Research Council - junior project, principal investigator: Dr. Carazo, A - DIFFERENCES IN PARAMETERS OF PLATELETS AGGREGATION AND BLOOD COAGULATION BETWEEN HEALTHY INDIVIDUALS AND PATIENTS WITH METABOLIC DISEASES - final evaluation: excellent
- 2020-2023 ERASMUS+ project 2020-1-CZ01-KA203-078218, principal investigator: Assoc. Prof. Mladěnka P - OPEN ACCESS EDUCATIONAL MATERIALS ON NATURALLY OCCURRING MOLECULES - SOURCES, BIOLOGICAL ACTIVITY AND USE - final evaluation of the project: 89%
- 2021-2022 project start, principal investigator: Moravcová Z, MSc. - ANALYSIS OF INTERACTION OF SEVERAL BIOLOGICALLY RELEVANT METALS WITH CHELATORS FROM DIFFERENT POINTS OF VIEW
- 2020-2022 Charles University, principal investigator: Hrubša M, MSc. - TESTING OF POTENTIALLY NOVEL ANTIPLATELET COMPOUNDS USING METABOLITES OF NATURAL PHENOLIC COMPOUNDS AS TEMPLATES
- 2020-2022 Charles University, principal investigator: Dias P, MSc. - ARTERIAL BLOOD PRESSURE DECREASING EFFECTS OF SMALL PHENOLIC METABOLITES OF FLAVONOIDS: MECHANISTIC EX VIVO AND IN VIVO STUDY
- 2019-2021 Charles University, principal investigator: Tvrdy V, MSc. - THE INFLUENCE OF BISPHENOLS ON THE CARDIOVASCULAR SYSTEM – IN VITRO AND IN VIVO STUDY
- 2018-2020 Czech Science Foundation, principal investigator: Assoc. Prof. Valentová K, co-investigator: Assoc. Prof. Mladěnka P. - THE ROLE OF OPTICALLY PURE FLAVONOLIGNANS IN CARDIOVASCULAR EFFECTS OF SILYMARIN
- 2017-2019 Charles University in Prague, principal investigator: Migkos T, MSc. - FLAVONOID METABOLITES, THEIR INTERACTION WITH TRANSITION METALS AND PHARMACOKINETICS - final evaluation of the project: exceptionally good
- 2015-2017 ERASMUS+ project 2015-1-ES01-KA203-015957 principal investigator: Prof. Morales AI (Universita of Salamanca, Spain), co-investigators from FaF UK: Assoc. Prof. Mladěnka P, Dr. Pourová J and Dr. Vopršalová M - LEARNING TOXICOLOGY THROUGH OPEN EDUCATIONAL RESOURCES - final evaluation of the project: 90%
- 2015-2017 Charles University in Prague, principal investigator: Najmanová I, MSc. / Applová L, MSc. - EFFECTS OF FLAVONOIDS AND THEIR METABOLITES ON VASCULAR SMOOTH MUSCLE EX VIVO AND IN VIVO
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2014-2015 Charles University in Prague, principal investigator: Horňasová V
SCREENING OF COPPER CHELATORS OF NATURAL AND SYNTHETIC ORIGIN -
2012-2014 Charles University in Prague, principal investigator: Filipský T, MSc. / Říha M, MSc.
CATECHOLAMINE CARDIOVASCULAR IMPAIRMENT AND ITS MODULATION BY IRON CHELATORS -
2010 Ministry of Education, Youth and Sports Principal investigator: Zatloukalová Z, MSc.
IMPROVEMENT OF THEORETICAL EDUCATION OF PHARMACOLOGY BY A PRACTICAL EXAMPLE OF HEART FUNCTION PARAMETERS MEASUREMENT -
2008 Ministry of Education, Youth and Sports Principal investigator: Prof. Hrdina R, Ph.D.
INNOVATION OF THE LAB FOR PRACTICAL EDUCATION OF PHARMACOLOGY -
2007-2009 Charles University in Prague principal investigator: Bobrovová Z , MSc.
