ADINACO Research Group

The research group (Alzheimer’s DIsease and NAtural COmpounds) deals with a wider study of substances isolated from plants and fungi of the Eumycota division from the point of view of their effects on patophysiological processes influencing the development of the Alzheimer’s disease. The group carries out isolation and identification of substances, determination of biological activity on a wide group of enzymes in CNS. In cooperation with other workplaces the group prepares partial derivatives of substances, and deals also with the study of the possibility of using substances in Alzheimer disease prevention in the form of food additives.

Selected publications (2009 – 2020)


CAHLÍKOVÁ, L., KAWANO, I., ŘEZÁČOVÁ, M., BLUNDEN, G., HULCOVÁ, D., HAVELEK, R.: The Amaryllidaceae alkaloids haemanthamine, haemanthidine and their semisynthetic derivatives as potential drugs. Phytochem. Rev. (2020)

PEŘINOVÁ, R., MAAFI, M., KORÁBEČNÝ, J., KOHELOVÁ, E., DE SIMONE, A., AL MAMMUN, A., HULCOVÁ, D.,MARKOVÁ, J., KUČERA, T., JUN, D., ŠAFRATOVÁ, M., MAŘÍKOVÁ, J., ANDRISANO, V., JENČO, J., KUNEŠ, J., MARTINEZ, A., NOVÁKOVÁ, L., CAHLÍKOVÁ, L.: Functionalized aromatic esters of the Amaryllidaceae alkaloid haemanthamine and their in vitro and in silico biological activity connected to Alzheimer´s disease. Bioorg. Chem. 100, 103928 (2020).

KOUTOVA, D., MAAFI, M., HAVELEK, R., OPLETAL, L., BLUNDEN, G., ŘEZÁČOVÁ, M., CAHLÍKOVÁ, L.: Chemical and Biological Aspects of Montanine-Type Alkaloids Isolated from Plants of the Amaryllidaceae Family. Molecules 25, 2337 (2020).

MAŘÍKOVÁ, J., RITOMSKÁ, A., KORÁBEČNÝ, J., PEŘINOVÁ, R., AL MAMMUN, A., KUČERA, T., KOHELOVÁ, E., HULCOVÁ, D., KOBRLOVÁ, T., KUNEŠ, J., NOVÁKOVÁ, L., CAHLÍKOVÁ, L.: Aromatic Esters of the Crinane Amaryllidaceae Alkaloid Ambelline as Selective Inhibitors of Butyrylcholinesterase. J. Nat. Prod. 83, 1359-1367 (2020).

AL MAMMUN, A., MAŘÍKOVÁ, J., HULCOVÁ, D., JANOUŠEK, J., ŠAFRATOVÁ, M., NOVÁKOVÁ, L., KUČERA, T., HRABINOVÁ, M.,  KUNEŠ, J., KORÁBEČNÝ, J., CAHLÍKOVÁ, L: Amaryllidaceae alkaloids of belladine-type from Narcissus pseudonarcissus cv. Carlton as new selective inhibitors of butyrylcholinesterase. Biomolecules 10, 800 (2020).

BREITEROVÁ, K., KOUTOVÁ, D., HAVELEK, R., KUNEŠ, J., MAJOROŠOVÁ, M., OPLETAL, L., HOŠŤÁLKOVÁ, A., JENČO, J., ŘEZÁČOVÁ, M., CAHLÍKOVÁ, L.: Amaryllidaceae alkaloids of different structural types from Narcissus L. cv. Professor Einstein and their cytotoxic activity. Plants 9, 137, (2020).

AL SHAMMARI, L., AL MAMUN, A., KOUTOVÁ, D., MAJOROŠOVÁ, M., HULCOVÁ, D., ŠAFRATOVÁ, M., BREITEROVÁ, K. MAŘÍKOVÁ, J., HAVELEK, R., CAHLÍKOVÁ, L.: Alkaloid profiling of Hippeastrum Cultivars by GC-MS, isolation of Amaryllidaceae alkaloids and evaluation of their cytotoxicity. Rec. Nat. Prod. 14, 154-159 (2020).

KOUTOVA, D., KULHAVA, M., HAVELEK, R., MAJOROSOVA, M., KRALOVEC, K., HABARTOVA, K., HOSTALKOVA, A., OPLETAL, L., CAHLIKOVA, L., REZACOVA, M.: Bersavine: a novel bisbenzylisoquinoline alkaloid with cytotoxic, antiproliferative and apoptosis-inducing effect on human leukemic cells. Molecules 25, 964 (2020).


