Current position
PostDoc at the Department of Pharmaceutical Chamistry and Pharmaceutical Analysis
Member of Design and Development of New Antimicrobial Agents research group
Education
2023 Doctoral studies (Ph.D.) in Pharmaceutical Chemistry, Charles University, Faculty of Pharmacy in Hradec Králové
- Thesis: Preparation of Pyrazinamide Derivatives as Potential Antiinfectives. (Study of Structure Activity Relationships)
- Supervisor: doc. PharmDr. Jan Zitko, Ph.D.
2018 Post-Master’s Examination (PharmDr.) in Pharmaceutical Chemistry, Charles University, Faculty of Pharmacy in Hradec Králové
2018 Master’s study (Mgr.) in Pharmacy, graduated summa cum laude, Charles University, Faculty of Pharmacy in Hradec Králové
- Thesis: Definition of the carbohydrate binding capacities of the novel enterotoxin LT-IIc
- Supervisor: prof. Susann Teneberg, MD, PhD (University of Gothenburg); prof. PharmDr. Martin Doležal, Ph.D.
Experience abroad
5 / 2022 – 7 / 2022 University of Vienna, Faculty of Life Sceinces, Vienna, Austria
Post-graduate Internship in the Pharmacoinformatics Research Group under supervision of prof. Gerhard Ecker, working on proteochemometric modeling of inhibitors of SLC transporters using machine learning algorithms
9 / 2020 – 12 / 2020 University of Ljubljana, Faculty of Pharmacy, Ljubljana, Slovenia
Post-graduate Erasmus+ Internship Mobility at the Department of Pharmaceutical Chemistry under supervision of dr. Izidor Sosič, working on enzymatic testing of MetAP and InhA inhibitors and click-chemistry synthesis of new potential inhibitors of InhA
8 / 2017 – 12 / 2017 University of Gothenburg, Sahlgrenska Academy, Gothenburg, Sweden
1-semester Erasmus+ Study Mobility at the Department of Medical Biochemistry and Cell Biology under supervision of prof. Susann Teneberg, working on separation of glycosphingolipids and identification of their binding capacities by radiolabeled assay
Grant projects
1. 1. 2023 – (31. 12. 2025) Project „National Institute of virology and bacteriology (Programme EXCELES, ID Project No. LX22NPO5103) - Funded by the European Union - Next Generation EU.“ (Team member)
1. 4. 2021 – 31. 3. 2023 Grant Schemes at Charles University - reg. no. CZ.02.2.69/0.0/0.0/19_073/0016935 - Design, synthesis and biological evaluation of 2-aminooxazoles as antibacterial compounds. (Principal investigator)
1. 10. 2021 – 31. 12. 2022 Grant Agency of Czech Republic - reg. n. 19-14886Y - Reliable calculations and predictions of NMR chemical shifts for the structural characterization of phosphorylated intrinsically disordered proteins. (Team member)
Publications
Pallabothula, V. S. K.; Abdalrahman, N. T.; Mori M.; Fekri, A.H.; Janďourek, O.; Konečná, K.; Paterová, P.; Novák, M.; Dudášová-Hatoková, P.; Štěrbová-Kovaříková, P.; Castellano, C.; Meneghetti, F.; Villa, S.; Kuneš J.; Juhás, M.; Zitko, J. A Hit Expansion of 3-Benzamidopyrazine-2-carboxamide: Towards Inhibitors of Prolyl-tRNA Synthetase with Antimycobacterial Activity. Archiv Der Pharmazie, accepted
Pallabothula, V. S. K.; Kerda, M.; Juhas, M. et al. Adenosine-Mimicking Derivatives of 3-Aminopyrazine-2-Carboxamide: Towards Inhibitors of Prolyl-tRNA Synthetase with Antimycobacterial Activity. Biomolecules, 2022, 12(11), 1561. IF2022 = 5.5
Juhás, M.; Bachtíková, A.; Nawrot, D.E. et al. Improving Antimicrobial Activity and Physico-Chemical Properties by Isosteric Replacement of 2-Aminothiazole with 2-Aminooxazole. Pharmaceuticals, 2022, 15(5), 580. IF2022 = 4.6
Zalem, D.*; Juhás, M.*; Terrinoni, M. et al. Characterization of the ganglioside recognition profile of Escherichia coli heat-labile enterotoxin LT-IIc. Glycobiology 2022, 32(5), 391-403. *contributed equally IF2022 = 4.3
Juhás, M.; Pallabothula, V. S. K.; Grabrijan, K. et al. Design, synthesis and biological evaluation of substituted 3-amino-N-(thiazol-2-yl)pyrazine-2-carboxamides as inhibitors of mycobacterial methionine aminopeptidase 1. Bioorganic Chemistry 2022, 118, 105489. IF2022 = 5.1
Pang, L.; Weeks, Stephen D.; Juhás, M.; Strelkov, Sergei V. et al. Towards Novel 3-Aminopyrazinamide-Based Prolyl-tRNA Synthetase Inhibitors: In Silico Modelling, Thermal Shift Assay and Structural Studies. International Journal of Molecular Sciences 2021, 22(15), 7793. IF2021 = 6.208
Juhás, M.*; Zitko, J.* Molecular Interactions of Pyrazine-based Compounds to Proteins. Journal of Medicinal Chemistry 2020, 63(17), 8901–8916. *contributed equally, IF2020 = 7.446 D1(3/62), AIS: Q1(4/62).
Juhás, M.; Kučerová, L.; Horáček, O. et al. N-Pyrazinoyl Substituted Amino Acids as Potential Antimycobacterial Agents—the Synthesis and Biological Evaluation of Enantiomers. Molecules 2020, 25(7), 1518. IF2020 = 4.412
Bouz, G.; Juhás, M.; Pausas Otero, L.; et al. Substituted N-(Pyrazin-2-yl)benzenesulfonamides; Synthesis, Anti-Infective Evaluation, Cytotoxicity, and In Silico Studies. Molecules 2019, 25(1), 138. IF2019 = 3.267
Bouz, G.; Juhas, M.; Niklova, P. et al. Ureidopyrazine Derivatives: Synthesis and Biological Evaluation as Anti-Infectives and Abiotic Elicitors. Molecules 2017, 22 (10), E1797. IF2017 = 3.098