Research Group Of Cellular Pharmacology & Oncology

Research conducted by our team is focused on membrane transport systems, especially on ABC and SLC transporters involved in transfer of drugs, nutrients and endogenous molecules across cellular membranes. This thematic line is followed with regard to the phenomenon of drug resistance, pharmacokinetic drug-drug or drug-nutrient interactions, but also addressing the role of membrane transporters in pathophysiological processes.

Our current mail goal is to address the role of membrane transporters in hematological malignancies, especially acute myeloid leukemia (AML). Using cellular and patient-derived models alongside techniques such as flow cytometry, cell sorting and digital PCR, we aim to evaluate the role of transporters in highly resistant subsets of AML cells in formation of the pathological bone marrow microenvironment and persistence of minimal residual disease. Recently, we have started to explore the transport of essential molecules (e.g. L-carnitine, cytokines) in pathological (inflammatory and pre-malignant) tissue models using besides the leukemia-related models also our years-long expertise in the placenta and trophoblast-based research and aim to understand the intercellular communication.

 

Latest news

  • 3rd place at the supranational round of Student Scientific Conference (read more)
  • Paper published in Biomedicine & Pharmacotherapy (IF 7.419) (read more)
  • First place in XXIX. Student Scientific Conference (read more)
  • Paper published in Toxicology and Applied Pharmacology (IF 4.219) (read more)
  • ToxCon 2021 (read more)
  • Manuscript created in cooperation with our Austrian colleagues got accepted in Archives of Toxicology (IF 5.059) (read more)
  • Simona Dudičová is joining our team as PhD student (read more)
  • Lenka Ťupová successfully finished her doctoral studies (read more)
  • Manuscript got accepted in Biomedicine & Pharmacotherapy (IF 4.545) (read more)
  • Aleš Šorf wins 2nd place in the prestige Sanofi prize in Pharmacy (read more)

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