Assoc. Prof. PharmDr. Ludmila Matysová, Ph.D.

Previous Education and Employment:

• 2015 – habilitation in Analytical Chemistry; Thesis: Validation of Chromatographic Methods for Monitoring of Stability of Pharmaceutical Formulations

• 2006 – Ph.D.: Drug Control , Faculty of Pharmacy in Hradec Králové, Charles University in Prague, Thesis: Development and Validation of HPLC methods for Analysis of Pharmaceutical Formulations

• 1996 – specialty degree (1^st level) in Drug Control - IPVZ

• 1996 – senior lecturer at the Department of Analytical Chemistry

• 1991 – rigorosis procedure, obtainingPharmDr. degree, Faculty of Pharmacy in Hradec Králové, Charles University in Prague

• 1990 – pharmacist-analyst in State Institute of Drug Control, Prague

• 1990 – graduation from Pharmacy, obtainingMgr. degree, Faculty of Pharmacy in Hradec Králové, Charles University in Prague

Research Interests:                              

• Development and validation of HPLC methods for analysis and stability testing of topical pharmaceutical formulations and their application in pharmaceutical companies and firms

• Dissolution and liberation studies of pharmaceutical formulations with normal and prolonged liberation, monitoring of long-term processes (2006)

• Development and validation of HPLC and UHPLC methods for analysis of new developed pharmaceutical formulation in cooperation with Department of pharmaceutical technology on Faculty of Pharmacy, University Hospital in Prague-Motol and State Institute of Drug Control, creation of articles in pharmacopoeia

Professional Membership:

• Member of Czech Pharmaceutical Society ČLS JEP

Research fellowships:

• 2014 (February, 1 week) – University in Gothenburg, Gothenburg, Sweden

• 2014 (September, 4 weeks) – Jagiellonian University, Krakov, Poland

Teaching:

• Analytical chemistry (+ e-learning)

• Instrumental methods (+ e-learning)

• Special methods of instrumental analysis (+ e-learning)

• Calculations in analytical chemistry

• Evaluation in instrumental methods

• Supervisor of diploma, rigorosis and Ph.D. projects

Grants Received:

• 2011 – Ministry of Education – New lectures in Analytical Chemistry and Instrumental Methods

• 2009 – Ministry of Education – Innovation of spectrophotometric lecture in Instrumental Methods by installation of new instrumentation

Other activities:

• head of the Pharmacopoeia Commission of Ministry of Health of the Czech Republic

• head of the Accreditation committee laboratory and examination methods in health care, Ministry of Health of the Czech Republic

• the Responsible person in the case of narcotic drugs and psychotropic substances at the Charles University

• member of the working group Stability of pharmaceutical preparations, Pharmacy Section of the pharmacopoeial commission, Ministry of Health

• head of The certified control laboratory 541, Department of Analytical Chemistry

List of most cited publications (WoS – January 2024)

1. Novakova L, Matysova L, Solich P: Advantages of application of UPLC in pharmaceutical analysis, Talanta, 2006,Volume 68,Issue 3, Pages: 908-918 , cited 377x

2. Havlikova L, Novakova L, Matysova L, Sicha J, Solich P: Determination of Estradiol and its Degradation Products by Liquid Chromatography.  J. Chromatogr. A., 2006, Volume 1119, Issue 1-2, Pages: 216 – 223, cited 56x

3. Dvorak J, Hajkova R, Matysova L, Novakova L, Koupparis M A, Solich P: HPLC Determination of Ketoprofen and its Degradation Products in Presence of Preservatives in Pharmaceuticals. J. Pharm. Biomed. Anal., 2004, Volume 36, Issue 3, Pages: 625 – 629, cited 52x

4. Novakova L, Solich P, Matysova L, Sicha, J: HPLC Determination of Estradiol, its Degradation Product and Preservatives in new Topical Formulation Estrogel HBF. Anal. Bioanal. Chem., 2004, Volume 379, Issue 5-6,Pages: 781 – 787, cited 45x

5. Novakova L, Matysova L, Solichova D, Koupparis M A, Solich P: Comparison of Performance of C18 Monolithic Columns and C18 Conventional Particle-Packed Columns in HPLC Analysis of Pharmaceuticals. J. Chromatogr. B., 2004, Volume 813, Issue 1-2, Pages: 191 – 197, cited 44x