Research Projects

Dexrazoxane

J. Med. Chem. 2021

Topoisomerase II Inhibitors

In this part of our work, we focus on the development and structure-activity relationships of topoisomerase II inhibitors. Special attention is paid to the research and development of inhibitors that could selectively inhibit individual isoforms of topoisomerase II. The unique selective topoisomerase II beta inhibitors developed so far are being studied as potential cardioprotective agents against anthracycline cardiotoxicity and as a tool to study the role of this topoisomerase II isoform in cellular processes. Selective inhibitors of the alpha isoform are being developed as potential anticancer drugs.

Anti-Tuberculosis Agents

J. Med. Chem. 2024

We focus on the development and study of structure-activity relationships of different structural types of potential anti-tuberculosis drugs. In one part of our research we focus on nitro compounds, mainly with a 3,5-dinitrophenyl fragment in the molecule. Depending on the structure, these compounds are potent inhibitors of DprE1 or act by a deazaflavin-dependent nitroreductase-mediated mechanisms. Other groups studied are mainly heterocyclic compounds acting by different mechanisms of anti-TB action.