Assoc. Prof. PharmDr. Martina Čečková, Ph.D.

Research interests

• Multidrug resistance, anticancer pharmacotherapy
• Interaction of cyclin-dependent kinase inhibitors with ABC transporters
• Pharmacokinetics of novel drug entities, interactions with drug transporters
• Drug transport across the placenta, role of ABC and SLC transporters

Positions, education

Stays abroad

Teaching activities

Awards

Professional memberships

• ITTS - International Transmembrane Transporter Society
• Czech Society for Experimental and Clinical Pharmacology and Toxicology
• Czech Society for Biochemistry and Molecular Biology

Publication activity

(based on Web of Science database search as of 2021-10-01)
Author and co-author of 48 publications in extenso, 1 chapter in an international textbook
> 1400 citations (excluding self-citations)
h-index: 21

List of the important publications (*corresponding author)

2020

• Tupova L, Hirschmugl B, Sucha S, Pilarova V, Székely V, Bakos É, Novakova L, Özvegy-Laczka C, Wadsack C, Ceckova M.*: Interplay of drug transporters P-glycoprotein (MDR1), MRP1, OATP1A2 and OATP1B3 in passage of maraviroc across human placenta. Biomed Pharmacother. 2020 Sep;129:110506.
• Granitzer S, Ellinger I, Khan R, Gelles K, Widhalm R, Hengstschläger M, Zeisler H, Desoye G, Tupova L, Ceckova M, Salzer H, Gundacker C.*: In vitro function and in situ localization of Multidrug Resistance-associated Protein (MRP)1 (ABCC1) suggest a protective role against methyl mercury-induced oxidative stress in the human placenta. Arch Toxicol. 2020 Nov;94(11):3799-3817.
• Sorf A, Sucha S, Morell A, Novotna E, Staud F, Zavrelova A, Visek B, Wsol V, Ceckova M.*: Targeting Pharmacokinetic Drug Resistance in Acute Myeloid Leukemia Cells with CDK4/6 Inhibitors. Cancers (Basel). 2020 Jun 16;12(6):159

2019

• Hofman J*, Sorf A, Vagiannis D, Sucha S, Kammerer S, Küpper JH, Chen S, Guo L, Ceckova M, Staud F.: Brivanib Exhibits Potential for Pharmacokinetic Drug-Drug Interactions and the Modulation of Multidrug Resistance through the Inhibition of Human ABCG2 Drug Efflux Transporter and CYP450 Biotransformation Enzymes. Mol Pharm. 2019 Nov 4;16(11):4436-4450. 

• Tupova L, Ceckova M, Ambrus C, Sorf A, Ptackova Z, Gaborik Z, Staud F.*: Interactions between Maraviroc and the ABCB1, ABCG2, and ABCC2 Transporters: An Important Role in Transplacental Pharmacokinetics. Drug Metab Dispos. 2019 Sep;47(9):954-960.
• Hofman J*, Sorf A, Vagiannis D, Sucha S, Novotna E, Kammerer S, Küpper JH, Ceckova M, Staud F.: Interactions of Alectinib with Human ATP-Binding Cassette Drug Efflux Transporters and Cytochrome P450 Biotransformation Enzymes: Effect on Pharmacokinetic Multidrug Resistance. Drug Metab Dispos. 2019 Jul;47(7):699-709.
• Sorf A, Novotna E, Hofman J, Morell A, Staud F, Wsol V, Ceckova M.*: Cyclin-dependent kinase inhibitors AZD5438 and R547 show potential for enhancing efficacy of daunorubicin-based anticancer therapy: Interaction with carbonyl-reducing enzymes and ABC transporters. Biochem Pharmacol. 2019 May;163:290-298 (IF₂₀₁₈ =
• Karahoda R, Ceckova M*, Staud F.: The inhibitory effect of antiretroviral drugs on the L-carnitine uptake in human placenta. Toxicol Appl Pharmacol. 2019 Apr 1;368:18-25. (IF₂₀₁₈ =

2018

• Ceckova M, Reznicek J, Deutsch B, Fromm MF, Staud F*.: Efavirenz reduces renal excretion of lamivudine in rats by inhibiting organic cation transporters (OCT, Oct) and multidrug and toxin extrusion proteins (MATE, Mate). PLoS One. 2018 Aug 16;13(8):e0202706. (IF₂₀₁₇ = 2.766)