CAHLIKOVA, L., VANECKOVA, N., SAFRATOVA, M., BREITEROVA, K., BLUNDEN, G., HULCOVA, D., OPLETAL, L.: The Genus Nerine Herb. (Amaryllidaceae): Ethnobotany, Phytochemistry, and Biological Activity. Molecules 24, 4238 (2019).

HULCOVÁ, D., MAŘÍKOVÁ, J., KORÁBEČNÝ, J., HOŠŤÁLKOVÁ, A., JUN, D., KUNEŠ, J. CHLEBEK, J., OPLETAL, L., DE SIMONE, A., NOVAKOVA, L., ANDRISANO, V., RŮŽIČKA, A., CAHLÍKOVÁ, L.: Amaryllidaceae alkaloids from Narcissus pseudonarcissus L. cv. Dutch Master as potential drugs in treatment of Alzheimer's disease. Phytochemistry 165, 112055, (2019).

CHLEBEK, J., KORÁBEČNÝ, J., DOLEŽAL, R., ŠTĚPÁNKOVÁ, Š., PÉREZ, D.I., HOŠŤÁLKOVÁ, A., OPLETAL, L., CAHLÍKOVÁ, L., MACÁKOVÁ, K., KUČERA, T., HRABINOVÁ, M., JUN, D.: In vitro and in silico acetylcholinesterase inhibitory activity of thalictricavine and canadine and their predicted penetration across the blood-brain barrier. Molecules 24, 1340 (2019).

KOHELOVÁ, E., PEŘINOVÁ, R., MAAFI, N., KORABEČNÝ, J., HULCOVÁ, D., MAŘÍKOVÁ, J., KUČERA, T., GONZÁLEZ, L.M., HRABINOVÁ, M., VORČÁKOVÁ, K., NOVÁKOVÁ, L.,  DE SIMONE, A., HAVELEK, R., CAHLÍKOVÁ, L. Derivatives of the β-crinane Amaryllidaceae alkaloid haemanthamine as multi-target directed ligands for Alzheimer’s disease. Molecules 24, 1307 (2019).

HOSTALKOVA, A., MARIKOVA, J., OPLETAL, L., KORABECNY, J., HULCOVA, D., KUNES, J., NOVAKOVA, L., PEREZ, D.I, JUN, D., KUCERA, T., ANDRISANO, V., CAHLIKOVA, L. Isoquinoline alkaloids from Berberis vulgaris as potential lead compounds for the treatment of Alzheimer’s disease. J. Nat. Prod. 82, 239-248 (2019).


BREITEROVÁ, K., LOČÁREK, M., KOHELOVÁ, E., TALACKOVÁ, M., HULCOVÁ, D., OPLETAL, L., CAHLÍKOVÁ, L.: Daffodils as potential crops of biologically-active compounds: Assesment of 40 ornamental taxa for their alkaloid profile and cholinesterase inhibition activity. Nat. Prod. Commun. 13, 419-422 (2018). 

ŠAFRATOVÁ, M., HOŠŤÁLKOVÁ, A., HULCOVÁ, D., BREITEROVÁ, K., HRABCOVÁ, V., MACHADO, M., FONTINHA, D., PRUDENCIO, M., KUNEŠ, J., CHLEBEK, J., JUN, D., HRABINOVÁ, M., NOVÁKOVÁ, L., HAVELEK, R., SEIFERTOVÁ, M., OPLETAL, L., CAHLÍKOVÁ, L: Alkaloids from Narcissus poeticus cv. Pink Parasol of various structural types and their biological activity. Arch. Pharm. Res. 41, 208-218 (2018). 

HABARTOVÁ, K., HAVELEK, R., SEIFERTOVÁ, M., KRÁLOVEC, K., CAHLÍKOVÁ, L., CHLEBEK, J., ČERMÁKOVÁ, E., MAZÁNKOVÁ, N., MAŘÍKOVÁ, J., KUNEŠ, J., NOVÁKOVÁ, L., ŘEZÁČOVÁ, M.: Scoulerine affects microtubule structure, inhibits proliferation, arrests cell cycle and thus culminates in the apoptotic death of cancer cells. Sci. Reports 8, article number: 4829 (2018).

