Publications

Design and Development of New Antimicrobial Agents

2026

JUHÁS, M.; BOUZ, G.; PANG, L.; WEEKS, S. D.; JANĎOUREK, O.; KONEČNÁ, K.; PATEROVÁ, P.; BÁRTA, P.; HALÍŘOVÁ, M.; KUČEROVÁ-CHLUPÁČOVÁ, M.; DOLEŽAL, M.; ZITKO, J. Targeting Mycobacterium tuberculosis: The Role of Alkyl Substitution in Pyrazinamide Derivatives. ACS Omega, 2026. [ISSN: 2470-1343], IF₂₀₂₄ = 4.3 (Q2), AIS₂₀₂₄ = 0.673 (Q2), doi: 10.1021/acsomega.5c07249
JUHÁS, M.; ECKER, G. A. Proteochemometric Model for Ligands of the SLC5 Transporter Family. Arch. Pharm., 2026, vol. 359, no. 1, e70183. [ISSN 0365-6233], IF₂₀₂₄ = 3.6 (Q2Q2Q2), AIS₂₀₂₄ = 0.526 (Q3Q2Q3), doi: 10.1002/ardp.70183

2025

DIEPOLTOVÁ, A.; NAWROT, D. E.; JANĎOUREK, O.; JUHÁS, M.; BÁRTA, P.; VÁVROVÁ, P.; PALLABOTHULA, V. S. K.; DUDÁŠOVÁ-HATOKOVÁ, P.; VEJSOVÁ, M.; VOXOVÁ, B.; ÖSTERREICHER, J.; ŠTĚRBOVÁ-KOVAŘÍKOVÁ, P.; NACHTIGAL, P.; ZITKO, J.; KONEČNÁ, K. A new bactericidal chlorinated derivative containing 2-aminooxazole potentiates antibacterial action of colistin against multidrug-resistant acinetobacter baumannii. Medical Microbiology and Immunology, 2025, vol. 214. no.1, article no. 44. [ISSN: 1432-1831], IF₂₀₂₄ = 3.0 (Q3Q3), AIS₂₀₂₄ = 0.845 (Q3Q2), doi: 10.1007/s00430-025-00854-y
HOUNGBEDJI, P.-A.; NAWROT, D. E.; JANĎOUREK, O.; KONEČNÁ, K.; NOVÁK, M.; PATEROVÁ, P.; BÁRTA, P.; RAMBAHER, M. H.; NOVOTNÁ, E.; CASTELLANO, C.; MORI, M.; MENEGHETTI, F.; ZÁHORSZKÁ, M.; KORDULÁKOVÁ, J.; ZITKO, J. Investigating the Mechanism of Antimycobacterial and Antiproliferative Activity of (E)-N’-Benzylidenepyrazine-2-Carbohydrazides and their Derivatives. ChemMedChem, 2025, e202500085. [ISSN:1860-7179 Print, ISSN:1860-7187 Online], IF₂₀₂₄ = 3.4 (Q2Q2), AIS₂₀₂₄ = 0.626 (Q2Q2), doi: 10.1002/cmdc.202500085
KERDA, M.; NAWROT, D.; SLECHTA, P.; DOMANSKÝ, M.; ASKARI, A.; KAMANGAR, H.; JANĎOUREK, O.; KONEČNÁ, K.; PATEROVÁ, P.; HLBOČANOVÁ, I.; MACHÁČEK, M.; MORI, M.; MENEGHETTI, F.; DOLEŽAL, M.; ZITKO, J.; BOUZ, G. Novel quinazolinones active against multidrug-resistant Mycobacterium tuberculosis: synthesis, antimicrobial evaluation and in silico exploration of PonA1 as a potential target. ChemMedChem, 2025, e202500147. [ISSN:1860-7179 Print, ISSN:1860-7187 Online], IF₂₀₂₃ = 3.6 (Q2Q2), AIS₂₀₂₃ = 0.713 (Q2Q2), doi: 10.1002/cmdc.202500147
KUČEROVÁ, M.: Kovalentní léčiva. Čes. slov. farm. 2025, 74(1), E11–E16; DOI: 10.36290/csf.2025.001
KUČEROVÁ-CHLUPÁČOVÁ, M.: Systematic Review on 1,2,3-Oxadiazoles, 1,2,4-Oxadiazoles, and 1,2,5-Oxadiazoles in the Antimycobacterial Drug Discovery, ChemMedChem 2025, e202400971, [ISSN:1860-7179 Print, ISSN:1860-7187 Online], IF₂₀₂₃ = 3.6 (Q2Q2), AIS₂₀₂₃ = 0.713 (Q2Q2), https://doi.org/10.1002/cmdc.202400971
NAWROT, D.; KOUTNÍKOVÁ, B.; JANĎOUREK, O.; KONEČNÁ, K.; NOVÁK, M.; PATEROVÁ, P.; BÁRTA, P.; BOUZ, G.; ZITKO, J.; DOLEŽAL, M. Antimicrobial and Antiproliferative Properties of 2-Phenyl-N-(Pyridin-2-yl)acetamides. Chem. Biol. Drug Des., 2025, vol. 105, no. 1, e70030. [eISSN 1521-4184], IF₂₀₂₃ = 3.2 (Q3), AIS₂₀₂₃ = 0.505 (Q3), doi: 10.1111/cbdd.70030
SALAM, R.; BAKKER, M.; KRUTÁKOVÁ, M.; ŠTEFELA, A.; PÁVEK, P.; DUINTJER TEBBENS, J.; ZITKO, J. The discovery of a new nonbile acid modulator of Takeda G protein-coupled receptor 5: An integrated computational approach. Arch. Pharm., 2025, vol. 358, no. 1, e2400423. [eISSN 1521-4184], IF₂₀₂₃ = 4.3 (Q1Q2), AIS₂₀₂₃ = 0.559 (Q2Q3), doi: 10.1002/ardp.202400423,
DOLEŽAL, M.; KASTNER, P. Kontaminace léčiv nitrosaminy, staronový problém. Česk. Slov. Farm., 2024, vol. 73, no. 4, pp. 228–232. [ISSN 1210-7816], doi: 10.36290/csf.2024.041

2024

KUČEROVÁ, M.: Vazebné síly: typy interakcí léčiv s molekulovými cíli v organismu. Klin. Farmakol. Farm. 2024, 38(3), 188–122, [ISSN 1803-5353] https://doi.org/10.36290/far.2024.019
ŠLECHTA, P., VITÁK, R., BÁRTA, P., KOUCKÁ, K., BERKOVÁ, M., ŽĎÁROVÁ, D., PETRÍKOVÁ, A., KUNEŠ, J., KUBÍČEK, V., KUČERA, R., DOLEŽAL, M., and KUČEROVÁ-CHLUPÁČOVÁ., M.*: Replacement of nitro function by free boronic acid in non-steroidal anti-androgens, RSC Med. Chem. 2024, 15, 4018–4038. [ISSN 2632-8682], IF₂₀₂₃ = 4.1 (Q2Q2), AIS₂₀₂₃ = 0.894 (Q2Q2), https://doi.org/10.1039/D4MD00343H
BAKKER, M. J.; GAFFOUR A.; JUHAS, M.; ZAPLETAL, V.; STOSEK, J.; BRATHOLM, L. A.; PRECECHTELOVA PAVLIKOVA, J. Streamlining NMR Chemical Shift Predictions for Intrinsically Disordered Proteins: Design of Ensembles with Dimensionality Reduction and Clustering. J. Chem. Inf. Model., 2024, vol. 64, pp. 6542-6556. [ISSN 1549-9596], IF₂₀₂₃ = 5.7 (Q1), doi: 10.1021/acs.jcim.4c00809
PALLABOTHULA, V. S. K.; ABDALRAHMAN, N. T.; MORI, M.; FEKRI, A. H.; JANĎOUREK, O.; KONEČNÁ, K.; PATEROVÁ, P.; NOVÁK, M.; DUDÁŠOVÁ-HATOKOVÁ, P.; ŠTĚRBOVÁ-KOVAŘÍKOVÁ, P.; CASTELLANO, C.; MENEGHETTI, F.; VILLA, S.; KUNEŠ, J.; JUHÁS, M.; ZITKO, J. A hit expansion of 3-benzamidopyrazine-2-carboxamide: Toward inhibitors of prolyl-tRNA synthetase with antimycobacterial activity. Arch. Pharm., 2024, vol. 357, e2400171. [ISSN 0365-6233], IF₂₀₂₃ = 4.3 (Q2), doi: doi.org/10.1002/ardp.202400171
NAWROT, D.; AMBROŻKIEWICZ-MOSLER, W.; DOLEŽAL, M.; BOUZ, G. Antistaphylococcal discovery pipeline; where are we now? Eur. J. Med. Chem., 2024, vol. 266, 116077 [ISSN 0223-5234], IF₂₀₂₃ = 6.0 (Q1), doi: 10.1016/j.ejmech.2023.116077