THE EXTENDED STUDY OF INFLUENCE OF IRON CHELATORS IN A MODEL OF ACUTE MYOCARDIAL INFARCTION -
2007-2009 GAUK principal investigator: Dr. Řeháková Z, MSc. / Macáková K, MSc.
THE STUDY OF THE INFLUENCE OF PHENOLIC COMPOUNDS ON A MODEL OF ISCHAEMIC-REPERFUSION MYOCARDIAL IMPAIRMENT IN RELATION TO THEIR IRON CHELATING AND ANTIPLATELET ACTIVITY -
2007 Ministry of Education, Youth and Sports Principal investigator: Bobrovová Z, MSc.
EXTENSION OF SEMINAR EDUCATION OF THE SUBJECT PHARMACOLOGY BY AN EXPERIMENTAL TASK FROM PHARMACODYNAMICS -
2007 Ministry of Education, Youth and Sports Principal investigator: Hübl M, MSc.
INNOVATION OF EDUCATION OF PHARMACOLOGY AND PATHOLOGY BY THE INCORPORATION OF ACUTE MYOCARDIAL INFARCTION MODEL -
2006-2008 GAUK principal investigator: Vykrutová E / Škrle J / Filipová V
THE STUDY OF THE INFLUENCE OF IRON CHELATOR LACTOFERRIN ON A MODEL OF ACUTE MYOCARDIAL INFARCTION AND ON HISTOLOGY OF THE SELECTED ORGAN SYSTEMS -
2005-2006 GAUK principal investigator: Mladěnka P, MSc.
THE INFLUENCE OF IRON CHELATORS AND FLAVONOIDS ON THE MODEL OF ACUTE MYOCARDIAL INFARCTION.
Experimental works
Doctoral dissertations
currently solved
- Adler B, MSc. - Homocysteine: interaction with physiological metals and other biological effects with cardiovascular relevance (supervisors: Dr. Lomozová & Prof. Mladěnka)
- Acharya A, MSc. - Diabetes mellitus, inhibition of intestinal glucosidases and platelet aggregation (supervisors: Dr. Lomozová & Prof. Mladěnka)
- Dussa G, MSc. - Cardiovascular effects of new bisphenol analogues (supervisor: Assoc. Prof. Pourová)
- Gunaseelan C, MSc. - Differences in hemocoagulation in patients with metabolic disorders II (supervisors: Dr. Carazo & Prof. Mladěnka)
- Harčárová P, MSc. - Biological effects of the compounds from Crateegus spp. (supervisors: Dr. Lomozová & Prof. Mladěnka)
- Parvin MS, MSc. - Alkaloids of plant origin and their biological activity II (supervisor: Prof. Mladěnka)
- Taborská L. MSc. - Pharmacological and toxicological effects of pollutants on the cardiovascular system (supervisors: Prof. Mladěnka & Dr. Jirkovský)
- Walková M, MSc. - Abnormalities in platelet aggregation in patients suffering from diabetes mellitus (supervisors: Prof. Mladěnka & Dr. Carazo)
succesfully defended
- 2025 - Tvrdý V, MSc. - Analysis of cardiovascular effects of flavolignans isolated from Silybum marianum and their metabolites (supervisor: Prof. Mladěnka & Assoc. Prof. Pourová)
- 2025: Konečný L, MSc. - Antiplatelet effects of 4-methylcatechol and its derivatives in healthy persons and in patients suffering from metabolic diseases (supervisors: Prof. Mladěnka & Dr. Carazo)
- 2025: Moravcová M, MSc. - Cobalt toxicity and its modulation by chelators (supervisors: Prof. Mladěnka & Dr. Jirkovský)
- 2025: Alva R, MSc. - Interaction of industrial pollutants and their derivates with estrogen receptors (supervisors: Dr. Carazo & Prof. Mladěnka)
- 2024: Fadraersada J, MSc. – Differences in hemocoagulation in patients with metabolic disorders
- 2023: Dias P, MSc. - Study of the mechanisms of action of phenolic compounds on the vascular smooth muscle
- 2023: Migkos T, MSc. - Effects of isoflavonoids and their metabolites on vascular smooth muscles in vitro and in vivo
- 2023: Hrubša M, MSc. - The influence of metabolites and their parent phenolic compounds on blood platelets
- 2023: Lomozová Z, MSc. - Interactions of natural phenolic compounds with biogenic metals
- 2020: Catapano MC, MSc. - Screening of novel chelators of microbiogenic metals
