Publications

 Selected publications (2016–2026)

2025

SAFRATOVA, M., CHEN, Y.L., HOSTALKOVA, A., CHLEBEK, J., HSIEH, C.F., CHEN, B.H., CAHLIKOVA, L., KOSTURKO, S., BACKLUND, A., HORNG, J.Z., HWANG, T.L., KORINEK, M.: Anticoronavirus isoquinoline alkaloids: Unraveling the secrets of their structure-activity relationship. Influenza Other Respir. Viruses 19, e70166 (2025).  https://doi.org/10.1111/irv.70166

KIMIZIBEKMEZ, H., ARU, B., KŘOUSTKOVÁ, J., ERDOGAN, M., TORRENCE, I., ANDO, K., TANTILLO, D.J., MALANÍK, M., KOSTURKO, Š., KUNEŠ, J., CAHLÍKOVÁ, L.: Cytotoxic stilbenoids, hetero- and homodimers of homoisoflavonoids from Prospero autumnale. J. Nat. Prod. 88, 458-468 (2025). https://doi.org/10.1021/acs.jnatprod.4c01263

VRABEC, R., DRASAR, P., OPLETAL, L., KOSTURKO, S., BLUNDEN, G., CAHLÍKOVÁ, L.: Alkaloids from the genus Vinca L. (Apocynaceae): a comprehensive biological and structural review. Phytochem. Rev. 24, 3665-3735 (2025). https://doi.org/10.1007/s11101-025-10102-z

2024

KŘOUSTKOVÁ, J., KOHELOVÁ, E., MUTHNÁ, D., KUNEŠ, J., HAVELEK, R., VRABEC, R., MALANÍK, M., SUCHÁNKOVÁ, D., CHLEBEK, J., JENČO, J., KOSTURKO, Š., CAHLÍKOVÁ, L. (2024). Undescribed   Amaryllidaceae alkaloids from Zephyranthes citrina and their cytotoxicity. J. Nat. Prod. 87, 2317-2326 (2024). https://doi.org/10.1021/acs.jnatprod.4c00825

PIDANY, F., KROUSTKOVA, J., JENCO, J., HRADISKA-BREOTEROVÁ, K., MUCKOVA, L., NOVAKOVA, L., KUNES, J.,  FIBIGAR, J., KUČERA, T., NOVAK, M., SORF, A., HRABINOVA, M., PULKRABOVA, L., JANOUSEK, J., SOUKUP, O., JUN, D., KORABECNY, J., CAHLIKOVA, L.:  Carltonine-derived compounds for targeted butyrylcholinesterase inhibition, RSC Med. Chem. 15, 1601-1625 (2024). https://doi.org/10.1039/d4md00060a

TIMBILLA, A. A., VRABEC, R., HAVELEK, R., ŘEZÁČOVÁ, M., CHLEBEK, J., BLUNDEN, G., CAHLÍKOVÁ, L. The anticancer properties of harmine and its derivatives. Phytochem. Rev. (2024). https://doi.org/10.1007/s11101-024-09978-0.

ŠAFRATOVÁ, M., VRABEC, R., BLUNDEN, G., CAHLÍKOVÁ, L. KŘOUSTKOVÁ, J. Specialized metabolites of the genus Zephyranthes Herb.: a critical review on taxonomy and phytochemistry. Phytochem. Rev. 24, 2235-2270 (2024). https://doi.org/10.1007/s11101-024-09931-1

2023

VRABEC, R., BLUNDEN, G., CAHLÍKOVÁ, L.: Natural alkaloids as multi-target compounds towards factors implicated in Alzheimer's disease. Int. J. Mol. Sci. 24, 4399 (2023). https://doi.org/10.3390/ijms24054399

RITOMSKÁ, A., KOUTOVÁ, D., KŘOUSTKOVÁ, J., KRÁLOVEC, K., MUTHNÁ, D., KUNEŠ, J., NOVÁKOVÁ, L., HAVELEK, R., CAHLÍKOVÁ, L.: Design of semisynthetic derivatives of the Amaryllidaceae alkaloid ambelline and exploration of their in vitro cytotoxic activities. Saudi Pharm. J. 31, 101684 (2023). https://doi.org/10.1016/j.jsps.2023.06.017