2023

KERDA, M.; ŠLECHTA, P.; JAND'OUREK, O.; KONEČNÁ, K.; HATOKOVÁ, P.; PATEROVÁ, P.; ZITKO, J. N-Pyrazinylhydroxybenzamides as biologically active compounds: a hit-expansion study and antimicrobial evaluation. Future Med. Chem., 2023, vol. 15, no. 19, p. 1791-1806. [ISSN 1756-8927], IF₂₀₂₂= 4.2 (Q2), doi: 10.4155/fmc-2023-0189
NAWROT, D. E.; BOUZ, G.; JANĎOUREK, O.; KONEČNÁ, K.; PATEROVÁ, P.; BÁRTA, P.; NOVÁK, M.; KUČERA, R.; ZEMANOVÁ, J.; FORBAK, M.; KORDULÁKOVÁ, J.; PAVLIŠ, O.; KUBÍČKOVÁ, P.; DOLEŽAL, M.; ZITKO, J. Antimycobacterial pyridine carboxamides: From design to in vivo activity. Eur. J. Med. Chem., 2023, vol. 258, 115617. [ISSN 0223-5234], IF₂₀₂₂= 6.700 (Q1), doi: 10.1016/j.ejmech.2023.115617
ŠLECHTA, P., NEEDLE, A. A., JANĎOUREK, O., PATEROVÁ, P., KONEČNÁ, K., BÁRTA, P., KUNEŠ., J., KUBÍČEK, V., DOLEŽAL, M., and KUČEROVÁ-CHLUPÁČOVÁ, M.: Design, Synthesis, and Antimicrobial Evaluation of New N-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-6-yl)(hetero)aryl-2-carboxamides as Potential Inhibitors of Mycobacterial Leucyl-tRNA Synthetase, Int. J. Mol. Sci. 2023, vol. 24, no. 3, article no. 2951. [ISSN 1422-0067], IF₂₀₂₃ = 4.9 (Q1Q2), AIS₂₀₂₃ = 1.053 (Q2Q2), doi: 10.3390/ijms24032951
STEPANIĆ, V. andKUČEROVÁ-CHLUPÁČOVÁ, M.: Review and Chemoinformatic Analysis of Ferroptosis Modulators with a Focus on Natural Plant Products, Molecules, 2023, vol. 28, article no. 475. [ISSN 1420-3049], IF₂₀₂₃ = 4.2 (Q2Q2), AIS₂₀₂₃ = 0.676 (Q2Q3), doi: 10.3390/molecules28020475
BOUZ, G.; ŠLECHTA, P.; JAND’OUREK, O.; KONEČNÁ, K.; PATEROVÁ, P.; BÁRTA, P.; NOVÁK, M.; KUČERA, R.; DAL, N.-J. K.; FENAROLI, F.; ZEMANOVÁ, J.; FORBAK, M.; KORDULÁKOVÁ, J.; PAVLIŠ, O.; KUBÍČKOVÁ, P.; DOLEŽAL, M.; ZITKO, J. Hybridization Approach Toward Novel Antituberculars: Design, Synthesis, and Biological Evaluation of Compounds Combining Pyrazinamide and 4-Aminosalicylic Acid. ACS Infect. Dis., 2023, vol. 9, no. 1, p. 79-96. [ISSN 2373-8227], IF₂₀₂₁=5.578 (D1), doi: 10.1021/acsinfecdis.2c00433 Free Access Link (Valid for 50 downloads, for 1 year)
STEPANIĆ, V. and KUČEROVÁ-CHLUPÁČOVÁ, M. (Eds.): Redox Active Molecules in Cancer Treatments (reprint of the Special Issue Redox Active Molecules in Cancer Treatments that was published in Molecules), MDPI February 2023, pp. 298, ISBN 978-3-0365-6731-0 (hardback); ISBN 978-3-0365-6730-3 (PDF); https://doi.org/10.3390/books978-3-0365-6730-3

2022

PALLABOTHULA, V.S.K.; KERDA, M.; JUHÁS, M.; JANĎOUREK, O.; KONEČNÁ, K.; BÁRTA, P.; PATEROVÁ, P.; ZITKO, J. Adenosine-Mimicking Derivatives of 3-Aminopyrazine-2-Carboxamide: Towards Inhibitors of Prolyl-tRNA Synthetase with Antimycobacterial Activity. Biomolecules, 2022, vol. 12, article no. 1561. [ISSN 2218-273X], IF₂₀₂₁= 6.064, doi: 10.3390/biom12111561
KONEČNÁ, K.; DIEPOLTOVÁ, A.; HOLMANOVÁ, P.; JAND’OUREK, O.; VEJSOVÁ, M.; VOXOVÁ, B.; BÁRTA, P.; MAIXNEROVÁ, J.; TREJTNAR, F.; KUČEROVÁ-CHLUPÁČOVÁ. M. Comprehensive insight into anti-staphylococcal and anti-enterococcal action of brominated and chlorinated pyrazine-based chalcones. Front. Microbiol., 2022, vol. 13, article no. 912467. [ISSN 1664-302X], IF₂₀₂₂ = 5.2 (Q2), AIS₂₀₂₂ = 1.159 (Q2), https://doi.org/10.3389/fmicb.2022.912467
JUHÁS, M.; BACHTÍKOVÁ, A.; NAWROT, D.E.; HATOKOVÁ, P.; PALLABOTHULA, V.S.K.; DIEPOLTOVÁ, A.; JANĎOUREK, O.; BÁRTA, P.; KONEČNÁ, K.; PATEROVÁ, P.; ŠESTÁK, V.; ZITKO, J. Improving Antimicrobial Activity and Physico-Chemical Properties by Isosteric Replacement of 2-Aminothiazole with 2-Aminooxazole. Pharmaceuticals, 2022, vol. 15, article no. 580. [ISSN 1424-8247], IF₂₀₂₀= 5.863 (Q1Q1), doi: 10.3390/ph15050580
ZALEM, D.; JUHÁS, M.; TERRINONI, M.; KING-LYONS, N.; LEBENS, M.; VARROT, A.; CONNELL, T. D.; TENEBERG, S. Characterization of the ganglioside recognition profile of Escherichia coli heat-labile enterotoxin LT-IIc. Glycobiology, 2021. Accepted manuscript. ISSN [0959-6658], IF₂₀₂₀ = 4.313, doi: 10.1093/glycob/cwab133
JUHÁS, M.; PALLABOTHULA, V. S. K.; GRABRIJAN, K.; ŠIMOVIČOVÁ, M.; JANĎOUREK, O.; KONEČNÁ, K.; BÁRTA, P.; PATEROVÁ, P.; GOBEC, S.; SOSIČ, I.; ZITKO, J. Design, synthesis and biological evaluation of substituted 3-amino-N-(thiazol-2-yl)pyrazine-2-carboxamides as inhibitors of mycobacterial methionine aminopeptidase 1. Bioorg. Chem., 2022, vol. 118, article no. 105489. [ISSN 0045-2068], IF₂₀₂₀ = 5.275, doi: 10.1016/j.bioorg.2021.105489 Free Access link until Jan 20, 2022

