PharmDr. Tomáš Smutný, Ph.D.

Research interests

• nuclear receptors
• in vitro liver cell models
• hepatotoxicity
• drug metabolism
• drug-drug interactions

Education

2011 - 2017   Doctoral study – Faculty of Pharmacy in Hradec Kralove, Charles University, Department of Pharmacology and Toxicology (Prof. Petr Pavek); Doctoral dissertation: Novel approaches for development of in vitro liver cell models

2006 - 2011   Master study – Faculty of Pharmacy in Hradec Kralove, Charles University, Department of Pharmacology and Toxicology (Prof. Petr Pavek); Master thesis: The effect of statins on Ras/Raf/ERK cell signaling pathway in A431 model cell line

Publications

Scopus (4/2024): H-index 16, 32 documents, 662 citations (604 without self-citations)

WoS (4/2024): H-index 16, 31 documents, 624 citations (571 without self-citations)

    Top 5

1. Smutny, T., Bernhauerova, V., Smutna, L., Tebbens, J. D., & Pavek, P. (2022). Expression dynamics of pregnane X receptor-controlled genes in 3D primary human hepatocyte spheroids. Arch Toxicol, 96(1): 195-210. IF₂₀₂₂ = 6,1
2. Smutny, T., Hyrsova, L., Braeuning, A., Ingelman-Sundberg, M., & Pavek, P. (2021). Transcriptional and post-transcriptional regulation of the pregnane X receptor: a rationale for interindividual variability in drug metabolism. Arch Toxicol, 95(1): 11-25. IF₂₀₂₁ = 6,168
3. Smutny, T., Dusek, J., Hyrsova, L., Nekvindova, J., Horvatova, A., Micuda, S., Gerbal-Chaloin, S., & Pavek, P. (2020). The 3'-untranslated region contributes to the pregnane X receptor (PXR) expression down-regulation by PXR ligands and up-regulation by glucocorticoids. Acta Pharm Sin B, 10(1): 136-152. IF₂₀₂₀ = 11,614
4. Smutny, T., Nova, A., Drechslerova, M., Carazo, A., Hyrsova, L., Rania Hruskova, Z., Kunes, J., Pour, M., Spulak, M., & Pavek, P. 2-(3-Methoxyphenyl)quinazoline Derivatives: A New Class of Direct Constitutive Androstane Receptor (CAR) Agonists. (2016). J Med Chem, 59(10): 4601-10. IF₂₀₁₆ = 6,259
5. Smutny, T., Bitman, M., Urban, M., Dubecka, M., Vrzal, R., Dvorak, Z., & Pavek, P. (2014). U0126, a mitogen-activated protein kinase kinase 1 and 2 (MEK1 and 2) inhibitor, selectively up-regulates main isoforms of CYP3A subfamily via a pregnane X receptor (PXR) in HepG2 cells. Arch Toxicol, 88(12): 2243-59. IF₂₀₁₄ = 5,980

Awards

2022   The prize for the best published article in 2022 in category Toxicology awarded by Czech Society for Experimental and Clinical                    Pharmacology and Toxicology (Smutny et al., Arch Toxicol, 2022)

2022   The winner of the poster session at 70^th Czech-Slovak Pharmacological Days conference

2020   The prize for the best published article in 2020 in category Experimental pharmacology awarded by Czech Society for                                   Experimental and Clinical Pharmacology and Toxicology (Smutny et al., Acta Pharm Sin B. 2020)

2019   Dean´s Medal for research achievements (Faculty of Pharmacy, Charles University)

2018   The prize for the best published article in 2018 in category Toxicology awarded by Czech Society for Experimental and Clinical                    Pharmacology and Toxicology (Smutny et al., Toxicol In Vitro. 2018)

2018   1^st place winner of the poster session at 68^th Czech-Slovak Pharmacological Days conference (out of 52 presented posters)

2016   The prize for the best published experimental article in 2016 awarded by Czech Medical Association of J. E. Purkyně (Smutny et                al., J Med Chem. 2016)

2016   The prize for the best published article in 2016 in category Toxicology awarded by Czech Society for Experimental and Clinical                    Pharmacology and Toxicology (Smutny et al., J Med Chem. 2016)

2016   Dimitris N. Chorafas Prize (The Dimitris N. Chorafas Foundation and the Weizmann Institute of Science award scientific prizes for                outstanding work in several fields including medicine and the natural sciences)

2016   2^nd place in the Sanofi Prize for Pharmacy (for PhD research work in experimental biomedical and pharmaceutical research)

2011   Student research award (Czech Pharmaceutical Society)

Research stays

• Visiting postdoctoral researcher (1.5 + 1 months) – Inserm laboratory at Institute for Regenerative Medicine and Biotherapy (IRMB), Montpellier, France
• Visiting postdoctoral researcher (9 months) – Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
• Visiting doctoral student (1 year) – Division of Pharmaceutical Biosciences, Faculty of Pharmacy, University of Helsinki, Finland

Teaching activities

•  Teaching Pharmacology (CZ), Preclinical drug testing (CZ), and Gene therapy (CZ) for M.Sc. students at Faculty of Pharmacy                        in Hradec Kralove, Charles University