Research interests
- nuclear receptors
- in vitro liver cell models
- hepatotoxicity
- drug metabolism
- drug-drug interactions
Education
2011 - 2017 Doctoral study – Faculty of Pharmacy in Hradec Kralove, Charles University, Department of Pharmacology and Toxicology (Prof. Petr Pavek); Doctoral dissertation: Novel approaches for development of in vitro liver cell models
2006 - 2011 Master study – Faculty of Pharmacy in Hradec Kralove, Charles University, Department of Pharmacology and Toxicology (Prof. Petr Pavek); Master thesis: The effect of statins on Ras/Raf/ERK cell signaling pathway in A431 model cell line
Publications
Scopus (4/2024): H-index 16, 32 documents, 662 citations (604 without self-citations)
WoS (4/2024): H-index 16, 31 documents, 624 citations (571 without self-citations)
Top 5
- Smutny, T., Bernhauerova, V., Smutna, L., Tebbens, J. D., & Pavek, P. (2022). Expression dynamics of pregnane X receptor-controlled genes in 3D primary human hepatocyte spheroids. Arch Toxicol, 96(1): 195-210. IF2022 = 6,1
- Smutny, T., Hyrsova, L., Braeuning, A., Ingelman-Sundberg, M., & Pavek, P. (2021). Transcriptional and post-transcriptional regulation of the pregnane X receptor: a rationale for interindividual variability in drug metabolism. Arch Toxicol, 95(1): 11-25. IF2021 = 6,168
- Smutny, T., Dusek, J., Hyrsova, L., Nekvindova, J., Horvatova, A., Micuda, S., Gerbal-Chaloin, S., & Pavek, P. (2020). The 3'-untranslated region contributes to the pregnane X receptor (PXR) expression down-regulation by PXR ligands and up-regulation by glucocorticoids. Acta Pharm Sin B, 10(1): 136-152. IF2020 = 11,614
- Smutny, T., Nova, A., Drechslerova, M., Carazo, A., Hyrsova, L., Rania Hruskova, Z., Kunes, J., Pour, M., Spulak, M., & Pavek, P. 2-(3-Methoxyphenyl)quinazoline Derivatives: A New Class of Direct Constitutive Androstane Receptor (CAR) Agonists. (2016). J Med Chem, 59(10): 4601-10. IF2016 = 6,259
- Smutny, T., Bitman, M., Urban, M., Dubecka, M., Vrzal, R., Dvorak, Z., & Pavek, P. (2014). U0126, a mitogen-activated protein kinase kinase 1 and 2 (MEK1 and 2) inhibitor, selectively up-regulates main isoforms of CYP3A subfamily via a pregnane X receptor (PXR) in HepG2 cells. Arch Toxicol, 88(12): 2243-59. IF2014 = 5,980
Awards
2022 The prize for the best published article in 2022 in category Toxicology awarded by Czech Society for Experimental and Clinical Pharmacology and Toxicology (Smutny et al., Arch Toxicol, 2022)
2022 The winner of the poster session at 70th Czech-Slovak Pharmacological Days conference
2020 The prize for the best published article in 2020 in category Experimental pharmacology awarded by Czech Society for Experimental and Clinical Pharmacology and Toxicology (Smutny et al., Acta Pharm Sin B. 2020)
2019 Dean´s Medal for research achievements (Faculty of Pharmacy, Charles University)
2018 The prize for the best published article in 2018 in category Toxicology awarded by Czech Society for Experimental and Clinical Pharmacology and Toxicology (Smutny et al., Toxicol In Vitro. 2018)
2018 1st place winner of the poster session at 68th Czech-Slovak Pharmacological Days conference (out of 52 presented posters)
2016 The prize for the best published experimental article in 2016 awarded by Czech Medical Association of J. E. Purkyně (Smutny et al., J Med Chem. 2016)
2016 The prize for the best published article in 2016 in category Toxicology awarded by Czech Society for Experimental and Clinical Pharmacology and Toxicology (Smutny et al., J Med Chem. 2016)
2016 Dimitris N. Chorafas Prize (The Dimitris N. Chorafas Foundation and the Weizmann Institute of Science award scientific prizes for outstanding work in several fields including medicine and the natural sciences)
2016 2nd place in the Sanofi Prize for Pharmacy (for PhD research work in experimental biomedical and pharmaceutical research)
2011 Student research award (Czech Pharmaceutical Society)
Research stays
- Visiting postdoctoral researcher (1.5 + 1 months) – Inserm laboratory at Institute for Regenerative Medicine and Biotherapy (IRMB), Montpellier, France
- Visiting postdoctoral researcher (9 months) – Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
- Visiting doctoral student (1 year) – Division of Pharmaceutical Biosciences, Faculty of Pharmacy, University of Helsinki, Finland
Teaching activities
- Teaching Pharmacology (CZ), Preclinical drug testing (CZ), and Gene therapy (CZ) for M.Sc. students at Faculty of Pharmacy in Hradec Kralove, Charles University