• Široká J*, Čečková M, Urbánek L, Kryštof V, Gucký T, Hofman J, Strnad M, Štaud F.: LC-MS/MS method for determination of cyclin-dependent kinase inhibitors, BP-14 and BP-20, and its application in pharmacokinetic study in rat. J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Jul 1;1089:24-32. (IF₂₀₁₇ = 2.441)

• Cerveny L, Ptackova Z, Ceckova M, Karahoda R, Karbanova S, Jiraskova L, Greenwood SL, Glazier JD, Staud F.*: Equilibrative nucleoside transporter 1 (ENT1, SLC29A1) facilitates transfer of the antiretroviral drug abacavir across the placenta. Drug Metab Dispos. 2018 Aug 10. pii: dmd.118.083329. (IF₂₀₁₇ = 3.641)

• Sorf A, Hofman J, Kučera R, Staud F, Ceckova M.*: Ribociclib shows potential for pharmacokinetic drug-drug interactions being a substrate of ABCB1 and potent inhibitor of ABCB1, ABCG2 and CYP450 isoforms in vitro. Biochem Pharmacol. 2018 Aug;154:10-17

• Soukup O, Korabecny J, Malinak D, Nepovimova E, Pham NL, Musilek K, Hrabinova M, Hepnarova V, Dolezal R, Pavek P, Jost P, Kobrlova T, Jankockova J, Gorecki L, Psotka M, Nguyen TD, Box K, Outhwaite B, Ceckova M, Sorf A, Jun D, Kuca K.*: In vitro and in silico Evaluation of Non-Quaternary Reactivators of AChE as Antidotes of Organophosphorus Poisoning - a New Hope or a Blind Alley? Med Chem. 2018;14(3):281-292. (IF₂₀₁₆ = 2.759)

2017

• Karbanova S, Cerveny L, Ceckova M, Ptackova Z, Jiraskova L, Greenwood S, Staud F.*: Role of nucleoside transporters in transplacental pharmacokinetics of nucleoside reverse transcriptase inhibitors zidovudine and emtricitabine. Placenta. 2017 Dec;60:86-92. (IF₂₀₁₆ = 2.759)
• Reznicek J, Ceckova M, Ptackova Z, Martinec O, Tupova L, Cerveny L, Staud F.*: MDR1 and BCRP Transporter-Mediated Drug-Drug Interaction between Rilpivirine and Abacavir and Effect on Intestinal Absorption. Antimicrob Agents Chemother. 2017 Aug 24;61(9). (IF₂₀₁₅ = 4.415)
• Zelena L, Reznicek J, Ceckova M, Sklenarova H.*: Universal efavirenz determination in transport study, rat placenta perfusion and placenta lysate by HPLC-UV. J Pharm Biomed Anal. 2017 Apr 15;137:70-77. (IF₂₀₁₆= 3.169)

2016

• Reznicek J, Ceckova M, Tupova L, Staud F.*: Etravirine inhibits ABCG2 drug transporter and affects transplacental passage of tenofovir disoproxil fumarate. Placenta. 2016 Nov;47:124-129. (IF₂₀₁₅ = 2.972)
• Ceckova M, Reznicek J, Ptackova Z, Cerveny L, Müller F, Kacerovsky M, Fromm MF, Glazier JD, Staud F.*: Role of ABC and Solute Carrier Transporters in the Placental Transport of Lamivudine. Antimicrob Agents Chemother. 2016 Aug 22;60(9):5563-72. (IF₂₀₁₅ = 4.415)
• Reznicek J, Ceckova M, Staud F*: Emtricitabine is a substrate of MATE1 but not of OCT1, OCT2, P-gp, BCRP or MRP2 transporters. Xenobiotica 2016, in press (IF 2.20)
• Neumanova Z, Cerveny L, Ceckova M, Staud F.*: Role of ABCB1, ABCG2, ABCC2 and ABCC5 transporters in placental passage of zidovudine. Biopharm Drug Dispos. 2016 Jan;37(1):28-38. (IF 2.34)
• Hofman J, Kučera R, Neumanova Z, Klimes J, Ceckova M, Staud F.*: Placental passage of olomoucine II, but not purvalanol A, is affected by p-glycoprotein (ABCB1), breast cancer resistance protein (ABCG2) and multidrug resistance-associated proteins (ABCCs). Xenobiotica. 2016 May;46(5):416-23. (IF 2.20)

