Ing. Galina Karabanovich, PhD.

Born: October 26, 1985, Saint-Petersburg, Russian Federation.

Education, Academic and Scientific Degrees:

2014 – PhD in Bioorganic chemistry (Faculty of Pharmacy, Charles University, Czech Republic), 2009 – Engineer (Faculty of Chemical and Biotechnology, Saint-Petersburg State Institute of Technology (Technical University), Russian Federation)

Working Experience:

Since 2014 – Research fellow (FaF UK, Department of Organic and Bioorganic Chemistry)

Research Interests

Synthesis of dexrazoxane analogues; Design and synthesis of compounds with potential antimycobacterial activity; Study of the relationships between structure and antimycobacterial activity of prepared substances.

Teaching

Since 2016 – teaching of Chemical Laboratory Techniques (practical classes) and Organic Chemistry (seminars) (Czech language, FaF UK)

Memberships in Scientific Societies:

Czech Chemical Society

Selected Posters at Conferences

  • Gordon Research Conference: Tuberculosis Drug Discovery & Development, June, 25-30, 2017, Lucca, Italy
  • Conference „Tuberculosis 2016: “Interdisciplinary research on tuberculosis and pathogenic mycobacteria“, September, 19-23, 2016, Paris, France.
  • Gordon Research Seminar and Conference: Tuberculosis Drug Discovery & Development, July, 1-17, 2015, Girona, Spain.

Grant Projects

As a principal investigator GAUK 55610/2010: „Synthesis and properties of selenium analogs of sulfur-containing compounds with antimycobacterial activity’’ (2009-2011)

As a co-investigator: GA ČR (2x), PRVOUK (1x), EU-funded projects Pre-Seed I and Pre-Seed II

Publications and Citations (in total):

  • Number of publications in WoS/Scopus: 9/9
  • Number of citations in WoS/Scopus – total 47/41, without self-citations 34/26.
  • H-index in WoS/Scopus (with self-citations) = 5/4.

Patents and patent applications:

– 6 Czech patents/patent applications; 2 PCT patent applications

Summary of Publications (in last 5 years, 2012-2017):

in WoS/Scopus: 7/7, cumulative IF (summa IF) = 26.53, average IF = 3.79.

Summary of all publications:

  1. Němeček J., Sychra P., Macháček M., Benková M., Karabanovich G,. Konečná K., Kavková V., Stolaříková J., Hrabálek A., Vávrová K., Soukup O., Roh J., Klimešová V., Structure-activity relationship studies on 3,5-dinitrophenyl tetrazoles as antitubercular agents. Eur. J. Med. Chem. 2017; 130: 419-432. (IF 2016: 4.519)
  2. Karabanovich G., Nemecek J., Valaskova L., Carazo A., Konecna K., Stolarikova J., Hrabalek A., Pavlis O., Pavek P., Vavrova K., Roh J., Klimesova V. S-substituted 3,5-dinitrophenyl 1,3,4-oxadiazole-2-thiols and tetrazole-5-thiols as highly efficient antitubercular agents.  Eur. J. Med. Chem. 2017; 126: 369-383 (IF 2016: 4.519).
  3. Roh J., Karabanovich G., Novakova V., Simunek T., Vavrova K. Large-Scale Synthesis of Piperazine-2,6-dione and Its Use in the Synthesis of Dexrazoxane Analogues. Synthesis. 2016; 48(24): 4580-4588 (IF 2015: 2.650).
  4. Karabanovich G., Zemanová J., Smutný T., Székely R., Šarkan M., Centárová I., Vocat A., Pávková I., Čonka P., Němeček J., Stolaříková J., Vejsová M., Vávrová K., Klimešová V., Hrabálek A., Pávek P., Cole S. T., Mikušová K., Roh J., Development of 3,5-Dinitrobenzylsulfanyl-1,3,4-Oxadiazoles and Thiadiazoles as Selective Antitubercular Agents Active Against Replicating and Nonreplicating Mycobacterium tuberculosis. J. Med. Chem. 2016; 59 (6): 2362-2380 (IF 2016: 6.259).
  5. Karabanovich G., Roh J., Soukup O., Pávková I., Pasdiorová M., Tambor V., Stolaříková J., Vejsová M., Vávrová K., Klimešová V., Hrabálek A., Tetrazole Regioisomers in the Development of Nitro Group-Containing Antitubercular Agents. Med. Chem. Commun. 2015; 6: 174–181 (IF 2015: 2.319).
  6. Karabanovich G., Roh J., Smutný T., Něměcek J., Vicherek P., Stolaříková J., Vejsová M., Dufková I., Vávrová K., Pávek P., Klimešová V., Hrabálek A., 1-Substituted-5-[(3,5-dinitrobenzyl)sulfanyl]-1H-tetrazoles and their isosteric analogs: A new class of selective antitubercular agents active against drug-susceptible and multidrug-resistant mycobacteria. Eur. J. Med. Chem. 2014; 82: 324-340 (IF 2014: 3.447).
  7. Karabanovich G., Roh J., Padělková Z., Novák Z., Vávrová K., Hrabálek A. One-pot synthesis of 1-substituted-5-alkylselanyl-1H-tetrazoles from isoselenocyanates: Unexpected formation of N-alkyl-N-arylcyanamides and (Z)-Se-alkyl-N-cyano-N,N’-diarylisoselenoureas. Tetrahedron. 62013; 69: 8798-8808 (IF 2013: 2.817).
  8. Efimova Y. A., Karabanovich, G., Artamonova T. V., Koldobskii G. I. Tetrazoles: LV. Perparation of 2-Anilino-5-aryl(hetaryl)-1,3,4-oxadiazoles from 5-Substituted Tetrazoles under Microwave Activation. Rus. J. Org. Chem. 2009; 45 (8): 1241-1243 (IF 2009: 0.525).
  9. Efimova Y. A., Karabanovich G., Artamonova T. V., Koldobskii G. I. Microwave-assisted synthesis of 2-aryl(hetaryl)-5-phenylamino-1,3,4-thiadiazoles from 5-substituted tetrazoles. Rus. J. Org. Chem. 2009; 45 (4): 631-632 (IF 2009: 0.525).

© 2017 Charles University, Faculty of Pharmacy in Hradec Králové, Akademika Heyrovského 1203, 500 05 Hradec Králové, Czech Republic
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