2021

BOUZ, G.; DOLEŽAL, M. Advances in Antifungal Drug Development: An Up-To-Date Mini Review. Pharmaceuticals, 2021, vol. 14, article no.1312. [ISSN 1424-8247], IF₂₀₂₀ = 5.863 (Q1Q1), doi: 10.3390/ph14121312
BOUZ, G.; BOUZ, S.; JANĎOUREK, O.; KONEČNÁ, K.; BÁRTA, P.; VINŠOVÁ, J.; DOLEŽAL, M.; ZITKO, J. Synthesis, Biological Evaluation, and In Silico Modeling of N-Substituted Quinoxaline-2-Carboxamides. Pharmaceuticals, 2021, vol. 14, article no. 768. [ISSN 1424-8247], IF₂₀₂₀ = 5.863 (Q1Q1), doi: 10.3390/ph14080768
PANG, L.; WEEKS, S.D.; JUHÁS, M.; STRELKOV, S.V.; ZITKO, J.; VAN AERSCHOT, A. Towards Novel 3-Aminopyrazinamide-Based Prolyl-tRNA Synthetase Inhibitors: In Silico Modelling, Thermal Shift Assay and Structural Studies. Int. J. Mol. Sci., 2021, vol. 22, article no. 7793. [ISSN 1422-0067], IF₂₀₂₀ = 5.923 (Q1Q2), doi: 10.3390/ijms22157793
TENHUNEN, J.; KUČERA, T.; HUOVINEN, M.; KÜBLBECK, J.; BISENIEKS, E.; VIGANTE, B.; OGLE, Z.; DUBURS, G.; DOLEŽAL, M.; MOADDEL, R.; LAHTELA-KAKKONEN, M.; RAHNASTO-RILLA, M. Screening of SIRT6 modulators and activators: A novel activator has an impact on breast cancer cells. Biomed. Pharmacother., 2021, vol. 138, art. no. 111452. [ISSN 0753-3322], IF₂₀₂₀ = 6.529, JCR category rank: 15/186 (D1) in Medicine, Research & Experimental, 20/352 (Q1) in Pharmacology & Pharmacy, doi: 10.1016/j.biopha.2021.111452
BOUZ, G.; ZITKO J. Inhibitors of aminoacyl-tRNA synthetases as antimycobacterial compounds: An up-to-date review. Bioorg. Chem., 2021, vol. 110, article no. 104806. [ISSN 0045-2068], IF₂₀₂₀ = 5.275, doi: 10.1016/j.bioorg.2021.104806
NAWROT, D.; SUCHÁNKOVÁ, E.; JANĎOUREK, O.; KONEČNÁ, K.; BÁRTA, P.; DOLEŽAL, M.; ZITKO, J. N‐pyridinylbenzamides: an isosteric approach towards new antimycobacterial compounds. Chem. Biol. Drug. Des., 2021, vol. 97, p. 686–700. [ISSN 1747-0277], IF₂₀₂₀ = 2.817, doi: 10.1111/cbdd.13804

2020

KUCEROVA-CHLUPACOVA, M., HALAKOVA, D., MAJEKOVA, M., TREML, J., STEFEK, M., SOLTESOVA PRNOVA, M.: (4-Oxo-2-thioxothiazolidin-3-yl)acetic acids as potent and selective aldose reductase inhibitors. Chem.-Biol. Interact. 2020, vol. 332, 109286. [ISSN 0009-2797], IF₂₀₂₀ = 5.192 (Q1Q1Q2), AIS₂₀₂₀ = 0.727 (Q2Q2Q3), doi: 10.1016/j.cbi.2020.109286
KAPKOWSKI, M.; LUDYNIA, M.; RUDNICKA, M.; DZIDA, M.; ZORĘBSKI, E.; MUSIAŁ, M.; DOLEŽAL, M.; POLANSKI, J. Enhancing the CO₂ capturing ability in leaf via xenobiotic auxin uptake. Science of the Total Environment, 2020, vol. 745, article no. 141032. [ISSN 0048-9697], IF₂₀₂₀ = 7.963, (Q1) in ‚Environmental Chemistry‘, doi: 10.1016/j.scitotenv.2020.141032
JUHÁS, M.; ZITKO, J. Molecular Interactions of Pyrazine-based Compounds to Proteins. J. Med. Chem. 2020, vol. 63, no. 17, p. 8901–8916. [ISSN 0022-2623], IF₂₀₂₀ = 7.446 (D1), doi: 10.1021/acs.jmedchem.9b02021
AMBROŻKIEWICZ, W.; KUČEROVÁ-CHLUPÁČOVÁ, M.; JANĎOUREK, O.; KONEČNÁ, K.; PATEROVÁ, P.; BÁRTA, P.; VINŠOVÁ, J.; DOLEŽAL, M.; ZITKO, J. 5-Alkylamino-N-phenylpyrazine-2-carboxamides: Design, Preparation, and Antimycobacterial Evaluation. Molecules, 2020, vol. 25, article no. 1561. [ISSN 1420-3049], IF₂₀₂₀ = 4.412 (Q2Q2), AIS₂₀₂₀ = 0.694 (Q2Q3), doi: 10.3390/molecules25071561
JUHÁS, M.; KUČEROVÁ, L.; HORÁČEK, O.; JANĎOUREK, O.; KUBÍČEK, V.; KONEČNÁ, K.; KUČERA, R.; BÁRTA, P.; JANOUŠEK, J.; PATEROVÁ, P.; KUNEŠ, J.; DOLEŽAL, M.; ZITKO, J. N-Pyrazinoyl Substituted Amino Acids as Potential Antimycobacterial Agents—The Synthesis and Biological Evaluation of Enantiomers. Molecules, 2020, vol. 25, article no. 1518. [ISSN 1420-3049], IF₂₀₂₀ = 4.411 (Q2Q2), doi: 10.3390/molecules25071518
BOUZ, G.; JUHÁS, M.; PAUSAS OTERO, L.; PAREDES DE LA RED, C.; JANĎOUREK, O.; KONEČNÁ, K.; PATEROVÁ, P.; KUBÍČEK, V.; JANOUŠEK, J.; DOLEŽAL, M.; ZITKO, J. Substituted N-(pyrazin-2-yl)benzenesulfonamides; Synthesis, Anti-infective Evaluation, Cytotoxicity, and In silico Studies. Molecules, 2020, vol. 25, no. 1, article no. 138. [ISSN 1420-3049], IF₂₀₂₀ = 4.411 (Q2Q2), doi: 10.3390/molecules25010138
BEEGUM, S.; MARY, Y. S.; MARY, Y. S.; THOMAS, R.; ARMAKOVIĆ, S.; ARMAKOVIĆ, S. J.; ZITKO, J.; DOLEŽAL, M.; VAN ALSENOY, C. Exploring the detailed spectroscopic characteristics, chemical and biological activity of two cyanopyrazine-2-derivatives using experimental and theoretical tools. Spectrochim. Acta Part A: Mol. Biomol. Spectr., 2020, vol. 224, art. no. 117414. [ISSN 1386-1425], IF₂₀₂₀ = 4.098, doi: 10.1016/j.saa.2019.117414

2019

KAPKOWSKI, M.; LUDYNIA, M.; POLAŃSKI, J.; RUDNICKA, M.; DZIDA, M.; BALIN, K.; DOLEŽAL, M.; KASTNER, P. Kompozycja poprawiająca penetrację substancji biologicznie aktywnych przez powierzchnie organów roślinnych. Zgloszenie patentowe, P.430248; 02-07-2019 PDF
KAPKOWSKI, M.; LUDYNIA, M.; POLAŃSKI, J.; RUDNICKA, M.; DZIDA, M.; BALIN, K.; DOLEŽAL, M.; KASTNER, P. Směs usnadňující penetraci biologicky aktivních látek povrchem do rostlinných orgánů. Přihláška českého patentu PV 2019-614; 02-10-2019 PDF
STEPANIĆ, V., MATIJAŠIĆ, M., HORVAT, T., VERBENAC, D., KUČEROVÁ-CHLUPÁČOVÁ, M., SASO, L., ŽARKOVIĆ, N.: Antioxidant Activities of Alkyl Substituted Pyrazine Derivatives of Chalcones— In Vitro and In Silico Study. Antioxidants, 2019, vol. 8, no. 4, article no. 90. [ISSN 2076-3921], IF₂₀₁₉ = 5.014 (Q1Q2Q2) doi:10.3390/antiox8040090;
BOUZ, G.; SEMELKOVÁ, L.; JANĎOUREK, O.; KONEČNÁ, K.; PATEROVÁ, P.; NAVRÁTILOVÁ, L.; KUBÍČEK, V.; KUNEŠ, J.; DOLEŽAL, M.; ZITKO, J. Derivatives of 3-Aminopyrazine-2-carboxamides: Synthesis, Antimicrobial Evaluation, and in Vitro Cytotoxicity. Molecules, 2019, vol. 24, no. 7, article no. 1212. [ISSN 1420-3049], IF₂₀₁₉ = 3.267, doi: 10.3390/molecules24071212