PIDANY, F., KROUSTKOVA, J., AL MAMUN, A., SUCHANKOVA, D., BRAZZOLOTTO, X., NACHON, F., CHANTEGREIL, F., DOLEZAL, R., PULKRABKOVÁ, L., MUCKOVA, L., HRABINOVA, M., FINGER, V., KUFA, M., SOUKUP, O., JUN, D., JENCO, J., KUNES, J., NOVAKOVA, L., KORABECNY, J., CAHLIKOVA, L.:  Highly selective butyrylcholinesterase inhibitors related to Amaryllidaceae alkaloids - design, synthesis, and biological evaluation. Eur. J. Med. Chem. 252, 115301 (2023).  https://doi.org/10.1016/j.ejmech.2023.115301

KOUTOVÁ, D., MAAFI, N., MUTHNÁ, D., KRÁLOVEC, K., KROUSTKOVA, J., PIDANY, F., TIMBILLA, A., CERMAKOVA, E., CAHLIKOVA, L., REZACOVA, M., HAVELEK, R.: Antiproliferative activity and apoptosis-inducing mechanism of Amaryllidaceae alkaloid montanine on A549 and MOLT-4 human cancer cells. Biomed. Pharmacother. 166, 115295 (2023). https://doi.org/10.1016/j.biopha.2023.115295

2022

JANSA, P., BARVÍK, I., HULCOVÁ, D., MATOUŠOVÁ, E.: Synthesis and cholinesterase inhibitory activity study of Amaryllidaceae alkaloid analogues with N-methyl substitution.  Org. Biomol. Chem. 20, 3960 (2022). https://doi.org/10.1039/D2OB00553K

FERNANDES, F., BARROSO, F.M., DE SIMONE, A., EMRIKOVÁ, E., DIAS-TEIXEIRA, M., PEREIRA, J.P., CHLEBEK, J., CRUZ-FERNANDES, V., RODRIGUES, F., ANDRISANO, V., DELERUE-MATOS, C., GROSSO, C.: J. Ethnopharmacol. 290, 115107 (2022). J. Ethnopharmacol. 290, 115107 (2022).  https://doi.org/10.1016/j.jep.2022.115107

WIJAYA, V., JANDOUREK, O., KROUSTKOVA, J., HRADISKA-BREITEROVA, K., KORABECNY, O., SOBOLOVA, K., KOHELOVA, E., HOSTALKOVA, A., KONECNA, K., SAFRATOVA, M., VRABEC, R., KUNES, J., OPLETAL, O., CHLEBEK, J., CAHLIKOVA, L.: Alkaloids of Dicranostigma franchetianum (Papaveraceae) and berberine derivatives as a novel class of antimycobacterial agents. Biomolecules 12, 844 (2022). https://doi.org/10.3390/biom12060844

UHER, M., HROCH, M., PERINOVA, R., HAVELEK, R., KROUSTKOVA, J., REZACOVA, M., MUTHNA, D., KOUTOVA, D., KUNES, J., CAHLIKOVA, L.: Semisynthetic derivatives of haemanthamine and their in vitro antiproliferative activity evaluation against a panel of human cell lines. Arab. J. Chem. 15,103746 (2022). https://doi.org/10.1016/j.arabjc.2022.103746

2021

MAAFI, N., PIDANY, F., MARIKOVA, J., KORABECNY, J., HULCOVA, D., KUCERA, T., SCHMIDT, M., AL SHAMMARI, L., SPULAK, M., CATAPANO, M.C., MECAVA, M., PRCHALD, L., KUNES, J., JANOUSEK, J., KOHELOVA, E., JENCO, J., NOVAKOVA, L., CAHLIKOVA, L.: Derivatives of montanine-type alkaloids and their implication for the treatment of Alzheimer´s disease: Synthesis, biological activity and in silico study. Bioorg. Med. Chem. Let. 51, 128374 (2021). https://doi.org/10.1016/j.bmcl.2021.128374