- 2019: Applová L, MSc. - The influence of polyphenolic compounds and their metabolites on platelet activation
- 2017: Najmanová I, MSc. - The effect of polyphenolic substances on vascular smooth muscle
- 2015: Říha M, MSc. - Screening of new iron- and copper-chelating substances – in vivo and in vitro studies
- 2013: Filipsky T, MSc. - Screening of iron-chelating substances and their potential use in the therapy of acute myocardial infarction
- 2012: Zatloukalová L, MSc. - Influence of Polyphenolic Substances with Iron Chelating Activity in Model of Acute Myocardial Infarction and Oxidation Stress Induced by Catecholamines
Rigorous theses (for the title Dr.)
in realization
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Jandorová E, MSc.: Tvorba agregátů destička-monocyt v kolagenem stimulované lidské krvi ех vivo а vliv preinkubace 4-metylkatecholem (Dr. Carazo)
successfully defended rigorous theses
| year | candidate | title | supervisor |
| 2022 | Uramová D, MSc. |
The copper - chelating activity of xanthen-3-ones derivates |
Přemysl Mladěnka |
| 2021 | Gavurová L, MSc. | Comparison of interaction of cyanidin and cyanidin-3-glucoside with copper and iron | Přemysl Mladěnka |
| Kantorová T, MSc. |
Copper chelating activity of flavanons |
Přemysl Mladěnka | |
| Kopková N, MSc. | Copper reducing properties of a series of xanthen-3-ones | Přemysl Mladěnka | |
| Lavičková B, MSc. | Interaction of tamarixetin and isorhamnetin with iron | Jana Karlíčková | |
| 2020 | Hodinová V, MSc. | The ex vivo study of mechanism of vasodilatation effect of 3,4,-dihydroxyphenylacetic acid and 4-methylcatechol | Jana Pourová |
| Katiová D, MSc. | Mechanism of the vasorelaxant effect of biochanin A studied ex vivo on isolated rat aorta | Jana Pourová | |
| Nováková J, MSc. | Zinc - chelating activity of selected novel chelators from 4-acylpyrazol-5-one group | Přemysl Mladěnka | |
| Šimánková L, MSc. | Study of vasodilatory effects of selected silymarin flavonolignans ex vivo on isolated rats aorta | Jana Pourová | |
| 2019 | Kříž J, MSc. | Copper chelating potential of iron chelators from the group of aroylhydrazones | Přemysl Mladěnka |
| Rohová M, MSc. |
Administration of cytostatic drugs and extravasation |
Marie Vopršalová | |
| 2018 | Gorbunovová E, MSc. | Comparison of copper ion chelation by benzoic acids | Jana Karlíčková |
| Horáčková M, MSc. |
The vasorelaxing effects of selected quercetin metabolites on rat isolated aorta |
Marie Vopršalová | |
| Mocová K, MSc. | Determination of the stoichiometry of the copper complexes with 7,8-dihydroxycoumarins | Přemysl Mladěnka | |
| 2017 | Herbolt D, MSc. | Development of a novel spectrophotometric method for zinc ions chelatation screening | Přemysl Mladěnka |
| Šumpelová K, MSc. | The effect of quercetin and its selected metabolites on isolated aortal rings of rat | Marie Vopršalová | |
| Tamborová B, MSc. | Assessment of chelation of cupric ions with flavones by use of hematoxylin method | Jana Karlíčková | |
| 2016 | Horňasová V, MSc. | Copper-chelating properties of isoflavonoids - acknowledged diploma thesis on the base of a publication | Přemysl Mladěnka |
| 2015 | Jeřábková M, MSc. | Copper reducing effects of flavones | Jana Karlíčková |
| Koblásová A, MSc. | Copper reducing properties of flavanones | Jana Karlíčková | |
| Kolouch J, MSc. | Assessment of chelating properties of 6,7-dihydroxycoumarin | Tomáš Filipský | |
| Morkusová M, MSc. | Antiplatelet effects of 5,7-dihydroxy-4-methylcoumarins | Přemysl Mladěnka | |