HULCOVÁ, D., BREITEROVÁ, K., SIATKA, T., KLÍMOVÁ, K., DAVANI, L., ŠAFRATOVÁ, M., HOŠŤÁLKOVÁ, A., DE SIMONE, A., ANDRISANO, A., CAHLÍKOVÁ, L.: Amaryllidaceae alkaloids as potential glycogen synthase kinase-3 beta inhibitors. Molecules 23, article number: 719 (2018).


HAVELEK, R., MUTHNA, D., TOMSIK, P., KRALOVEC, K., SEIFRTOVÁ, M., CAHLÍKOVÁ, L., HOŠŤÁLKOVÁ, A., ŠAFRATOVÁ, M., PERWEIN, M., ČERMÁKOVÁ, E.,  ŘEZÁČOVÁ, M.: Anticancer potential of Amaryllidaceae alkaloids evaluated by a screening with a panel of human cells, real-time cellular analysis and Ehrlich tumor-bearing mice.  Chem. Biol. Interact. 275, 121-132 (2017).

SEIFRTOVÁ, M., HAVELEK ,R., CAHLÍKOVÁ, L., HULCOVÁ, D., MAZÁNKOVÁ, N., ŘEZÁČOVÁ, M.: Haemanthamine alters sodium butyrate-induced histone acetylation, p21WAF1/Cip1 expression, Chk1 and Chk2 activation leading to increased growth inhibition and death in A2780 ovarian cancer cells. Phytomedicine 35, 1-10 (2017).

HAVELEK ,R., SEIFRTOVA, M., KRALOVEC, K., HABARTOVA, Klara., CAHLIKOVA, L., REZACOVA, M.: Chelidonine and homochelidonine induce cell death through cell cycle checkpoints and MAP kinase pathways. Nat. Prod. Commun. 12, 1419-1430 (2017).

SIATKA, T., ADAMCOVÁ, M., OPLETAL, L., CAHLÍKOVÁ, L.,  JUN, D., HRABINOVÁ, M., KUNEŠ, J., CHLEBEK, J.: Cholinesterase and prolyl oligopeptidase Inhibitory activities of alkaloids from Argemone platyceras (Papaveraceae). Molecules 22, 1181 (2017).

HULCOVÁ, D., BREITEROVÁ, K., ZEMANOVÁ, L., SIATKA, T., ŠAFRATOVÁ, M., VANĚČKOVÁ, N., HOŠŤÁLKOVÁ, A., WSÓL, V., CAHLÍKOVÁ, L.: Screening of AKR1C3 inhibitory potency of naturally occuring Amaryllidaceae alkaloids of different structural types. Nat. Prod. Commun. 12, 245-246 (2017).

OPLETAL, L., CHOCHOLOUŠOVÁ-HAVLÍKOVÁ, L., SIATKA, T., CAHLÍKOVÁ, L., LOČÁREK, M., BADRELDIN, H. A., MANOJ, P., RAMKUMAR, A., Al SULEIMANI, Y. M., AL ZA‘ABI, M., KARACA, T., NEMMAR, A.: Preparation and validated analysis of anthocyanin concentrate from the calyces of Hibiscus sabdariffa. Nat. Prod. Commun. 12, 43-45 (2017).

ALI, B. H., CAHLÍKOVÁ, L., OPLETAL, L., KARACA, T., MANOJ, P., RAMKUMAR, A., AL SULEIMANI Y. M., AL ZA'ABI, M., NEMMAR, A., CHOCHOLOUŠOVÁ-HAVLÍKOVÁ, L., LOČÁREK, M., SIATKA, T., BLUNDEN, G.: Effect of aqueous extract and anthocyanins of calces of Hibiscus sabdariffa (Malvaceae) in rats with adenine-induced chronic kidney disease. J. Pharm. Pharmacol. 69, 1219-1229 (2017).

TŮMOVÁ, L., DOLEČKOVÁ, I., HENDRYCHOVÁ, H., KAŠPAROVÁ, M.: Arbutin content and tyrosine activity of Bergenia extracts. Nat. Prod. Commun. 12, 549 -552 (2017).

TŮMOVÁ, L., DUČAIOVÁ, Z., CHEEL, J., VOKŘÁL, I., SEPÚLVEDA, B., VOKURKOVÁ, D.: Azorella compacta infusion activates human immune cells and scavenges free radicals in vitro. Pharmacogn. Mag. 13, 260-264, (2017).

