The research of the Bioorganic and Medicinal Chemistry Group is mainly focused on pharmaceutical (medicinal) chemistry of the compounds with potential antimicrobial activities. Based on current knowledge in this particular field, we design and synthesize selected compounds of various chemical structures and study their structure-activity relationships with respect to antimicrobial activity, cytotoxicity and selectivity. In cooperation with several research groups, we study the mode of action of our compounds. The majority of the studied compounds with antimicrobial activities belong to the group of salicylanilides and salicylic derivatives, isoniazid analogues, nitrogen heterocycles and nitro group-containing compounds.
Second line of our research is focused on the structure-activity relationships of dexrazoxane, the only approved drug capable of preventing anthracycline-induced cardiotoxicity both in experimental models and clinical practice. As a part of this research, we also study the acylhydrazone-type and thiosemicarbazone-type iron chelators.
Additionally, we investigate also potential inhibitors of acetylcholinesterase and butyrylcholinesterase, especially those based on carbamate moiety and phenolic derivatives.
We are open to collaborations in those areas of research; feel free to contact us.
News
- Ph.D. positions available (both in Czech and English language; starting in October 2023, applications are accepted until April 30, 2023)
Topics:
1. Structure-activity relationship study of potential topoisomerase II inhibitors
2. Synthesis and evaluation of potential antimycobacterial drugs and prodrugs
3. Synthesis and evaluation of agents active against drug-resistant Gram-positive cocci
For more information click here