KOUTOVA, D., HAVELEK, R., PETEROVA, E., MUTHNA, D., KRALOVEC, K., BREITEROVA, K., CAHLIKOVA, L., REZACOVA, M.: Pancracine, a montanine-type Amaryllidaceae alkaloid, inhibits proliferation of A549 lung adenocarcinoma cells and induces apoptotic cell death in MOLT-4 leukemic cells. Int. J. Mol. Sci. 22, 7014 (2021). https://doi.org/10.3390/ijms22137014

AL MAMUN, A., PIDANY, F., HULCOVA, D., MARIKOVA, J., KUCERA, T., SCHMIDT, M., CATAPANO, M.C., HRABINOVA, M., JUN, D., MUCKOVA, L., KUNES, J., JANOUSEK, J., ANDRYS R., NOVAKOVA, L., PERINOVA, R., MAAFI, N., SOUKUP, O., KORABECNY, J., CAHLIKOVA, L.: Amaryllidaceae alkaloids of norbelladine-type as inspiration for development of highly selective butyrylcholinesterase inhibitors: Synthesis, biological activity evaluation, and docking studies. In. J. Mol. Sci. 22, 8308 (2021).  https://doi.org/10.3390/ijms22158308

MAAFI, N., AL MAMUN, A., JANĎOUREK, O., MAŘÍKOVA, J., BREITEROVÁ, K., DIEPOLTOVÁ, A., KONEČNÁ, K., HOŠŤÁLKOVÁ, A., HULCOVÁ, D., KUNEŠ, J., KOHELOVÁ, E., KOUTOVÁ, D., ŠAFRATOVÁ, M., NOVÁKOVÁ, L., CAHLÍKOVÁ, L.: Semisynthetic derivatives of selected Amaryllidaceae alkaloids as a new class of antimycobacterial agents. Molecules 26, 6023 (2021). https://doi.org/10.3390/molecules26196023

AL SHAMMARI, L., HULCOVÁ, D., MAŘÍKOVÁ, J., KUČERA, T., ŠAFRATOVÁ, M., NOVÁKOVÁ, L., SCHMIDT, M., PULKRÁBKOVÁ, L., JANOUŠEK, J., SOUKUP, O., KUNEŠ, J., OPLETAL, L., CAHLÍKOVÁ, L.: Amaryllidaceae alkaloids from Hippeastrum x hybridum cv. Ferrari, and preparation of vittatine derivatives as potential ligands for Alzheimer’s disease. S. Afr. J. Bot. 136, 137-146 (2021). https://doi.org/10.1016/j.sajb.2020.06.024

MAŘÍKOVÁ, J., AL MAMUN, A., AL SHAMMARI, L., KORABEČNÝ, J., KUČERA, T., HULCOVÁ, D., KUNEŠ, J., MALANÍK, M., VAŠKOVÁ, M., KOHELOVÁ, E., NOVÁKOVÁ, L., CAHLÍKOVÁ, L., POUR, M.: Structure Elucidation and cholinesterase inhibition activity of two new minor Amaryllidaceae alkaloids; Molecules 26, 1279 (2021). https://doi.org/10.3390/molecules26051279

KOHELOVÁ, E., MAŘÍKOVÁ, J., KORÁBEČNÝ, J., HULCOVÁ, D., KUČERA, T., JUN, D., CHLEBEK, J., JENČO, J., ŠAFRATOVÁ, M., HRABINOVÁ, M., RITOMSKÁ, A., MALANÍK, M., PEŘINOVÁ, R., BREITEROVÁ, K., KUNEŠ, J., NOVÁKOVÁ, L., OPLETAL, L., CAHLÍKOVÁ, L.: Alkaloids of Zephyrantes citrina (Amaryllidaceae) and their implication to Alzheimerʼs disease: isolation, structural elucidation and biological activity. Bioorg. Chem. 107, 104567 (2021). https://doi.org/10.1016/j.bioorg.2020.104567

CAHLÍKOVÁ, L., KAWANO, I., ŘEZÁČOVÁ, M., BLUNDEN, G., HULCOVÁ, D., HAVELEK, R.: The Amaryllidaceae alkaloids haemanthamine, haemanthidine and their semisynthetic derivatives as potential drugs. Phytochem. Rev. 20, 303–323 (2021). https://doi.org/10.1007/s11101-020-09675-8