2018

BOUZ, G. The zebrafish model of tuberculosis - no lungs needed. Critical Reviews in Microbiology, 2018, vol. 44, no.6, pp 779-792. [ISSN 1040-841X], IF₂₀₁₈: 5.697 (Q1), doi: 10.1080/1040841X.2018.1523132
ZITKO, J.; MINDLOVÁ, A.; VALÁŠEK, O.; JANĎOUREK, O.; PATEROVÁ, P.; JANOUŠEK, J.; KONEČNÁ, K.; DOLEŽAL, M. Design, Synthesis and Evaluation of N-pyrazinylbenzamides as Potential Antimycobacterial Agents. Molecules, 2018, vol. 23, no. 9, article no. 2390. [ISSN 1420-3049], IF₂₀₁₇ = 3.098, doi: 10.3390/molecules23092390
ZITKO, J.; JANĎOUREK, O.; PATEROVÁ, P.; NAVRÁTILOVÁ, L.; KUNEŠ, J.; VINŠOVÁ, J.; DOLEŽAL, M. Design, synthesis and antimycobacterial activity of hybrid molecules combining pyrazinamide with 4-phenylthiazol-2-amine scaffold. MedChemComm, 2018, vol. 9, p. 685–696. [ISSN 2040-2503], IF₂₀₁₆: 2.608, doi: 10.1039/C8MD00056E
ZITKO, J.; DOLEŽAL, M. Old Drugs and New Targets as an Outlook for the Treatment of Tuberculosis. Curr. Med. Chem., 2018, vol. 25, No. 38, p. 5142–5167. [ISSN 1875-533X], IF₂₀₁₇: 3.469, doi: 10.2174/0929867324666170920154325
KUCEROVA-CHLUPACOVA, M.; DOSEDEL, M.; KUNES, J.; SOLTESOVA-PRNOVA, M.; MAJEKOVA, M.; STEFEK, M.: Chalcones and their pyrazine analogs: synthesis, inhibition of aldose reductase, antioxidant activity, and molecular docking study. Mon. Chem. 2018, vol. 149, No. 5, p. 921–929. [ISSN 0026-9247], IF₂₀₁₈ = 1.501 (Q3), AIS₂₀₁₈ = 0.209 (Q3), doi: 10.1007/s00706-018-2146-6

2017

MUCAJI, P.; ATANASOV, A. G.; BAK, A.; KOZIK, V.; SIERON, K.; OLSEN, M.; PAN, W.; LIU, Y.; HU, S.; LAN, J.; HAIDER, N.; MUSIOL, R.; VANCO, J.; DIEDERICH, M.; JI, S.; ZITKO, J. The Forty-Sixth Euro Congress on Drug Synthesis and Analysis: Snapshot †. Molecules, 2017, vol. 22, no. 11, article no. 1848. [ISSN 1420-3049], IF₂₀₁₆ = 2.861, doi:10.3390/molecules22111848
BOUZ, G.; JUHÁS, M.; NIKLOVÁ, P.; JANĎOUREK, O.; PATEROVÁ, P.; JANOUŠEK, J.; TŮMOVÁ, L.; KOVALÍKOVÁ, Z.; KASTNER, P.; DOLEŽAL, M.; ZITKO, J. Ureidopyrazine Derivatives: Synthesis and Biological Evaluation as Anti-Infectives and Abiotic Elicitors. Molecules, 2017, vol. 22, no. 10, article no. 1797. [ISSN 1420-3049], IF₂₀₁₆ = 2.861, doi: 10.3390/molecules22101797
SEMELKOVÁ, L.; JANOŠCOVÁ, P.; FERNANDES, C.; BOUZ, G.; JANĎOUREK, O.; KONEČNÁ, K.; PATEROVÁ, P.; NAVRÁTILOVÁ, L.; KUNEŠ, J.; DOLEŽAL, M.; ZITKO, J. Design, Synthesis, Antimycobacterial Evaluation, and In Silico Studies of 3-(Phenylcarbamoyl)-pyrazine-2-carboxylic Acids. Molecules, 2017, vol. 22, no. 9, Article No. 1491. [ISSN 1420-3049], IF₂₀₁₆ = 2.861, doi: 10.3390/molecules22091491
JOSEPH, T.; VARGHESE, H. T.; PANICKER, C. Y.; VISWANATHAN, K.; DOLEŽAL, M.; ALSENOY, C. V. Spectroscopic (FT-IR, FT-Raman), first order hyperpolarizability, NBO analysis, HOMO and LUMO analysis of N-[(4-(trifluoromethyl)phenyl]pyrazine-2-carboxamide by density functional methods. Arab. J. Chem., 2017, vol. 10, no. S2, p. S2281–S2294. [ISSN 1878-5352], IF₂₀₁₆ = 4.553, doi: 10.1016/j.arabjc.2013.08.004
SEMELKOVÁ, L.; JANĎOUREK, O.; KONEČNÁ, K.; PATEROVÁ, P.; NAVRÁTILOVÁ, L.; TREJTNAR, F.; KUBÍČEK, V.; KUNEŠ, J.; DOLEŽAL, M.; ZITKO, J. 3-Substituted N-Benzylpyrazine-2-carboxamide Derivatives: Synthesis, Antimycobacterial and Antibacterial Evaluation. Molecules, 2017, vol. 22, no. 3, Article No. 495. [ISSN 1420-3049] IF₂₀₁₅ = 2.465, doi:10.3390/molecules22030495
JANDOUREK, O.; TAUCHMAN, M.; PATEROVA, P.; KONECNA, K.; NAVRATILOVA, L.; KUBICEK, V.; HOLAS, O.; ZITKO, J.; DOLEZAL, M. Synthesis of Novel Pyrazinamide Derivatives Based on 3-Chloropyrazine-2-carboxamide and Their Antimicrobial Evaluation. Molecules, 2017, vol. 22, no. 2, Article No. 223. [ISSN 1420-3049] IF₂₀₁₅ = 2.465, doi: 10.3390/molecules22020223
P.K. RANJITH, ; EBTEHAL S. AL-ABDULLAH, FATMAH A.M. AL-OMARY, ALI A. EL-EMAM, P.L. ANTO, MARY Y. SHEENA, STEVAN ARMAKOVIĆ, SANJA J. ARMAKOVIĆ, JAN ZITKO, MARTIN DOLEZAL, C. VAN ALSENOY. FT-IR and FT-Raman characterization and investigation of reactive properties of N-(3-iodo-4-methylphenyl)pyrazine-2-carboxamide by molecular dynamics simulations and DFT calculations. J. Mol. Struct., 2017, vol. 1136, p. 14–24. [ISSN 0022-2860] IF₂₀₁₅ = 1.780, doi: 10.1016/j.molstruc.2017.01.079
BEEGUM, S.; MARY, Y. S.; VARGHESE, H. T.; PANICKER, C. Y.; ARMAKOVIĆ, S.; ARMAKOVIĆ, S. J.; ZITKO, J.; DOLEŽAL, M.; VAN ALSENOY, C. Vibrational spectroscopic analysis of cyanopyrazine-2-carboxamide derivatives and investigation of their reactive properties by DFT calculations and molecular dynamics simulations. J. Mol. Struct., 2017, vol. 1131, p. 1–15. [ISSN 0022-2860] IF₂₀₁₅ = 1.780, doi: 10.1016/j.molstruc.2016.11.044

