RNDr. Jaroslav Jenčo, Ph.D.

Research fellowship

• 2016 University of Tartu, Estonia, Department of Analytical Chemistry – supervisor prof. Ivo Leito (4 months)

Award

HPLC 2017 - 45. International symposium on high performance liquid phase separations and related techniques, Prague - Springer Best Poster Award: Chromatographic analysis of thiamine and its derivatives for routine diagnostics in whole blood

Publications

Original papers

2023

PIDANY, F., KROUSTKOVA, J., AL MAMUN, A., SUCHANKOVA, D., BRAZZOLOTTO, X., NACHON, F., CHANTEGREIL, F., DOLEZAL, R., PULKRABKOVÁ, L., MUCKOVA, L., HRABINOVA, M., FINGER, V., KUFA, M., SOUKUP, O., JUN, D., JENCO, J., KUNES, J., NOVAKOVA, L., KORABECNY, J., CAHLIKOVA, L.:  Highly selective butyrylcholinesterase inhibitors related to Amaryllidaceae alkaloids - design, synthesis, and biological evaluation. Eur. J. Med. Chem. 252, 115301 (2023).  https://doi.org/10.1016/j.ejmech.2023.115301

2022

VRABEC, R., MAŘÍKOVÁ, J., LOČÁREK, M., KORÁBEČNÝ, J., HULCOVÁ, D., HOŠŤÁLKOVÁ, A., KUNEŠ, J., CHLEBEK, J., KUČERA, T., HRABINOVÁ, M., JUN, D., SOUKUP, O., ANDRISANO, V., JENČO, J., ŠAFRATOVÁ, M., NOVÁKOVÁ, L., OPLETAL, L., CAHLÍKOVÁ, L.: Monoterpene indole alkaloids from Vinca minor L. (Apocynaceae): identification of new structural scaffold for treatment of Alzheimer´s disease. Phytochemistry 194, 113017 (2022). https://doi.org/10.1016/j.phytochem.2021.113017

2021

KOHELOVÁ, E., MAŘÍKOVÁ, J., KORÁBEČNÝ, J., HULCOVÁ, D., KUČERA, T., JUN, D., CHLEBEK, J., JENČO, J., ŠAFRATOVÁ, M., HRABINOVÁ, M., RITOMSKÁ, A., MALANÍK, M., PEŘINOVÁ, R., BREITEROVÁ, K., KUNEŠ, J., NOVÁKOVÁ, L., OPLETAL, L., CAHLÍKOVÁ, L.: Alkaloids of Zephyrantes citrina (Amaryllidaceae) and their implication to Alzheimerʼs disease: isolation, structural elucidation and biological activity. Bioorg. Chem. 107, 104567 (2021). https://doi.org/10.1016/j.bioorg.2020.104567

MAAFI, N., PIDANY, F., MARIKOVA, J., KORABECNY, J., HULCOVA, D., KUCERA, T., SCHMIDT, M., AL SHAMMARI, L., SPULAK, M., CATAPANO, M.C., MECAVA, M., PRCHALD, L., KUNES, J., JANOUSEK, J., KOHELOVA, E., JENCO, J., NOVAKOVA, L., CAHLIKOVA, L.: Derivatives of montanine-type alkaloids and their implication for the treatment of Alzheimer´s disease: Synthesis, biological activity and in silico study. Bioorg. Med. Chem. Let. 51, 128374 (2021). https://doi.org/10.1016/j.bmcl.2021.128374

2020

PEŘINOVÁ, R., MAAFI, M., KORÁBEČNÝ, J., KOHELOVÁ, E., DE SIMONE, A., AL MAMUN, A., HULCOVÁ, D.,MARKOVÁ, J., KUČERA, T., JUN, D., ŠAFRATOVÁ, M., MAŘÍKOVÁ, J., ANDRISANO, V., JENČO, J., KUNEŠ, J., MARTINEZ, A., NOVÁKOVÁ, L., CAHLÍKOVÁ, L.: Functionalized aromatic esters of the Amaryllidaceae alkaloid haemanthamine and their in vitro and in silico biological activity connected to Alzheimer´s disease. Bioorg. Chem. 100, 103928 (2020). https://doi.org/10.1016/j.bioorg.2020.103928

BREITEROVÁ, K., KOUTOVÁ, D., HAVELEK, R., KUNEŠ, J., MAJOROŠOVÁ, M., OPLETAL, L., HOŠŤÁLKOVÁ, A., JENČO, J., ŘEZÁČOVÁ, M., CAHLÍKOVÁ, L.: Amaryllidaceae alkaloids of different structural types from Narcissus L. cv. Professor Einstein and their cytotoxic activity. Plants 9, 137, (2020). https://doi.org/10.3390/plants9020137

JENČO, J., KRČMOVÁ, L., SOBOTKA, L., BLÁHA, V., SOLICH, P., ŠVEC, F.: Development of novel liquid chromatography method for clinical monitoring of vitamin B₁ metabolites and B₆ status in the whole blood. Talanta 211, 120702 (2020). https://doi.org/10.1016/j.talanta.2019.120702

2017

JENČO, J., KRČMOVÁ, L., SOLICHOVÁ, D., SOLICH, P. Recent trends in determination of thiamine and its derivatives in clinical practice J. Chromatograph. A 1510, 1-12 (2017). https://doi.org/10.1016/j.chroma.2017.06.048

TSHEPELEVITSCH, S., HERNITS, K., JENČO, J., HAWKINS, J.M., MUTEKI, K.,SOLICH, P., LEITO, I. Systematic optimization of liquid-liquid extraction for Isolation of unidentified components. ACS OMEGA 2(11), 7772-7776 (2017). https://doi.org/10.1021/acsomega.7b01445