2020

CAHLÍKOVÁ, L., KAWANO, I., ŘEZÁČOVÁ, M., BLUNDEN, G., HULCOVÁ, D., HAVELEK, R.: The Amaryllidaceae alkaloids haemanthamine, haemanthidine and their semisynthetic derivatives as potential drugs. Phytochem. Rev. 20, 303–323 (2020). https://doi.org/10.1007/s11101-020-09675-8

PEŘINOVÁ, R., MAAFI, M., KORÁBEČNÝ, J., KOHELOVÁ, E., DE SIMONE, A., AL MAMMUN, A., HULCOVÁ, D.,MARKOVÁ, J., KUČERA, T., JUN, D., ŠAFRATOVÁ, M., MAŘÍKOVÁ, J., ANDRISANO, V., JENČO, J., KUNEŠ, J., MARTINEZ, A., NOVÁKOVÁ, L., CAHLÍKOVÁ, L.: Functionalized aromatic esters of the Amaryllidaceae alkaloid haemanthamine and their in vitro and in silico biological activity connected to Alzheimer´s disease. Bioorg. Chem. 100, 103928 (2020). https://doi.org/10.1016/j.bioorg.2020.103928

KOUTOVA, D., MAAFI, M., HAVELEK, R., OPLETAL, L., BLUNDEN, G., ŘEZÁČOVÁ, M., CAHLÍKOVÁ, L.: Chemical and Biological Aspects of Montanine-Type Alkaloids Isolated from Plants of the Amaryllidaceae Family. Molecules 25, 2337 (2020). https://doi.org/10.3390/molecules25102337

MAŘÍKOVÁ, J., RITOMSKÁ, A., KORÁBEČNÝ, J., PEŘINOVÁ, R., AL MAMMUN, A., KUČERA, T., KOHELOVÁ, E., HULCOVÁ, D., KOBRLOVÁ, T., KUNEŠ, J., NOVÁKOVÁ, L., CAHLÍKOVÁ, L.: Aromatic esters of the crinane Amaryllidaceae alkaloid ambelline as selective inhibitors of butyrylcholinesterase. J. Nat. Prod. 83, 1359-1367 (2020). https://doi.org/10.1021/acs.jnatprod.9b00561

AL MAMMUN, A., MAŘÍKOVÁ, J., HULCOVÁ, D., JANOUŠEK, J., ŠAFRATOVÁ, M., NOVÁKOVÁ, L., KUČERA, T., HRABINOVÁ, M.,  KUNEŠ, J., KORÁBEČNÝ, J., CAHLÍKOVÁ, L: Amaryllidaceae alkaloids of belladine-type from Narcissus pseudonarcissus cv. Carlton as new selective inhibitors of butyrylcholinesterase. Biomolecules 10, 800 (2020). https://doi.org/10.3390/biom10050800

BREITEROVÁ, K., KOUTOVÁ, D., HAVELEK, R., KUNEŠ, J., MAJOROŠOVÁ, M., OPLETAL, L., HOŠŤÁLKOVÁ, A., JENČO, J., ŘEZÁČOVÁ, M., CAHLÍKOVÁ, L.: Amaryllidaceae alkaloids of different structural types from Narcissus L. cv. Professor Einstein and their cytotoxic activity. Plants 9, 137, (2020). https://doi.org/10.3390/plants9020137

AL SHAMMARI, L., AL MAMUN, A., KOUTOVÁ, D., MAJOROŠOVÁ, M., HULCOVÁ, D., ŠAFRATOVÁ, M., BREITEROVÁ, K. MAŘÍKOVÁ, J., HAVELEK, R., CAHLÍKOVÁ, L.: Alkaloid profiling of Hippeastrum cultivars by GC-MS, isolation of Amaryllidaceae alkaloids and evaluation of their cytotoxicity. Rec. Nat. Prod. 14, 154-159 (2020). http://doi.org/10.25135/rnp.147.19.06.1302

KOUTOVA, D., KULHAVA, M., HAVELEK, R., MAJOROSOVA, M., KRALOVEC, K., HABARTOVA, K., HOSTALKOVA, A., OPLETAL, L., CAHLIKOVA, L., REZACOVA, M.: Bersavine: a novel bisbenzylisoquinoline alkaloid with cytotoxic, antiproliferative and apoptosis-inducing effect on human leukemic cells. Molecules 25, 964 (2020). https://doi.org/10.3390/molecules25040964