2016

Sebastian, S. H. R.; Al-Alshaikh, M. A.; El-Emam, A. A.; SHEENA MARY, Y.; Panicker, C. Y.; JOJO, P. J.; Zitko, J.; Doležal, m. Synthesis, spectroscopic investigations, quantum chemical studies, molecular docking and antiviral activity of 5-chloro-N-(2-chlorophenyl)pyrazine-2-carboxamide. Sci. Adv. Today, 2016, vol. 2, art. no. 25239. [ISSN 2455-2321], https://fac.ksu.edu.sa/sites/default/files/synthesis_spectroscopic_investigations_quantum.pdf
ZITKO, J.; DOLEŽAL, M. Enoyl acyl carrier protein reductase inhibitors: an updated patent review (2011 – 2015). Exp. Opin. Ther. Pat., 2016, vol. 26, p. 1079-1094. [ISSN 1354-3776 (Print)], [ISSN 1744-7674 (Online)]. IF₂₀₁₅: 4.626. doi: 10.1080/13543776.2016.1211112.
OPLETALOVA, V.; DOLEZEL, J.; KUNES, J.; BUCHTA, V.; VEJSOVA, M.; KUCEROVA-CHLUPACOVA, M.: Synthesis and Antifungal Screening of 2-{[1-(5-Alkyl/arylalkylpyrazin-2-yl)ethylidene]hydrazono}-1,3-thiazolidin-4-ones. Molecules 2016, vol. 21, no. 11, p. 1592. [ISSN 1420-3049] IF₂₀₁₆ = 2.861 (Q2), AIS₂₀₁₆ = 0.628 (Q2), doi:10.3390/molecules21111592
KUCEROVA-CHLUPACOVA, M.; VYSKOVSKA-TYLLOVA, V.; RICHTEROVA-FINKOVA, L.; KUNES, J.; BUCHTA, V.; VEJSOVA, M.; PATEROVA, P.; SEMELKOVA, L.; JANDOUREK, O.; OPLETALOVA, V.: Novel Halogenated Pyrazine-Based Chalcones as Potential Antimicrobial Drugs. Molecules 2016, vol. 21, no. 11, p. 1421. [ISSN 1420-3049], IF₂₀₁₆ = 2.861 (Q2), AIS₂₀₁₆ = 0.628 (Q2), doi: 10.3390/molecules21111421
DOLEŽAL, M.; ZITKO, J.; JANĎOUREK, O.; SERVUSOVÁ-VAŇÁSKOVÁ B. Substituted 2-(2-phenylhydrazinyl)pyrazine, process for its preparation, its use and a pharmaceutical composition containing the same. WO 2016/095877 A1 (PCT/CZ2015/000127).
DOLEŽAL, M.; ZITKO, J.; JANĎOUREK, O.; SERVUSOVÁ-VAŇÁSKOVÁ B. Substituovaný 2-(2-fenylhydrazinyl)pyrazin, způsob jeho přípravy, jeho použití a farmaceutický přípravek ho obsahující. PV 2014-925.
SEBASTIAN, S. H. R.; AL-ALSHAIKH, M. A.; EL-EMAM, A. A.; PANICKER, C. Y.; ZITKO, J.; DOLEZAL, M.; VAN ALSENOY, C. Spectroscopic, quantum chemical studies, Fukui functions, in vitro antiviral activity and molecular docking of 5-chloro-N-(3-nitrophenyl)pyrazine-2-carboxamide. J. Mol. Struct., 2016, vol. 1119, p. 188–199. [ISSN 0022-2860] IF₂₀₁₅ = 1.780, doi: 10.1016/j.molstruc.2016.04.088
HROCH, L.; BENEK, O.; GUEST, P.; AITKEN, L.; SOUKUP, O.; JANOČKOVÁ, J.; MUSIL, K.; DOHNAL, V.; DOLEŽAL, R.; KUČA, K.; SMITH, T. K.; GUNN-MOORE, F.; MUSÍLEK, K. Design, synthesis and in vitro evaluation of benzothiazole-based ureas as potential ABAD/17β-HSD10 modulators for Alzheimer’s disease treatment. Bioorg. Med. Chem. Lett., 2016, vol. 26, p. 3675–3678. [ISSN 0960-894X]. IF₂₀₁₅ = 2.486, doi: 10.1016/j.bmcl.2016.05.087
TŮMOVÁ, L.; TŮMA, J.; DOLEŽAL, M.; DUČAIOVÁ, Z.; KUBEŠ J. New Synthetic Pyrazinecarboxamide Derivatives as Potential Elicitors in Production of Secondary Metabolite in In vitro Cultures. Pharmacogn. Mag., 2016, vol. 12, no. 45, Suppl. 1, p. 57–62. [ISSN 0976-4062], IF₂₀₁₄ = 1.256, doi: 10.4103/0973-1296.176117
ZITKO, J.; SERVUSOVA-VANASKOVA, B.; PATEROVA, P.; NAVRATILOVA, L.; TREJTNAR, F.; KUNES, J.; DOLEZAL, M. Design, Synthesis and Antimycobacterial Evaluation of Some New N-Phenylpyrazine-2-Carboxamides. Chem. Pap., 2016, vol. 70, no. 5, p. 649–657. [ISSN (Online) 1336-9075], [ISSN (Print) 0366-6352], IF₂₀₁₄ = 1.468. doi: 10.1515/chempap-2015-0246