| Sedlářová L., MSc. | Analysis of oxidative stress in the model of isoprenaline cardiotoxicity after intravenous administration of rutin | Tomáš Filipský | |
| Stonawská M, MSc. | Comparison of ferrozine and direct spectrophotometry by assessment of iron chelation | Přemysl Mladěnka | |
| 2014 | Bechná K, MSc. | Copper chelating properties of 8-hydroxyquinolines | Přemysl Mladěnka |
| Linhartová A, MSc. | Oxidative stress in the model of catecholamine cardiotoxicity | Tomáš Filipský | |
| Michalicová A, MSc. | Assessment of copper chelation of flavones by bathocuproine method | Jana Karlíčková | |
| Řihošková P, MSc. | Interactions of catechins with copper ions | Jana Karlíčková | |
| 2012 | Staňová Z, MSc. | The assessment of stoichiometric ratio of the complex chelator-iron by use of the method of Job | Přemysl Mladěnka |
| Šulcová M, MSc. | Comparison of iron chelating activity of 8-hydroxyquinolines by direct spectrophotometry | Přemysl Mladěnka | |
| 2011 | Zárubová P, MSc. | Comparison of iron-chelating effects of clinically used peroral iron chelators and 8-hydroxyquinolines | Přemysl Mladěnka |
| Matula A, MSc. | Iron-chelating properties of selected novel chelators from 4-acyl-5-pyrazolone group | Přemysl Mladěnka | |
| Jarkovská S, MSc. | Assesment of iron chelation by 4-acyl-5-pyrazolones by direct spectrophotometry | Přemysl Mladěnka |
Experimental diploma theses
currently measured diploma theses
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2027 (planned year of defence): Čumová E - Investigation of the effect of selected molecules from seaweed on calcium regulation in blood platelets (Dr. Carazo)
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2027 Kmecová M – Inhibition of alpha-glucosidases by natural phenolic compounds (Dr. Lomozová)
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2027 Matula D - Investigation of the effect of mitragynine on platelets (Dr. Carazo)
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2027 Papcunová N - Determination of the cytotoxicity of xenobiotics on a cardiac tissue cell model I (Dr. Jirkovský)
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2027 Polášová N - Determination of the cytotoxicity of xenobiotics on a cardiac tissue cell model II (Dr. Jirkovský)
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2027 Vávrová K - Effect of selected molecules from seaweed on calcium homeostasis in blood platelets (Dr. Carazo)
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2028: Štorková V - Interactions of halogenated quercetin derivatives with biogenic metals and their biological consequences (Dr. Lomozová)
theses before the defense
- 2025: Bobková E - Effects of quercetin on cobalt chloride cytotoxicity in H9c2 cell line (Dr. Jirkovský)
- 2026: Bervidová D – Interaction of 6,8-dibromoquercetin with copper and iron (Dr. Lomozová/Mgr. Harčárová)
- 2026: Horová J - Evaluation of the effect of Latrunculin A and B on platelet reactivity (Dr. Carazo)
- 2026: Karami M - Effect of chelators from the class of 8-hydroxyquinolines on magnesium-containing bacterial alkaline phosphatase (Dr. Hrubša/Prof. Mladěnka)
- 2026: Kociánová K - Interaction of vitexin and isovitexin with copper (Dr. Lomozová)
- 2026: Mahshad J - Chelation of magnesium ions by flavonoids and their effects on magnesium-containing bacterial alkaline phosphatase (Prof. Mladěnka/Dr. Hrubša)
- 2026: Ondrišíková L: Screening of the vasodilatory effect of eleven bisphenol analogues on isolated vessels ex vivo (Assoc. Prof. Pourová)
- 2026: Pavelková Z - Interaction of aurones with copper (Dr. Lomozová)
