Education
- 2010-2015 Charles University, Faculty of Pharmacy, (Master degree), Thesis: Neurotropní a antioxidační aktivita vybraných druhů jednoděložných alkaloidních rostlin. VIII.
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2015-2019 Charles University, Faculty of Pharmacy i Hradec Králové, Department of Pharmaceutical Botany, (Doctoral degree), Thesis: Alkaloids of the Amaryllidaceae family as potential drugs in therapy of diseases of affluence
Current position
- a staff position and postdoc (InoMed) at Charles University, Faculty of Pharmacy in Hradec Králové, Department of Pharmaceutical Botany
Teaching activities
- Pharmaceutical botany (practicals for czech and foreign students)
- Phytochemical methods (practicals for czech and foreign students)
Award
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Conference Trends in Natural Products Research:A Young Scientists‘ Meeting of PSE and IUNG-PIB v Pulawy, Poland; 30th May to – 2nd June in 2016 (Short presentation: Alkaloids from Narcissus cv. PROFESSOR EINSTEIN (Amaryllidaceae) – isolation and biological activity – rewarded by The Teva Award for the Best Oral Presentation).
Research fellowship
- 2018 MPrudencioLab, Instituto de Medicina Molecular, Lisboa, Portugal – supervisor prof. Miguel Prudêncio (6 months)
Professional membership
- Czech Apothecary Association (since 2016)
Research focus
- isolation of secondary metabolites from the family Amaryllidaceae (isolation, analysis, structural identification)
- in vitro biological activities of isolated compounds (AChE, BuChE, POP, antiplasmodial activity, and cytotoxicity)
Publications
Original papers
2021
MAAFI, N., AL MAMUN, A., JANĎOUREK, O., MAŘÍKOVA, J., BREITEROVÁ, K., DIEPOLTOVÁ, A., KONEČNÁ, K., HOŠŤÁLKOVÁ, A., HULCOVÁ, D., KUNEŠ, J., KOHELOVÁ, E., KOUTOVÁ, D., ŠAFRATOVÁ, M., NOVÁKOVÁ, L., CAHLÍKOVÁ, L.: Semisynthetic derivatives of selected Amaryllidaceae alkaloids as a new class of antimycobacterial agents. Molecules 26, 6023 (2021). https://doi.org/10.3390/molecules26196023
KOHELOVÁ, E., MAŘÍKOVÁ, J., KORÁBEČNÝ, J., HULCOVÁ, D., KUČERA, T., JUN, D., CHLEBEK, J., JENČO, J., ŠAFRATOVÁ, M., HRABINOVÁ, M., RITOMSKÁ, A., MALANÍK, M., PEŘINOVÁ, R., BREITEROVÁ, K., KUNEŠ, J., NOVÁKOVÁ, L., OPLETAL, L., CAHLÍKOVÁ, L.: Alkaloids of Zephyrantes citrina (Amaryllidaceae) and their implication to Alzheimerʼs disease: isolation, structural elucidation and biological activity. Bioorg. Chem. 107, 104567 (2021). https://doi.org/10.1016/j.bioorg.2020.104567
KOUTOVA, D., HAVELEK, R., PETEROVA, E., MUTHNA, D., KRALOVEC, K., BREITEROVA, K., CAHLIKOVA, L., REZACOVA, M.: Pancracine, a montanine-type Amaryllidaceae alkaloid, inhibits proliferation of A549 lung adenocarcinoma cells and induces apoptotic cell death in MOLT-4 leukemic cells. Int. J. Mol. Sci. 22, 7014 (2021). https://doi.org/10.3390/ijms22137014
2020
