PharmDr. Markéta Komlóová, Ph.D.

Education

Professional and research activity

• Past: synthesis and study of peripheral inhibitors of acetylcholinesterase as potential compounds for the treatment of myasthenia gravis
• Recent: synthesis and study of salicylanilide derivatives as potential antibacterial compounds, molecular modelling studies

Teaching activity

• Department of Pharmaceutical Chemistry and Drug Control, Faculty of Pharmacy in Hradec Kralove, Charles University in Prague, subject: Pharmaceutical chemistry
• Department of Chemistry, Faculty of Science, University of Jan Evangelista Purkynje in Usti nad Labem, subject: Toxicology, Military and agricultural toxicology, Toxicology of natural toxins

Publications

Monography chapter

1. Musilek, K., Komloova, M., Holas, O. et al. Myasthenia Gravis – Current Treatment Standards and Emerging Drugs, In: A Look into Myasthenia Gravis, Dr. Joseph A. Pruitt (ed.), InTech, 2012, ISBN: 978-953-307-821-2, DOI: 10.5772/31127. Available from: http://www.intechopen.com/books/a-look-into-myasthenia-gravis/myasthenia-graviscurrent-treatment-standards-and-emerging-drugs

Original papers

1. Musilek, K., Komloova, M., Zavadova, V. et al. Preparation and in vitro screening of symmetrical bispyridinium cholinesterase inhibitors bearing different connecting linkage - initial study for myasthenia gravis implications. Bioorg. Med. Chem. Let. 2010, 5 (20), 1763-1766.
2. Musilek, K., Roder, J., Komloova, M. et al. Preparation, in vitro screening and molecular modelling of symmetrical 4-tert-butylpyridinium cholinesterase inhibitors - Analogues of SAD-128. Bioorg. Med. Chem. Let. 2011, 21, 150–154.
3. Musilek, K., Pavlikova, R., Marek, J., Komloova, M. et al. The preparation, in vitro screening and molecular docking of symmetrical bisquaternary cholinesterase inhibitors containing a but-(2E)-en-1,4-diyl connecting linkage. J. Enzyme Inhib. Med. Chem. 2011, 26 (2), 245–253.
4. Komloova, M., Musilek, K., Horova, A. et al. Preparation, in vitro screening and molecular modelling of symmetrical bis-quinolinium cholinesterase inhibitors - implications for early Myasthenia gravis treatment. Bioorg. Med. Chem. Let. 2011, 21, 2505–2509.
5. Musilek, K., Komloova, M., Holas, O. et al. Preparation and in vitro screening of symmetrical bis-isoquinolinium cholinesterase inhibitors bearing various connecting linkage – Implications for early Myasthenia gravis treatment. Eur. J. Med. Chem. 2011, 46, 811–818.
6. Musilek, K., Komloova, M., Holas, O. et al. Mono-oxime bisquaternary acetylcholinesterase reactivators with prop-1,3-diyl linkage – Preparation, in vitro screening and molecular docking. Bioorg. Med. Chem. 2011, 19, 754-762.
7. Kassa, J., Musilek, K., Komloova, M. et al. A comparison of the efficacy of newly developer reversible inhibitors of acetylcholinesterase with commonly used pyridostigmine as pharmacological pre-treatment of soman-poisoned mice. Basic Clin. Pharmacol. Toxicol. 2012, 110, 322-326.
8. Komloova, M., Horova, A., Hrabinova, M., et al. Preparation, in vitro evaluation and molecular modelling of pyridinium–quinolinium/isoquinolinium non-symmetrical bisquaternary cholinesterase inhibitors. Bioorg. Med. Chem. Let. 2013, 23 (24), 6663–6666.
9. Rychtarcikova, Z., Kratky, M., Gazvoda, M., Komloova, M. et al. N-Substituted 2-Isonicotinoylhydrazinecarboxamides — New Antimycobacterial Active Molecules. Molecules 2014, 19 (4), 3851-3868.

Reviews

1. Komloova, M., Musilek, K., Dolezal, M. et al. Structure-activity relationship of quaternary acetylcholinesterase inhibitors – outlook for early myasthenia gravis treatment. Curr. Med. Chem. 2010, 17 (17), 1810-1824.
2. Komloova, M., Musilek, K., Kuca, K. Myasthenia gravis - současné terapeutické možnosti a nové trendy. Ceska slov. farm. 2011, 60, 47–53.

Selected conferences

1. 10th International Meeting on Cholinesterases, Sibenik (Croatia), 2009, poster Komloova M., Holas O., Musilek K., Kuca K., Dolezal M., Opletalova V.: Synthesis and In Vitro Screening of AChE Bisquaternary Inhibitors as Potential Compounds for Myasthenia Gravis Treatment. Book of Abstracts p. 99, ISBN 978-953-95551-3-7.
2. 9th Conference of Military Physicians, Pharmacists and Veterinarians, Hradec Kralove (Czech Republic), 2009, talk Komloova M., Holas O., Musilek K., Dolezal M. Preparation and In Vitro Evaluation of New Peripheral Inhibitors of Acetylcholinesterase., Book of Abstracts, p. 78, ISBN 978-80-254- 5956-0.
3. 53. Česko-slovenská psychofarmakologická konference, Jeseník (Czech Republic), 2011, poster Komlóová, M.; Holas, O.; Musílek, K.; Doležal, M. Syntéza a in vitro testování inhibitorů acetylcholinesterasy., Psychiatrie,vol. 15, supp.1, s. 58, ISSN 1211-7579.
4. 1st Meeting of the Paul Ehrlich MedChem Euro-PhD Network (7th Meeting oh the European Network of Doctoral Studies in Pharmaceutical Sciences), Madrid (Spain), 2011, talk Komloova, M., Musilek, K., Holas, O., Dolezal, M.: Preparation and in vitro evaluation of peripheral acetylcholinesterase inhibitors intended for early Myasthenia gravis treatment. Book of abstracts.