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2023

• PhD position available in our group !!! We are looking for a motivated student for a project dealing with the synthesis of acridine derivatives as DNA intercalators (see https://faf.cuni.cz/Study/Postgraduate/Dissertation-themes/260314/…). Deadline for applications is on 3^rd September 2023. PhD project will be a folow-up study on our recent paper in NAR.

• April 2023: our PhD student Filip Kostelansky, Ph.D. won prestigious Prize of Rector of Charles University and was awarded Prize of Mayor of Hradec Kralove for his research in the field of synthesis of new acridine derivatives that have the ability to stabilize DNA duplexes, which was done collaboration with the biotechnology company GENERI BIOTECH and recently published in Nucleic Acids Research.

2022

• May 2022: a new postdoc (EFSA-CDN project),  Jibin Alex Abraham, just joined our team. Welcome and many succes in your research!

2021

• December 2021: a new PhD student, Mary Angelia Alfred, just joined our team. Welcome! 

• July 2021: Our posdoc, great researcher and good friend Rahul Kaushik left our group because he received the Marie Curie Fellowship. We wish him all the best in his future career. Good Luck!

2020

• February 2020: Our new postdoc Rahul Kaushik and Erasmus student Wojciech Krzemien (Poznan, Poland) have already joined our research group!

2019

• July 2019: Our recent paper "Karlikova M, Cermakova V, Demuth J, Valer V, Miletin M, Novakova V, Zimcik P, Magnesium tetrapyrazinoporphyrazines: tuning of the pKa of red-fluorescent pH indicators, Dalton Transactions, 2019, 48, 6162-6173" was highlighted as a Hot paper  and is free to access until 23^rd August 2019 

• July 2019: Great success of Azaphthalocyanine group on the XIII International Conference "Sytnhesis and Application od Porphyrns and Their Analogues" in Kostroma!  Ivan Skvortsov was awarded for the Best Student Presentation for his project dealing with aza-analogues of subphthalocyanines, which he made during his research stay in our lab from January to June 2019. Furhter, Jan Kollár won a prize for the Best student poster with his project on water-soluble phthalocyanines for photodynamic therapy.

2018

• May 2018: Monika Steklá won also Supranational round of the Student´s Science conference with her work studying in vitro activity of amphiphilic (aza)phthalocyanines under supervision of Miloslav Machacek. Congratulation to Monika!

• April 2018: Great success of our diploma student Monika Steklá, who won the Biological section of XXVI. Students‘ Science Conference with her  work entitled "In vitro evaluation of the photodynamic activity of novel amphiphilic (aza)phthalocyanines". Congratulation to her! She was selected for the Supranational round of the Student´s Science conference that will take place on 9^th May 2018 at Zentiva a.s.

• February 2018: We have published a comprehensive review on the properties and application of tetrapyrazinoporphyrazines  in the Coordination Chemistry Reviews  (see Coordination Chemistry Reviews, 2018, 361: 1-73.). It is possible to download it for free until March 27, 2018.

2017

• June 2017: Great success of our two PhD students in the competition "Sanofi Prize For Pharmacy" arranged by French Embassy in the Czech Republic and Jean-Marie Lehn (laureate of Nobel Prize). Lukas Lochman ranked 2^nd place with his research work entitled "Study of recognition moieties of sensoric azaphthalocyanines" and Slavek Machacek took 3^rd place with research work "Study of the novel phthalocyanine and azaphthalocyanine photosensitizers for photodynamic therapy of cancer" (photo of Slavek and Lukas with Jean-Marie Lehn during the award ceremony) 

• April 2017: Our Diploma student Veronika Čermáková took second place in the Chemistry Section of XXV. Students‘ Science Conference with her  work entitled Phenol-Substituted Azaphthalocyanines: pH Sensors With Tunable pK_A. Congratulation! She was selected for Supranational round of the Student´s Science conference that will take place on 11th May at University of Veterinary and Pharmaceutical Sciences Brno.

• February 2017: Group meeting organized at restaurant U Mlejna with all diploma and PhD students working in our group was a good opportunity to share scientific results and especially to meet each other.

• January 2017: our publication Far-Red-Absorbing Cationic Phthalocyanine Photosensitizers: Synthesis and Evaluation of the Photodynamic Anticancer Activity and the Mode of Cell Death Induction in Journal of Medicinal Chemistry was recognized as highly cited paper published in 2015:
  

• January 2017: our paper OFF-ON-OFF Red-Emitting Fluorescent Indicators for a Narrow pH Window in Chemistry - A European Journal was highlighted in Chemistry Views and selected for Front Cover and Cover Profile. 

2016

• October 2016: new PhD student Jura Demuth came to our group. 

• August 2016: the youngest member of our group Katerina Novakova was born on 21st of August. We wish her beautiful life full of love and happiness!

• July 2016: our research group spent wonderful time in Najing in China on the 9^th International Conference on Porphyrins and Phthalocyanines (ICPP-9)

• May 2016: Filip Kostelanský won the Supranational round of the Student´s Science conference. Two different committees composed either of academic members or of members of Zentiva company found his student work as the best one. Congratulation!
   
• May 2016: Filip Kostelanský took second place in the Chemistry Section of XXIV. Students‘ Science Conference with his work entitled Synthesis of amphiphilic phthalocyanines with quaternized imidazoles. Congratulation! He was selected for Supranational round of the Student´s Science conference that will take place on 17^th May in Prague with cooperation of Zentiva.

2015

• November 2015: Veronika deepens her knowledge of fluorescence on a 13th European short course on “Principles and Applications of Time-resolved Fluorescence Spectroscopy”, where she discusses various problems with prof. Lakowicz, the famous guru in fluorescence.

• October 2015: our paper published in Chemistry - A European Journal dealing with pH fluorescence sensors was selected for Back Cover picture.

• October 2015: two new PhD students joined our group - Jan Kollár and Mona Abas Shalaby.

• September 2015: two members of our group (Lukáš Lochman, Jan Švec) went for a short research stay to the group of Assoc. Prof. kand. Sergey Borisov (Technical University of Graz, Austria). They work there on the preparation of sensor devices.

• May 2015: Pavel Cermak was highly successful also on the Supranational round of the Students´ Science Conference which was organized in cooperation with Zentiva. He was awarded second place by the committee composed of academic members and also second place by the committee of Zentiva. Congratulation!

• April 2015: Pavel Cermak, one of our diploma students, won the chemical section of the XXIII. Students´ Science Conference (held at the Faculty of Pharmacy in Hradec Kralove) with his talk "Preparation and photophysical evaluation of tetra-3,4-pyridoporphyrazines suitable for PDT".

• March 2015: Veronika Novakova became Docent (equiv. Assoc. Prof.) in Pharmaceutical Chemistry after succesful habilitation (thesis: The study of structural and photophysical aspects of azaphthalocyanines with the focus on their sensoric properties). Congratulation!

• February 2015: Slavek Machacek participated on a "7th European Short Course on “Time-resolved Microscopy and Correlation Spectroscopy" to deepen his knowledge in the principles of time-resolved fluorescence microscopy and its applications to the Life Sciences.

• January 2015: Detailed study of the PDT activity and the mode of cell death induction of cationic phthalocyanines was published in J. Med. Chem.

2014

• November 2014: Petr Zimcik is improving his knowledge of fluorescence measurements by participation on a 12th European short course on “Principles and Applications of Time-resolved Fluorescence Spectroscopy” which is held in cooperation with Prof. J.R. Lakowicz.