2019

KOHELOVÁ, E., PEŘINOVÁ, R., MAAFI, N., KORABEČNÝ, J., HULCOVÁ, D., MAŘÍKOVÁ, J., KUČERA, T., GONZÁLEZ, L.M., HRABINOVÁ, M., VORČÁKOVÁ, K., NOVÁKOVÁ, L.,  DE SIMONE, A., HAVELEK, R., CAHLÍKOVÁ, L. Derivatives of the β-crinane Amaryllidaceae alkaloid haemanthamine as multi-target directed ligands for Alzheimer’s disease. Molecules 24, 1307 (2019). https://doi.org/10.3390/molecules24071307

CHLEBEK, J., KORÁBEČNÝ, J., DOLEŽAL, R., ŠTĚPÁNKOVÁ, Š., PÉREZ, D.I., HOŠŤÁLKOVÁ, A., OPLETAL, L., CAHLÍKOVÁ, L., MACÁKOVÁ, K., KUČERA, T., HRABINOVÁ, M., JUN, D. In vitro and in silico acetylcholinesterase inhibitory activity of thalictricavine and canadine and their predicted penetration across the blood-brain barrier. Molecules 24, 1340 (2019). https://doi.org/10.3390/molecules24071340

HOSTALKOVA, A., MARIKOVA, J., OPLETAL, L., KORABECNY, J., HULCOVA, D., KUNES, J., NOVAKOVA, L., PEREZ, D.I, JUN, D., KUCERA, T., ANDRISANO, V., CAHLIKOVA, L. Isoquinoline alkaloids from Berberis vulgaris as potential lead compounds for the treatment of Alzheimer’s disease. J. Nat. Prod. 82, 239-248 (2019). https://doi.org/10.1021/acs.jnatprod.8b00592

HULCOVÁ, D., MAŘÍKOVÁ, J., KORÁBEČNÝ, J., HOŠŤÁLKOVÁ, A., JUN, D., KUNEŠ, J. CHLEBEK, J., OPLETAL, L., DE SIMONE, A., NOVAKOVA, L., ANDRISANO, V., RŮŽIČKA, A., CAHLÍKOVÁ, L.: Amaryllidaceae alkaloids from Narcissus pseudonarcissus L. cv. Dutch Master as potential drugs in treatment of Alzheimer's disease. Phytochemistry 165, 112055, (2019). https://doi.org/10.1016/j.phytochem.2019.112055

2018

BREITEROVÁ, K., LOČÁREK, M., KOHELOVÁ, E., TALACKOVÁ, M., HULCOVÁ, D., OPLETAL, L., CAHLÍKOVÁ, L.: Daffodils as potential crops of biologically-active compounds: Assesment of 40 ornamental taxa for their alkaloid profile and cholinesterase inhibition activity. Nat. Prod. Commun. 13, 419-422 (2018). https://doi.org/10.1177/1934578X1801300410

ŠAFRATOVÁ, M., HOŠŤÁLKOVÁ, A., HULCOVÁ, D., BREITEROVÁ, K., HRABCOVÁ, V., MACHADO, M., FONTINHA, D., PRUDENCIO, M., KUNEŠ, J., CHLEBEK, J., JUN, D., HRABINOVÁ, M., NOVÁKOVÁ, L., HAVELEK, R., SEIFERTOVÁ, M., OPLETAL, L., CAHLÍKOVÁ, L: Alkaloids from Narcissus poeticus cv. Pink Parasol of various structural types and their biological activity. Arch. Pharm. Res. 41, 208-218 (2018).  https://doi.org/10.1007/s12272-017-1000-4

HABARTOVÁ, K., HAVELEK, R., SEIFERTOVÁ, M., KRÁLOVEC, K., CAHLÍKOVÁ, L., CHLEBEK, J., ČERMÁKOVÁ, E., MAZÁNKOVÁ, N., MAŘÍKOVÁ, J., KUNEŠ, J., NOVÁKOVÁ, L., ŘEZÁČOVÁ, M.: Scoulerine affects microtubule structure, inhibits proliferation, arrests cell cycle and thus culminates in the apoptotic death of cancer cells. Sci. Reports 8,  4829 (2018). https://doi.org/10.1038/s41598-018-22862-0

