Education, Academic and Scientific Degrees:
2014 – Assistant professor at Department of Biological and Medical Sciences (FParm HK), 2014 – Ph.D. in Pharmacology (FPharm HK), 2014 – PharmDr. (FPharm HK), 2009 – MSc. in Pharmacy (FPharm HK).
Working Experience:
2014 – Assistant professor, 2012 – Research assistant (all appointments at Faculty of Pharmacy (FPharm HK), Department of Biological and Medical Sciences).
Research Interests
Experimental atherosclerosis, mouse models of atherosclerosis, endothelial dysfunction
Teaching
Since 2020 - garant of subjects Immunology and Immunopharmacology
Since 2010 – teaching of seminars and practical classes of Microbiology (2010), Immunology (since 2010, since 2014 also in English), Morphology and Physiology (2011), Pathological Physiology (since 2011, since 2014 also in English) in Pharmacy students, since 2014 seminars of Pathology in Healthcare Bioanalytics students, since 2016 examiner of Pathology
Supervisor of bachelor (12x), diploma (27x) and rigorous (9x) theses, PhD student consultant (1x).
Memberships in Scientific Societies:
European Atherosclerosis Society since 2009, Czech Society for Atherosclerosis since 2010
Czech Society of Allergology and Clinical Immunology since 2023
Awards
2011 – Best original article of the year (1st place) awarded by Czech Society for Atherosclerosis (co-author) – “Cholesterol effects on endoglin and its downstream pathways in ApoE/LDLR double knockout mice” (Circulation Journal)
2014 - Best original article of the year (1st place) awarded by Czech Society for Atherosclerosis (1st author) – “Endoglin is not expressed with cell adhesion molecules in aorta during atherogenesis in apoE-deficient mice” (Histology and Histopathology)
2016 - Best original article of the year (3rd place) awarded by Czech Society for Atherosclerosis (1st author) - "High Levels of Soluble Endoglin Induce a Proinflammatory and Oxidative-Stress Phenotype Associated with Preserved NO-Dependent Vasodilatation in Aortas from Mice Fed a High-Fat Diet" (Journal of Vascular Research)
Selected Lectures at Conferences
– 19th Congress of Czech Society for Atherosclerosis, Spindleruv Mlyn (Czechia), 2015.
Peer Review
– Reviewer of 2 manuscripts submitted into scientific journal with IF (JCPT, Sci Rep)
– Reviewer of 1 grant application - Czech agency GA UK
– Bachelor/Diploma theses (20x/FaF), rigorous theses – (5x/FaF).
Grant Projects
As a principal investigator (1x): “Study of endoglin/Smad signaling cascade in different stages of atherogenesis and after statin treatment”
As a co-investigator: GA ČR (2x), GA UK (3x), UNCE (1x), PRVOUK (1x)
Publications and Citations (in total):
– Number of publications in WoS/Scopus: 17/17, all with IF
– Number of citations in WoS/Scopus without self-citations: 394/368.
– H-index in WoS/Scopus (with self-citations) = 14/15.
Book chapters:
Book title: Atherogenesis (ISBN 978-953-307-992-9)
Chapter title: The Role of TGF-β and TGF-β Receptors in Atherosclerosis. p. 327-344
Nachtigal P., Rathouska J., Vecerova L., Strasky Z. (2012)
http://www.intechopen.com/books/atherogenesis
Summary of all publications
2019
Vicen M, Vitverova B, Havelek R, Blazickova K, Machacek M, Rathouska J, Najmanová I, Dolezelova E, Prasnicka A, Sternak M, Bernabeu C, Nachtigal P. Regulation and role of endoglin in cholesterol-induced endothelial and vascular dysfunction in vivo and in vitro. FASEB J 2019:fj201802245R. FASEB 2018;271:15-25. [IF= 5,595], Article Influence Score 1,9; (Q1) (povinná platba za open access)
2017
Varejckova M, Gallardo-Vara E, Vicen M, Vitverova B, Fikrova P, Dolezelova E, Rathouska J, Prasnicka A, Blazickova K, Micuda S, Bernabeu C, Nemeckova I, Nachtigal P. Soluble endoglin modulates the pro-inflammatory mediators nf-kappab and il-6 in cultured human endothelial cells. Life Sci 2017;175:52-60. [IF= 3,234], Article Influence Score 0,7; (Q1) (povinná platba za open access)
Rathouska J, Fikrova P, Mrkvicova A, Blazickova K, Varejckova M, Dolezelova E, Nemeckova I, Vitverova B, Peslova L, Gallardo-Vara E, Pericacho M, Nachtigal P. High soluble endoglin levels do not induce changes in structural parameters of mouse heart. Heart Vessels 2017;30:241-248. [IF= 3,434]; Article Influence Score 0,4; (Q2) (povinná platba za open access)