- 2026: Soukupová K - Analysis of the effect of astaxanthin on platelets (Dr. Carazo)
- 2026: Šajnová M: Study of the mechanism of the vasodilatory effect of bisphenol BPS-MAE in an ex vivo rat aorta model (Assoc. Prof. Pourová)
- 2026: Vargová I: The influence of bisphenols on differentiation markers in H9c2 cells (Dr. Jirkovský)
- 2027: Heidari Lari Nezhad M - Study of the vasodilatory effects of natural substances in an ex vivo vessel model (Assoc. Prof. Pourová)
successfully defended diploma theses
| year | student | title of diploma thesis | supervisor(s) | |
| 2025 | Hudáková B | Platelet aggregation in patients suffering from hypercholesterolemia | Přemysl Mladěnka | |
| Joklová J | Aggregation of platelets in patients suffering from diabetes mellitus type I | Přemysl Mladěnka | ||
| Lichnerová L | Platelet aggregation in diabetes mellitus type II patients | Alejandro Carazo | ||
| Mochorovská N | Study of the vasodilatory effect of isorhamnetin in an ex vivo porcine coronary vessel | Jana Pourová | ||
| Podlesná K | The impact of metabolites of flavonoids (phenylacetic acids) on the iron-catalysed Fenton reaction | Zuzana Lomozová | ||
| Salimiborojeni Y |
Platelet aggregation in geriatric polymorbid patients (defended at the UNIVERSITY OF ROME “TOR VERGATA”) |
Přemysl Mladěnka/Saverio Muscoli | ||
| Toman L | Effect of fatty acids on platelet reactivity | Alejandro Carazo | ||
| Walková M | The impact of flavonoid metabolites on copper and iron-catalyzed Fenton reaction and copper-triggered lysis of erythrocytes | Zuzana Lomozová / Laura Mercolini | ||
| 2024 | Gaidosová B | Study of the vasodilatory effect of tamarixetin in an ex vivo porcine coronary vessel model | Jana Pourová | |
| Hubová N | Study of platelet-monocyte aggregates induction in vitro | Alejandro Carazo | ||
| Kolářová Z | Evaluation of marine alcaloid fascaplysin as a potential antiplatelet agent | Alejandro Carazo | ||
| Spiller S | The impact of small phenolic metabolites of flavonoids (propionic acids) on the iron-catalysed Fenton reaction | Zuzana Lomozová | ||
| Streďanská A | Interaction of 7,8-dihydroxyflavone with physiological metals | Přemysl Mladěnka / Zuzana Lomozová | ||
| Wehde M | The effect of selected phenolic metabolites of flavonoids on the copper and iron catalyzed Fenton reaction and copper triggered lysis of erythrocytes (defended at University Tor Vergata, Rome) | Přemysl Mladěnka / Zuzana Lomozová / Maria Rosa Ciriolo | ||
| 2023 | Argento R | Chelation of physiological metals by 3-hydroxyflavone and biological consequences (defence at the University of Bologna, diploma thesis in Italian) | Přemysl Mladěnka, Laura Mercolini | |
| Brychta D | Analysis of the molecular pathways and interactome of FUBP3 (diploma thesis elaborated within ERASMUS programme) | Eduard Jirkovský | ||
| Černotová V | The influence of LDL-apheresis on aggregation of platelets, blood coagulation, and the effect of standard drugs | Přemysl Mladěnka | ||
| Gardiánová A | Characterization of different differentiation protocols of H9c2 cardiomyoblasts | Eduard Jirkovský | ||
| Harčárová P | The influence of benzoic acids (metabolites of flavonoids) on the copper-triggered Fenton reaction and hemolysis | Zuzana Lomozová | ||
| Kašpárková K | Search for new natural α-glukosidase inhibitors | Jana Karlíčková | ||
| Klenovičová A | The impact of benzoic acids, metabolites of flavonoids, on the iron-catalysed Fenton reaction | Přemysl Mladěnka, Zuzana Lomozová | ||
