Mgr. Veronika Bernhauerová, Ph.D.

Department of Biophysics and Physical Chemistry,
Faculty of Pharmacy in Hradec Králové, Charles University,
Heyrovského 1203, Hradec Králové, 500 05, Czech Republic

Member of the research group Clinical and Molecular Pharmacotherapy.

Email: bernhauve@faf.cuni.cz
Phone: +420 495 067 490
ORCID: orcid.org/0000-0002-5595-4579

Employment

2020 - present   (Assistant Professor) Charles University, Faculty of Pharmacy, Department of Biophysics and Physical Chemistry, Hradec Kralove, Czech Republic
2017 - 2019   (Postdoctoral Researcher) Institut Pasteur, Department of Virology, Viral Populations and Pathogenesis Unit (Laboratory of Marco Vignuzzi), Paris, France
2015 - 2017   (Postdoctoral Researcher) St. Jude Children's Research Hospital, Department of Infectious Diseases (Laboratory of Amber M. Smith), Memphis, TN, USA 

Research Interests

I study biological systems using mathematical and statistical modelling. Currently, I mainly focus on developing mathematical models to

  • describe viral replication and infection in vitro (e.g. SARS-CoV-2, Zika, chikungunya),
  • study ecological and evolutionary dynamics of infectious disesases,
  • understand drug-induced gene expression in hepatocytes.

Teaching

Education

2011 - 2015   (Ph.D., study program Probability, Statistics and Mathematical Modelling) Masaryk University, Faculty of Science, Department of Mathematics and Statistics, Brno, Czech Republic
2009 - 2011   (Mgr. with honors, study program Mathematical Analysis) Silesian University, Mathematical institute, Opava, Czech Republic
2008 - 2010   (Bc., study program Mathematical Methods in Economy) Silesian University, Mathematical institute, Opava, Czech Republic
2006 - 2009   (Bc., study program Applied Mathematics) Silesian University, Mathematical institute, Opava, Czech Republic

Short-term research fellowships

2014   (3 month summer internship) University of Michigan, Department of Ecology and Evolutionary Biology (Laboratory of Pejman Rohani), Ann Arbor, MI, USA
2012   (1 week workshop) The Helsinki Summer School on Mathematical Ecology and Evolution: Theory of Speciation, Turku, Finland

Professional development

2018   (3 day course) Next-Generation Sequencing Data Analysis: A Practical Introduction, Munich, Germany
2018   (4 day course) RNA-Seq Data Analysis Workshop, Berlin, Germany

Awards

2011   3rd prize in SVOČ, section Mathematical Models of Dynamics (thesis: Stability in Darwinan Dynamics), Jan Evangelista Purkyně University, Ústí nad Labem, Czech Republic

Funding

2022 - 2025 PRIMUS/22/MED/017 (PI) Mathematical modelling of gene expression dynamics regulated by nuclear receptors in hepatocyte spheroids

Publications

-2021-

[12] Smutný T., V. Bernhauerová, L. Smutná, J. Duintjer Tebbens and P. Pávek (2021). Expression dynamics of pregnane X receptor-controlled genes in 3D primary human hepatocyte spheroids. Archives of Toxicology (online first)https://doi.org/10.1007/s00204-021-03177-y

[11] Bernhauerová V., B. Lisowski, V.V. Rezelj, M. Vignuzzi (2021). Mathematical modelling of SARS-CoV-2 infection of human and animal host cells reveals differences in the infection rates and delays in viral particle production by infected cells. Journal of Theoretical Biology 531. https://doi.org/10.1016/j.jtbi.2021.110895 

[10] Rezelj V. V., L. Carrau, F. Merwaiss, L. I. Levi, D. Erazo-Quintero, D. Tran, A. Henrion-Lacritick, V. Gausson, Y. Suzuki, D. Shenguler, B. Meyer, T. Vallet, J. Weger-Lucarelli, V. Bernhauerová, A. Titievsky, V. Sharov, S. Pietropaoli, M. A. Diaz-Salinas, V. Legros, N. Pardigon, G. Barba-Spaeth, L. Brodsky, M. C. Saleh, M. Vignuzzi (2021). High fitness deletion hotspots in defective viral genomes enable the development of therapeutic interfering particles against flavivirus infection. Nature Communications 12(1): 2290. https://doi.org/10.1038/s41467-021-22341-7

[9] Levi L. I., V. V. Rezelj, A. Henrion-Lacritick, D. Erazo, J. Boussier, T. Vallet, V. Bernhauerová, Y. Suzuki, L. Carrau, J. Weger-Lucarelli, M. C. Saleh, M. Vignuzzi (2021). Defective viral genomes from chikungunya virus are broad-spectrum antivirals and prevent virus dissemination in mosquitoes. PLoS Pathogens 17(2): e1009110. https://doi.org/10.1371/journal.ppat.1009110

-2020-

[8] Bernhauerová V., V. V. Rezelj and M. Vignuzzi (2020). Modelling degradation and replication kinetics of the Zika virus in vitro infection. Viruses 12(5). https://doi.org/10.3390/v12050547 (IF2020=5.048; QAIS,2020=Q2)

-2018-

[7] Smith A. P., D. J. Moquin, V. Bernhauerová and A. M. Smith (2018). Influenza virus infection model with density dependence supports biphasic viral decay. Frontiers in Microbiology 9. https://doi.org/10.3389/fmicb.2018.01554 (IF2018=4.259; QAIS,2018=Q2)

[6] Berec L., V. Bernhauerová and B. Boldin (2018). Evolution of mate-finding Allee effects in prey. Journal of Theoretical Biology 441. https://doi.org/10.1016/j.jtbi.2017.12.024 (IF2018=1.875; QAIS,2018=Q2)

[5] Berec L., A. M. Kramer, V. Bernhauerová and J. M. Drake (2018). Density-dependent selection on mate-searching traits and evolution of mate-finding Allee effects. Journal of Animal Ecology 87(1). https://doi.org/10.1111/1365-2656.12662 (IF2018=4.364; QAIS,2018=Q1)

-2016-

[4] Bernhauerová V. (2016). Vaccine-driven evolution of parasite virulence and immune evasion in age-structured population: the case of pertussis. Theoretical Ecology 9(4):431-442. https://doi.org/10.1007/s12080-016-0300-5 (IF2016=1.221; QAIS,2016=Q2)

[3] Berec L., D. Maxin and V. Bernhauerová (2016). Male-killing bacteria as agents of insect pest control. Journal of Applied Ecology 53(4):1270-1279. https://doi.org/10.1111/1365-2664.12638 (IF2016=5.301; QAIS,2016=Q1)

-2015-

[2] Bernhauerová V., L. Berec and D. Maxin (2015). Evolution of early male-killing in horizontally transmitted parasites. Proceedings of the Royal Society of London B: Biological Sciences 282(1818). http://doi.org/10.1098/rspb.2015.2068 (IF2015=4.823; QAIS,2015=Q1)

[1] Bernhauerová V., L. Berec (2015). Role of trade-off between sexual and vertical routes for evolution of pathogen transmission. Theoretical Ecology 8(1). https://doi.org/10.1007/s12080-014-0234-8 (IF2015=2.085; QAIS,2015=Q2)

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