HULCOVÁ, D., BREITEROVÁ, K., SIATKA, T., KLÍMOVÁ, K., DAVANI, L., ŠAFRATOVÁ, M., HOŠŤÁLKOVÁ, A., DE SIMONE, A., ANDRISANO, A., CAHLÍKOVÁ, L.: Amaryllidaceae alkaloids as potential glycogen synthase kinase-3 beta inhibitors. Molecules 23, 719 (2018). https://doi.org/10.3390/molecules23040719

2017

SEIFRTOVÁ, M., HAVELEK ,R., CAHLÍKOVÁ, L., HULCOVÁ, D., MAZÁNKOVÁ, N., ŘEZÁČOVÁ, M.: Haemanthamine alters sodium butyrate-induced histone acetylation, p21WAF1/Cip1 expression, Chk1 and Chk2 activation leading to increased growth inhibition and death in A2780 ovarian cancer cells. Phytomedicine 35, 1-10 (2017). https://doi.org/10.1016/j.phymed.2017.08.019

HAVELEK ,R., SEIFRTOVA, M., KRALOVEC, K., HABARTOVA, Klara., CAHLIKOVA, L., REZACOVA, M.: Chelidonine and homochelidonine induce cell death through cell cycle checkpoints and MAP kinase pathways. Nat. Prod. Commun. 12, 1419-1430 (2017). https://doi.org/10.1177/1934578X1701200910

HAVELEK, R., MUTHNA, D., TOMSIK, P., KRALOVEC, K., SEIFRTOVÁ, M., CAHLÍKOVÁ, L., HOŠŤÁLKOVÁ, A., ŠAFRATOVÁ, M., PERWEIN, M., ČERMÁKOVÁ, E.,  ŘEZÁČOVÁ, M.: Anticancer potential of Amaryllidaceae alkaloids evaluated by a screening with a panel of human cells, real-time cellular analysis and Ehrlich tumor-bearing mice.  Chem. Biol. Interact. 275, 121-132 (2017). https://doi.org/10.1016/j.cbi.2017.07.018

HULCOVÁ, D., BREITEROVÁ, K., ZEMANOVÁ, L., SIATKA, T., ŠAFRATOVÁ, M., VANĚČKOVÁ, N., HOŠŤÁLKOVÁ, A., WSÓL, V., CAHLÍKOVÁ, L.: Screening of AKR1C3 inhibitory potency of naturally occuring Amaryllidaceae alkaloids of different structural types. Nat. Prod. Commun. 12, 245-246 (2017). https://doi.org/10.1177/1934578X1701200226

ALI, B. H., CAHLÍKOVÁ, L., OPLETAL, L., KARACA, T., MANOJ, P., RAMKUMAR, A., AL SULEIMANI Y. M., AL ZA'ABI, M., NEMMAR, A., CHOCHOLOUŠOVÁ-HAVLÍKOVÁ, L., LOČÁREK, M., SIATKA, T., BLUNDEN, G.: Effect of aqueous extract and anthocyanins of calces of Hibiscus sabdariffa (Malvaceae) in rats with adenine-induced chronic kidney disease. J. Pharm. Pharmacol. 69, 1219-1229 (2017). https://doi.org/10.1111/jphp.12748

OPLETAL, L., CHOCHOLOUŠOVÁ-HAVLÍKOVÁ, L., SIATKA, T., CAHLÍKOVÁ, L., LOČÁREK, M., BADRELDIN, H. A., MANOJ, P., RAMKUMAR, A., Al SULEIMANI, Y. M., AL ZA‘ABI, M., KARACA, T., NEMMAR, A.: Preparation and validated analysis of anthocyanin concentrate from the calyces of Hibiscus sabdariffa. Nat. Prod. Commun. 12, 43-45 (2017). https://doi.org/10.1177/1934578X1701200112

SIATKA, T., ADAMCOVÁ, M., OPLETAL, L., CAHLÍKOVÁ, L.,  JUN, D., HRABINOVÁ, M., KUNEŠ, J., CHLEBEK, J.: Cholinesterase and prolyl oligopeptidase Inhibitory activities of alkaloids from Argemone platyceras (Papaveraceae). Molecules 22, 1181 (2017). https://doi.org/10.3390/molecules22071181