BREITEROVÁ, K., KOUTOVÁ, D., HAVELEK, R., KUNEŠ, J., MAJOROŠOVÁ, M., OPLETAL, L., HOŠŤÁLKOVÁ, A., JENČO, J., ŘEZÁČOVÁ, M., CAHLÍKOVÁ, L.: Amaryllidaceae alkaloids of different structural types from Narcissus L. cv. Professor Einstein and their cytotoxic activity. Plants 9, 137, (2020). https://doi.org/10.3390/plants9020137
AL SHAMMARI, L., AL MAMUN, A., KOUTOVÁ, D., MAJOROŠOVÁ, M., HULCOVÁ, D., ŠAFRATOVÁ, M., BREITEROVÁ, K. MAŘÍKOVÁ, J., HAVELEK, R., CAHLÍKOVÁ, L.: Alkaloid profiling of Hippeastrum cultivars by GC-MS, isolation of Amaryllidaceae alkaloids and evaluation of their cytotoxicity. Rec. Nat. Prod. 14, 154-159 (2020). http://doi.org/10.25135/rnp.147.19.06.1302
2018
BREITEROVÁ, K., LOČÁREK, M., KOHELOVÁ, E., TALACKOVÁ, M., HULCOVÁ, D., OPLETAL, L., CAHLÍKOVÁ, L.: Daffodils as potential crops of biologically-active compounds: Assesment of 40 ornamental taxa for their alkaloid profile and cholinesterase inhibition activity. Nat. Prod. Commun. 13, 419-422 (2018). https://doi.org/10.1177/1934578X1801300410
ŠAFRATOVÁ, M., HOŠŤÁLKOVÁ, A., HULCOVÁ, D., BREITEROVÁ, K., HRABCOVÁ, V., MACHADO, M., FONTINHA, D., PRUDENCIO, M., KUNEŠ, J., CHLEBEK, J., JUN, D., HRABINOVÁ, M., NOVÁKOVÁ, L., HAVELEK, R., SEIFERTOVÁ, M., OPLETAL, L., CAHLÍKOVÁ, L: Alkaloids from Narcissus poeticus cv. Pink Parasol of various structural types and their biological activity. Arch. Pharm. Res. 41, 208-218 (2018). https://doi.org/10.1007/s12272-017-1000-4
HULCOVÁ, D., BREITEROVÁ, K., SIATKA, T., KLÍMOVÁ, K., DAVANI, L., ŠAFRATOVÁ, M., HOŠŤÁLKOVÁ, A., DE SIMONE, A., ANDRISANO, A., CAHLÍKOVÁ, L.: Amaryllidaceae alkaloids as potential glycogen synthase kinase-3 beta inhibitors. Molecules 23, 719 (2018). https://doi.org/10.3390/molecules23040719
2017
HULCOVÁ, D., BREITEROVÁ, K., ZEMANOVÁ, L., SIATKA, T., ŠAFRATOVÁ, M., VANĚČKOVÁ, N., HOŠŤÁLKOVÁ, A., WSÓL, V., CAHLÍKOVÁ, L.: Screening of AKR1C3 inhibitory potency of naturally occuring Amaryllidaceae alkaloids of different structural types. Nat. Prod. Commun. 12, 245-246 (2017). https://doi.org/10.1177/1934578X1701200226
2016
CHLEBEK, J., DOSKOČIL, I., HULCOVÁ, D., BREITEROVÁ, K., ŠAFRATOVÁ, M., HAVELEK, R., HABARTOVÁ, K., HOŠŤÁLKOVÁ, A., VOLŠTÁTOVÁ, T., CAHLÍKOVÁ, L.: Cytotoxicity of naturally occurring isoquinoline alkaloids of different structural types. Nat. Prod. Commun. 11, 753-756 (2016). https://doi.org/10.1177/1934578X1601100614.
Reviews
2020
CAHLÍKOVÁ, L., BREITEROVÁ, K., OPLETAL, L.: Chemistry and biological activity of alkaloids from the genus Lycoris (Amaryllidaceae). Molecules 25, 4797 (2020). https://doi.org/10.3390/molecules25204797
2019
CAHLIKOVA, L., VANECKOVA, N., SAFRATOVA, M., BREITEROVA, K., BLUNDEN, G., HULCOVA, D., OPLETAL, L.: The genus Nerine Herb. (Amaryllidaceae): ethnobotany, phytochemistry, and biological activity. Molecules 24, 4238 (2019). https://doi.org/10.3390/molecules24234238
Others
2020
CAHLÍKOVÁ, L., ŠAFRATOVÁ, M., HOŠŤÁLKOVÁ, A., CHLEBEK, J., HULCOVÁ, D., BREITEROVÁ, K., OPLETAL, L.: Pharmacognosy and its role in the system of profile disciplines in Pharmacy. Nat. Prod. Commun. 15, 1-7 (2020). https://doi.org/10.1177/1934578X20945450