2015

• Cihalova D, Ceckova M, Kucera R, Klimes J, Staud F.*: Dinaciclib, a cyclin-dependent kinase inhibitor, is a substrate of human ABCB1 and ABCG2 and an inhibitor of human ABCC1 in vitro. Biochem Pharmacol. 2015 Dec 1;98(3):465-72. (IF 5.01)
• Neumanova Z, Cerveny L, Greenwood SL, Ceckova M, Staud F.*: Effect of drug efflux transporters on placental transport of antiretroviral agent abacavir. Reprod Toxicol. 2015 Nov;57:176-82.  (IF 3.23)
• Cihalova D, Staud F, Ceckova M.*: Interactions of cyclin-dependent kinase inhibitors AT-7519, flavopiridol and SNS-032 with ABCB1, ABCG2 and ABCC1 transporters and their potential to overcome multidrug resistance in vitro. Cancer Chemother Pharmacol. 2015 Jul;76(1):105-16. (IF 2.77)
• Cermanova J, Kadova Z, Zagorova M, Hroch M, Tomsik P, Nachtigal P, Kudlackova Z, Pavek P, Dubecka M, Ceckova M, Staud F, Laho T, Micuda S.*: Boldine enhances bile production in rats via osmotic and farnesoid X receptor dependent mechanisms. Toxicol Appl Pharmacol. 2015 May 15;285(1):12-22. (IF 3.71)
• Staud F*, Ceckova M.: Regulation of drug transporter expression and function in the placenta. Expert Opin Drug Metab Toxicol. 2015 Jan 20:1-23. (IF 2.93)

2014

• Neumanova Z, Cerveny L, Ceckova M, Staud F.*: Interactions of tenofovir and tenofovir disoproxil fumarate with drug efflux transporters ABCB1, ABCG2, and ABCC2; role in transport across the placenta. AIDS. 2014 Jan 2;28(1):9-17. (IF 6.57)

2013

• Cihalova D, Hofman J, Ceckova M, Staud F.*: Purvalanol A, olomoucine II and roscovitine inhibit ABCB1 transporter and synergistically potentiate cytotoxic effects of daunorubicin in vitro. PLoS One. 2013 Dec 23;8(12). (IF 3.53)
• Hofman J, Kučera R, Cihalova D, Klimes J, Ceckova M, Staud F.*: Olomoucine II, but not purvalanol A, is transported by breast cancer resistance protein (ABCG2) and P-glycoprotein (ABCB1). PLoS One. 2013 Oct 8;8(10). (IF 3.53)
• Staud F*, Cerveny L, Ahmadimoghaddam D, Ceckova M.: Multidrug and toxin extrusion proteins (MATE/SLC47); role in pharmacokinetics. Int J Biochem Cell Biol. 2013 Sep;45(9):2007-11. (IF 4.24)
• Ahmadimoghaddam D, Zemankova L, Nachtigal P, Dolezelova E, Neumanova Z, Cerveny L, Ceckova M, Kacerovský M, Micuda S, Staud F.*: Organic cation transporter 3 (OCT3/SLC22A3) and multidrug and toxin extrusion 1 (MATE1/SLC47A1) transporter in the placenta and fetal tissues: expression profile and fetus protective role at different stages of gestation. Biol Reprod. 2013 Mar 7;88(3). (IF 3.45)
• Cerveny L*, Straskova A, Dankova V, Hartlova A, Ceckova M, Staud F, Stulik J.: Tetratricopeptide repeat motifs in the world of bacterial pathogens: role in virulence mechanisms. Infect Immun. 2013 Mar;81(3):629-35. (IF 4.16)

2012

• Staud F*, Cerveny L, Ceckova M.:  Pharmacotherapy in pregnancy; effect of ABC and SLC transporters on drug transport across the placenta and fetal drug exposure. (2012) Journal of Drug Targeting Nov;20(9):736-63. (IF 2.70)
• Ahmadimoghaddam D., Hofman J., Zemankova L., Nachtigal P., Dolezelova E., Cerveny L., Ceckova M., Micuda S., Staud F.* Synchronized activity of Organic Cation Transporter 3 (Oct3/SLC22A3) and Multidrug and Toxin Extrusion 1 (Mate1/SLC47A1) transporter in transplacental passage of MPP+ in rat. (2012) Toxicological Sciences, Aug;128(2):471-81 (IF 4.65)

