PharmDr. Kateřina Hradiská Breiterová, Ph.D.

Education

  • 2010-2015 Charles University, Faculty of Pharmacy, (Master degree), Thesis: Neurotropní a antioxidační aktivita vybraných druhů jednoděložných alkaloidních rostlin. VIII.
  • 2015-2019 Charles University, Faculty of Pharmacy i Hradec Králové, Department of Pharmaceutical Botany, (Doctoral degree), Thesis: Alkaloids of the Amaryllidaceae family as potential drugs in therapy of diseases of  affluence

Current position

  • a staff position and postdoc (InoMed) at Charles University, Faculty of Pharmacy in Hradec Králové, Department of Pharmaceutical Botany

Teaching activities

  • Pharmaceutical botany (practicals for czech and foreign students)
  • Phytochemical methods (practicals for czech and foreign students)

Award

  • Conference Trends in Natural Products Research:A Young Scientists‘ Meeting of PSE and IUNG-PIB v Pulawy, Poland; 30th May to – 2nd June in 2016 (Short presentation: Alkaloids from Narcissus cv. PROFESSOR EINSTEIN (Amaryllidaceae) – isolation and biological activity – rewarded by The Teva Award for the Best Oral Presentation).

Research fellowship

  • 2018 MPrudencioLab, Instituto de Medicina Molecular, Lisboa, Portugal  – supervisor prof. Miguel Prudêncio (6 months)

Professional membership

  • Czech Apothecary Association (since 2016)

Research focus

  • isolation of secondary metabolites from the family Amaryllidaceae (isolation, analysis, structural identification)
  • in vitro biological activities of isolated compounds (AChE, BuChE, POP, antiplasmodial activity, and cytotoxicity)

Publications

Original papers

2021

MAAFI, N., AL MAMUN, A., JANĎOUREK, O., MAŘÍKOVA, J., BREITEROVÁ, K., DIEPOLTOVÁ, A., KONEČNÁ, K., HOŠŤÁLKOVÁ, A., HULCOVÁ, D., KUNEŠ, J., KOHELOVÁ, E., KOUTOVÁ, D., ŠAFRATOVÁ, M., NOVÁKOVÁ, L., CAHLÍKOVÁ, L.: Semisynthetic derivatives of selected Amaryllidaceae alkaloids as a new class of antimycobacterial agents. Molecules 26, 6023 (2021). https://doi.org/10.3390/molecules26196023

KOHELOVÁ, E., MAŘÍKOVÁ, J., KORÁBEČNÝ, J., HULCOVÁ, D., KUČERA, T., JUN, D., CHLEBEK, J., JENČO, J., ŠAFRATOVÁ, M., HRABINOVÁ, M., RITOMSKÁ, A., MALANÍK, M., PEŘINOVÁ, R., BREITEROVÁ, K., KUNEŠ, J., NOVÁKOVÁ, L., OPLETAL, L., CAHLÍKOVÁ, L.: Alkaloids of Zephyrantes citrina (Amaryllidaceae) and their implication to Alzheimerʼs disease: isolation, structural elucidation and biological activity. Bioorg. Chem. 107, 104567 (2021). https://doi.org/10.1016/j.bioorg.2020.104567

KOUTOVA, D., HAVELEK, R., PETEROVA, E., MUTHNA, D., KRALOVEC, K., BREITEROVA, K., CAHLIKOVA, L., REZACOVA, M.: Pancracine, a montanine-type Amaryllidaceae alkaloid, inhibits proliferation of A549 lung adenocarcinoma cells and induces apoptotic cell death in MOLT-4 leukemic cells. Int. J. Mol. Sci. 22, 7014 (2021). https://doi.org/10.3390/ijms22137014

2020

BREITEROVÁ, K., KOUTOVÁ, D., HAVELEK, R., KUNEŠ, J., MAJOROŠOVÁ, M., OPLETAL, L., HOŠŤÁLKOVÁ, A., JENČO, J., ŘEZÁČOVÁ, M., CAHLÍKOVÁ, L.: Amaryllidaceae alkaloids of different structural types from Narcissus L. cv. Professor Einstein and their cytotoxic activity. Plants 9, 137, (2020). https://doi.org/10.3390/plants9020137