| Kleplová D | Study of the expression and toxicity of catechol derivates in MCF-7 cell line | Alejandro Carazo | ||
| Kuzdřalová K | Vasodilatory effects of 4-methyl catechol: ex vivo mechanism of action | Jana Pourová | ||
| Macáková B | Comparison of the effect of bisphenols on parental and differentiated H9c2 cells | Eduard Jirkovský | ||
| Minarovičová J | Comparison of platelet aggregation in healthy population | Přemysl Mladěnka | ||
| Rotternbornová L | The evaluation of senescence markers in the H9c2 cell line after cobalt exposure | Eduard Jirkovský | ||
| Skoupilová K | Are currently used chelators of heavy metals also chelators of calcium and magnesium? | Přemysl Mladěnka | ||
| Štefancová M |
Vasodilatory effects of 3-hydroxy phenylacetic acid: ex vivo mechanism of action |
Jana Pourová | ||
| 2022 | Afshari M | Differences in platelet and coagulation responses between healthy persons and patients with metabolic disorders | Alejandro Carazo | |
| Conti L | The effect of selected phenolic metabolites of flavonoids on the copper-catalyzed Fenton reaction and copper-triggered lysis of erythrocytes (in English, defended at the University of Bologna) | Přemysl Mladěnka/ Zuzana Lomozová / Laura Mercolini | ||
| Elbelová J | Study of the influence of natural drugs on estrogen receptor and confirmation of their effect in cell cultures | Alejandro Carazo | ||
| Kadlecová K | Searching for natural cobalt chelators | Jana Karlíčková, Monika Moravcová | ||
| Nadějová J | Interactions of essential amino acids with iron ions | Jana Karlíčková | ||
| Nosková K | Search for an efficient cobalt chelator | Přemysl Mladěnka, Monika Moravcová | ||
| Šmídová K | Vasodilatory effects of 3-hydroxyphenylacetic acid ex vivo | Jana Pourová | ||
| Vyoralová T | Study of the expression and toxicity of 4-methylcatechol derivates in breast cancer cell lines | Alejandro Carazo | ||
| 2021 | Faberová J | Interaction of chalcones with transition metals I. | Kateřina Macáková | |
| Holotíková N | Can essential amino acids be considered as copper chelators ? | Jana Karlíčková | ||
| Konečný L | Preparation of a method for detection of the extent of calcium chelation | Přemysl Mladěnka | ||
| Kuchařová N | Vasodilatory effects of bisphenol AF ex vivo | Jana Pourová | ||
| Pelnařová K | Search of effective cobalt chelators – 8-hydroxyquinolines | Přemysl Mladěnka | ||
| Sobolová Z | The impact of zinc chelators on alcohol dehydrogenase | Přemysl Mladěnka | ||
| Šulcová M | Interaction of chalcones with transition metals II | Kateřina Macáková | ||
| Ždárová D | Effects of cobalt-chelating compounds on H9c2 cell line | Eduard Jirkovský | ||
| 2020 | Carbone G | Effects of selected bisphenols on H9c2 cell line, diploma thesis in English, defended the at the University of Palermo | Eduard Jirkovský | |
| Conte F | Effect of flavonoids on copper trigerred hemolysis, diploma thesis in English, defended at the University of Rome 2 | Přemysl Mladěnka | ||
| Kladivová A | Chelation of copper ions by thiol containing chelators | Přemysl Mladěnka | ||
| Kreibichová M | Flavonols as zinc chelators and their interaction with alcohol dehydrogenase | Eduard Jirkovský | ||
| Moravcová M | Preparation of a novel method for screeing of cobalt chelators | Přemysl Mladěnka | ||
| Salanciova I | Determination of interaction of reduced and oxidized glutathione with copper, iron and zinc | Jana Karlíčková | ||
| Silva K | Effect of chelators on iron and copper based Fenton Chemistry, diploma thesis in English via ERASMUS program, defended at the University of Alcalá de Henares | Přemysl Mladěnka / Maria Carmen Catapano | ||