KAŠPAROVÁ, T., MARTIN, J., TŮMOVÁ, L., SPILKOVÁ, J.: Production of podophyllotoxin by plant tissue cultures of Juniperus virginiana. Nat Prod. Commun. 12, 101-103 (2017).


HABARTOVÁ, K., CAHLÍKOVÁ, L., ŘEZÁČOVÁ M., HAVELEK, R.: The biological activity of alkaloids from the Amaryllidaceae: from cholinesterases inhibition to anticancer activity. Nat. Prod. Commun., accepted manuscript.

VANĚČKOVÁ, N., HOŠŤÁLKOVÁ, A., ŠAFRATOVÁ, M., KUNEŠ, J., HULCOVÁ, D., HRABINOVÁ, H., DOSKOČIL, I., ŠTĚPÁNKOVÁ, Š., OPLETAL, L., NOVÁKOVÁ, L., JUN, D., CHLEBEK, J., CAHLÍKOVÁ, L.: Alkaloids from Nerine bowdenii W. Watson (Amaryllidaceae) and their biological activity. RSC Advances 6, 80114-80120 (2016).

DOSKOČIL, I., HAVLÍK, J., VERLOTTA, R., TAUCHEN, J., VESELA, L., MACAKOVA, K., OPLETAL, L., KOKOSKA, L., RADA, V.: In vitro immunomodulatory activity, cytotoxicity and Chemistry of some central European polypores.  Pharm. Biol. 54, 2369-2376 (2016).

HAVELEK, R., SEIFERTOVÁ, M., KRÁLOVEC, K., KROCOVÁ, E., TEJKALOVÁ, V., NOVOTNÝ, I., CAHLÍKOVÁ, L., ŠAFRATOVÁ, M., OPLETAL, L., BÍLKOVÁ, Z., VÁVROVÁ, J., ŘEZÁČOVÁ, M.: Homochelidonine, the dimethoxy analogue of chelidonine isolated from Chelidonium majus L. (Papaveraceae), decreases proliferation via G1 and G2/M cell cycle arrest and induces cell death through apoptosis. Phytomedicine  23, 253-266 (2016).

HROCH, M., HAVELEK, R., CAHLÍKOVÁ, L., HOŠŤÁLKOVÁ, A., HULCOVÁ, D., CERMANOVÁ, J., MIČUDA, S.: LC-MS/MS method for determination of haemanthamine in rat plasma, bile and urine: application to a pilot pharmacokinetic study. Biomed. Chrom. 30, 1083-1091 (2016).

CHLEBEK, J., DOSKOČIL, I., HULCOVÁ, D., BREITEROVÁ, K., ŠAFRATOVÁ, M., HAVELEK, R., HABARTOVÁ, K., HOŠŤÁLKOVÁ, A., VOLŠTÁTOVÁ, T., CAHLÍKOVÁ, L.: Cytotoxicity of naturally occurring isoquinoline alkaloids of different structural types. Nat. Prod. Commun11, 753-756 (2016).

CHLEBEK, J., NOVÁK, Z., KASSEMOVÁ, D., ŠAFRATOVÁ, M., KOSTELNÍK, J., MALÝ, L., LOČÁREK, M., OPLETAL, L., HOŠŤÁLKOVÁ, A., HRABINOVÁ, M., KUNEŠ, J., NOVOTNÁ, P., URBANOVÁ, M., NOVÁKOVÁ, L., MACÁKOVÁ, K., HULCOVÁ, D., SOLICH, P., MARTÍN, C.P., JUN, D., CAHLÍKOVÁ, L..: Isoquinoline alkaloids from Fumaria officinalis L. and their biological activities related to Alzheimer’s disease. Chem. Biodivers. 13, 91-99 (2016).

CHLEBEK, J., DE SIMONE, A., HOŠŤÁLKOVÁ, A., OPLETAL, L., PERÉZ, C., PERÉZ, D.I., HAVLÍKOVÁ, L., CAHLÍKOVÁ, L., ANDRISANO, V.: Application of BACE1 immobilized enzyme reactor for the characterization of multifunctional alkaloids from Corydalis cava (Fumariaceae) as Alzheimer’s disease targets. Fitoterapia 109, 241-247 (2016).