AL SHAMMARI, L., AL MAMUN, A., KOUTOVÁ, D., MAJOROŠOVÁ, M., HULCOVÁ, D., ŠAFRATOVÁ, M., BREITEROVÁ, K. MAŘÍKOVÁ, J., HAVELEK, R., CAHLÍKOVÁ, L.: Alkaloid profiling of Hippeastrum cultivars by GC-MS, isolation of Amaryllidaceae alkaloids and evaluation of their cytotoxicity. Rec. Nat. Prod. 14, 154-159 (2020). http://doi.org/10.25135/rnp.147.19.06.1302

2018

BREITEROVÁ, K., LOČÁREK, M., KOHELOVÁ, E., TALACKOVÁ, M., HULCOVÁ, D., OPLETAL, L., CAHLÍKOVÁ, L.: Daffodils as potential crops of biologically-active compounds: Assesment of 40 ornamental taxa for their alkaloid profile and cholinesterase inhibition activity. Nat. Prod. Commun. 13, 419-422 (2018). https://doi.org/10.1177/1934578X1801300410

ŠAFRATOVÁ, M., HOŠŤÁLKOVÁ, A., HULCOVÁ, D., BREITEROVÁ, K., HRABCOVÁ, V., MACHADO, M., FONTINHA, D., PRUDENCIO, M., KUNEŠ, J., CHLEBEK, J., JUN, D., HRABINOVÁ, M., NOVÁKOVÁ, L., HAVELEK, R., SEIFERTOVÁ, M., OPLETAL, L., CAHLÍKOVÁ, L: Alkaloids from Narcissus poeticus cv. Pink Parasol of various structural types and their biological activity. Arch. Pharm. Res. 41, 208-218 (2018).  https://doi.org/10.1007/s12272-017-1000-4

HULCOVÁ, D., BREITEROVÁ, K., SIATKA, T., KLÍMOVÁ, K., DAVANI, L., ŠAFRATOVÁ, M., HOŠŤÁLKOVÁ, A., DE SIMONE, A., ANDRISANO, A., CAHLÍKOVÁ, L.: Amaryllidaceae alkaloids as potential glycogen synthase kinase-3 beta inhibitors. Molecules 23, 719 (2018). https://doi.org/10.3390/molecules23040719

2017

HULCOVÁ, D., BREITEROVÁ, K., ZEMANOVÁ, L., SIATKA, T., ŠAFRATOVÁ, M., VANĚČKOVÁ, N., HOŠŤÁLKOVÁ, A., WSÓL, V., CAHLÍKOVÁ, L.: Screening of AKR1C3 inhibitory potency of naturally occuring Amaryllidaceae alkaloids of different structural types. Nat. Prod. Commun. 12, 245-246 (2017). https://doi.org/10.1177/1934578X1701200226

2016

CHLEBEK, J., DOSKOČIL, I., HULCOVÁ, D., BREITEROVÁ, K., ŠAFRATOVÁ, M., HAVELEK, R., HABARTOVÁ, K., HOŠŤÁLKOVÁ, A., VOLŠTÁTOVÁ, T., CAHLÍKOVÁ, L.: Cytotoxicity of naturally occurring isoquinoline alkaloids of  different structural types. Nat. Prod. Commun11, 753-756 (2016). https://doi.org/10.1177/1934578X1601100614.

Reviews

2020

CAHLÍKOVÁ, L., BREITEROVÁ, K., OPLETAL, L.: Chemistry and biological activity of alkaloids from the genus Lycoris (Amaryllidaceae). Molecules 25, 4797 (2020). https://doi.org/10.3390/molecules25204797

2019

CAHLIKOVA, L., VANECKOVA, N., SAFRATOVA, M., BREITEROVA, K., BLUNDEN, G., HULCOVA, D., OPLETAL, L.: The genus Nerine Herb. (Amaryllidaceae): ethnobotany, phytochemistry, and biological activity. Molecules 24, 4238 (2019).  https://doi.org/10.3390/molecules24234238

Others

2020

CAHLÍKOVÁ, L., ŠAFRATOVÁ, M., HOŠŤÁLKOVÁ, A., CHLEBEK, J., HULCOVÁ, D., BREITEROVÁ, K., OPLETAL, L.: Pharmacognosy and its role in the system of profile disciplines in Pharmacy. Nat. Prod. Commun. 15, 1-7 (2020). https://doi.org/10.1177/1934578X20945450

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