| Slougki T | The effect of silymarin flavonolignans and their sulfated conjugates on blood vessels ex vivo | Jana Pourová | ||
| 2019 | Deriu I | Interactions of selected alkaloids with iron, diploma thesis in English, defended the at the University of Sassari | Jana Karlíčková & Přemysl Mladěnka | |
| Fišrová M |
The effects of some flavonoids on isolated rat aortic rings |
Marie Vopršalová | ||
| Gutieres C | Effect of chelators on alcohol dehydrogenase, a zinc containing enzyme, diploma thesis in English, defended the at the University of Lisbon | Přemysl Mladěnka | ||
| Hetman A | Sulfates as Phase II metabolites of natural phenolic compounds (diploma thesis at the Academy of Sciences - consultant: Assoc. Prof. Valentová, in English, proposed also as rigorous thesis ) | Přemysl Mladěnka | ||
| Kalinová T | Effect of cholinesterase inhibitors on monoaminergic system and energic metabolism (diploma thesis at 1. Faculty of medicine of CU - consultant: Dr. Hroudová, proposed also as rigorous thesis) | Přemysl Mladěnka | ||
| Klimková K | Determination of the stoichiometry of the copper complexes with dehydrosilybine A (consultant: Assoc. Prof. Valentová, proposed also as rigorous thesis) | Přemysl Mladěnka | ||
| Lomozová Z | Interactions of tamarixetin and isorhamnetin with copper (proposed also as rigorous thesis) | Jana Karlíčková | ||
| Pupalová D | Molecular changes in plateles activated by different inducers | Eduard Jirkovský | ||
| Rajtmajerová I | The in vitro effects of selected fenolic substances on isolated rat vessels (proposed also as rigorous thesis) | Jana Pourová | ||
| Zsáková E | Interference of reducing agents with the hematoxylin assay for determination of cupric chelation (proposed also as rigorous thesis) | Přemysl Mladěnka | ||
| 2018 | Benčová S | Transcriptomic analysis of cutaneous inflammatory biomarkers in a mouse model of small fiber neuropathy (diploma thesis in English, ERASMUS , proposed also as rigorous thesis ) | Přemysl Mladěnka | |
| Beránková A | The in vitro effects of selected substances on isolated rat aorta | Jana Pourová | ||
| Hanuščinová L | Ability of copper chelators to interact with iron and zinc, proposed also as rigorous thesis | Přemysl Mladěnka | ||
| Němcová H | Comparison of interactions of equol and desmethylangolensin with iron and copper, proposed also as rigorous thesis | Jana Karlíčková | ||
| Morávková T | Assessment of the complex stoichiometry of the active dexrazoxane metabolite - ADR-925 with iron and copper | Přemysl Mladěnka / Tomáš Filipský | ||
| Rudišarová S | The effect of quercetin metabolite on the rat isolated arteries | Marie Vopršalová | ||
| 2017 | Gorová B | Iron-chelating properties of fruit extracts of various elderberries | Přemysl Mladěnka / Michal Říha | |
| Novýsedláková A | The in vitro effects of selected isoflavonoids on isolated rat aorta, acknowledged also as rigorous thesis | Jana Pourová | ||
| Pešková H | Effects of some flavonoids in isolated rat aortic rings | Marie Vopršalová | ||
| Pohanová L | Chelation of ferrous ions by derivatives of xanthene-3-one | Přemysl Mladěnka | ||
| Svobodová M | Microglia control adenosine A2A-receptor mediated astrogliosis - ERASMUS, diploma thesis in English, acknowledged also as rigorous thesis | |||
| Zemanová K | Interaction of phenylpropionic acids with copper, acknowledged also as rigorous thesis | Jana Karlíčková | ||