DOSKOČIL, I., HOŠŤÁLKOVÁ, A., ŠAFRATOVÁ, M., BENEŠOVÁ, N., HAVLÍK, J., HAVELEK, R., KUNEŠ, J., KRÁLOVEC, K., CHLEBEK, J., CAHLÍKOVÁ, L.: Cytotoxic activities of Amaryllidaceae alkaloids against gastrointestinal cancer cells. Phytochem. Lett. 13, 394-398 (2015).

NOVÁK, Z., HOŠŤÁLKOVÁ, A., OPLETAL, L., NOVÁKOVÁ, L., HRABINOVÁ, M., KUNEŠ, J., CAHLÍKOVÁ, L.: (+)-Chenabinol (revised NMR data) and two new alkaloids from Berberis vulgaris L. and their biological activity. Nat. Prod. Commun. 10, 1695-1697 (2015). 

CAHLÍKOVÁ, L., PÉREZ, D.I., ŠTĚPÁNKOVÁ, Š, CHLEBEK, J., ŠAFRATOVÁ, M., HOŠŤÁLKOVÁ, A., OPLETAL, L.: In vitro inhibitory effects of 8-O-Demethylmaritidine and undulatine on acetylcholinesterase, and their predicted penetration across the blood-brain barrier. J. Nat. Prod. 78, 1189-1192 (2015).

HOŠŤÁLKOVÁ, A., OPLETAL, L., KUNEŠ, J., NOVÁK, Z., HRABINOVÁ, M., CHLEBEK, J., CAHLÍKOVÁ, L.: Alkaloids from Peumus boldus Mol. and their acetylcholinesterase, butyrylcholinesterase and prolyl oligopeptidase inhibition activity. Nat.. Prod. Commun. 10, 577-580 (2015).

CAHLÍKOVÁ, L., HULOVÁ, L., HRABINOVÁ, M., CHLEBEK, J., HOŠŤÁLKOVÁ, A., ADAMCOVÁ, M., ŠAFRATOVÁ, M., JUN, D., OPLETAL, L., LOČÁREK, M., MACÁKOVÁ, K.: Isoquinoline alkaloids as potential prolyl oligopeptidase inhibitors. Fitoterapia 103, 192-196 (2015).

CAHLÍKOVÁ, L., ALI B.H., HAVLÍKOVÁ L., LOČÁREK, M., SIATKA, T., OPLETAL, L., BLUNDEN, G.: Anthocyanins of Hibiscus sabdiffera Calyces from Sudan. Nat. Prod. Commun.  10, 77-79 (2015).


MACÁKOVÁ, K., KOLEČKÁŘ, V., CAHLÍKOVÁ, L., CHLEBEK, J., HOŠŤÁLKOVÁ, A., KUČA, K., JUN, D., OPLETAL, L.: Tannins and their influence on health. Recent Advances in Medicinal Chemistry. Bentham Science Publishers 1, 159-208 (2014).

CAHLÍKOVÁ, L., MACÁKOVÁ, K., BENEŠOVÁ, N., CHLEBEK, J., HOŠŤÁLKOVÁ, A., OPLETAL, L.: Natural Componuds (Small Molecules) as Potential and Real Drugs of Alzheimer´s Disease: A Critical Review, in: Studies in Natural Products Chemistry (ATTA-ur-RAHMAN, ed.), Chapter 6, Elsevier: Amsterdam 2014, pp. 153-194, ISBN: 978-0-44

OPLETAL, L., LOČÁREK, M., FRAŇKOVÁ, A., CHLEBEK, J., ŠMÍD, J., HOŠŤÁLKOVÁ, A., ŠAFRATOVÁ, M., HULCOVÁ, D., KLOUČEK P., ROZKOT, M., CAHLÍKOVÁ, L.: Antimicrobial activity of extracts and isoquinoline alkaloids of selected Papaveraceae plants. Nat. Prod. Commun. 9, 1709-1712 (2014).

ŠKARYDOVÁ, L., HOFMAN, J., CHLEBEK, J., HAVRÁNKOVÁ, J., KOŠANOVÁ, K., SKARKA, A., HOŠŤÁLKOVÁ, A., PLUCHA, T., CAHLÍKOVÁ, L., WSÓL, V.: Isoquinoline alkaloids as a novel type of AKR1C3 inhibitors. J. Steroid Biochem. Mol. Biol. 143, 250-258 (2014).