2015

ZITKO, J.; DOLEŽAL, M. Indole-carboxamide derivatives: a patent evaluation of WO2015036412A1. Exp. Opin. Ther. Pat., 2015, vol. 25, p. 1487–1494. [ISSN 1354-3776]. IF₂₀₁₄ = 4.297. doi: 10.1517/13543776.2015.1101066
HIRSOVA, P.; DOLEZEL, J.; KUCEROVA-CHLUPACOVA, M.; KUNES, J.; PILAROVA, V.; NOVAKOVA, L.; OPLETALOVA, V. (Z)-3-Amino-5-(pyridin-2-ylmethylidene)-2-thioxo-1,3-thiazolidin-4-one. Molbank, 2015, vol. 2015, M872. [ISSN 1422-8599]. doi: 10.3390/M872
MAREK, J.; MALIŇÁK, D.; DOLEŽAL, R.; SOUKUP, O.; PASDIOROVÁ, M.; DOLEŽAL, M.; KUČA, K. Synthesis and disinfection effect of the pyridine-4-aldoxime based salts. Molecules, 2015, vol. 20, no. 3, p. 3681-3696. [ISSN 1420-3049], IF₂₀₁₄ = 2.095; doi: 10.3390/molecules20033681
RESMI, K. S.; PANICKER, C. Y.; ZITKO, J.; DOLEZAL, M.; WAR, J.A.; SRIVASTAVA, S. K.; VAN ALSENOY, C. FT-IR, FT-Raman, NBO, HOMO-LUMO analysis and molecular docking study of 5-chloro-N-(2-fluorophenyl)pyrazine-2-carboxamide. Sci. Lett., 2015, vol. 4, p. 216. [ISSN 2454–7239].
SERVUSOVA-VANASKOVA, B.; JANDOUREK, O.; PATEROVA, P.; KORDULAKOVA, J.; PLEVAKOVA, M.; KUBICEK, V.; KUCERA, R.; GARAJ, V.; NAESENS, L.; KUNES, J.; DOLEZAL, M.; ZITKO, J. Alkylamino derivatives of N-benzylpyrazine-2-carboxamide: Synthesis and antimycobacterial evaluation. MedChemComm, 2015, vol. 6, p. 1311–1317. [ISSN 2040-2503], IF₂₀₁₃ = 2.626. doi: 10.1039/C5MD00178A
SEMELKOVA, L.; KONECNA, K.; PATEROVA, P.; KUBICEK, V.; KUNES, J.; NOVAKOVA, L.; MAREK, J.; NAESENS, L.; PESKO, M.; KRALOVA, K.; DOLEZAL, M.; ZITKO, J. Synthesis and Biological Evaluation of N-Alkyl-3-(alkylamino)-pyrazine-2-carboxamides. Molecules, 2015, vol. 20, p. 8687–8711. [ISSN 1420-3049], IF₂₀₁₃ = 2.095. doi: 10.3390/molecules20058687
ZITKO, J.; FRANCO, F.; PATEROVÁ, P. Synthesis and anti-infective evaluation of 5-amino-N-phenylpyrazine-2-carboxamides. Čes. Slov. Farm., 2015, vol. 64, p. 19–24. [ISSN 1210-7816].
JANĎOUREK, O.; KUNEŠ, J.; DOLEŽAL, M.; Microwave-Assisted Synthesis of Pyrazinamide Derivatives: the Coupling Reaction of 3-Chloropyrazine-2-Carboxamide and Ring-Substituted Anilines. Curr. Org. Synthesis, 2015, vol. 12, no. 2, p. 189–196. [ISSN 1875-6271], IF₂₀₁₄ = 2.117. doi: 10.2174/1570179411999141106101501
HOLAS, O.; SLOVÁK, F.; DOLEŽAL, M. Computational approach to search for novel antituberculotics. Čes. Slov. Farm., 2015, vol. 64, no. 1-2, p. 32–33. [ISSN 1803-6597].
SERVUSOVÁ-VAŇÁSKOVÁ, B.; PATEROVÁ P.; GARAJ, V.; MANDÍKOVA, J.; KUNEŠ J.; NAESENS, L.; JÍLEK, P.; DOLEŽAL, M.; ZITKO, J. Synthesis and antimicrobial evaluation of 6-alkylamino-N-phenyl-pyrazine-2-carboxamides. Chem. Biol. Drug Des., 2015, vol. 86, p. 674–681. [ISSN 1747-0285]. IF₂₀₁₃= 2.507. doi: 10.1111/cbdd.12536
KUCEROVA-CHLUPACOVA, M.; KUNES, J.; BUCHTA, V.; VEJSOVA, M.; OPLETALOVA, V. Novel Pyrazine Analogs of Chalcones: Synthesis and Evaluation of Their Antifungal and Antimycobacterial Activity. Molecules, 2015, vol. 20, p. 1104–1117. [ISSN 1420-3049], IF₂₀₁₅ = 2.465 (Q2), AIS₂₀₁₅ = 0.579 (Q2), doi: 10.3390/molecules20011104.
HROCH, L.; AITKEN, L.; BENEK, O.; DOLEŽAL, M.; KUČA, K.; GUNN-MOORE, F.; MUSÍLEK, K. Benzothiazoles - Scaffold of Interest for CNS Targeted Drugs. Curr. Med. Chem., 2015, vol. 22, in press. [0929-8673], IF₂₀₁₃ = 3.715. doi: 10.2174/0929867322666141212120631
ZITKO, J.; SERVUSOVÁ, B.; JANOUTOVÁ, A.; PATEROVÁ, P.; MANDÍKOVÁ, J.; GARAJ, V.; VEJSOVÁ, M.; MAREK, J.; DOLEŽAL, M. Synthesis and antimycobacterial evaluation of 5-alkylamino-N-phenylpyrazine-2-carboxamides. Bioorg. Med. Chem., 2015, vol. 23, p. 174–183. [ISSN 0968-0896], IF₂₀₁₃ = 2.951. doi: 10.1016/j.bmc.2014.11.014
BHAGYASREE, J. B.; VARGHESE, H. T.; PANICKER, C. Y.; VAN ALSENOY, C.; AL-SAADI, A. A.; DOLEZAL, M.; SAMUEL, J. Spectroscopic (FT-IR, FT-Raman), first order hyperpolarizability, NBO analysis, HOMO and LUMO analysis of 5-tert-Butyl-6-chloro-N-[(4-(trifluoromethyl)phenyl]pyrazine-2-carboxamide. Spectrochim. Acta Part A: Mol. Biomol. Spectr., 2015, vol. 137, p. 193–206. [ISSN 1386-1425]. doi: 10.1016/j.saa, IF₂₀₁₃ = 2.129
DOLEŽAL, M.; ZITKO, J. Pyrazine Derivatives: a patent review (June 2012-present). Exp. Opin. Ther. Pat., 2015, vol. 25, p. 33–47. [ISSN 1354-3776]. IF₂₀₁₃ = 3.441. doi: 10.1517/13543776.2014.982533
HOLAS, O.; ONDREJČEK, P.; DOLEŽAL, M. Recent progress in discovery of novel Mycobacterium tuberculosis enoyl-ACP reductase inhibitors. J. Enzym. Inhib. Med. Chem., 2015, vol. 30, p. 629-648. [ISSN 1475-6366] doi: 10.3109/14756366.2014.959512, IF₂₀₁₃ = 2.383

2014

OPLETALOVÁ, V.; DOLEŽEL, J.; BUCHTA, V.; VEJSOVÁ, P. PATEROVÁ. Antifungal effects of (5Z)-5-arylmethylidenerhodanines with special view to the members of Mucorales. Folia Pharm. Univ. Carol. 2014, vol. 42, p. 7–13. [ISSN 1210-9495]
NEPOVIMOVA, E.; ULIASSI, E.; KORABECNY, J.; PENA-ALTAMIRA, L. E.; SAMEZ, S.; PESARESI, A.; GARCIA, G. E.; BARTOLINI, M.; ANDRISANO, V.; BERGAMINI, C.; FATO, R.; LAMBA, D.; ROBERTI, M.; KUCA, K.; MONTI, B.; BOLOGNESI, M. L. Multitarget Drug Design Strategy: Quinone-Tacrine Hybrids Designed To Block Amyloid-β Aggregation and To Exert Anticholinesterase and Antioxidant Effects. J. Med. Chem. 2014, vol. 57, p. 8576–8589. [ISSN 0022-2623]; doi:10.1021/jm5010804; IF₂₀₁₃ = 5.480
MALINAK, D.; DOLEZAL, R.; MAREK, J.; SALAJKOVA, S.; SOUKUP, O.; VEJSOVA, M.; KORABECNY, J.; HONEGR, J.; PENHAKER, M.; MUSILEK, K.; KUCA, K., 6-Hydroxyquinolinium salts differing in the length of alkyl side-chain: Synthesis and antimicrobial activity. Bioorg. Med. Chem. Lett., 2014, vol. 24, p. 5238––5241. [ISSN 0960-894X] IF₂₀₁₂ = 2.338, doi: 10.1016/j.bmcl.2014.09.060
HAMULAKOVÁ, S.; IMRICH, J.; JANOVEC, L.; KRISTIAN, P.; DANIHEL, I.; HOLAS, O.; POHANKA, M.; BÖHM, S.; KOZURKOVÁ, M.; KUČA K. Tacrine/acridine anticholinesterase inhibitors with piperazine and thiourea linkers. Int. J. Biol. Macromol., 2014, vol. 7, p. 435–439. IF₂₀₁₃ = 2.60. doi: 10.1016/j.ijbiomac.2014.06.064
JANĎOUREK, O.; DOLEŽAL, M.; KUNEŠ, J.; KUBÍČEK, V.; PATEROVÁ, P.; PEŠKO, M.; BUCHTA, V.; KRÁĽOVÁ, K.; ZITKO, J. New potentially active pyrazinamide derivatives synthesized under microwave conditions. Molecules, 2014, vol. 19, p. 9318–9338. [ISSN 1420-3049], IF₂₀₁₃ = 2.095. doi: 10.3390/molecules19079318
KORABECNY, J.; DOLEZAL, R.; CABELOVA, P.; HOROVA, A.; HRUBA, E.; RICNY, J.; SEDLACEK, L.; NEPOVIMOVA, E.; SPILOVSKA, K.; ANDRS, M.; MUSILEK, K.; OPLETALOVA, V.; SEPSOVA, V.; RIPOVA, D.; KUCA, K. 7-MEOTA-donepezil like compounds as cholinesterase inhibitors: Synthesis, pharmacological evaluation, molecular modeling and QSAR studies. Eur. J. Med. Chem., 2014, vol. 82, p. 426–438. [ISSN 0223-5234], IF₂₀₁₂ = 3.849. DOI: 10.1016/j.ejmech.2014.05.066
KORABECNY, J.; SOUKUP, O.; DOLEZAL, R.; SPILOVSKA, K.; NEPOVIMOVA, E.; ANDRS, M.; NGUYEN, T. D.; JUN, D.; MUSILEK, K.; KUCEROVA-CHLUPACOVA, M.; KUCA, K. From Pyridinium-based to Centrally Active Acetylcholinesterase Reactivators. Mini Rev. Med. Chem., 2014, vol. 14, p. 215–221. [ISSN 1389-5575], IF₂₀₁₄ = 2.903 (Q2), AIS₂₀₁₄ = 0.690 (Q2), DOI: 10.2174/1389557514666140219103138
JANĎOUREK, O.; DOLEŽAL, M.; PATEROVÁ, P.; KUBÍČEK, V.; PEŠKO, M.; KUNEŠ, J.; COFFEY, A.; GUO, J.; KRÁĽOVÁ, K. N-Substituted 5-amino-6-methylpyrazine-2,3-dicarbonitriles: Microwave-assisted synthesis and biological properties. Molecules, 2014, vol. 19, no. 1, p. 651–671. [ISSN 1420-3049], IF₂₀₁₃ = 2.095, doi: 10.3390/molecules19010651
SERVUSOVÁ, B.; MANDÍKOVÁ, J.; PATEROVÁ, P.; KUBÍČEK, V.; KUČERA, R.; DOLEŽAL, M.; ZITKO, J. Alkylamino derivatives of pyrazinamide: Synthesis and antimycobacterial evaluation. Bioorg. Med. Chem. Lett., 2014, vol. 24, no. 2, p. 450–453. [ISSN 0960-894X] IF₂₀₁₂ = 2.338, doi: 10.1016/j.bmcl.2013.12.054