2011

• Hofman J, Ahmadimoghaddam D, Hahnova L, Pavek P, Ceckova M, Staud F.*:  Olomoucine II and purvalanol A inhibit ABCG2 transporter in vitro and in situ and synergistically potentiate cytostatic effect of mitoxantrone (2011) Pharmacological Research. Dec 6. (IF 4.44)
• Hahnova-Cygalova, L., Ceckova, M., Staud, F.* Fetoprotective activity of breast cancer resistance protein (BCRP, ABCG2): Expression and function throughout pregnancy. (2011) Drug Metabolism Reviews, 43 (1), pp. 53-68. (IF 6.40 )

2010 and before

• Staud, F.*, Ceckova, M., Micuda, S., Pavek, P. Expression and function of p-glycoprotein in normal tissues: effect on pharmacokinetics.(2010) Methods in molecular biology (Clifton, N.J.), 596, pp. 199-222.
• Cygalova, L.H., Hofman, J., Ceckova, M., Staud, F.* Transplacental pharmacokinetics of glyburide, rhodamine 123, and BODIPY FL prazosin: Effect of drug efflux transporters and lipid solubility (2009) Journal of Pharmacology and Experimental Therapeutics, 331 (3), pp. 1118-1125. (IF 3.83)
• Pavek, P.*, Ceckova, M., Staud, F. Variation of drug kinetics in pregnancy (2009) Current Drug Metabolism, 10 (5), pp. 520-529. (IF 5.11)
• Ceckova, M., Vackova, Z., Radilova, H., Libra, A., Buncek, M., Staud, F.* Effect of ABCG2 on cytotoxicity of platinum drugs: Interference of EGFP (2008) Toxicology in Vitro, 22 (8), pp. 1846-1852. (IF 2.78)
• Cygalova, L., Ceckova, M., Pavek, P., Staud, F*. Role of breast cancer resistance protein (Bcrp/Abcg2) in fetal protection during gestation in rat (2008) Toxicology Letters, 178 (3), pp. 176-180. (IF 3.23)
• Vinsova J*, Imramovsky A, Buchta V, Ceckova M, Dolezal M, Staud F, Jampilek J, Kaustova J.  Salicylanilide acetates: synthesis and antibacterial evaluation. (2007) Molecules. Jan 1;12(1):1-12. (IF 2.39)
• Ceckova-Novotna M, Pavek P, Staud F*  P-glycoprotein in the placenta: Expression, localization, regulation and function. (2006) Reprod Toxicol  22(3):400-410.(IF 3.23)
• Staud F*, Vackova Z, Pospechova K, Pavek P, Ceckova M, Libra A, Cygalova L, Nachtigal P, Fendrich Z. Expression and transport activity of breast cancer resistance protein (Bcrp/Abcg2) in dually perfused rat placenta and HRP-1 cell line. (2006) J Pharmacol Exp Ther. Oct;319(1):53-62. (IF 3.83)
• Vinsova J*, Cermakova K, Tomeckova A, Ceckova M, Jampilek J, Cermak P, Kunes J, Dolezal M, Staud F. Synthesis and antimicrobial evaluation of new 2-substituted 5,7-di-tert-butylbenzoxazoles. Bioorg Med Chem. 2006 Sep 1;14(17):5850-65. (IF 2.55)
• Ceckova M, Libra A, Pavek P, Nachtigal P, Brabec M, Fuchs R, Staud F.* Expression and functional activity of breast cancer resistance protein (bcrp, abcg2) transporter in the human choriocarcinoma cell line bewo. (2006) Clin Exp Pharmacol Physiol  33(1-2):58-65. (IF 1.85)
• Pavek P, Merino G, Wagenaar E, Bolscher E, Novotna M, Jonker JW, Schinkel AH.* Human breast cancer resistance protein: interactions with steroid drugs, hormones, the dietary carcinogen 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine, and transport of cimetidine. J Pharmacol Exp Ther. (2005) Jan;312(1):144-52. (IF 3.83)
• Novotna M, Libra A, Kopecky M, Pavek P, Fendrich Z, Semecky V, Staud F.* P-glycoprotein expression and distribution in the rat placenta during pregnancy. (2004) Reprod Toxicol  18(6):785-792. (IF 3.23)
• Pavek P, Staud F, Fendrich Z, Sklenarova H, Libra A, Novotna M, Kopecky M, Nobilis M, Semecky V.* Examination of the Functional Activity of P-glycoprotein in the Rat Placental Barrier Using Rhodamine 123. (2003)  J Pharmacol Exp Ther  305(3):1239-1250. (IF 3.83)