SCHRAMM, A., JÄHNE, E., BABURIN, I., HERING, S., CAHLÍKOVÁ, L., CHLEBEK, J., HAMBURGER, M.: Natural products as potential hERG channel inhibitors –  screening of plant-derived alkaloids. Planta Med. 80, 740-746 (2014).

ŠAFRATOVÁ, M., NOVÁK, Z., KULHÁNKOVÁ, A., KUNEŠ, J., HRABINOVÁ, M., JUN, D., MACÁKOVÁ, K., OPLETAL, L., CAHLÍKOVÁ, L.: Revised NMR data for 9-O-demethylgalanthine: an alkaloid from Zephyranthes robusta (Amaryllidaceae) and its biological activity. Nat. Prod. Commun. 9, 787-788 (2014).

HAVLASOVÁ, J., ŠAFRATOVÁ, M., SIATKA T., ŠTĚPÁNOVÁ, Š., LOČÁREK, M., OPLETAL, L., HRABINOVÁ, M., JUN, D., BENEŠOVÁ, N., NOVÁK, Z., KUNEŠ, J., CAHLÍKOVÁ, L.: Chemical composition of bioactive alkaloid extracts from some Narcissus species and varieties and their biological activity. Nat. Prod. Commun. 9, 1151-1155 (2014).

HAVELEK, R., SEIFERTOVÁ, M., KRÁLOVEC, K., BRŮČKOVÁ, L., CAHLÍKOVÁ, L., DALECKÁ, M., VÁVROVÁ, J., ŘEZÁČOVÁ, M., OPLETAL, L., BÍLKOVÁ, Z.: The effect of Amaryllidaceae alkaloids haemanthamine and haemanthidine on cell cycle progression and apoptosis in p53-negative human leukemic Jurkat cell. Phytomedicine 21, 479-490 (2014).

ŘEHÁKOVÁ, Z., KOLEČKÁŘ, V., JAHODÁŘ, L., OPLETAL, L., MACÁKOVÁ, K., CAHLÍKOVÁ, L., JUN, D., KUČA, K.: Evaluation of the antioxidants activity of several naturally occuring coumarins and their synthesized analouges by „ferric reducing antioxidant power“ assay. J. Enzyme Inhib. Med. Chem. 29, 49-54 (2014).


CAHLÍKOVÁ, L., HRABINOVÁ, M., KULHÁNKOVÁ, A., BENEŠOVÁ, N., CHLEBEK, J., JUN, D., NOVÁK, Z., KUČA, K., MACÁKOVÁ, K., OPLETAL, L. Alkaloids from Chlidanthus fragrans Herb. and their acetylcholinesterase, butyrylcholinesterase and prolyl oligopeptidase inhibition activity. Nat. Prod. Commun. 8, 1541-1544 (2013).

CAHLÍKOVÁ, L., LOČÁREK, M., BENEŠOVÁ, N., KUČERA, R., CHLEBEK, J., NOVÁK, Z., OPLETAL, L.: Isolation and cholinesterase inhibitory activity of Narcissus extracts and Amaryllidaceae alkaloid. Nat. Prod. Commun. 8, 781-785 (2013).

HOŠŤÁLKOVÁ, A., NOVÁK, Z., POUR, M., JIROŠOVÁ, A., OPLETAL, L., KUNEŠ, J., CAHLÍKOVÁ, L.: Berbanine: a new isoquinoline alkaloid from Berberis vulgaris (Berberidaceae). Nat. Prod. Commun. 8, 441-442 (2013).

KULHÁNKOVÁ, A., CAHLÍKOVÁ, L., NOVÁK, Z., MACÁKOVÁ, K., KUNEŠ, J., OPLETAL, L.: Alkaloids from Zephyranthes robusta Baker and their acetylcholinesterase and butyrylcholinesterase inhibition activity. Chem. Biodivers. 10, 1120-1127 (2013).

DALECKÁ, M., HAVELEK, R., KRALOVEC, K., BRUČKOVÁ, L., CAHLÍKOVÁ, L.: Amaryllidaceae family alkaloids as potential drugs for cancer treatment. Chem. listy 107, 701-708 (2013).


NOVÁK, Z., CHLEBEK, J., OPLETAL, L., JIROŠ, P., MACÁKOVÁ, K., KUNEŠ, J., CAHLÍKOVÁ, L.: Corylucinine, a new Alkaloid from Corydalis cava (Fumariaceae), and its Cholinesterase Activity. Nat. Prod. Commun. 7, 859-860 (2012).