2016

HABARTOVÁ, K., CAHLÍKOVÁ, L., ŘEZÁČOVÁ M., HAVELEK, R.: The biological activity of alkaloids from the Amaryllidaceae: from cholinesterases inhibition to anticancer activity. Nat. Prod. Commun. 11, 1587-1594 (2016). https://doi.org/10.1177/1934578X1601101038

VANĚČKOVÁ, N., HOŠŤÁLKOVÁ, A., ŠAFRATOVÁ, M., KUNEŠ, J., HULCOVÁ, D., HRABINOVÁ, H., DOSKOČIL, I., ŠTĚPÁNKOVÁ, Š., OPLETAL, L., NOVÁKOVÁ, L., JUN, D., CHLEBEK, J., CAHLÍKOVÁ, L.: Isolation of Amaryllidaceae alkaloids from Nerine bowdenii W. Watson (Amaryllidaceae) and their biological activity. RSC Advances 6, 80114-80120 (2016). https://doi.org/10.1039/C6RA20205E

HAVELEK, R., SEIFERTOVÁ, M., KRÁLOVEC, K., KROCOVÁ, E., TEJKALOVÁ, V., NOVOTNÝ, I., CAHLÍKOVÁ, L., ŠAFRATOVÁ, M., OPLETAL, L., BÍLKOVÁ, Z., VÁVROVÁ, J., ŘEZÁČOVÁ, M.: Comparative cytotoxicity of chelidonine and homochelidonine, the dimethoxy analogues isolated from Chelidonium majus L. (Papaveraceae), against human leukemic and lung carcinoma cells. Phytomedicine  23, 253-266 (2016). https://doi.org/10.1016/j.phymed.2016.01.001

HROCH, M., HAVELEK, R., CAHLÍKOVÁ, L., HOŠŤÁLKOVÁ, A., HULCOVÁ, D., CERMANOVÁ, J., MIČUDA, S.: LC-MS/MS method for determination of haemanthamine in rat plasma, bile and urine: application to a pilot pharmacokinetic study. Biomed. Chrom. 30, 1083-1091 (2016). https://doi.org/10.1002/bmc.3653

CHLEBEK, J., DOSKOČIL, I., HULCOVÁ, D., BREITEROVÁ, K., ŠAFRATOVÁ, M., HAVELEK, R., HABARTOVÁ, K., HOŠŤÁLKOVÁ, A., VOLŠTÁTOVÁ, T., CAHLÍKOVÁ, L.: Cytotoxicity of naturally occurring isoquinoline alkaloids of  different structural types. Nat. Prod. Commun. 11, 753-756 (2016). https://doi.org/10.1177/1934578X1601100614

CHLEBEK, J., NOVÁK, Z., KASSEMOVÁ, D., ŠAFRATOVÁ, M., KOSTELNÍK, J., MALÝ, L., LOČÁREK, M., OPLETAL, L., HOŠŤÁLKOVÁ, A., HRABINOVÁ, M., KUNEŠ, J., NOVOTNÁ, P., URBANOVÁ, M., NOVÁKOVÁ, L., MACÁKOVÁ, K., HULCOVÁ, D., SOLICH, P., MARTÍN, C.P., JUN, D., CAHLÍKOVÁ, L..: Isoquinoline alkaloids from Fumaria officinalis L. and their biological activities related to Alzheimer’s disease. Chem. Biodivers. 13, 91-99 (2016). https://doi.org/10.1002/cbdv.201500033

CHLEBEK, J., DE SIMONE, A., HOŠŤÁLKOVÁ, A., OPLETAL, L., PERÉZ, C., PERÉZ, D.I., HAVLÍKOVÁ, L., CAHLÍKOVÁ, L., ANDRISANO, V.: Application of BACE1 immobilized enzyme reactor for the characterization of multifunctional alkaloids from Corydalis cava (Fumariaceae) as Alzheimer’s disease targets. Fitoterapia 109, 241-247 (2016). https://doi.org/10.1016/j.fitote.2016.01.008