2016
Jezkova K & Rathouska J, Nemeckova I, Fikrova P, Dolezelova E, Varejckova M, Vitverova B, Tysonova K, Serwadczak A, Buczek E, Bernabeu C, Lopez-Novoa JM, Chlopicki S, Nachtigal P. High Levels of Soluble Endoglin Induce a Proinflammatory and Oxidative-Stress Phenotype Associated with Preserved NO-Dependent Vasodilatation in Aortas from Mice Fed a High-Fat Diet. J Vasc Res 2016; 53:149-162. [IF= 2,186], Article Influence Score 0,7; (Q2) (povinná platba za open access)
Sahebkar A, Rathouska J, Simental-Mendia LE, Nachtigal P: Statin therapy and plasma cortisol concentrations: A systematic review and meta-analysis of randomized placebo-controlled trials. Pharmacol Res 2016;103:17-25. [IF= 4,408], Article Influence Score 1,1; (Q1) (povinná platba za open access)
Sahebkar A, Rathouska J, Derosa G, Maffioli P, Nachtigal P: Statin impact on disease activity and C-reactive protein concentrations in systemic lupus erythematosus patients: A systematic review and meta-analysis of controlled trials. Autoimmun Rev 2016;15:344-353. [IF= 8,490], Article Influence Score 1,7; (Q1) (povinná platba za open access)
2015
Rathouska J, Jezkova K, Nemeckova I, Nachtigal P. Soluble endoglin, hypercholesterolemia and endothelial dysfunction. Atherosclerosis 2015;243:383-388. [IF= 3,994], Article Influence Score 1,2; (Q1) (povinná platba za open access)
Zemankova L, Varejckova M, Dolezalova E, Fikrova P, Jezkova K, Rathouska J, Cerveny L, Botella LM, Bernabeu C, Nemeckova I, Nachtigal P. Atorvastatin-induced endothelial nitric oxide synthase expression in endothelial cells is mediated by endoglin. J Physiol Pharmacol 2015;66:403-413. [IF= 2.804], Article Influence Score 0,4; (Q3) (open access časopis)
Nemeckova I, Serwadczak A, Oujo B, Jezkova K, Rathouska J, Fikrova P, Varejckova M, Bernabeu C, Lopez-Novoa JM, Chlopicki S, Nachtigal P. High soluble endoglin levels do not induce endothelial dysfunction in mouse aorta. PLoS One 2015;10:e0119665. [IF= 3.057], Article Influence Score 1,1; (Q1) (open access časopis)
Rathouska J & Jezkova K, Nemeckova I, Zemankova L, Varejckova M, Nachtigal P. Endoglin is not expressed with cell adhesion molecules in aorta during atherogenesis in apoe-deficient mice. Histol Histopathol 2015;30:233-244. [IF= 2.281], Article Influence Score 0,6; (Q2) (povinná platba za open access)
Rathouska J, Nemeckova I, Zemankova L, Strasky Z, Jezkova K, Varejckova M, Nachtigal P. Cell adhesion molecules and enos expression in aorta of normocholesterolemic mice with different predispositions to atherosclerosis. Heart Vessels 2015;30:241-248. [IF= 2.293], Article Influence Score 0,4; (Q2) (povinná platba za open access)
2013
Strasky Z, Zemankova L, Nemeckova I, Rathouska J, Wong RJ, Muchova L, Subhanova I, Vanikova J, Vanova K, Vitek L, Nachtigal P. Spirulina platensis and phycocyanobilin activate atheroprotective heme oxygenase-1: A possible implication for atherogenesis. Food & function. 2013;4:1586-1594 [IF= 2.694]
2012
Vecerova L, Strasky Z, Rathouska J, Slanarova M, Brcakova E, Micuda S, Nachtigal P. Activation of tgf-beta receptors and smad proteins by atorvastatin is related to reduced atherogenesis in apoe/ldlr double knockout mice. J Atheroscler Thromb. 2012;19:115-126 [IF=2.933]
Nachtigal P, Zemankova Vecerova L, Rathouska J, Strasky Z. The role of endoglin in atherosclerosis. Atherosclerosis. 2012;224:4-11 [IF= 3.706]
2011
Strasky Z, Vecerova L, Rathouska J, Slanarova M, Brcakova E, Kudlackova Z, Andrys C, Micuda S, Nachtigal P. Cholesterol effects on endoglin and its downstream pathways in apoe/ldlr double knockout mice. Circ J. 2011;75:1747-1755 [IF= 3.578]
Rathouska J, Vecerova L, Strasky Z, Slanarova M, Brcakova E, Mullerova Z, Andrys C, Micuda S, Nachtigal P. Endoglin as a possible marker of atorvastatin treatment benefit in atherosclerosis. Pharmacol Res. 2011;64:53-59 [IF= 4.346]
2009
Zadak Z, Hyspler R, Ticha A, Hronek M, Fikrova P, Rathouska J, Hrnciarikova D, Stetina R. Antioxidants and vitamins in clinical conditions. Physiol Res. 2009;58 Suppl 1:S13-17 (IF=1.43)