2013

JOSEPH, T.; VARGHESE, H. T.; PANICKER, C. Y.; VISWANATHAN, K.; DOLEŽAL, M.; MANOJKUMAR, T. K.; VAN ALSENOY, C. Vibrational spectroscopic (FT-IR, FT-Raman) investigations and computational study of N-(4-trifluoromethylphenyl)pyrazine-2-carboxamide. Spectrochim. Acta Part A, 2013, vol. 113, p. 203–214. [ISSN 1386-1425], IF₂₀₁₁ = 2.098
SPILOVSKA, K.; KORABECNY, J.; KRAL, J.; HOROVA, A.; MUSILEK, K.; SOUKUP, O.; DRTINOVA, L.; GAZOVA, Z.; SIPOSOVA, K.; KUCA, K. 7-Methoxytacrine-Adamantylamine Heterodimers as Cholinesterase Inhibitors in Alzheimer’s Disease Treatment - Synthesis, Biological Evaluation and Molecular Modeling Studies. Molecules, 2013, vol. 18, no. 2, p. 2397–2418. [ISSN 1420-3049], IF₂₀₁₂ = 2.428. doi:10.3390/molecules18022397
KOMLÓOVÁ, M.; HOROVÁ, A.; HRABINOVÁ, M.; JUN, D.; DOLEŽAL, M.; VINŠOVÁ, J.; KUČA, K.; MUSÍLEK, K. Preparation, in vitro evaluation and molecular modelling of pyridinium-quinolinium/isoquinolinium non-symmetrical bisquaternary acetylcholinesterase inhibitors. Bioorg. Med. Chem. Lett., 2013, vol. 23, no. 24, p. 6663–6666. [ISSN 0960-894X] IF₂₀₁₂= 2.338, doi: http://dx.doi.org/10.1016/j.bmcl.2013.10.043
ZITKO, J.; SERVUSOVÁ, B.; PATEROVÁ, P.; MANDÍKOVÁ, J.; KUBÍČEK, V.; KUČERA, R.; HRABCOVÁ, V.; KUNEŠ, J.; SOUKUP, O.; DOLEŽAL, M. Synthesis, Antimycobacterial Activity and in Vitro Cytotoxicity of 5-Chloro-N-phenylpyrazine-2-carboxamides. Molecules, 2013, vol. 18, no. 12, p. 14807–14825. [ISSN 1420-3049], IF₂₀₁₂ = 2.428, doi: 10.3390/molecules181214807
Singh, N.; Karpichev, Y.; Gupta, B.; Satnami, M. L.; Marek, J.; Kuča, K.; Ghosh, K. K. Physicochemical Properties and Supernucleophilicity of Oxime Functionalized Surfactants: Hydrolytic Catalysts towards Dephosphorylation of Di- and Tri-phosphate Esters. J. Phys. Chem. B, 2013, vol. 117, no. 14, p. 3806–3817. [ISSN 1520-6106], IF₂₀₁₁= 3.696, DOI: 10.1021/jp310010q
Doležal, M.; Vobicková, J.; Servusová, B.; Paterová, P. Aminopyrazinoic acid esters as potential antimycobacterial drugs. Česk. Slov. Farm., 2013, vol. 62, no. 2, p. 84–88. [ISSN 1803-6597]
ZITKO, J.; PATEROVÁ, P.; KUBÍČEK, V.; MANDÍKOVÁ, J.; TREJTNAR, F.; KUNEŠ, J.; DOLEŽAL, M. Synthesis and antimycobacterial evaluation of pyrazinamide derivatives with benzylamino substitution. Bioorg. Med. Chem. Lett., 2013, vol. 23, no. 2, p. 476–479. [ISSN: 0960-894X], http://dx.doi.org/10.1016/j.bmcl.2012.11.052, IF₂₀₁₁= 2.554
SERVUSOVÁ, B.; VOBICKOVÁ, J.; PATEROVÁ, P.; KUBÍČEK, V.; KUNEŠ, J.; DOLEŽAL, M.; ZITKO, J. Synthesis and antimycobacterial evaluation of N-substituted 5-chloropyrazine-2-carboxamides. Bioorg. Med. Chem. Lett., 2013, vol. 23, 3589–3591. [ISSN 0960-894X], DOI: 10.1016/j.bmcl.2013.04.021. IF = 2.554
OPLETALOVÁ V.; DOLEŽEL, J. Thiosemicarbazones and their antimycobacterial effects. Česk. Slov. Farm. 2013, vol. 62, 78–83. [ISSN 1803-6597]
OPLETALOVÁ, V.; KASTNER, P.; KUČEROVÁ-CHLUPÁČOVÁ, M.; PALÁT, K. jr. Study of hydrophobic properties of biologically active open analogues of flavonoids. J. Mol. Graph. Model. 2013, 39, 61–64. [ISSN 1093-3263], IF₂₀₁₃ 2.022 (Q1Q2Q2Q3Q3), AIS₂₀₁₃ = 0.466 (Q2Q3Q3Q4Q4), http://doi.org/10.1016/j.jmgm.2012.07.009,