CAHLÍKOVÁ, L., KUČERA, R., HOŠŤÁLKOVÁ, A., KLIMEŠ, J., OPLETAL, L.: Identification of pavinane alkaloids in the genera Argemone and Eschscholzia by GC-MS. Nat. Prod. Commun. 7, 1279-1281 (2012).

CAHLÍKOVÁ, L., BENEŠOVÁ, N., MACÁKOVÁ, K., KUČERA, R., HRSTKA, V., KLIMEŠ, J., JAHODÁŘ, L., OPLETAL, L.: Alkaloids of some Amaryllidaceae species and their cholinesterase activity. Nat. Prod. Commun. 7, 571-574 (2012).


CAHLÍKOVÁ, L., MACÁKOVÁ, K., ZAVADIL, S., JIROŠ, P., OPLETAL, L., URBANOVÁ, K., JAHODÁŘ, L.: Analysis of Amaryllidaceae alkaloids from Chlidanthus fragrans and their cholinesterase activity. Nat. Prod. Commun. 6, 603-606 (2011).

CAHLÍKOVÁ, L., VALTEROVÁ, I., MACÁKOVÁ, K., OPLETAL, L.: Analysis of Amaryllidaceae alkaloids from Zephyranthes grandiflora Lindl. by GC/MS and their cholinesterase activity. Rev. Brasil. Farmacogn. 21, 575-580 (2011).

CAHLÍKOVÁ, L., ZAVADIL, S., MACÁKOVÁ, K., VALTEROVÁ, I., KULHÁNKOVÁ, A., HOŠŤÁLKOVÁ, A., KUNEŠ, J., OPLETAL, L.: Isolation and cholinesterase activity of Amaryllidaceae alkaloids from Nerine bowdenii. Nat. Prod. Commun. 6, 1827-1830 (2011).

CHLEBEK, J., MACÁKOVÁ, K., CAHLÍKOVÁ, L., KURFÜRST, M., KUNEŠ, J, OPLETAL, L.: Acetylcholinesterase and butyrylcholinesterase inhibitory compounds from Corydalis cava Schweigger. & Korte (Fumariaceae). Nat. Prod. Commun. 6, 607-610 (2011).


CAHLÍKOVÁ, L., KULHÁNKOVÁ, A., URBANOVÁ, K., VALTEROVÁ, I., MACÁKOVÁ, K., KUNEŠ, J.: Analysis of Amaryllidaceae Alkaloids from Zephyranthes robusta by GC-MS and Their Cholinesterase Activity. Nat. Prod. Commun. 5, 1201-1204 (2010).

CAHLÍKOVÁ, L., MACÁKOVÁ, K., KUNEŠ, J., KURFÜRST, M., OPLETAL, L., CVAČKA, J., CHLEBEK, J., BLUNDEN, G.: Acetylcholinesterase and butyrylcholinesterase inhibitory compounds from Eschscholzia californica (Papaveraceae). Nat. Prod. Commun. 5, 1035-1038 (2010).

CAHLÍKOVÁ, L., OPLETAL, L., KURFÜRST, M., MACÁKOVÁ, K., KULHÁNKOVÁ, A., HOŠŤÁLKOVÁ, A.: Acetylcholinesterase and butyrylcholinesterase inhibitory compounds from Chelidonium majus (Papaveraceae). Nat. Prod. Commun. 5, 1751-1754 (2010).

MACÁKOVÁ, K., OPLETAL, L., POLÁŠEK, M., SAMKOVÁ, V.: Free-radical scavenging activity of some european Polyporales. Nat. Prod. Commun. 5, 923-926 (2010).

OPLETAL, L.: Přírodní látky a jejich biologická aktivita. Sv. 1. Nutraceutika. Primární metabolity a látky obsažené ve strukturovaných biologických systémech (Natural Compounds and Their Biological Activity, Vol. 1. Nutraceutics. Primary Metabolites and Compounds Contained in Structured Biological Systems). Karolinum, Praha 2010, ISBN 978-80-246-1884-5, 378 pp.


MACÁKOVÁ, K., OPLETAL, L., POLÁŠEK, M., SAMKOVÁ, V., JAHODÁŘ, L.: Free-radical scavenging activity of some European Boletales. Nat. Prod. Commun. 4, 261-264 (2009).

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