Secondary metabolites of plants as potential drugs

The research group deals with the isolation, structural elucidation, and biological activity of secondary metabolites of plants, especially alkaloids. Plants are selected for phytochemical research based on previous screening studies, including the study of biological activity (cholinesterase inhibition, cytotoxicity, antimicrobial activity, etc.) and analysis of extracts (GC/MS, HPLC/MS) to identify the constituents. On the basis of the results of these studies, plants are selected for the isolation of the secondary metabolites in pure form. The isolated compounds have been tested for various biological activities related to the potential therapy of neurodegenerative and anti-invasive diseases. Substances isolated in sufficient quantities are used to prepare derivatives to expand the portfolio of tested substances. Structures of compounds that have interesting biological activity but are present in plant material in low concentrations are used as lead structures for the synthesis of compounds whose structures are based on these substances.

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Members of the group

  • in a greenhouse of the Garden of Medicinal Plants, Faculty of Pharmacy in Hradec Králové, Charles University.

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From the left side: Lubomír Opletal, Rozálie Peřinová, Jaroslav Jenčo, Jakub Chlebek, Abdullah Al Mamun, Aneta Ritomská, Eliška Kohelová, Viriyanata Wijaya, Lenka Tůmová, a column, Rudolf Vrabec, Daniela Suchánková, Filip Pidaný, Anna Hošťálková, Marcela Šafratová, Tomáš Siatka, Lucie Cahlíková (the head of the group), Petra Němcová, and Kateřina Breiterová. Other members of the group, Jiří Janoušek and Negar Maafi were not present.

Doctoral students of the group

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From the left side: Aneta Ritomská, Filip Pidaný, Viriyanata Wijaya, Abdullah Al Mamun, Rozálie Peřinová, Rudolf Vrabec, and Eliška Kohelová.

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