| 2016 | Babič A | The assesment of interaction of 3, 4- dihydroxyphenylacetic acid, a metabolite of flavonoids, with iron and copper by use of direct spectrophotometrical approach, diploma thesis in English, defended the at the University of Ljubljana | Přemysl Mladěnka | |
| Fontana T | Determination of antioxidant capacity of bioactive compounds via Fenton reaction and LC-ED (Determinazione della capacita antiossidante di molecole bioattive mediante reazione di Fenton e LC-ED) - diploma thesis in Italian, performed and defended at the University of Bologna | Laura Mercolini / Přemysl Mladěnka | ||
| Kříž J | Copper chelation by clinically used iron chelators | Přemysl Mladěnka | ||
| Mísař J | Copper reducing effects of quercetin metabolites | Jana Karlíčková | ||
| Mocová K | Determination of the stoichiometry of genistein complex with iron and copper | Tomáš Filipský / Michal Říha | ||
| 2015 | Ambrožová K | Copper reducing effects of isoflavonoids | Jana Karlíčková | |
| Antonsson M | In vitro analysis of iron and copper chelating activity of phenylacetic acids, metabolites of flavonoids - diploma thesis in English, defended at the University of Gothenburg | Přemysl Mladěnka | ||
| Hloch K | Differences in expression of selected genes between “gambler”and “non-gambler” rats - ERASMUS, diploma thesis in English | Přemysl Mladěnka | ||
| Horňasová V | Copper-chelating properties of isoflavonoids | Přemysl Mladěnka | ||
| Todorovic L | Interaction of baicalein with iron - diploma thesis in English | Přemysl Mladěnka | ||
| 2014 | Jeřábková M | Copper chelating activity of flavonols | Jana Karlíčková | |
| Liddawieh E | Assessment of the stoichiometry of 3-hydroxyflavone-iron complexes by UV-Vis spectrophotometry - diploma thesis in English | Tomáš Filipský | ||
| Malátová V | Copper reducing activity of flavonols | Přemysl Mladěnka | ||
| Migkos T | The effects of flavonoids on vascular smooth muscles - diploma thesis in English | Přemysl Mladěnka | ||
| Nerat M | The effect of 6,7-dihydroxygroup in flavones on iron chelation - diploma thesis in English, defended at the University of Ljubljana | Přemysl Mladěnka | ||
| Ševčíková A | The assessment of copper chelation by use of direct spectrophotometry | Přemysl Mladěnka | ||
| 2013 | Sedlářová L | Standardization of a method for in vitro assessment of copper chelation | Přemysl Mladěnka | |
| Morkusová M | Chelation ability of experimentally used iron chelators | Přemysl Mladěnka | ||
| 2012 | Kyjovská V | Comparison of iron reducing properties of flavonols and flavanones | Přemysl Mladěnka | |
| Břečková A | Iron-chelating properties of selected novel chelators from 4-acyl-5-pyrazolone group II | Přemysl Mladěnka | ||
| 2011 | Šulcová M | Spectrophotometric assessment of iron chelation at different pH | Přemysl Mladěnka | |
| Zárubová P | Comparison of iron-chelating properties of synthetic iron chelators | Přemysl Mladěnka | ||
| 2010 | Hrabalíková J | The influence of pH on iron chelation | Přemysl Mladěnka | |
| Jarkovská S | Evaluation of antioxidant activity of hydroxytyrosyl lipophilic esters – ERASMUS, diploma thesis in English | Přemysl Mladěnka | ||
| Landíková K | Identification of the peptide conjugate with toxic acetaminophen metabolite N-acetyl-p-benzoquinone imine – ERASMUS, diploma thesis in English | Přemysl Mladěnka | ||
| 2009 | Havránková L | Pharmacological screening of substances with iron chelating activity | Přemysl Mladěnka | |
| Mazurová M | Interrelationship of basic biochemical parameters in patients of type II diabetes | Přemysl Mladěnka |