2012

SERVUSOVA, B.; EIBINOVA, D.; DOLEZAL, M.; KUBICEK, V.; PATEROVA, P.; PESKO, M.; KRALOVA, K. Substituted N-Benzylpyrazine-2-carboxamides: Synthesis and Biological Evaluation. Molecules, 2012, vol. 17, no. 11, p. 13183–13198. [ISSN 1420-3049], IF₂₀₁₁ = 2.386. doi: 10.3390/molecules171113183
HOLAS, O.; MUSÍLEK, K.; POHANKA, M.; KUČA, K. The progress in the cholinesterase quantification methods. Exp. Opin. Drug Discov., 2012, vol. 7, no. 12, p. 1207–1223. [ISSN 1746-0441], DOI:10.1517/17460441.2012.729037, IF₂₀₁₁ = 2.116
HERICH, P.; KAMENÍČEK, J.; POHANKA, M.; HOLAS, O.; KOŽÍŠEK, J.; DLHÁŇ, L.; KUČA, K. Planar Ni(II) 1,2-dithiolenes involving tridentate P-donor ligands. J. Coordin. Chem., 2012, vol. 65, no. 1, p. 156–164. [ISSN 0095-8972], DOI:10.1080/00958972.2011.644543, IF₂₀₁₁ = 1.547
MUSÍLEK, K.; KOMLÓOVÁ, M.; HOLAS, O.; HOROVÁ, A.; ŽĎÁROVÁ-KARASOVÁ, J.; KUČA, K. Myasthenia Gravis – Current Treatment Standards and Emerging Drugs, Chapter 3, p. 23–42. In „A Look into Myasthenia Gravis“ by Joseph A. Pruitt (Ed.), 1^st ed., Vienna, InTech, January 2012, 106 p. [ISBN: 978-953-307-821-2], DOI: 10.5772/31127. Available from: http://www.intechopen.com/books/a-look-into-myasthenia-gravis/myasthenia-gravis-current-treatment-standards-and-emerging-drugs
JANĎOUREK, O.; DOLEŽAL, M.; KLEMENTOVÁ, M.; KRÁĽOVÁ, K.; PEŠKO, M. Microwave assisted synthesis of new pyrazinamide analogues and their biological evaluation. The 16th International Electronic Conference on Synthetic Organic Chemistry, Presented in Section B, Bioorganic, Medicinal and Natural Products Chemistry, November, 1^st – 30^th, 2012. Published in 2013 by MDPI, Basel, Switzerland [ISBN: 3-906980-26-X], http://www.sciforum.net/presentation/1092
DOLEŽAL, M.; ZITKO, J.; JAMPÍLEK, J. Pyrazinecarboxylic acid derivatives with antimycobacterial activity. Chapter 10, p. 233–262. In “Understanding Tuberculosis - New approaches for fighting against drug-resistance“ by Pere-Joan Cardona (ed.), 1^st ed., Vienna, InTech, February 2012, 376 p. [ISBN 978-953-307-948-6]
Małecki, J. G.; Maroń, A.; Serda, M.; Doležal, M.; Polański, J. Synthesis, characterization and molecular structure of Ru(II) complex with benzoylpyrazine carboxylic acid derivatives. Polyhedron, 2012, vol. 41, no. 1, 104–114. [ISSN 0277-5387], http://dx.doi.org/10.1016/j.poly.2012.04.033, IF₂₀₁₁ = 2.057
Joseph, T.; Varghese, H. T.; Panicker, C. Y.; Viswanathan, K.; Sundaraganesan, N.; Subramanian, N.; Doležal, M. Vibrational spectroscopic studies and computational study of 6-chloro-N-(4-trifluoromethylphenyl)-pyrazine-2-carboxamide. Glob. J. Anal. Chem., 2012, vol. 3, no. 18, p. 1–12. [ISSN 0976-5514]
ZITKO, J.; JAMPÍLEK, J.; DOBROVOLNÝ, L.; SVOBODOVÁ, M.; KUNEŠ, J.; DOLEŽAL, M. Synthesis and antimycobacterial evaluation of N-substituted 3-aminopyrazine-2,5-dicarbonitriles. Bioorg. Med. Chem. Lett., 2012, vol. 22, no. 4, p. 1598–1601. DOI: 10.1016/j.bmcl.2011.12.129, [ISSN 0960-894X], IF₂₀₁₁ = 2.554
DOLEŽAL, M. Přehled H₁ antihistaminik určených nejen pro sezónní pylovou alergii. Prakt. Lékáren., 2012, vol. 8, no. 2, p. 55–61 . [ISSN 1801-2434]
DOLEŽAL, M. Perspektivy ve skupině návykových látek. Prakt. Lékáren., 2012, vol. 8, no. 4, p. 170–174. [ISSN 1801-2434]
Korábečný, J.; Hrubá, E.; Soukup, O.; Zemek, F.; Musílek, K.; Nepovímová, E.; Špilovská, K.; Opletalová, V.; Kuča, K. Zvažované farmakoterapeutické přístupy léčby Alzheimerovy choroby (Intended pharmacotherapeutical approaches of Alzheimer´s disease therapy). Čes. Slov. Farm., 2012, vol. 61, no. 1, p. 4–10. [ISSN 1210-7816]
Holas, O.; Musílek, K.; Horová, A.; Opletalová, V., Kamil, K. SAR Study on reactivators of ethyl-paraoxon inhibited acetylcholinesterase. Lett. Drug Des. & Discov., 2012, vol. 9, no. 6, p. 587–594. [ISSN 1570-1808], DOI:10.2174/157018012800673083, IF₂₀₁₁ = 0.872
Opletalová, V.; Doležel, J.; Buchta V.; Vejsová M.; Paterová. P. Antifungal Effects of (5Z)-5-Arylmethylidenerhodanines with a special view to the members of Mucorales. Folia Pharm. Univ. Carol. 2012, vol. 42, in press [ISSN 1210-9495]

2011

Opletalová, V.; Doležel, J.; Kráľová, K.; Peško, M.; Kuneš, J.; Jampílek, J. Synthesis and Characterization of (Z)-5-Arylmethylidene-rhodanines with Photosynthesis-Inhibiting Properties. Molecules 2011, vol. 16, no. 6, p. 5207–5227, [ISSN 1420-3049], DOI:10.3390/molecules16065207, IF₂₀₁₁ = 2.386
Korábečný, J.; Musílek, K.; Zemek, F.; Horová, A.; Holas, O.; Nepovímová, E.; Opletalová, V.; Hroudová, J.; Fišar, Z.; Jung, Y. S.; Kuča, K. Synthesis and in vitro evaluation of 7-methoxy-N-(pent-4-enyl)-1,2,3,4-tetrahydroacridin-9-amine-new tacrine derivate with cholinergic properties. Bioorg. Med. Chem. Lett., 2011, vol. 21, no. 21, p. 6563–6566, [ISSN 0960-894X], DOI: 10.1016/j.bmcl.2011.08.042, IF₂₀₁₁ = 2.554
Doležal, M.; Kráľová, K. Synthesis and evaluation of pyrazine derivatives with herbicidal activity. Chapter 27, p. 581–610. In "Herbicides, Theory and Applications" by Sonia Soloneski and Marcelo L. Larramendy (eds.), 27 chapters, 1^st ed., Vienna, InTech, January 2011, 610 p. [ISBN 978-953-307-975-2]
TŮMOVÁ, L.; TŮMA, J.; Doležal, M. Pyrazinecarboxamides as potential elicitors of flavonolignan and flavonoid production in Silybum marianum and Ononis arvensis cultures in vitro. Molecules, 2011, vol. 16, no. 11, p. 9142–9152. [ISSN 1420-3049] DOI: 10.3390/molecules16119142, IF₂₀₁₁ = 2.386
Musílek, K.; Pavlíková, R.; Komlóová, M.; Holas, O.; Hrabinová, M.; Pohanka, M.; Dohnal, V.; Doležal, M.; Gunn-Moore, F.; Kuča, K. Preparation, in vitro screening and molecular docking of symmetrical bisquaternary cholinesterase inhibitors bearing but-(2E)-en-1,4-diyl connecting linkage. J. Enzym. Inhib. Med. Chem., 2011, vol. 26, no. 2, p. 245–253. [ISSN 1475-6366], IF₂₀₁₁ = 1.617
ZITKO, J.; DOLEŽAL, M.; Svobodová, M.; VEJSOVÁ, M.; Kuneš, J.; KUČERA, R.; JÍLEK, P. Synthesis and antimycobacterial properties of N-substituted 6-amino-5-cyanopyrazine-2-carboxamides. Bioorg. Med. Chem., 2011, vol. 19, no. 4, p. 1471–1476. [ISSN 0968-0896], IF₂₀₁₁ = 2.921
Musílek, K.; Komlóová, M.; Holas, O.; Hrabinová, M.; Pohanka, M.; Dohnal, V.; Nachon, F.; Doležal, M.; Kuča, K. Preparation and in vitro screening of symmetrical bis-isoquinolinium cholinesterase inhibitors bearing various connecting linkage - Implications for early Myasthenia gravis treatment, Eur. J. Med. Chem., 2011, vol. 46, no. 1, p. 811–818. [ISSN 0223-5234], IF₂₀₁₁ = 3.346
Musílek, K.; Komlóová, M.; Holas, O.; Horová, A.; Pohanka, M.; Gunn-Moore, F.; Dohnal, V.; Doležal, M.; Kuča, K. Mono-oxime bisquaternary acetylcholinesterase reactivators with prop-1,3-diyl linkage - Preparation, in vitro screening and molecular docking, Bioorg. Med.Chem., 2011, vol. 19, no. 1, p. 754–762. [ISSN 0968-0896], IF₂₀₁₁ = 2.921
Musílek, K.; Doležal, M.; Kuča, K.; Gunn-Moore, F. Design, evaluation and structure-activity relationship studies of the AChE reactivators against organophosphorus pesticides. Med. Res. Rev., 2011, vol. 31, no. 4, p. 548–575. [ISSN 0198-6325], IF₂₀₁₁ = 10.700
Doležal, M.; Kešetovič, D.; Zitko, J. Antimycobacterial evaluation of pyrazinecarboxylic acid derivatives. Curr. Pharm. Design, 2011, vol. 17, no. 32, p. 3506–3514. [ISSN 1381-6128], IF₂₀₁₁ = 3.870
Musílek, K.; Röder, J.; Komlóová, M.; Holas; O., Hrabinová, M.; Pohanka, M.; Dohnal, V.; Opletalová, V.; Kuča, K.; Jung, J. S. Preparation, in vitro screening and modelling: Analogues of SAD-128. Bioorg. Med. Chem. Lett., 2011, vol. 21, no. 1, p. 150–154, [ISSN 0960-894X], DOI: 10.1016/j.bmcl.2010.08.051, IF₂₀₁₁ = 2.554